GREMLIN Database
Q980U3 - Uroporphyrinogen III synthase, putative
UniProt: Q980U3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (224)
Sequences: 4402 (3358)
Seq/√Len: 224.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_L24_K3.9771.00
194_S200_T3.7271.00
123_R146_D3.4171.00
49_Y140_D3.4121.00
174_S202_T2.9061.00
200_T214_E2.7261.00
121_R141_E2.5731.00
116_S138_K2.5591.00
51_A76_Y2.4471.00
132_I135_G2.4011.00
178_K202_T2.3401.00
168_A193_F2.3221.00
77_A83_A2.2971.00
35_F148_E2.2391.00
49_Y118_L2.1961.00
35_F146_D2.1611.00
18_K22_L2.1351.00
50_E115_N2.0831.00
106_A132_I2.0731.00
177_A203_L1.9831.00
61_I85_L1.9471.00
33_P150_I1.9241.00
16_N28_E1.9071.00
150_I179_L1.8731.00
192_I208_N1.8611.00
54_F60_V1.8521.00
194_S203_L1.8201.00
194_S214_E1.7691.00
95_I108_R1.7651.00
85_L88_K1.7581.00
121_R125_A1.7491.00
75_I91_N1.7191.00
18_K221_K1.7101.00
34_I147_S1.7001.00
51_A74_K1.6701.00
51_A117_I1.6651.00
127_E131_N1.6411.00
22_L228_L1.6331.00
201_E204_K1.6321.00
200_T204_K1.6231.00
168_A227_I1.6171.00
181_G206_V1.6151.00
171_F180_I1.6081.00
5_F16_N1.6081.00
36_K62_C1.5771.00
102_S129_M1.5611.00
16_N26_G1.5611.00
101_T104_E1.5561.00
201_E205_R1.5511.00
43_S46_T1.5391.00
54_F63_F1.5241.00
34_I58_N1.5181.00
11_E58_N1.4971.00
116_S140_D1.4831.00
130_R134_N1.4691.00
99_R104_E1.4631.00
213_I226_T1.4561.00
193_F213_I1.4461.00
62_C144_V1.4341.00
192_I203_L1.4331.00
195_I199_T1.4271.00
76_Y105_L1.4231.00
218_H222_G1.4041.00
171_F177_A1.4011.00
4_L166_V1.3961.00
178_K206_V1.3821.00
33_P148_E1.3631.00
215_S222_G1.3391.00
196_G199_T1.3321.00
170_A223_I1.3301.00
130_R141_E1.3241.00
217_T222_G1.3241.00
202_T205_R1.3221.00
50_E116_S1.3081.00
103_I126_S1.2881.00
57_R81_E1.2861.00
123_R143_Y1.2771.00
172_T176_M1.2681.00
17_E21_I1.2651.00
131_N134_N1.2511.00
203_L210_V1.2491.00
77_A86_L1.2461.00
168_A191_I1.2421.00
171_F192_I1.2421.00
203_L208_N1.2381.00
48_D116_S1.2331.00
98_E108_R1.2321.00
5_F12_D1.2311.00
16_N20_M1.2231.00
17_E20_M1.2181.00
74_K94_P1.2091.00
193_F223_I1.2091.00
83_A87_M1.1911.00
149_I182_P1.1881.00
191_I213_I1.1831.00
19_L26_G1.1811.00
31_N179_L1.1271.00
197_P218_H1.1171.00
27_I166_V1.1101.00
102_S106_A1.1081.00
20_M26_G1.0811.00
117_I137_I1.0691.00
160_I165_E1.0641.00
53_A109_I1.0551.00
119_S130_R1.0551.00
174_S198_M1.0491.00
155_N159_K1.0491.00
18_K21_I1.0431.00
219_S222_G1.0391.00
52_L120_I1.0311.00
147_S175_L1.0291.00
77_A96_T1.0251.00
