GREMLIN Database
Y193 - Protein SSO0193
UniProt: Q980T4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (175)
Sequences: 1075 (878)
Seq/√Len: 66.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_L193_F5.6251.00
101_L109_I3.7551.00
114_T195_G3.5091.00
119_P142_I3.4411.00
153_L171_E3.1791.00
20_L84_A2.9811.00
89_K93_F2.9711.00
144_E150_S2.9231.00
144_E189_R2.8661.00
57_L101_L2.8641.00
28_I92_A2.7751.00
120_E192_R2.7581.00
164_D167_T2.7181.00
117_T194_H2.4791.00
59_K108_N2.3421.00
138_E194_H2.3351.00
144_E191_K2.2991.00
121_E189_R2.2481.00
74_V152_L2.2091.00
139_D194_H2.0611.00
31_E93_F2.0221.00
78_A86_S1.9151.00
28_I111_I1.8721.00
153_L172_T1.8071.00
135_K138_E1.7271.00
139_D192_R1.7191.00
24_A84_A1.7080.99
90_A94_S1.6790.99
112_E156_Q1.6780.99
158_P168_F1.6490.99
156_Q195_G1.6250.99
158_P163_W1.6120.99
31_E89_K1.5800.99
143_V172_T1.5650.99
53_A152_L1.5610.99
23_I85_A1.5560.99
28_I88_A1.5360.99
130_L190_I1.5130.99
25_R200_E1.4830.99
53_A83_I1.4740.98
30_E34_L1.4600.98
135_K139_D1.4190.98
32_F93_F1.4110.98
93_F101_L1.3950.98
39_L42_Y1.3530.97
173_C182_C1.3200.97
74_V193_F1.3110.97
86_S94_S1.3060.97
131_P166_E1.3020.97
117_T196_I1.2880.96
68_R105_E1.2870.96
32_F103_E1.2860.96
33_K103_E1.2830.96
23_I27_S1.2730.96
74_V142_I1.2550.96
28_I93_F1.2460.96
53_A80_L1.2380.96
75_E150_S1.2350.95
27_S85_A1.2320.95
120_E194_H1.2120.95
17_G196_I1.1600.94
84_A115_V1.1480.93
143_V190_I1.1360.93
21_I113_V1.1320.93
58_E112_E1.1300.93
64_T108_N1.1280.93
29_K33_K1.1260.93
27_S89_K1.1140.92
29_K106_L1.1050.92
145_K188_V1.1040.92
57_L111_I1.0760.91
121_E191_K1.0670.90
141_L172_T1.0530.90
173_C188_V1.0450.90
56_T157_V1.0390.89
145_K187_S1.0380.89
32_F101_L1.0320.89
161_Y171_E1.0220.88
158_P162_C1.0160.88
73_Y77_V1.0150.88
173_C176_A0.9950.87
133_I192_R0.9890.87
48_D81_K0.9830.86
57_L109_I0.9770.86
141_L151_G0.9750.86
23_I84_A0.9490.84
99_N141_L0.9320.83
27_S30_E0.9300.83
131_P169_L0.9300.83
145_K182_C0.9200.83
112_E197_I0.9160.82
52_L76_A0.9140.82
16_I46_I0.9110.82
135_K165_E0.9090.82
59_K109_I0.8930.81
136_V165_E0.8840.80
55_V87_A0.8750.79
17_G113_V0.8740.79
153_L161_Y0.8640.78
170_A190_I0.8560.78
56_T114_T0.8550.78
170_A180_P0.8540.78
89_K110_I0.8520.77
86_S90_A0.8460.77
122_I192_R0.8430.77
21_I25_R0.8400.76
78_A83_I0.8340.76
134_I139_D0.8310.76
149_H176_A0.8270.75
102_Q176_A0.8250.75
27_S88_A0.8210.75
123_K133_I0.8170.74
73_Y78_A0.8160.74
153_L193_F0.8140.74
37_L89_K0.8120.74
32_F106_L0.8040.73
58_E160_E0.8000.73
54_F71_I0.7960.72
81_K84_A0.7930.72
113_V143_V0.7930.72
170_A181_D0.7920.72
27_S84_A0.7920.72
22_E200_E0.7900.72
65_S110_I0.7870.72
134_I165_E0.7770.71
52_L83_I0.7720.70
83_I87_A0.7630.69
114_T157_V0.7610.69
32_F111_I0.7540.68
23_I81_K0.7520.68
169_L190_I0.7510.68
91_A105_E0.7400.67
167_T171_E0.7390.67
76_A119_P0.7330.66
144_E147_I0.7300.66
157_V168_F0.7270.66
49_K80_L0.7260.65
18_R198_F0.7240.65
73_Y87_A0.7200.65
