Q980T9 - SULSO - GREMLIN Contacts

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Q980T9 - Uncharacterized protein

UniProt:	Q980T9	Sequences: MQSLVKILPNGAILIGKRFTIDGHHERPFRVVTHFHADHITGLEKSISISDGIIATPITLDILSLDYAIPPRKAFGLNYDIKMTFEDENIVLKKSDHVIGSAQVLITLENGLEIGYTGDFKNPGKGTPILHPDILIIEATYGRPDFRRPFKDDVESLFADYVRDALMYGPVRIYGYHGKLQEVMISLRKMGVDAPFIVGGKISKMTNIAIKYGYNISQVFDESQSEAKEIMRDSWYISFSHYNEFKRRNGKYYNFLLSGWEFKNVVKKIDEKSYTVSFSDHADFDDLIYYVERTSAKYIITDGGRRSYGKELAEYISKKLGKIAISMP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	328 (292)
Sequences:	6855 (4585)
Seq/√Len:	268.3

BACSU - RNJ1 RNJ2
HALSA - Q9HS54 RNJ Q9HMJ7
SULSO - Q980T9 Q7LYL5 Q980D0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_V	104_V	3.935	1.00
30_R	43_L	3.884	1.00
82_K	89_N	3.735	1.00
107_T	113_E	3.694	1.00
89_N	107_T	3.241	1.00
55_A	60_L	3.211	1.00
56_T	102_A	3.205	1.00
105_L	113_E	2.991	1.00
32_V	63_L	2.852	1.00
84_T	89_N	2.759	1.00
31_V	90_I	2.732	1.00
134_I	300_I	2.669	1.00
82_K	91_V	2.665	1.00
79_Y	102_A	2.651	1.00
21_I	49_I	2.644	1.00
92_L	104_V	2.470	1.00
238_S	241_H	2.441	1.00
160_D	164_D	2.384	1.00
78_N	81_I	2.318	1.00
133_D	297_K	2.314	1.00
33_T	116_Y	2.292	1.00
147_R	285_D	2.256	1.00
52_G	75_F	2.177	1.00
54_I	77_L	2.147	1.00
61_D	212_Y	2.109	1.00
238_S	242_Y	2.103	1.00
137_I	301_T	2.092	1.00
91_V	107_T	2.085	1.00
57_P	78_N	2.077	1.00
60_L	76_G	2.006	1.00
77_L	83_M	1.988	1.00
60_L	74_A	1.934	1.00
90_I	106_I	1.927	1.00
61_D	211_K	1.922	1.00
179_K	182_E	1.889	1.00
77_L	92_L	1.880	1.00
103_Q	115_G	1.870	1.00
159_A	191_G	1.788	1.00
169_G	177_H	1.750	1.00
115_G	132_P	1.734	1.00
198_V	206_T	1.728	1.00
274_Y	277_S	1.719	1.00
30_R	46_S	1.705	1.00
31_V	92_L	1.692	1.00
173_I	176_Y	1.679	1.00
153_D	156_S	1.678	1.00
91_V	105_L	1.651	1.00
63_L	74_A	1.640	1.00
90_I	104_V	1.604	1.00
93_K	103_Q	1.604	1.00
172_R	176_Y	1.583	1.00
105_L	115_G	1.582	1.00
31_V	106_I	1.563	1.00
30_R	51_D	1.562	1.00
64_S	68_A	1.560	1.00
93_K	105_L	1.555	1.00
169_G	176_Y	1.552	1.00
136_I	302_D	1.528	1.00
32_V	55_A	1.508	1.00
230_I	235_W	1.502	1.00
55_A	63_L	1.495	1.00
29_F	54_I	1.495	1.00
135_L	294_T	1.477	1.00
57_P	76_G	1.464	1.00
169_G	172_R	1.420	1.00
135_L	291_V	1.408	1.00
148_R	283_D	1.398	1.00
240_S	243_N	1.393	1.00