202_T206_V1.0211.00
125_A141_E1.0121.00
52_L75_I1.0061.00
159_K163_E0.9881.00
87_M92_V0.9871.00
57_R85_L0.9821.00
149_I179_L0.9691.00
158_S162_T0.9691.00
128_D132_I0.9611.00
9_D13_N0.9591.00
124_K175_L0.9571.00
103_I128_D0.9471.00
13_N28_E0.9381.00
156_E160_I0.9381.00
9_D12_D0.9351.00
185_R188_C0.9311.00
84_E88_K0.9130.99
34_I62_C0.9130.99
181_G208_N0.9120.99
51_A95_I0.9110.99
33_P151_R0.9100.99
67_T70_K0.8920.99
108_R112_D0.8860.99
131_N135_G0.8860.99
114_V137_I0.8820.99
31_N180_I0.8820.99
59_S119_S0.8820.99
95_I105_L0.8800.99
60_V85_L0.8800.99
15_L170_A0.8740.99
45_P140_D0.8710.99
37_I146_D0.8700.99
3_V168_A0.8670.99
81_E84_E0.8650.99
156_E159_K0.8570.99
191_I211_K0.8520.99
32_I147_S0.8450.99
174_S199_T0.8440.99
78_I105_L0.8420.99
61_I88_K0.8320.99
59_S120_I0.8270.99
32_I179_L0.8270.99
179_L183_F0.8240.99
170_A227_I0.8190.99
170_A193_F0.8160.99
134_N139_Y0.8160.99
37_I40_V0.8160.99
53_A105_L0.8140.99
86_L91_N0.8120.99
83_A96_T0.8090.99
85_L89_M0.8080.99
54_F75_I0.8080.99
58_N62_C0.8080.99
31_N183_F0.8070.99
101_T197_P0.8060.99
63_F120_I0.8020.99
80_E100_F0.8000.99
118_L142_I0.8000.99
87_M93_N0.7980.99
60_V82_T0.7960.99
120_I144_V0.7940.99
225_E229_V0.7920.99
102_S128_D0.7850.98
197_P201_E0.7840.98
110_L132_I0.7830.98
13_N17_E0.7770.98
5_F19_L0.7760.98
97_P100_F0.7730.98
203_L207_N0.7720.98
172_T220_I0.7650.98
197_P214_E0.7550.98
122_S143_Y0.7530.98
77_A93_N0.7510.98
63_F144_V0.7490.98
84_E87_M0.7480.98
37_I143_Y0.7440.98
100_F104_E0.7400.98
74_K112_D0.7380.98
216_K225_E0.7380.98
104_E107_K0.7360.98
222_G226_T0.7360.98
133_L137_I0.7350.98
9_D28_E0.7330.98
193_F226_T0.7320.98
124_K147_S0.7210.97
100_F219_S0.7200.97
7_R176_M0.7140.97
32_I175_L0.7140.97
5_F170_A0.7090.97
76_Y108_R0.7080.97
107_K132_I0.7070.97
78_I102_S0.7070.97
58_N61_I0.7060.97
169_I190_I0.7050.97
27_I160_I0.7020.97
53_A76_Y0.7000.97
45_P48_D0.6980.97
52_L118_L0.6960.97
5_F26_G0.6950.97
225_E228_L0.6950.97
119_S139_Y0.6940.97
5_F28_E0.6930.97
226_T229_V0.6930.97
32_I173_S0.6920.97
75_I86_L0.6910.96
51_A108_R0.6890.96
152_D183_F0.6880.96
126_S198_M0.6860.96
105_L109_I0.6850.96
169_I192_I0.6810.96
12_D28_E0.6800.96
51_A115_N0.6790.96
128_D131_N0.6770.96
204_K209_K0.6720.96
121_R127_E0.6700.96
15_L19_L0.6670.96
164_C189_N0.6570.95
60_V86_L0.6550.95
106_A109_I0.6530.95
51_A109_I0.6530.95
127_E141_E0.6490.95
90_Y93_N0.6480.95
195_I215_S0.6450.95
102_S147_S0.6450.95
7_R11_E0.6440.95
