GREMLIN Database
Q980U1 - Sarcosine oxidase, subunit alpha related (SoxA), putative (SoxA-like)
UniProt: Q980U1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (394)
Sequences: 3424 (2455)
Seq/√Len: 123.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
236_I306_S4.2711.00
254_R257_I4.0071.00
234_K257_I3.8461.00
112_G138_S3.3801.00
225_Y310_V3.0281.00
343_S347_K2.8331.00
239_G242_D2.7721.00
258_N262_L2.7281.00
253_K275_L2.6451.00
375_V380_L2.6091.00
293_G309_L2.4651.00
278_E302_R2.4241.00
179_D182_I2.4031.00
236_I296_K2.3961.00
289_R293_G2.3421.00
107_N199_F2.3311.00
249_F275_L2.3131.00
106_E128_K2.3071.00
287_V309_L2.2431.00
112_G133_S2.2271.00
147_P150_N2.2181.00
107_N123_I2.2061.00
447_G450_T2.1991.00
234_K305_D2.1961.00
105_L130_L2.1921.00
271_L275_L2.1821.00
146_L151_K2.1621.00
59_R63_S2.1551.00
154_F162_I2.1481.00
269_K273_D2.1341.00
60_V63_S2.1281.00
260_G263_F2.1151.00
108_L132_I2.1091.00
295_L303_S2.0951.00
59_R62_T2.0861.00
158_L162_I2.0651.00
417_V428_V2.0261.00
423_I427_E2.0091.00
125_K161_T2.0011.00
280_I302_R1.9911.00
370_S373_T1.9911.00
157_L161_T1.9621.00
211_F287_V1.9601.00
286_K297_I1.9381.00
161_T164_E1.9251.00
234_K307_N1.8941.00
159_R163_N1.8941.00
146_L150_N1.8711.00
288_K295_L1.8691.00
155_S159_R1.8571.00
78_K82_K1.8421.00
288_K303_S1.8281.00
148_Q151_K1.8261.00
154_F161_T1.8241.00
146_L149_I1.8001.00
156_K160_D1.7941.00
259_N262_L1.7901.00
380_L384_I1.7321.00
158_L161_T1.7221.00
235_A308_I1.7151.00
289_R292_G1.7101.00
110_I200_L1.7011.00
417_V425_L1.6991.00
211_F214_N1.6911.00
67_N70_L1.6771.00
83_H86_N1.6741.00
119_V199_F1.6741.00
288_K297_I1.6311.00
424_T427_E1.6241.00
345_E348_T1.6021.00
417_V420_C1.6021.00
411_Y414_K1.6001.00
448_L462_L1.5931.00
161_T167_D1.5891.00
122_E372_K1.5871.00
183_G194_R1.5861.00
155_S161_T1.5791.00
271_L274_E1.5721.00
287_V293_G1.5611.00
428_V431_Q1.5601.00
239_G243_D1.5601.00
149_I152_D1.5561.00
297_I303_S1.5411.00
179_D184_F1.5371.00
359_R370_S1.5331.00
427_E431_Q1.5211.00
432_V442_I1.5101.00
147_P152_D1.5041.00
105_L108_L1.4971.00
154_F158_L1.4961.00
181_G184_F1.4951.00
216_I287_V1.4871.00
180_E184_F1.4801.00
353_Y382_E1.4721.00
427_E430_R1.4621.00
294_M297_I1.4591.00
197_R351_N1.4481.00
153_E161_T1.4461.00
262_L265_S1.4411.00
413_N429_N1.4401.00
161_T165_N1.4351.00
211_F311_Y1.4111.00
63_S66_H1.4081.00
109_I199_F1.4071.00
106_E196_K1.4011.00
60_V66_H1.3971.00
423_I428_V1.3831.00
212_D286_K1.3801.00
293_G296_K1.3741.00
121_S125_K1.3681.00
159_R162_I1.3661.00
155_S162_I1.3611.00
