GREMLIN Database
Q980T5 - Glutaredoxin related protein
UniProt: Q980T5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (196)
Sequences: 1176 (812)
Seq/√Len: 58.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_T123_S4.0631.00
147_I165_A3.9481.00
129_L148_E3.5471.00
60_K113_R3.3111.00
147_I205_I3.2971.00
119_I124_Q3.0801.00
117_E121_R2.9731.00
114_A118_T2.7741.00
216_V221_N2.7361.00
155_C158_C2.6911.00
30_V35_D2.5261.00
206_A212_E2.5091.00
129_L183_E2.4421.00
81_K84_E2.3861.00
168_V222_F2.3231.00
30_V34_V2.3051.00
218_Y221_N2.2861.00
162_A166_H2.2601.00
128_G184_V2.1861.00
157_Y217_P2.0941.00
118_T124_Q2.0051.00
164_M219_E1.9581.00
222_F226_I1.9241.00
96_F119_I1.8791.00
32_V35_D1.8721.00
67_L71_I1.8521.00
168_V219_E1.7600.99
150_V187_A1.7560.99
61_D117_E1.7540.99
197_Y208_N1.7520.99
31_Y35_D1.7300.99
151_V184_V1.7290.99
161_A222_F1.6810.99
69_V73_D1.6690.99
153_P188_Y1.6070.99
54_M112_I1.6060.99
164_M167_M1.6000.99
133_T136_A1.5930.99
116_V120_V1.5850.99
157_Y201_S1.5760.98
174_R177_K1.5750.98
149_T184_V1.5640.98
134_V138_K1.5480.98
144_K181_I1.5250.98
31_Y34_V1.4790.98
125_G132_E1.4710.98
191_Q194_A1.4530.97
180_V226_I1.4270.97
152_T188_Y1.4170.97
150_V199_V1.4120.97
130_S133_T1.4050.97
134_V150_V1.3920.97
24_M30_V1.3650.96
149_T205_I1.3360.96
164_M218_Y1.3140.95
149_T162_A1.3130.95
24_M32_V1.3050.95
146_K183_E1.2930.95
147_I182_S1.2910.95
145_V207_I1.2910.95
149_T161_A1.2680.94
152_T159_P1.2530.94
174_R223_I1.2470.94
67_L73_D1.2370.93
160_Y164_M1.2320.93
108_L111_E1.2310.93
168_V182_S1.1980.92
70_H73_D1.1910.92
134_V139_S1.1890.92
213_F221_N1.1510.91
92_P96_F1.1250.90
187_A194_A1.1160.89
186_E189_E1.1140.89
152_T156_P1.1120.89
153_P186_E1.1110.89
171_E223_I1.1110.89
94_V112_I1.1110.89
146_K181_I1.1090.89
201_S217_P1.0750.87
49_K53_F1.0700.87
187_A199_V1.0680.87
169_A182_S1.0640.87
161_A164_M1.0640.87
52_E55_A1.0550.86
57_A113_R1.0520.86
126_E130_S1.0490.86
49_K52_E1.0490.86
149_T158_C1.0430.86
129_L133_T1.0360.85
29_D32_V1.0260.85
31_Y36_N1.0260.85
165_A226_I1.0190.85
219_E222_F1.0180.84
94_V98_N1.0140.84
33_F36_N1.0040.84
155_C201_S0.9960.83
109_G113_R0.9790.82
174_R227_L0.9770.82
152_T155_C0.9710.82
79_S82_I0.9680.81
152_T163_L0.9580.81
152_T157_Y0.9520.80
162_A184_V0.9440.80
91_V97_Y0.9320.79
175_A178_C0.9290.79
126_E183_E0.9250.78
133_T137_I0.9230.78
156_P217_P0.9130.77
193_I196_K0.9120.77
194_A197_Y0.9100.77
133_T138_K0.9080.77
135_E196_K0.9060.77
53_F56_S0.8930.76
119_I125_G0.8920.76
138_K141_L0.8880.75
187_A202_V0.8870.75
126_E134_V0.8860.75
157_Y187_A0.8860.75
92_P97_Y0.8850.75
145_V179_N0.8850.75
156_P161_A0.8770.74
130_S138_K0.8770.74
205_I217_P0.8760.74
126_E169_A0.8750.74
155_C204_A0.8720.74
161_A168_V0.8700.74
156_P201_S0.8650.73
56_S60_K0.8560.73
68_K73_D0.8540.72
165_A182_S0.8510.72
47_T51_L0.8500.72
129_L138_K0.8490.72
167_M219_E0.8480.72
92_P98_N0.8430.71
130_S190_N0.8350.71
161_A217_P0.8300.70
106_A111_E0.8250.70
122_L190_N0.8170.69
103_W175_A0.8170.69
71_I74_R0.8170.69
156_P163_L0.8080.68
150_V213_F0.8050.68
137_I142_N0.7920.67
136_A141_L0.7840.66
149_T157_Y0.7810.66
152_T186_E0.7690.64
131_Q193_I0.7650.64
131_Q134_V0.7620.64
163_L217_P0.7610.64
65_S68_K0.7540.63
51_L55_A0.7520.63
165_A169_A0.7520.63
152_T202_V0.7500.62
129_L146_K0.7490.62