170_P	176_Y	1.386	1.00
311_E	314_E	1.383	1.00
117_T	135_L	1.374	1.00
187_L	196_F	1.372	1.00
174_Y	177_H	1.355	1.00
56_T	59_T	1.355	1.00
169_G	174_Y	1.354	1.00
40_I	63_L	1.353	1.00
120_F	137_I	1.350	1.00
79_Y	94_K	1.342	1.00
20_T	27_R	1.342	1.00
222_E	230_I	1.338	1.00
301_T	309_G	1.336	1.00
156_S	160_D	1.335	1.00
137_I	291_V	1.334	1.00
291_V	299_I	1.333	1.00
282_A	286_D	1.317	1.00
84_T	87_D	1.302	1.00
137_I	299_I	1.300	1.00
56_T	92_L	1.283	1.00
170_P	174_Y	1.282	1.00
172_R	177_H	1.276	1.00
29_F	52_G	1.273	1.00
157_L	160_D	1.270	1.00
139_A	312_L	1.269	1.00
115_G	135_L	1.264	1.00
21_I	24_H	1.261	1.00
115_G	294_T	1.250	1.00
132_P	135_L	1.250	1.00
37_A	66_D	1.234	1.00
139_A	304_G	1.234	1.00
23_G	26_E	1.228	1.00
137_I	312_L	1.224	1.00
82_K	107_T	1.206	1.00
45_K	49_I	1.205	1.00
169_G	173_I	1.190	1.00
33_T	104_V	1.187	1.00
227_A	230_I	1.185	1.00
80_D	93_K	1.177	1.00
306_R	310_K	1.177	1.00
231_M	234_S	1.176	1.00
98_V	280_D	1.170	1.00
173_I	177_H	1.168	1.00
165_A	171_V	1.154	1.00
188_R	217_S	1.147	1.00
248_R	252_Y	1.147	1.00
143_R	307_S	1.146	1.00
33_T	136_I	1.140	1.00
60_L	64_S	1.139	1.00
162_V	171_V	1.138	1.00
223_S	226_E	1.138	1.00
137_I	287_L	1.134	1.00
170_P	177_H	1.129	1.00
123_P	289_Y	1.128	1.00
207_N	211_K	1.113	1.00
310_K	313_A	1.082	1.00
175_G	255_F	1.076	1.00
65_L	208_I	1.072	1.00
285_D	288_I	1.067	1.00
162_V	169_G	1.058	1.00
299_I	312_L	1.058	1.00
29_F	85_F	1.054	1.00
159_A	163_R	1.054	1.00
289_Y	292_E	1.051	1.00
197_I	227_A	1.049	1.00
18_R	22_D	1.046	1.00
159_A	192_V	1.045	1.00
95_S	103_Q	1.040	1.00
99_I	209_A	1.039	1.00
232_R	248_R	1.037	1.00
238_S	243_N	1.037	1.00
32_V	43_L	1.030	1.00
101_S	118_G	1.027	1.00
172_R	175_G	1.026	1.00
18_R	21_I	1.026	1.00
284_F	311_E	1.025	1.00
69_I	72_R	1.022	1.00
54_I	75_F	1.021	1.00
230_I	234_S	1.021	1.00
39_H	303_G	1.016	1.00
181_Q	185_I	1.015	1.00
31_V	85_F	1.007	1.00
285_D	289_Y	1.004	1.00
180_L	198_V	0.997	1.00
161_Y	274_Y	0.992	1.00
308_Y	312_L	0.983	1.00
32_V	59_T	0.972	1.00
147_R	283_D	0.969	1.00
166_L	194_A	0.967	1.00
185_I	188_R	0.965	1.00
122_N	286_D	0.964	1.00
149_P	153_D	0.962	1.00
219_V	222_E	0.958	1.00
61_D	208_I	0.955	1.00
207_N	210_I	0.955	1.00
220_F	223_S	0.951	1.00
142_G	287_L	0.945	1.00
117_T	137_I	0.945	1.00