144_Y227_R1.3581.00
380_L383_F1.3501.00
361_I370_S1.3491.00
252_E277_V1.3491.00
235_A251_V1.3491.00
337_I340_P1.3441.00
77_V80_Y1.3371.00
89_D92_T1.3351.00
62_T65_L1.3341.00
244_I312_A1.3311.00
174_L177_K1.3221.00
375_V379_Y1.3161.00
61_G65_L1.3121.00
234_K256_I1.3111.00
418_C422_D1.3021.00
354_I358_M1.3001.00
253_K271_L1.3001.00
78_K81_S1.2901.00
270_E274_E1.2871.00
145_P151_K1.2841.00
60_V65_L1.2741.00
168_R171_E1.2711.00
380_L385_N1.2641.00
328_P339_M1.2601.00
73_F76_I1.2531.00
296_K309_L1.2521.00
257_I278_E1.2521.00
122_E375_V1.2501.00
420_C423_I1.2481.00
147_P151_K1.2420.99
59_R66_H1.2410.99
130_L193_V1.2400.99
160_D163_N1.2350.99
62_T66_H1.2310.99
348_T354_I1.2290.99
154_F159_R1.2240.99
198_V352_I1.2210.99
263_F266_K1.2180.99
162_I167_D1.1960.99
67_N71_R1.1930.99
413_N426_S1.1930.99
197_R353_Y1.1910.99
153_E162_I1.1880.99
195_A198_V1.1870.99
59_R65_L1.1800.99
145_P149_I1.1730.99
130_L169_I1.1670.99
132_I174_L1.1650.99
168_R172_G1.1570.99
87_L92_T1.1570.99
106_E130_L1.1460.99
430_R433_G1.1430.99
182_I186_T1.1380.99
367_S371_G1.1360.99
178_F181_G1.1320.99
236_I304_F1.1310.99
69_L73_F1.1280.99
161_T166_K1.1160.99
212_D216_I1.1140.99
246_K250_K1.1110.99
155_S166_K1.1090.99
335_F339_M1.0980.99
240_N243_D1.0910.99
61_G66_H1.0900.99
199_F379_Y1.0860.99
411_Y418_C1.0810.99
418_C423_I1.0750.99
440_E443_K1.0750.99
425_L429_N1.0720.98
225_Y308_I1.0720.98
272_I279_I1.0660.98
362_S366_T1.0630.98
155_S167_D1.0620.98
443_K447_G1.0610.98
78_K86_N1.0540.98
199_F355_V1.0540.98
115_S355_V1.0530.98
328_P349_N1.0510.98
78_K83_H1.0500.98
213_G219_I1.0450.98
398_Y401_N1.0420.98
145_P148_Q1.0390.98
369_L373_T1.0380.98
70_L74_P1.0250.98
83_H87_L1.0230.98
162_I166_K1.0210.98
65_L69_L1.0190.98
280_I298_I1.0010.98
80_Y83_H0.9980.98
162_I165_N0.9940.98
254_R262_L0.9850.97
148_Q152_D0.9850.97
124_S165_N0.9790.97
428_V442_I0.9790.97
205_R318_K0.9780.97
213_G286_K0.9780.97
81_S86_N0.9750.97
235_A256_I0.9710.97
169_I172_G0.9700.97
415_G418_C0.9660.97
77_V86_N0.9630.97
347_K382_E0.9540.97
80_Y86_N0.9520.97
335_F340_P0.9520.97
418_C424_T0.9490.97
395_D398_Y0.9420.97
441_E445_T0.9380.96
178_F182_I0.9370.96
177_K198_V0.9350.96
426_S429_N0.9340.96
290_E294_M0.9320.96
153_E164_E0.9220.96
212_D215_D0.9210.96
155_S158_L0.9170.96
372_K376_N0.9170.96
406_P409_Y0.9110.96
424_T428_V0.9100.96
289_R294_M0.9080.96
82_K86_N0.9070.96
412_G415_G0.9050.96
453_C458_C0.9030.96
246_K268_Y0.8980.95
178_F184_F0.8960.95
77_V82_K0.8950.95
59_R64_I0.8950.95
394_Y398_Y0.8930.95
78_K85_I0.8910.95
