GREMLIN Database
Q980T9 - Uncharacterized protein
UniProt: Q980T9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (292)
Sequences: 6855 (4585)
Seq/√Len: 268.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_V104_V3.9351.00
30_R43_L3.8841.00
82_K89_N3.7351.00
107_T113_E3.6941.00
89_N107_T3.2411.00
55_A60_L3.2111.00
56_T102_A3.2051.00
105_L113_E2.9911.00
32_V63_L2.8521.00
84_T89_N2.7591.00
31_V90_I2.7321.00
134_I300_I2.6691.00
82_K91_V2.6651.00
79_Y102_A2.6511.00
21_I49_I2.6441.00
92_L104_V2.4701.00
238_S241_H2.4411.00
160_D164_D2.3841.00
78_N81_I2.3181.00
133_D297_K2.3141.00
33_T116_Y2.2921.00
147_R285_D2.2561.00
52_G75_F2.1771.00
54_I77_L2.1471.00
61_D212_Y2.1091.00
238_S242_Y2.1031.00
137_I301_T2.0921.00
91_V107_T2.0851.00
57_P78_N2.0771.00
60_L76_G2.0061.00
77_L83_M1.9881.00
60_L74_A1.9341.00
90_I106_I1.9271.00
61_D211_K1.9221.00
179_K182_E1.8891.00
77_L92_L1.8801.00
103_Q115_G1.8701.00
159_A191_G1.7881.00
169_G177_H1.7501.00
115_G132_P1.7341.00
198_V206_T1.7281.00
274_Y277_S1.7191.00
30_R46_S1.7051.00
31_V92_L1.6921.00
173_I176_Y1.6791.00
153_D156_S1.6781.00
91_V105_L1.6511.00
63_L74_A1.6401.00
90_I104_V1.6041.00
93_K103_Q1.6041.00
172_R176_Y1.5831.00
105_L115_G1.5821.00
31_V106_I1.5631.00
30_R51_D1.5621.00
64_S68_A1.5601.00
93_K105_L1.5551.00
169_G176_Y1.5521.00
136_I302_D1.5281.00
32_V55_A1.5081.00
230_I235_W1.5021.00
55_A63_L1.4951.00
29_F54_I1.4951.00
135_L294_T1.4771.00
57_P76_G1.4641.00
169_G172_R1.4201.00
135_L291_V1.4081.00
148_R283_D1.3981.00
240_S243_N1.3931.00
170_P176_Y1.3861.00
311_E314_E1.3831.00
117_T135_L1.3741.00
187_L196_F1.3721.00
174_Y177_H1.3551.00
56_T59_T1.3551.00
169_G174_Y1.3541.00
40_I63_L1.3531.00
120_F137_I1.3501.00
79_Y94_K1.3421.00
20_T27_R1.3421.00
222_E230_I1.3381.00
301_T309_G1.3361.00
156_S160_D1.3351.00
137_I291_V1.3341.00
291_V299_I1.3331.00
282_A286_D1.3171.00
84_T87_D1.3021.00
137_I299_I1.3001.00
56_T92_L1.2831.00
170_P174_Y1.2821.00
172_R177_H1.2761.00
29_F52_G1.2731.00
157_L160_D1.2701.00
139_A312_L1.2691.00
115_G135_L1.2641.00
21_I24_H1.2611.00
115_G294_T1.2501.00
132_P135_L1.2501.00
37_A66_D1.2341.00
139_A304_G1.2341.00
23_G26_E1.2281.00
137_I312_L1.2241.00
82_K107_T1.2061.00
45_K49_I1.2051.00
169_G173_I1.1901.00
33_T104_V1.1871.00
227_A230_I1.1851.00
80_D93_K1.1771.00
306_R310_K1.1771.00
231_M234_S1.1761.00
98_V280_D1.1701.00
173_I177_H1.1681.00
165_A171_V1.1541.00
188_R217_S1.1471.00
248_R252_Y1.1471.00
143_R307_S1.1461.00
33_T136_I1.1401.00
60_L64_S1.1391.00
162_V171_V1.1381.00
223_S226_E1.1381.00
137_I287_L1.1341.00
170_P177_H1.1291.00
123_P289_Y1.1281.00
207_N211_K1.1131.00
310_K313_A1.0821.00
175_G255_F1.0761.00
65_L208_I1.0721.00
285_D288_I1.0671.00
162_V169_G1.0581.00
299_I312_L1.0581.00
29_F85_F1.0541.00
159_A163_R1.0541.00
289_Y292_E1.0511.00
197_I227_A1.0491.00
18_R22_D1.0461.00
159_A192_V1.0451.00
95_S103_Q1.0401.00
99_I209_A1.0391.00
232_R248_R1.0371.00
238_S243_N1.0371.00
32_V43_L1.0301.00
101_S118_G1.0271.00
172_R175_G1.0261.00
18_R21_I1.0261.00
284_F311_E1.0251.00
69_I72_R1.0221.00
54_I75_F1.0211.00
230_I234_S1.0211.00
39_H303_G1.0161.00
181_Q185_I1.0151.00