154_S159_P0.7480.62
223_I227_L0.7430.62
25_K33_F0.7420.62
27_P31_Y0.7400.61
163_L204_A0.7390.61
161_A182_S0.7380.61
159_P163_L0.7360.61
129_L134_V0.7360.61
165_A205_I0.7360.61
51_L142_N0.7350.61
46_V201_S0.7330.61
155_C202_V0.7320.61
197_Y207_I0.7300.60
101_I105_G0.7290.60
115_L124_Q0.7260.60
148_E187_A0.7200.59
132_E216_V0.7200.59
205_I222_F0.7180.59
145_V178_C0.7150.59
72_V183_E0.7150.59
161_A188_Y0.7140.59
88_V112_I0.7100.58
96_F124_Q0.7060.58
117_E147_I0.6970.57
50_F55_A0.6950.57
48_T52_E0.6940.56
133_T185_I0.6920.56
148_E208_N0.6920.56
65_S73_D0.6910.56
148_E183_E0.6890.56
61_D106_A0.6860.56
28_V31_Y0.6830.55
94_V97_Y0.6810.55
117_E229_K0.6760.55
174_R226_I0.6740.54
25_K28_V0.6740.54
221_N224_N0.6720.54
46_V50_F0.6710.54
157_Y202_V0.6700.54
152_T158_C0.6680.54
50_F108_L0.6670.54
206_A210_S0.6670.54
68_K71_I0.6660.53
214_I228_E0.6580.53
73_D76_N0.6580.53
61_D113_R0.6480.51
129_L181_I0.6450.51
70_H74_R0.6450.51
139_S142_N0.6450.51
159_P217_P0.6440.51
26_N29_D0.6410.51
105_G111_E0.6400.51
113_R117_E0.6350.50
135_E139_S0.6340.50
128_G182_S0.6320.50
138_K146_K0.6300.49
26_N30_V0.6270.49
151_V201_S0.6260.49
110_E143_G0.6260.49
25_K29_D0.6250.49
58_A153_P0.6240.49
47_T50_F0.6230.49
83_F86_F0.6170.48
28_V32_V0.6130.48
70_H79_S0.6100.47
211_I225_A0.6080.47
92_P95_A0.6050.47
79_S142_N0.6040.47
182_S217_P0.6010.46
108_L193_I0.6000.46
204_A217_P0.5990.46
24_M27_P0.5980.46
151_V159_P0.5950.46
128_G149_T0.5900.45
69_V120_V0.5900.45
125_G216_V0.5890.45
207_I228_E0.5850.45
29_D34_V0.5850.45
155_C205_I0.5830.44
88_V109_G0.5830.44
46_V49_K0.5820.44
126_E133_T0.5800.44
155_C199_V0.5770.44
155_C217_P0.5760.44
147_I207_I0.5700.43
116_V124_Q0.5690.43
60_K117_E0.5690.43
28_V33_F0.5670.43
124_Q194_A0.5670.43
50_F54_M0.5650.42
134_V148_E0.5650.42
25_K32_V0.5640.42
130_S134_V0.5610.42
154_S202_V0.5590.42
60_K103_W0.5570.41
187_A190_N0.5570.41
149_T165_A0.5510.41
127_S133_T0.5510.41
127_S205_I0.5490.41
36_N228_E0.5490.41
154_S188_Y0.5470.40
135_E138_K0.5440.40
56_S109_G0.5430.40
30_V33_F0.5430.40
129_L132_E0.5420.40
67_L75_A0.5410.40
215_G221_N0.5400.40
54_M57_A0.5400.40
216_V225_A0.5390.40
91_V108_L0.5370.39
29_D33_F0.5360.39
132_E228_E0.5340.39
119_I122_L0.5330.39
31_Y98_N0.5320.39
146_K209_E0.5320.39
166_H184_V0.5310.39
95_A98_N0.5310.39
57_A65_S0.5300.39
166_H220_E0.5300.39
180_V207_I0.5290.39
169_A227_L0.5270.38
89_E120_V0.5200.38
169_A190_N0.5200.38
185_I194_A0.5170.37
43_Y53_F0.5170.37
135_E175_A0.5170.37
157_Y161_A0.5150.37
110_E225_A0.5150.37
31_Y94_V0.5130.37
127_S218_Y0.5110.37
49_K107_P0.5100.37
123_S178_C0.5100.37
50_F53_F0.5100.37
87_N228_E0.5100.37
67_L121_R0.5050.36
92_P213_F0.5020.36
156_P162_A0.5020.36
130_S141_L0.5010.36
165_A202_V0.5010.36
84_E87_N0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uemA 1 0.9485 100 0.391 Contact Map
3wt1A 1 0.897 100 0.409 Contact Map
2b5eA 1 0.9399 100 0.41 Contact Map
3f8uA 2 0.9657 100 0.426 Contact Map
3apoA 1 0.927 100 0.431 Contact Map
4ekzA 1 0.927 100 0.431 Contact Map
3idvA 1 0.9485 100 0.481 Contact Map
2hlsA 5 0.9528 100 0.485 Contact Map
4tveA 1 0.9227 100 0.493 Contact Map
4tw5A 3 0.9142 100 0.497 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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