GREMLIN Database
DCD - Probable deoxycytidine triphosphate deaminase
UniProt: Q980T7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (168)
Sequences: 1898 (871)
Seq/√Len: 67.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_E117_K5.4231.00
10_Y14_K3.7411.00
35_R81_E3.6991.00
34_L140_I3.5061.00
112_V120_V3.2161.00
89_D146_R3.1471.00
19_I32_V2.7401.00
81_E136_S2.5031.00
92_A144_F2.3751.00
30_N114_A2.2611.00
11_Y16_W2.2461.00
98_S102_R2.2411.00
9_K24_E2.1261.00
93_F145_A2.0891.00
105_L131_V2.0871.00
37_G79_T2.0651.00
22_L32_V2.0541.00
26_T35_R2.0001.00
86_L92_A1.9301.00
51_D134_K1.8931.00
7_D10_Y1.8451.00
7_D148_L1.8211.00
83_Y117_K1.7501.00
79_T119_Q1.7321.00
7_D149_T1.7231.00
9_K152_E1.6800.99
12_L22_L1.6670.99
3_L7_D1.6550.99
117_K161_G1.6220.99
71_Q74_E1.6150.99
34_L142_L1.5970.99
4_S7_D1.5920.99
36_V133_L1.5650.99
11_Y90_V1.5630.99
102_R141_H1.5250.99
37_G136_S1.5200.99
112_V142_L1.4830.99
22_L27_I1.4630.98
86_L90_V1.4440.98
34_L84_I1.4200.98
81_E135_R1.4200.98
53_D134_K1.3860.98
67_E132_K1.3760.98
8_L32_V1.3610.98
28_R141_H1.3140.97
11_Y87_N1.3110.97
2_I145_A1.2740.96
98_S141_H1.2720.96
100_F137_T1.2710.96
69_I132_K1.2510.96
15_S18_K1.2320.96
33_D97_R1.2310.96
27_I32_V1.2180.95
43_F77_L1.2170.95
71_Q130_P1.1980.95
23_R122_I1.1930.95
106_F125_V1.1900.95
11_Y15_S1.1860.95
7_D11_Y1.1840.94
113_D159_Y1.1760.94
96_L101_A1.1760.94
20_Q83_Y1.1690.94
88_N154_P1.1520.94
116_F162_Q1.1460.93
67_E134_K1.1400.93
63_E67_E1.1330.93
87_N90_V1.1170.93
80_T122_I1.1120.92
93_F111_I1.1060.92
97_R138_R1.1050.92
10_Y18_K1.1000.92
78_L124_V1.0970.92
123_E162_Q1.0950.92
99_T168_P1.0940.92
113_D116_F1.0880.92
44_K58_S1.0870.91
78_L96_L1.0660.91
23_R26_T1.0620.91
11_Y89_D1.0540.90
6_R152_E1.0420.90
99_T141_H1.0340.89
119_Q164_G1.0270.89
4_S149_T1.0140.88
105_L126_G1.0130.88
92_A112_V1.0000.88
39_E79_T0.9890.87
92_A142_L0.9890.87
109_P130_P0.9830.87
57_P60_F0.9710.86
18_K85_E0.9650.86
122_I139_F0.9620.86
28_R33_D0.9490.85
23_R35_R0.9360.84
89_D150_P0.9300.84
4_S147_T0.9250.83
3_L146_R0.9220.83
36_V78_L0.9190.83
111_I116_F0.9170.83
108_P123_E0.9140.83
101_A123_E0.9080.82
76_V126_G0.9080.82
72_P105_L0.9020.82
2_I143_I0.8770.80
77_L105_L0.8760.80
97_R102_R0.8760.80
115_G155_Y0.8750.80
109_P124_V0.8730.80
97_R141_H0.8700.79
107_I140_I0.8630.79
113_D118_G0.8630.79
26_T138_R0.8580.78
78_L139_F0.8410.77
96_L108_P0.8380.77
9_K13_E0.8350.76
98_S101_A0.8290.76
147_T151_V0.8290.76
33_D143_I0.8270.76
151_V154_P0.8270.76
8_L16_W0.8210.75
2_I91_M0.8160.75
34_L80_T0.8130.75
95_N116_F0.8070.74
18_K83_Y0.8060.74
42_R104_G0.8050.74
10_Y24_E0.8020.74
34_L139_F0.8010.73
39_E61_Q0.7980.73
77_L121_T0.7960.73
16_W89_D0.7950.73
64_K67_E0.7950.73
96_L105_L0.7910.72
75_H125_V0.7870.72
110_T113_D0.7710.71
40_I68_F0.7610.70