379_Y383_F0.8910.95
79_I82_K0.8880.95
127_E385_N0.8880.95
76_I79_I0.8870.95
153_E156_K0.8860.95
371_G375_V0.8850.95
260_G264_L0.8840.95
233_T307_N0.8830.95
420_C427_E0.8830.95
258_N263_F0.8810.95
108_L195_A0.8800.95
157_L162_I0.8800.95
109_I129_T0.8800.95
117_L162_I0.8760.95
381_D384_I0.8710.95
222_K226_L0.8710.95
164_E167_D0.8690.95
118_G371_G0.8650.94
269_K279_I0.8640.94
106_E127_E0.8640.94
153_E160_D0.8620.94
76_I81_S0.8620.94
261_V298_I0.8620.94
327_I352_I0.8600.94
399_Q403_K0.8580.94
154_F166_K0.8580.94
251_V256_I0.8570.94
160_D164_E0.8560.94
121_S124_S0.8540.94
88_P91_I0.8530.94
260_G265_S0.8530.94
418_C428_V0.8490.94
322_S325_I0.8450.94
418_C427_E0.8430.94
81_S84_F0.8430.94
118_G368_F0.8370.93
183_G186_T0.8350.93
363_D366_T0.8330.93
259_N304_F0.8320.93
346_G370_S0.8290.93
141_D144_Y0.8270.93
406_P410_I0.8250.93
197_R382_E0.8220.93
431_Q446_I0.8210.93
294_M298_I0.8200.93
259_N280_I0.8190.93
211_F215_D0.8170.93
237_A310_V0.8160.93
154_F157_L0.8130.92
287_V311_Y0.8100.92
295_L305_D0.8100.92
220_I310_V0.8090.92
441_E444_R0.8070.92
80_Y84_F0.8070.92
287_V291_K0.8060.92
355_V371_G0.8050.92
412_G427_E0.8040.92
322_S329_Y0.8040.92
263_F267_Y0.8020.92
245_I260_G0.8020.92
272_I277_V0.8020.92
87_L90_L0.8020.92
138_S159_R0.8010.92
419_E422_D0.8000.92
261_V304_F0.8000.92
179_D183_G0.8000.92
76_I80_Y0.7990.92
417_V427_E0.7980.92
412_G418_C0.7960.92
237_A244_I0.7950.92
417_V423_I0.7940.92
427_E432_V0.7910.91
236_I261_V0.7880.91
323_Y329_Y0.7880.91
104_E128_K0.7870.91
200_L322_S0.7870.91
243_D246_K0.7850.91
288_K294_M0.7850.91
336_H340_P0.7840.91
421_E425_L0.7820.91
153_E157_L0.7820.91
419_E423_I0.7800.91
172_G186_T0.7760.91
424_T429_N0.7740.90
60_V64_I0.7720.90
244_I247_V0.7720.90
418_C421_E0.7700.90
423_I431_Q0.7700.90
226_L230_N0.7700.90
138_S169_I0.7690.90
68_K71_R0.7680.90
384_I387_L0.7650.90
270_E273_D0.7650.90
77_V81_S0.7600.90
81_S85_I0.7600.90
208_P215_D0.7580.90
243_D315_K0.7570.89
425_L428_V0.7570.89
66_H70_L0.7540.89
222_K247_V0.7520.89
131_L138_S0.7510.89
108_L184_F0.7470.89
216_I289_R0.7470.89
82_K85_I0.7460.89
107_N197_R0.7450.89
222_K312_A0.7450.89
172_G191_L0.7420.89
115_S367_S0.7420.89
377_E382_E0.7410.88
414_K419_E0.7400.88
87_L91_I0.7360.88
237_A247_V0.7360.88
245_I272_I0.7360.88
154_F167_D0.7350.88
145_P150_N0.7350.88
61_G64_I0.7340.88
402_P407_S0.7310.88
137_E143_P0.7300.88
76_I82_K0.7270.88
230_N250_K0.7250.87
247_V250_K0.7240.87
290_E293_G0.7230.87
443_K450_T0.7230.87
249_F253_K0.7210.87
343_S348_T0.7190.87
75_N79_I0.7170.87