210_V213_I0.6430.95
54_F120_I0.6420.95
216_K226_T0.6380.95
5_F10_N0.6360.94
91_N94_P0.6320.94
215_S226_T0.6300.94
124_K143_Y0.6270.94
119_S129_M0.6260.94
74_K115_N0.6230.94
34_I57_R0.6230.94
182_P185_R0.6210.94
159_K162_T0.6200.94
11_E57_R0.6170.94
24_K228_L0.6170.94
106_A110_L0.6160.93
15_L172_T0.6120.93
121_R130_R0.6090.93
115_N137_I0.6080.93
56_S82_T0.6080.93
134_N138_K0.6050.93
120_I142_I0.6040.93
54_F82_T0.6030.93
29_V152_D0.6000.93
78_I82_T0.5970.92
50_E71_N0.5950.92
109_I112_D0.5940.92
80_E219_S0.5930.92
106_A129_M0.5920.92
124_K178_K0.5920.92
100_F218_H0.5880.92
76_Y97_P0.5880.92
178_K205_R0.5870.92
13_N62_C0.5870.92
83_A93_N0.5860.92
95_I110_L0.5860.92
122_S198_M0.5850.92
20_M25_N0.5840.92
18_K224_I0.5830.91
193_F227_I0.5820.91
175_L196_G0.5790.91
101_T198_M0.5790.91
197_P204_K0.5790.91
53_A129_M0.5780.91
29_V154_I0.5780.91
215_S218_H0.5780.91
178_K182_P0.5760.91
31_N171_F0.5760.91
101_T218_H0.5740.91
122_S144_V0.5690.90
6_L176_M0.5660.90
98_E104_E0.5640.90
31_N150_I0.5630.90
20_M28_E0.5610.90
121_R143_Y0.5610.90
106_A128_D0.5590.90
119_S141_E0.5540.89
177_A206_V0.5520.89
8_P34_I0.5510.89
23_R26_G0.5500.89
168_A213_I0.5460.89
211_K214_E0.5450.89
161_L166_V0.5440.88
104_E108_R0.5430.88
7_R82_T0.5420.88
216_K229_V0.5400.88
38_K42_Y0.5400.88
3_V6_L0.5390.88
192_I210_V0.5380.88
67_T71_N0.5350.88
119_S172_T0.5350.88
150_I153_N0.5350.88
53_A133_L0.5330.87
32_I176_M0.5310.87
14_E17_E0.5300.87
224_I228_L0.5290.87
216_K222_G0.5270.87
125_A198_M0.5270.87
222_G225_E0.5250.87
76_Y95_I0.5240.87
55_T59_S0.5220.86
7_R126_S0.5220.86
14_E18_K0.5210.86
217_T225_E0.5200.86
119_S125_A0.5200.86
78_I122_S0.5180.86
171_F176_M0.5180.86
12_D16_N0.5180.86
54_F119_S0.5170.86
147_S179_L0.5160.86
107_K111_E0.5160.86
11_E14_E0.5110.85
9_D15_L0.5090.85
215_S219_S0.5080.85
53_A137_I0.5050.84
126_S147_S0.5030.84
5_F15_L0.5020.84
102_S126_S0.5010.84
194_S220_I0.5010.84
200_T211_K0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3re1A 1 0.9916 100 0.164 Contact Map
3d8tA 1 0.962 100 0.176 Contact Map
1wcwA 1 0.9705 100 0.178 Contact Map
1jr2A 1 0.962 100 0.181 Contact Map
3mw8A 1 0.9451 100 0.183 Contact Map
4es6A 1 0.962 100 0.185 Contact Map
3p9zA 1 0.8481 100 0.263 Contact Map
2cukA 2 0.9325 95.3 0.885 Contact Map
3qk7A 2 0.9662 95.2 0.886 Contact Map
3egcA 2 0.9451 95.1 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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