GREMLIN Database
HEM3 - Probable porphobilinogen deaminase
UniProt: Q980U4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (284)
Sequences: 3517 (2310)
Seq/√Len: 137.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
211_T216_L4.3821.00
149_R153_S4.0141.00
6_A69_A3.3031.00
4_L34_I3.2981.00
96_D167_K3.0341.00
21_G25_R2.9071.00
94_E212_H2.8981.00
9_G35_D2.7741.00
191_I219_A2.5931.00
116_T138_K2.5141.00
163_E177_R2.4601.00
254_Y258_K2.4041.00
197_R200_D2.3951.00
152_L174_S2.3561.00
9_G37_K2.2931.00
23_K26_K2.2661.00
86_E198_K2.1121.00
88_E198_K2.0961.00
125_K129_K2.0961.00
228_V280_L2.0511.00
249_Y264_S2.0301.00
138_K156_Y2.0211.00
144_V169_L2.0161.00
43_F46_E2.0081.00
116_T136_N1.9851.00
107_N110_K1.9591.00
11_K145_D1.9551.00
212_H215_T1.9221.00
5_I21_G1.9141.00
140_I159_L1.8981.00
263_V278_L1.8971.00
265_I281_L1.8941.00
88_E204_K1.8791.00
247_E266_S1.8741.00
90_F196_G1.8681.00
62_E66_E1.8541.00
61_N195_L1.8321.00
18_D22_E1.8171.00
93_I192_I1.8031.00
76_M188_N1.7981.00
216_L220_L1.7591.00
225_T250_G1.7201.00
19_M23_K1.6991.00
27_I209_E1.6861.00
263_V281_L1.6771.00
17_V33_V1.6561.00
91_A211_T1.6511.00
14_R35_D1.6081.00
65_L87_L1.6071.00
37_K42_L1.5911.00
270_D273_T1.5881.00
69_A72_A1.5881.00
279_G283_K1.5791.00
179_N182_D1.5781.00
280_L284_K1.5621.00
187_A239_V1.5251.00
131_I182_D1.5171.00
275_G279_G1.5071.00
7_A33_V1.5051.00
201_E205_E1.4911.00
283_K286_M1.4851.00
18_D21_G1.4841.00
63_A68_K1.4781.00
218_E243_K1.4771.00
145_D171_I1.4651.00
271_P275_G1.4621.00
196_G204_K1.4611.00
23_K27_I1.4481.00
129_K137_T1.4421.00
200_D203_V1.4411.00
92_V191_I1.4371.00
281_L285_E1.4351.00
263_V285_E1.4231.00
275_G283_K1.4221.00
25_R30_E1.4211.00
109_H182_D1.4201.00
99_Y177_R1.4181.00
247_E264_S1.4151.00
238_G251_I1.4071.00
21_G31_Y1.4001.00
228_V276_S1.3981.00
4_L32_D1.3971.00
220_L272_Y1.3941.00
99_Y163_E1.3861.00
279_G286_M1.3561.00
90_F204_K1.3471.00
265_I278_L1.3451.00
117_I158_G1.3421.00
167_K172_S1.3261.00
76_M193_V1.3111.00
271_P274_I1.3031.00
221_A248_F1.3021.00
97_P163_E1.2981.00
213_K217_D1.2961.00
101_I163_E1.2841.00
15_V19_M1.2711.00
22_E26_K1.2581.00
217_D268_A1.2581.00
275_G286_M1.2461.00
249_Y262_T1.2311.00
125_K139_D1.2301.00
103_I148_I1.2221.00
156_Y159_L1.2131.00
242_R249_Y1.2121.00
253_S260_K1.2111.00
178_L183_F1.2101.00
138_K155_E1.2091.00
5_I71_V1.2051.00
34_I68_K1.1991.00
163_E167_K1.1981.00
3_I203_V1.1951.00
176_H182_D1.1810.99
203_V207_F1.1790.99
36_I60_V1.1780.99
17_V21_G1.1770.99
277_E281_L1.1750.99
89_I193_V1.1740.99
125_K137_T1.1710.99
276_S280_L1.1630.99
76_M219_A1.1610.99
150_K155_E1.1610.99
117_I128_I1.1580.99
28_G31_Y1.1520.99
111_L115_T1.1500.99
103_I166_I1.1480.99
244_E247_E1.1460.99
126_N253_S1.1380.99
214_D268_A1.1040.99
205_E208_K1.0920.99
36_I63_A1.0920.99
25_R31_Y1.0900.99
14_R18_D1.0890.99
109_H176_H1.0770.99
243_K268_A1.0770.99
225_T278_L1.0740.99
151_Y159_L1.0700.99
83_I195_L1.0650.99
242_R247_E1.0650.99
244_E266_S1.0610.99
107_N176_H1.0560.99
20_V93_I1.0500.99
22_E25_R1.0460.99
171_I174_S1.0440.99