31_V85_F1.0071.00
285_D289_Y1.0041.00
180_L198_V0.9971.00
161_Y274_Y0.9921.00
308_Y312_L0.9831.00
32_V59_T0.9721.00
147_R283_D0.9691.00
166_L194_A0.9671.00
185_I188_R0.9651.00
122_N286_D0.9641.00
149_P153_D0.9621.00
219_V222_E0.9581.00
61_D208_I0.9551.00
207_N210_I0.9551.00
220_F223_S0.9511.00
142_G287_L0.9451.00
117_T137_I0.9451.00
95_S101_S0.9421.00
103_Q120_F0.9411.00
88_E108_L0.9371.00
120_F287_L0.9301.00
132_P294_T0.9301.00
221_D225_S0.9281.00
170_P173_I0.9231.00
289_Y293_R0.9171.00
139_A301_T0.9161.00
162_V187_L0.9111.00
47_I53_I0.9111.00
61_D64_S0.9111.00
223_S227_A0.9071.00
226_E229_E0.9061.00
55_A74_A0.9051.00
65_L204_K0.9021.00
149_P157_L0.9011.00
172_R266_V0.8981.00
245_F248_R0.8981.00
35_F98_V0.8951.00
163_R167_M0.8911.00
161_Y165_A0.8861.00
186_S278_F0.8831.00
204_K207_N0.8821.00
161_Y164_D0.8781.00
216_I221_D0.8781.00
62_I205_M0.8701.00
170_P273_S0.8691.00
32_V40_I0.8671.00
239_F243_N0.8641.00
35_F59_T0.8601.00
58_I99_I0.8591.00
165_A169_G0.8591.00
260_W263_K0.8551.00
227_A231_M0.8541.00
123_P286_D0.8491.00
150_F153_D0.8461.00
170_P252_Y0.8461.00
187_L236_Y0.8461.00
309_G312_L0.8451.00
122_N290_Y0.8370.99
108_L111_G0.8350.99
39_H119_D0.8350.99
286_D289_Y0.8340.99
47_I70_P0.8260.99
79_Y101_S0.8230.99
58_I215_N0.8170.99
284_F287_L0.8150.99
88_E106_I0.8150.99
181_Q184_M0.8120.99
117_T290_Y0.8060.99
142_G311_E0.8040.99
80_D91_V0.8030.99
154_V157_L0.8030.99
131_H297_K0.7980.99
43_L70_P0.7930.99
113_E133_D0.7920.99
93_K115_G0.7920.99
55_A59_T0.7890.99
40_I66_D0.7840.99
169_G175_G0.7840.99
222_E226_E0.7840.99
36_H39_H0.7830.99
38_D140_T0.7820.99
224_Q229_E0.7800.99
103_Q290_Y0.7800.99
239_F242_Y0.7780.99
151_K154_V0.7750.99
175_G180_L0.7710.99
220_F224_Q0.7710.99
224_Q227_A0.7710.99
178_G182_E0.7710.99
64_S71_P0.7640.99
263_K267_K0.7630.99
135_L299_I0.7610.99
34_H38_D0.7600.99
42_G45_K0.7580.99
155_E186_S0.7540.99
184_M196_F0.7520.99
83_M90_I0.7500.99
261_E266_V0.7490.99
140_T303_G0.7450.99
20_T24_H0.7430.99
220_F227_A0.7420.99
231_M235_W0.7370.99
56_T100_G0.7360.99
64_S74_A0.7360.99
46_S50_S0.7350.99
92_L102_A0.7340.99
57_P61_D0.7320.99
120_F282_A0.7290.99
257_L260_W0.7280.99
57_P212_Y0.7260.99
265_V268_K0.7220.98
306_R309_G0.7140.98
38_D303_G0.7130.98
115_G129_I0.7120.98
94_K100_G0.7100.98
36_H281_H0.7100.98
157_L274_Y0.7050.98
116_Y136_I0.7030.98
124_G292_E0.7020.98
143_R311_E0.7020.98
34_H39_H0.7010.98
119_D303_G0.7010.98
234_S241_H0.6960.98
183_V236_Y0.6920.98
88_E110_N0.6920.98
310_K314_E0.6910.98
43_L67_Y0.6890.98
29_F86_E0.6870.98
35_F40_I0.6860.98
123_P151_K0.6850.98
71_P74_A0.6830.98
139_A309_G0.6770.98
217_S220_F0.6730.98
183_V187_L0.6720.98
43_L51_D0.6690.98
208_I212_Y0.6690.98
160_D163_R0.6670.97
96_D178_G0.6660.97
136_I300_I0.6650.97
179_K280_D0.6620.97
253_Y257_L0.6620.97
215_N219_V0.6610.97
155_E182_E0.6600.97
178_G181_Q0.6580.97
114_I136_I0.6570.97
203_S207_N0.6550.97
179_K187_L0.6550.97
182_E187_L0.6530.97
47_I73_K0.6520.97
20_T23_G0.6500.97
219_V224_Q0.6480.97
188_R220_F0.6480.97
22_D25_H0.6470.97
165_A252_Y0.6450.97
120_F290_Y0.6440.97
156_S159_A0.6430.97
21_I25_H0.6430.97
151_K186_S0.6420.97