156_K159_R0.7170.87
269_K272_I0.7170.87
268_Y275_L0.7170.87
345_E377_E0.7160.87
428_V432_V0.7160.87
153_E159_R0.7160.87
205_R320_D0.7150.87
77_V83_H0.7140.87
69_L74_P0.7130.87
78_K84_F0.7130.87
72_I76_I0.7130.87
319_I329_Y0.7120.86
403_K407_S0.7110.86
316_Q460_Y0.7090.86
84_F88_P0.7080.86
443_K446_I0.7050.86
411_Y415_G0.7020.86
176_G185_L0.7020.86
185_L192_M0.7010.86
65_L71_R0.7000.86
400_K406_P0.6980.85
447_G451_G0.6970.85
135_N144_Y0.6950.85
447_G458_C0.6930.85
61_G88_P0.6920.85
220_I225_Y0.6890.85
124_S166_K0.6890.85
206_Y313_I0.6860.84
249_F271_L0.6850.84
104_E194_R0.6850.84
298_I302_R0.6840.84
225_Y229_G0.6840.84
174_L183_G0.6830.84
69_L76_I0.6820.84
213_G216_I0.6810.84
414_K418_C0.6790.84
109_I120_L0.6780.84
67_N73_F0.6750.83
421_E424_T0.6750.83
64_I71_R0.6740.83
220_I308_I0.6700.83
209_P309_L0.6680.83
421_E427_E0.6660.83
436_F445_T0.6650.82
413_N425_L0.6640.82
86_N90_L0.6620.82
437_S442_I0.6620.82
384_I388_K0.6620.82
210_I214_N0.6610.82
412_G428_V0.6610.82
127_E380_L0.6600.82
412_G423_I0.6600.82
182_I185_L0.6590.82
177_K325_I0.6590.82
252_E275_L0.6560.82
180_E185_L0.6560.82
123_I129_T0.6550.82
319_I358_M0.6550.82
413_N419_E0.6550.82
421_E426_S0.6540.81
415_G419_E0.6540.81
204_G357_G0.6530.81
114_T364_E0.6530.81
343_S346_G0.6480.81
407_S410_I0.6470.81
416_Y424_T0.6460.81
70_L73_F0.6420.80
66_H71_R0.6420.80
422_D427_E0.6410.80
400_K403_K0.6410.80
357_G367_S0.6400.80
443_K455_G0.6390.80
157_L164_E0.6390.80
226_L247_V0.6380.80
181_G185_L0.6380.80
88_P92_T0.6360.80
227_R231_R0.6350.80
273_D279_I0.6340.79
393_I397_Y0.6340.79
273_D276_G0.6310.79
438_K444_R0.6300.79
311_Y419_E0.6290.79
168_R173_I0.6270.79
177_K180_E0.6270.79
197_R379_Y0.6260.79
65_L70_L0.6260.79
65_L74_P0.6240.78
158_L164_E0.6210.78
223_N226_L0.6190.78
252_E272_I0.6180.78
109_I131_L0.6170.78
79_I83_H0.6170.78
268_Y277_V0.6150.77
397_Y403_K0.6140.77
264_L267_Y0.6130.77
327_I349_N0.6120.77
177_K181_G0.6110.77
200_L325_I0.6110.77
439_V443_K0.6090.77
414_K426_S0.6080.77
153_E158_L0.6080.77
361_I366_T0.6070.76
395_D399_Q0.6060.76
417_V424_T0.6030.76
133_S138_S0.6010.76
396_Y400_K0.5970.75
123_I375_V0.5960.75
175_L190_I0.5910.74
284_N298_I0.5910.74
76_I83_H0.5900.74
248_L260_G0.5900.74
293_G298_I0.5890.74
265_S282_T0.5890.74
107_N383_F0.5880.74
208_P221_S0.5860.74
226_L250_K0.5840.74
381_D385_N0.5830.73
374_A379_Y0.5820.73
268_Y271_L0.5810.73
340_P343_S0.5800.73
324_N327_I0.5800.73
327_I350_D0.5790.73
272_I276_G0.5790.73
420_C424_T0.5780.73
227_R232_I0.5770.73
69_L72_I0.5760.73