44_S145_D1.0430.99
196_G207_F1.0390.99
265_I277_E1.0380.99
274_I283_K1.0310.99
130_Y260_K1.0280.99
47_P139_D1.0280.99
224_A228_V1.0200.99
273_T277_E0.9940.98
117_I135_I0.9930.98
9_G36_I0.9890.98
268_A271_P0.9890.98
4_L67_G0.9770.98
63_A69_A0.9740.98
144_V161_L0.9720.98
132_R135_I0.9710.98
128_I135_I0.9690.98
18_D33_V0.9660.98
282_L286_M0.9610.98
274_I286_M0.9570.98
172_S175_Y0.9570.98
5_I17_V0.9550.98
144_V171_I0.9550.98
5_I31_Y0.9500.98
272_Y276_S0.9490.98
61_N87_L0.9410.97
51_L55_V0.9370.97
184_T238_G0.9330.97
92_V219_A0.9320.97
225_T248_F0.9280.97
214_D218_E0.9270.97
109_H131_I0.9180.97
145_D149_R0.9110.97
39_K43_F0.9070.97
273_T276_S0.9050.97
87_L195_L0.9040.97
79_I193_V0.9030.97
46_E50_K0.9030.97
98_P240_L0.8920.97
228_V283_K0.8880.96
114_N135_I0.8710.96
248_F278_L0.8700.96
116_T156_Y0.8680.96
163_E175_Y0.8620.96
204_K208_K0.8530.96
115_T135_I0.8500.95
102_L105_E0.8480.95
70_D197_R0.8480.95
97_P167_K0.8470.95
167_K177_R0.8470.95
231_G237_I0.8450.95
53_K59_E0.8440.95
161_L165_S0.8390.95
24_L29_I0.8370.95
99_Y179_N0.8320.95
112_D115_T0.8250.95
191_I215_T0.8230.95
115_T132_R0.8230.95
130_Y262_T0.8180.94
34_I69_A0.8160.94
113_P134_E0.8130.94
88_E196_G0.8120.94
229_V237_I0.8120.94
39_K51_L0.8110.94
84_N87_L0.8020.94
113_P136_N0.8000.94
128_I137_T0.7960.94
272_Y275_G0.7930.93
108_L176_H0.7910.93
254_Y259_K0.7880.93
12_L144_V0.7860.93
271_P286_M0.7860.93
129_K136_N0.7860.93
217_D271_P0.7840.93
7_A13_S0.7840.93
48_L55_V0.7810.93
184_T249_Y0.7800.93
97_P177_R0.7800.93
178_L182_D0.7780.93
251_I260_K0.7730.93
199_K204_K0.7720.92
9_G14_R0.7710.92
201_E204_K0.7700.92
105_E152_L0.7680.92
101_I166_I0.7660.92
3_I31_Y0.7660.92
215_T219_A0.7630.92
251_I262_T0.7610.92
76_M89_I0.7580.92
180_V240_L0.7560.92
281_L284_K0.7500.91
39_K59_E0.7470.91
184_T240_L0.7450.91
206_V209_E0.7430.91
3_I71_V0.7430.91
274_I279_G0.7400.91
126_N257_G0.7390.91
218_E241_F0.7360.91
21_G33_V0.7360.91
140_I156_Y0.7320.90
101_I175_Y0.7320.90
19_M192_I0.7290.90
99_Y180_V0.7290.90
57_E81_S0.7230.90
253_S262_T0.7230.90
102_L158_G0.7230.90
57_E87_L0.7200.90
76_M92_V0.7200.90
118_G156_Y0.7180.90
208_K211_T0.7180.90
67_G199_K0.7140.89
14_R33_V0.7140.89
229_V252_A0.7110.89
229_V250_G0.7080.89
214_D243_K0.7080.89
239_V248_F0.7070.89
270_D274_I0.7060.89
185_P240_L0.7050.89
265_I274_I0.7040.89
12_L96_D0.7030.89
81_S232_G0.7030.89
91_A207_F0.7030.89
85_P198_K0.7010.88
225_T282_L0.7000.88
6_A34_I0.6990.88
151_Y156_Y0.6970.88
127_F183_F0.6940.88
23_K94_E0.6940.88
39_K42_L0.6930.88
11_K15_V0.6920.88
81_S126_N0.6920.88
92_V216_L0.6910.88
225_T239_V0.6890.88
127_F184_T0.6890.88
61_N83_I0.6880.87
61_N64_V0.6870.87
19_M93_I0.6850.87
15_V18_D0.6840.87
7_A35_D0.6800.87
187_A226_I0.6780.87
95_R218_E0.6780.87
65_L86_E0.6780.87
115_T134_E0.6750.86
71_V207_F0.6740.86
24_L206_V0.6730.86
91_A196_G0.6690.86
227_S272_Y0.6680.86
111_L114_N0.6670.86
114_N132_R0.6660.86
102_L108_L0.6630.85
19_M22_E0.6600.85
17_V31_Y0.6520.84
61_N79_I0.6510.84
20_V194_V0.6510.84
29_I206_V0.6470.84