95_S	101_S	0.942	1.00
103_Q	120_F	0.941	1.00
88_E	108_L	0.937	1.00
120_F	287_L	0.930	1.00
132_P	294_T	0.930	1.00
221_D	225_S	0.928	1.00
170_P	173_I	0.923	1.00
289_Y	293_R	0.917	1.00
139_A	301_T	0.916	1.00
162_V	187_L	0.911	1.00
47_I	53_I	0.911	1.00
61_D	64_S	0.911	1.00
223_S	227_A	0.907	1.00
226_E	229_E	0.906	1.00
55_A	74_A	0.905	1.00
65_L	204_K	0.902	1.00
149_P	157_L	0.901	1.00
172_R	266_V	0.898	1.00
245_F	248_R	0.898	1.00
35_F	98_V	0.895	1.00
163_R	167_M	0.891	1.00
161_Y	165_A	0.886	1.00
186_S	278_F	0.883	1.00
204_K	207_N	0.882	1.00
161_Y	164_D	0.878	1.00
216_I	221_D	0.878	1.00
62_I	205_M	0.870	1.00
170_P	273_S	0.869	1.00
32_V	40_I	0.867	1.00
239_F	243_N	0.864	1.00
35_F	59_T	0.860	1.00
58_I	99_I	0.859	1.00
165_A	169_G	0.859	1.00
260_W	263_K	0.855	1.00
227_A	231_M	0.854	1.00
123_P	286_D	0.849	1.00
150_F	153_D	0.846	1.00
170_P	252_Y	0.846	1.00
187_L	236_Y	0.846	1.00
309_G	312_L	0.845	1.00
122_N	290_Y	0.837	0.99
108_L	111_G	0.835	0.99
39_H	119_D	0.835	0.99
286_D	289_Y	0.834	0.99
47_I	70_P	0.826	0.99
79_Y	101_S	0.823	0.99
58_I	215_N	0.817	0.99
284_F	287_L	0.815	0.99
88_E	106_I	0.815	0.99
181_Q	184_M	0.812	0.99
117_T	290_Y	0.806	0.99
142_G	311_E	0.804	0.99
80_D	91_V	0.803	0.99
154_V	157_L	0.803	0.99
131_H	297_K	0.798	0.99
43_L	70_P	0.793	0.99
113_E	133_D	0.792	0.99
93_K	115_G	0.792	0.99
55_A	59_T	0.789	0.99
40_I	66_D	0.784	0.99
169_G	175_G	0.784	0.99
222_E	226_E	0.784	0.99
36_H	39_H	0.783	0.99
38_D	140_T	0.782	0.99
224_Q	229_E	0.780	0.99
103_Q	290_Y	0.780	0.99
239_F	242_Y	0.778	0.99
151_K	154_V	0.775	0.99
175_G	180_L	0.771	0.99
220_F	224_Q	0.771	0.99
224_Q	227_A	0.771	0.99
178_G	182_E	0.771	0.99
64_S	71_P	0.764	0.99
263_K	267_K	0.763	0.99
135_L	299_I	0.761	0.99
34_H	38_D	0.760	0.99
42_G	45_K	0.758	0.99
155_E	186_S	0.754	0.99
184_M	196_F	0.752	0.99
83_M	90_I	0.750	0.99
261_E	266_V	0.749	0.99
140_T	303_G	0.745	0.99
20_T	24_H	0.743	0.99
220_F	227_A	0.742	0.99
231_M	235_W	0.737	0.99
56_T	100_G	0.736	0.99
64_S	74_A	0.736	0.99
46_S	50_S	0.735	0.99
92_L	102_A	0.734	0.99
57_P	61_D	0.732	0.99
120_F	282_A	0.729	0.99
257_L	260_W	0.728	0.99
57_P	212_Y	0.726	0.99
265_V	268_K	0.722	0.98
306_R	309_G	0.714	0.98
38_D	303_G	0.713	0.98
115_G	129_I	0.712	0.98
94_K	100_G	0.710	0.98
36_H	281_H	0.710	0.98