403_K406_P0.5750.72
224_L227_R0.5730.72
295_L299_T0.5730.72
68_K74_P0.5720.72
418_C426_S0.5720.72
234_K259_N0.5710.72
355_V379_Y0.5710.72
394_Y397_Y0.5700.72
114_T371_G0.5700.72
143_P155_S0.5700.72
418_C425_L0.5670.71
172_G176_G0.5670.71
381_D389_D0.5660.71
450_T459_T0.5660.71
413_N418_C0.5660.71
346_G373_T0.5650.71
153_E166_K0.5650.71
217_P289_R0.5650.71
76_I86_N0.5630.71
370_S375_V0.5620.71
397_Y400_K0.5620.71
169_I173_I0.5600.71
106_E123_I0.5590.70
412_G419_E0.5590.70
423_I426_S0.5580.70
225_Y251_V0.5580.70
294_M300_N0.5520.69
170_L173_I0.5490.69
138_S168_R0.5490.69
123_I127_E0.5480.69
366_T370_S0.5480.69
413_N427_E0.5480.69
219_I287_V0.5470.69
419_E424_T0.5460.69
211_F216_I0.5460.69
70_L78_K0.5460.69
159_R167_D0.5450.68
401_N407_S0.5440.68
249_F268_Y0.5430.68
157_L163_N0.5410.68
288_K305_D0.5400.68
66_H69_L0.5400.68
413_N416_Y0.5400.68
427_E434_R0.5380.67
68_K72_I0.5380.67
447_G453_C0.5380.67
155_S164_E0.5370.67
451_G458_C0.5350.67
68_K73_F0.5350.67
238_L284_N0.5340.67
207_I316_Q0.5340.67
70_L76_I0.5330.67
200_L319_I0.5330.67
238_L309_L0.5320.67
420_C428_V0.5300.66
443_K449_G0.5300.66
156_K163_N0.5300.66
155_S165_N0.5290.66
443_K454_Q0.5270.66
254_R263_F0.5250.66
414_K434_R0.5250.66
325_I329_Y0.5240.65
222_K244_I0.5240.65
64_I68_K0.5230.65
418_C429_N0.5210.65
322_S354_I0.5210.65
239_G244_I0.5200.65
400_K407_S0.5200.65
177_K184_F0.5200.65
396_Y401_N0.5190.65
364_E368_F0.5190.65
398_Y402_P0.5190.65
322_S326_G0.5180.65
121_S158_L0.5180.65
181_G186_T0.5170.64
209_P287_V0.5170.64
260_G277_V0.5170.64
142_I250_K0.5160.64
95_T98_R0.5160.64
398_Y403_K0.5150.64
336_H339_M0.5150.64
262_L266_K0.5150.64
444_R447_G0.5140.64
61_G71_R0.5140.64
176_G179_D0.5110.64
259_N263_F0.5100.63
297_I301_E0.5090.63
139_N142_I0.5090.63
457_L461_S0.5090.63
201_A208_P0.5080.63
418_C431_Q0.5070.63
353_Y377_E0.5070.63
122_E380_L0.5040.62
320_D323_Y0.5040.62
244_I260_G0.5030.62
256_I307_N0.5020.62
296_K299_T0.5010.62
171_E177_K0.5010.62
284_N299_T0.5000.62
236_I259_N0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gagA 1 0.9669 100 0.529 Contact Map
1y56A 3 0.9027 100 0.588 Contact Map
2vdcG 1 0.7888 100 0.625 Contact Map
4ylfB 1 0.7764 100 0.631 Contact Map
1gteA 4 0.9627 100 0.65 Contact Map
3ctyA 2 0.5756 100 0.66 Contact Map
2q0lA 2 0.5735 100 0.661 Contact Map
3f8dA 2 0.5797 100 0.664 Contact Map
2q7vA 2 0.5776 100 0.668 Contact Map
4up3A 2 0.5714 100 0.67 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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