225_T279_G0.6460.84
58_K61_N0.6450.84
267_K270_D0.6450.84
232_G235_S0.6450.84
263_V282_L0.6440.84
20_V91_A0.6430.84
112_D132_R0.6410.83
64_V67_G0.6410.83
55_V231_G0.6410.83
15_V192_I0.6400.83
218_E242_R0.6360.83
87_L197_R0.6360.83
274_I278_L0.6360.83
4_L70_D0.6320.83
188_N191_I0.6320.83
18_D35_D0.6320.83
148_I152_L0.6310.83
51_L57_E0.6310.83
81_S226_I0.6310.83
230_G237_I0.6300.82
217_D275_G0.6300.82
217_D243_K0.6290.82
149_R152_L0.6260.82
24_L31_Y0.6250.82
250_G278_L0.6250.82
144_V165_S0.6180.81
53_K61_N0.6170.81
154_K158_G0.6160.81
227_S276_S0.6130.81
131_I134_E0.6130.81
25_R28_G0.6130.81
36_I145_D0.6100.80
277_E280_L0.6100.80
131_I178_L0.6090.80
246_K268_A0.6090.80
274_I277_E0.6080.80
71_V196_G0.6070.80
148_I151_Y0.6070.80
49_S234_H0.6060.80
47_P50_K0.6050.80
58_K65_L0.6050.80
9_G38_T0.6020.80
50_K234_H0.6010.79
20_V210_I0.6000.79
46_E49_S0.5950.79
271_P283_K0.5950.79
48_L52_G0.5940.79
271_P279_G0.5940.79
96_D162_A0.5910.78
246_K269_G0.5900.78
58_K63_A0.5900.78
17_V71_V0.5890.78
120_S139_D0.5880.78
254_Y257_G0.5870.78
60_V93_I0.5840.77
38_T59_E0.5840.77
181_Y249_Y0.5810.77
11_K169_L0.5790.77
217_D269_G0.5790.77
252_A257_G0.5760.76
164_A192_I0.5760.76
202_K205_E0.5750.76
96_D164_A0.5740.76
235_S252_A0.5730.76
108_L111_L0.5730.76
267_K271_P0.5700.76
160_I183_F0.5650.75
43_F51_L0.5630.75
269_G274_I0.5620.75
151_Y158_G0.5610.75
128_I160_I0.5590.74
42_L46_E0.5580.74
44_S122_I0.5570.74
214_D217_D0.5570.74
83_I87_L0.5550.74
205_E209_E0.5540.74
31_Y71_V0.5540.74
8_R12_L0.5530.74
118_G154_K0.5520.73
148_I166_I0.5520.73
6_A36_I0.5510.73
198_K204_K0.5510.73
44_S54_G0.5510.73
106_K157_D0.5510.73
15_V166_I0.5480.73
203_V206_V0.5480.73
64_V195_L0.5470.73
221_A239_V0.5450.72
43_F53_K0.5440.72
119_T125_K0.5440.72
53_K235_S0.5420.72
113_P132_R0.5400.72
184_T251_I0.5400.72
72_A185_P0.5400.72
113_P116_T0.5390.72
145_D169_L0.5370.71
43_F55_V0.5360.71
269_G275_G0.5360.71
129_K258_K0.5350.71
52_G122_I0.5340.71
280_L283_K0.5340.71
185_P241_F0.5300.70
82_E227_S0.5300.70
111_L132_R0.5280.70
75_S193_V0.5260.70
75_S194_V0.5250.70
50_K53_K0.5240.70
57_E60_V0.5200.69
4_L69_A0.5180.69
11_K18_D0.5180.69
58_K84_N0.5170.69
111_L117_I0.5150.68
234_H237_I0.5140.68
46_E51_L0.5120.68
36_I69_A0.5100.68
171_I175_Y0.5090.67
255_S259_K0.5090.67
39_K58_K0.5090.67
45_T51_L0.5080.67
232_G252_A0.5060.67
57_E188_N0.5060.67
224_A272_Y0.5050.67
111_L158_G0.5050.67
7_A17_V0.5050.67
127_F229_V0.5040.67
46_E234_H0.5030.66
104_A158_G0.5020.66
75_S162_A0.5010.66
18_D25_R0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gtkA 1 0.9454 100 0.057 Contact Map
4mlvA 1 0.9283 100 0.059 Contact Map
4htgA 2 0.9693 100 0.064 Contact Map
3ecrA 1 0.9488 100 0.066 Contact Map
4gotA 1 0.7065 97.2 0.928 Contact Map
3un6A 1 0.8464 97 0.93 Contact Map
4ef1A 1 0.7031 96.6 0.934 Contact Map
3l6gA 1 0.7509 96.5 0.935 Contact Map
4ib2A 1 0.7031 96.4 0.935 Contact Map
4qhqA 1 0.686 96.3 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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