157_L	274_Y	0.705	0.98
116_Y	136_I	0.703	0.98
124_G	292_E	0.702	0.98
143_R	311_E	0.702	0.98
34_H	39_H	0.701	0.98
119_D	303_G	0.701	0.98
234_S	241_H	0.696	0.98
183_V	236_Y	0.692	0.98
88_E	110_N	0.692	0.98
310_K	314_E	0.691	0.98
43_L	67_Y	0.689	0.98
29_F	86_E	0.687	0.98
35_F	40_I	0.686	0.98
123_P	151_K	0.685	0.98
71_P	74_A	0.683	0.98
139_A	309_G	0.677	0.98
217_S	220_F	0.673	0.98
183_V	187_L	0.672	0.98
43_L	51_D	0.669	0.98
208_I	212_Y	0.669	0.98
160_D	163_R	0.667	0.97
96_D	178_G	0.666	0.97
136_I	300_I	0.665	0.97
179_K	280_D	0.662	0.97
253_Y	257_L	0.662	0.97
215_N	219_V	0.661	0.97
155_E	182_E	0.660	0.97
178_G	181_Q	0.658	0.97
114_I	136_I	0.657	0.97
203_S	207_N	0.655	0.97
179_K	187_L	0.655	0.97
182_E	187_L	0.653	0.97
47_I	73_K	0.652	0.97
20_T	23_G	0.650	0.97
219_V	224_Q	0.648	0.97
188_R	220_F	0.648	0.97
22_D	25_H	0.647	0.97
165_A	252_Y	0.645	0.97
120_F	290_Y	0.644	0.97
156_S	159_A	0.643	0.97
21_I	25_H	0.643	0.97
151_K	186_S	0.642	0.97
226_E	230_I	0.640	0.97
95_S	290_Y	0.640	0.97
43_L	53_I	0.639	0.97
134_I	297_K	0.636	0.97
227_A	235_W	0.636	0.97
269_I	273_S	0.632	0.97
36_H	97_H	0.632	0.97
129_I	294_T	0.629	0.96
38_D	281_H	0.629	0.96
118_G	140_T	0.629	0.96
77_L	90_I	0.626	0.96
105_L	132_P	0.625	0.96
27_R	30_R	0.625	0.96
219_V	223_S	0.624	0.96
59_T	181_Q	0.622	0.96
114_I	134_I	0.622	0.96
143_R	308_Y	0.621	0.96
173_I	183_V	0.619	0.96
284_F	288_I	0.618	0.96
68_A	71_P	0.618	0.96
19_F	22_D	0.617	0.96
141_Y	179_K	0.616	0.96
255_F	260_W	0.615	0.96
58_I	212_Y	0.615	0.96
117_T	129_I	0.615	0.96
283_D	286_D	0.614	0.96
96_D	101_S	0.613	0.96
140_T	279_S	0.610	0.96
170_P	175_G	0.610	0.96
18_R	23_G	0.609	0.96
257_L	262_F	0.609	0.96
39_H	140_T	0.609	0.96
152_D	156_S	0.605	0.96
266_V	269_I	0.605	0.96
35_F	62_I	0.604	0.96
185_I	215_N	0.602	0.95
301_T	304_G	0.601	0.95
172_R	261_E	0.601	0.95
259_G	267_K	0.600	0.95
170_P	251_K	0.600	0.95
115_G	290_Y	0.599	0.95
308_Y	311_E	0.596	0.95
133_D	137_I	0.596	0.95
178_G	209_A	0.595	0.95
171_V	177_H	0.592	0.95
265_V	269_I	0.592	0.95
179_K	185_I	0.591	0.95
107_T	130_L	0.589	0.95
181_Q	206_T	0.586	0.95
176_Y	260_W	0.586	0.95
65_L	68_A	0.584	0.95
235_W	238_S	0.584	0.95
249_N	252_Y	0.577	0.94
234_S	242_Y	0.573	0.94
154_V	278_F	0.572	0.94