31_G111_I0.7590.69
74_E138_R0.7590.69
95_N108_P0.7560.69
72_P130_P0.7550.69
70_I124_V0.7550.69
10_Y13_E0.7530.69
80_T120_V0.7400.67
105_L111_I0.7400.67
124_V133_L0.7390.67
50_F54_N0.7360.67
8_L144_F0.7330.67
166_T169_K0.7300.66
80_T101_A0.7260.66
66_E69_I0.7240.66
80_T139_F0.7160.65
49_I69_I0.7140.65
86_L144_F0.7130.65
116_F120_V0.7030.63
87_N118_G0.7000.63
110_T116_F0.6990.63
160_Q164_G0.6810.61
88_N115_G0.6780.61
143_I147_T0.6770.61
124_V165_V0.6740.60
2_I48_K0.6720.60
11_Y17_I0.6690.60
19_I22_L0.6520.58
28_R99_T0.6500.57
93_F143_I0.6460.57
96_L162_Q0.6400.56
40_I67_E0.6380.56
21_P77_L0.6330.55
84_I142_L0.6320.55
11_Y144_F0.6320.55
20_Q23_R0.6300.55
80_T121_T0.6290.55
9_K27_I0.6270.55
9_K14_K0.6270.55
93_F110_T0.6250.54
8_L19_I0.6230.54
95_N123_E0.6210.54
6_R149_T0.6200.54
30_N126_G0.6200.54
14_K18_K0.6150.53
77_L123_E0.6130.53
95_N143_I0.6120.53
6_R37_G0.6090.53
5_D8_L0.6080.52
122_I140_I0.6080.52
4_S148_L0.6070.52
62_T65_G0.6060.52
36_V76_V0.6040.52
77_L96_L0.6010.52
91_M111_I0.5960.51
95_N101_A0.5960.51
21_P82_E0.5930.51
91_M110_T0.5930.51
105_L137_T0.5920.51
91_M113_D0.5920.51
91_M143_I0.5920.51
22_L26_T0.5910.50
103_L137_T0.5870.50
44_K48_K0.5860.50
97_R100_F0.5850.50
41_A126_G0.5840.50
34_L118_G0.5810.49
156_Q163_K0.5800.49
69_I134_K0.5800.49
70_I140_I0.5800.49
103_L168_P0.5790.49
13_E24_E0.5790.49
17_I87_N0.5780.49
69_I123_E0.5780.49
20_Q24_E0.5770.49
73_Y126_G0.5770.49
97_R158_K0.5750.49
44_K60_F0.5710.48
104_G126_G0.5700.48
94_V120_V0.5690.48
31_G157_G0.5680.48
98_S123_E0.5680.48
78_L123_E0.5660.47
76_V120_V0.5600.47
94_V112_V0.5580.47
54_N163_K0.5560.46
5_D9_K0.5560.46
31_G101_A0.5540.46
40_I78_L0.5540.46
12_L32_V0.5540.46
6_R10_Y0.5520.46
98_S110_T0.5520.46
108_P111_I0.5490.45
10_Y47_D0.5420.45
41_A167_L0.5420.45
42_R59_F0.5410.45
36_V98_S0.5400.44
101_A141_H0.5330.44
15_S152_E0.5320.43
130_P140_I0.5310.43
68_F76_V0.5260.43
2_I114_A0.5250.43
13_E38_N0.5250.43
119_Q163_K0.5220.42
136_S163_K0.5220.42
80_T96_L0.5200.42
105_L124_V0.5190.42
138_R143_I0.5190.42
101_A108_P0.5160.42
28_R80_T0.5150.42
36_V139_F0.5130.41
10_Y169_K0.5120.41
68_F71_Q0.5080.41
34_L92_A0.5070.41
51_D113_D0.5070.41
92_A120_V0.5060.40
30_N134_K0.5060.40
39_E164_G0.5030.40
64_K133_L0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xs1A 5 0.9402 100 0.224 Contact Map
2qxxA 3 0.962 100 0.23 Contact Map
4xjcA 3 0.9457 100 0.237 Contact Map
1pkhA 5 0.8261 100 0.242 Contact Map
4dhkA 5 0.8261 100 0.261 Contact Map
3km3A 4 0.7935 100 0.263 Contact Map
2yzjA 3 0.8587 100 0.275 Contact Map
2r9qA 4 0.8261 100 0.321 Contact Map
3lqwA 3 0.6413 99.9 0.61 Contact Map
1dunA 3 0.6467 99.8 0.625 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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