130_L133_I0.7150.64
161_Y172_T0.7120.64
141_L192_R0.7110.64
145_K185_D0.7090.64
18_R22_E0.7080.63
158_P172_T0.7020.63
59_K106_L0.7010.63
26_K35_D0.6970.62
43_D46_I0.6900.61
57_L92_A0.6890.61
98_F154_L0.6890.61
112_E117_T0.6870.61
166_E170_A0.6840.61
179_E182_C0.6820.61
115_V196_I0.6820.61
28_I31_E0.6720.59
59_K101_L0.6660.59
106_L109_I0.6650.59
156_Q197_I0.6640.59
114_T156_Q0.6620.58
152_L172_T0.6610.58
122_I133_I0.6600.58
51_G196_I0.6600.58
59_K102_Q0.6590.58
158_P165_E0.6560.58
110_I199_K0.6550.57
58_E199_K0.6540.57
145_K181_D0.6540.57
182_C188_V0.6510.57
136_V163_W0.6500.57
134_I141_L0.6470.57
93_F103_E0.6470.57
151_G190_I0.6460.56
122_I130_L0.6440.56
52_L198_F0.6360.55
103_E123_K0.6360.55
25_R29_K0.6350.55
173_C184_L0.6340.55
74_V83_I0.6320.55
17_G200_E0.6290.54
97_R154_L0.6280.54
143_V161_Y0.6270.54
24_A27_S0.6260.54
19_L44_N0.6230.54
130_L158_P0.6210.54
169_L176_A0.6210.54
188_V195_G0.6200.53
70_C175_K0.6200.53
178_L183_W0.6140.53
70_C157_V0.6140.53
27_S94_S0.6070.52
28_I151_G0.6050.52
14_E17_G0.6030.51
58_E195_G0.6030.51
26_K30_E0.6020.51
58_E110_I0.6010.51
27_S196_I0.6010.51
87_A163_W0.5990.51
131_P165_E0.5980.51
32_F92_A0.5980.51
49_K102_Q0.5950.50
103_E179_E0.5940.50
31_E36_K0.5940.50
88_A93_F0.5910.50
81_K113_V0.5870.50
144_E181_D0.5860.49
137_G163_W0.5850.49
74_V119_P0.5850.49
135_K194_H0.5850.49
30_E33_K0.5830.49
29_K35_D0.5820.49
44_N81_K0.5760.48
15_E26_K0.5760.48
182_C187_S0.5750.48
100_P120_E0.5750.48
179_E187_S0.5730.48
15_E42_Y0.5720.48
20_L47_L0.5700.48
112_E176_A0.5660.47
134_I168_F0.5650.47
99_N164_D0.5640.47
121_E179_E0.5630.47
67_L97_R0.5620.47
76_A117_T0.5590.46
153_L157_V0.5540.46
40_S44_N0.5540.46
169_L173_C0.5530.46
52_L74_V0.5520.45
113_V198_F0.5500.45
110_I200_E0.5490.45
54_F157_V0.5480.45
30_E35_D0.5460.45
87_A142_I0.5460.45
162_C165_E0.5450.45
21_I200_E0.5450.45
87_A90_A0.5370.44
96_P153_L0.5360.44
28_I90_A0.5340.43
68_R91_A0.5330.43
97_R116_L0.5280.43
16_I47_L0.5260.42
122_I136_V0.5260.42
168_F172_T0.5250.42
109_I200_E0.5230.42
36_K40_S0.5230.42
145_K149_H0.5220.42
53_A87_A0.5180.41
54_F70_C0.5130.41
130_L141_L0.5120.41
136_V162_C0.5120.41
26_K29_K0.5110.41
78_A82_Q0.5110.41
55_V193_F0.5100.41
54_F97_R0.5080.40
68_R98_F0.5070.40
153_L158_P0.5060.40
32_F102_Q0.5040.40
35_D186_S0.5030.40
14_E107_A0.5020.40
131_P136_V0.5010.40
43_D81_K0.5010.40
17_G198_F0.5000.39
173_C190_I0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wscA 1 0.9692 100 0.159 Contact Map
1zq7A 4 0.8811 100 0.18 Contact Map
1vajA 1 0.8855 100 0.183 Contact Map
2d2rA 2 0.3348 19.8 0.959 Contact Map
1hbnA 2 0.2687 7.3 0.966 Contact Map
3ewtE 1 0.0617 5.7 0.968 Contact Map
1k5nA 1 0.5022 5.5 0.968 Contact Map
2l2nA 1 0.2687 5.5 0.968 Contact Map
4j4rA 3 0.4053 5.3 0.969 Contact Map
2og0A 1 0.207 5.3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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