32_V	53_I	0.571	0.94
77_L	104_V	0.567	0.94
103_Q	294_T	0.567	0.94
163_R	192_V	0.566	0.94
291_V	296_A	0.566	0.94
233_D	237_I	0.565	0.94
31_V	86_E	0.565	0.94
176_Y	280_D	0.564	0.94
95_S	102_A	0.563	0.94
19_F	24_H	0.559	0.93
162_V	166_L	0.558	0.93
95_S	283_D	0.558	0.93
70_P	74_A	0.557	0.93
200_G	203_S	0.555	0.93
47_I	67_Y	0.553	0.93
197_I	248_R	0.551	0.93
19_F	23_G	0.550	0.93
73_K	76_G	0.550	0.93
221_D	227_A	0.548	0.93
218_Q	222_E	0.547	0.93
256_L	260_W	0.547	0.93
234_S	238_S	0.545	0.92
31_V	83_M	0.543	0.92
180_L	206_T	0.543	0.92
257_L	266_V	0.543	0.92
287_L	291_V	0.543	0.92
193_D	234_S	0.541	0.92
195_P	250_G	0.541	0.92
233_D	236_Y	0.539	0.92
33_T	114_I	0.537	0.92
244_E	247_R	0.537	0.92
138_E	303_G	0.537	0.92
235_W	241_H	0.536	0.92
34_H	281_H	0.534	0.92
134_I	298_Y	0.534	0.92
157_L	161_Y	0.533	0.92
121_K	280_D	0.533	0.92
45_K	48_S	0.533	0.92
288_I	292_E	0.531	0.91
291_V	312_L	0.528	0.91
65_L	205_M	0.526	0.91
196_F	220_F	0.525	0.91
231_M	238_S	0.525	0.91
161_Y	276_V	0.524	0.91
70_P	73_K	0.524	0.91
287_L	312_L	0.524	0.91
124_G	289_Y	0.524	0.91
246_K	272_K	0.523	0.91
116_Y	302_D	0.521	0.91
119_D	281_H	0.520	0.91
144_P	283_D	0.520	0.91
103_Q	117_T	0.516	0.90
40_I	62_I	0.516	0.90
43_L	46_S	0.515	0.90
159_A	186_S	0.515	0.90
137_I	290_Y	0.515	0.90
37_A	263_K	0.514	0.90
140_T	176_Y	0.514	0.90
188_R	215_N	0.514	0.90
148_R	278_F	0.513	0.90
158_F	162_V	0.513	0.90
218_Q	221_D	0.513	0.90
230_I	236_Y	0.512	0.90
140_T	281_H	0.509	0.90
252_Y	273_S	0.508	0.90
258_S	267_K	0.508	0.90
224_Q	230_I	0.508	0.90
63_L	71_P	0.508	0.90
34_H	97_H	0.507	0.89
234_S	237_I	0.506	0.89
222_E	229_E	0.506	0.89
36_H	119_D	0.503	0.89
224_Q	228_K	0.503	0.89
111_G	293_R	0.502	0.89
154_V	158_F	0.501	0.89
232_R	236_Y	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i7tA	1	0.878	100	0.409	Contact Map
2ycbA	2	0.9939	100	0.419	Contact Map
3iekA	3	0.9787	100	0.425	Contact Map
2xr1A	2	0.9848	100	0.431	Contact Map
3af5A	1	0.997	100	0.432	Contact Map
5ahoA	1	0.8963	100	0.447	Contact Map
3bk2A	2	0.9787	100	0.452	Contact Map
3zq4A	3	0.9817	100	0.462	Contact Map
4b87A	1	0.9299	100	0.471	Contact Map
2az4A	1	0.9573	100	0.513	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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