226_E230_I0.6400.97
95_S290_Y0.6400.97
43_L53_I0.6390.97
134_I297_K0.6360.97
227_A235_W0.6360.97
269_I273_S0.6320.97
36_H97_H0.6320.97
129_I294_T0.6290.96
38_D281_H0.6290.96
118_G140_T0.6290.96
77_L90_I0.6260.96
105_L132_P0.6250.96
27_R30_R0.6250.96
219_V223_S0.6240.96
59_T181_Q0.6220.96
114_I134_I0.6220.96
143_R308_Y0.6210.96
173_I183_V0.6190.96
284_F288_I0.6180.96
68_A71_P0.6180.96
19_F22_D0.6170.96
141_Y179_K0.6160.96
255_F260_W0.6150.96
58_I212_Y0.6150.96
117_T129_I0.6150.96
283_D286_D0.6140.96
96_D101_S0.6130.96
140_T279_S0.6100.96
170_P175_G0.6100.96
18_R23_G0.6090.96
257_L262_F0.6090.96
39_H140_T0.6090.96
152_D156_S0.6050.96
266_V269_I0.6050.96
35_F62_I0.6040.96
185_I215_N0.6020.95
301_T304_G0.6010.95
172_R261_E0.6010.95
259_G267_K0.6000.95
170_P251_K0.6000.95
115_G290_Y0.5990.95
308_Y311_E0.5960.95
133_D137_I0.5960.95
178_G209_A0.5950.95
171_V177_H0.5920.95
265_V269_I0.5920.95
179_K185_I0.5910.95
107_T130_L0.5890.95
181_Q206_T0.5860.95
176_Y260_W0.5860.95
65_L68_A0.5840.95
235_W238_S0.5840.95
249_N252_Y0.5770.94
234_S242_Y0.5730.94
154_V278_F0.5720.94
32_V53_I0.5710.94
77_L104_V0.5670.94
103_Q294_T0.5670.94
163_R192_V0.5660.94
291_V296_A0.5660.94
233_D237_I0.5650.94
31_V86_E0.5650.94
176_Y280_D0.5640.94
95_S102_A0.5630.94
19_F24_H0.5590.93
162_V166_L0.5580.93
95_S283_D0.5580.93
70_P74_A0.5570.93
200_G203_S0.5550.93
47_I67_Y0.5530.93
197_I248_R0.5510.93
19_F23_G0.5500.93
73_K76_G0.5500.93
221_D227_A0.5480.93
218_Q222_E0.5470.93
256_L260_W0.5470.93
234_S238_S0.5450.92
31_V83_M0.5430.92
180_L206_T0.5430.92
257_L266_V0.5430.92
287_L291_V0.5430.92
193_D234_S0.5410.92
195_P250_G0.5410.92
233_D236_Y0.5390.92
33_T114_I0.5370.92
244_E247_R0.5370.92
138_E303_G0.5370.92
235_W241_H0.5360.92
34_H281_H0.5340.92
134_I298_Y0.5340.92
157_L161_Y0.5330.92
121_K280_D0.5330.92
45_K48_S0.5330.92
288_I292_E0.5310.91
291_V312_L0.5280.91
65_L205_M0.5260.91
196_F220_F0.5250.91
231_M238_S0.5250.91
161_Y276_V0.5240.91
70_P73_K0.5240.91
287_L312_L0.5240.91
124_G289_Y0.5240.91
246_K272_K0.5230.91
116_Y302_D0.5210.91
119_D281_H0.5200.91
144_P283_D0.5200.91
103_Q117_T0.5160.90
40_I62_I0.5160.90
43_L46_S0.5150.90
159_A186_S0.5150.90
137_I290_Y0.5150.90
37_A263_K0.5140.90
140_T176_Y0.5140.90
188_R215_N0.5140.90
148_R278_F0.5130.90
158_F162_V0.5130.90
218_Q221_D0.5130.90
230_I236_Y0.5120.90
140_T281_H0.5090.90
252_Y273_S0.5080.90
258_S267_K0.5080.90
224_Q230_I0.5080.90
63_L71_P0.5080.90
34_H97_H0.5070.89
234_S237_I0.5060.89
222_E229_E0.5060.89
36_H119_D0.5030.89
224_Q228_K0.5030.89
111_G293_R0.5020.89
154_V158_F0.5010.89
232_R236_Y0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i7tA 1 0.878 100 0.409 Contact Map
2ycbA 2 0.9939 100 0.419 Contact Map
3iekA 3 0.9787 100 0.425 Contact Map
2xr1A 2 0.9848 100 0.431 Contact Map
3af5A 1 0.997 100 0.432 Contact Map
5ahoA 1 0.8963 100 0.447 Contact Map
3bk2A 2 0.9787 100 0.452 Contact Map
3zq4A 3 0.9817 100 0.462 Contact Map
4b87A 1 0.9299 100 0.471 Contact Map
2az4A 1 0.9573 100 0.513 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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