GREMLIN Database
Q980T1 - Uncharacterized protein
UniProt: Q980T1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (233)
Sequences: 984 (618)
Seq/√Len: 40.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_V243_L4.5051.00
186_I191_L4.0521.00
172_K184_E3.8001.00
211_L279_I3.7191.00
113_D117_N3.6281.00
214_M283_V3.2251.00
209_K240_N3.1841.00
163_L217_A2.9561.00
169_Y240_N2.8641.00
233_V241_P2.8231.00
164_S172_K2.7971.00
210_I241_P2.6111.00
100_I120_I2.5051.00
214_M260_L2.4811.00
186_I242_Y2.4411.00
253_E257_E2.3171.00
213_T243_L2.2731.00
215_R219_T2.2201.00
113_D119_I2.1730.99
133_K137_R2.1360.99
206_I235_I2.1220.99
121_V182_A2.1040.99
164_S173_P2.0910.99
95_R112_Y2.0720.99
206_I241_P2.0370.99
261_S265_I2.0290.99
169_Y213_T1.9650.99
224_T271_G1.9260.99
123_F180_A1.9130.99
215_R282_Y1.9110.99
102_I107_L1.9110.99
90_N175_G1.9080.99
275_D278_K1.7910.98
217_A246_W1.7790.98
119_I174_L1.7720.98
190_E193_K1.7610.97
210_I233_V1.7340.97
88_Y96_L1.7040.97
110_Y118_K1.6640.96
176_V179_N1.6540.96
207_L264_I1.6280.96
229_S262_N1.6070.96
92_I175_G1.5740.95
163_L246_W1.5690.95
96_L121_V1.5670.95
133_K136_F1.5500.95
191_L236_D1.5170.94
124_H181_V1.5140.94
144_S147_S1.4930.94
266_F270_K1.4930.94
234_L244_I1.4810.93
83_G178_Y1.4580.93
163_L168_G1.4520.93
226_G255_R1.4340.92
214_M228_L1.4340.92
155_R159_A1.4220.92
206_I210_I1.3870.91
163_L252_S1.3870.91
96_L111_G1.3850.91
135_K138_K1.3830.91
111_G119_I1.3550.90
212_Q216_I1.3530.90
79_L178_Y1.3520.90
179_N188_G1.3400.89
117_N172_K1.3250.89
157_F173_P1.3240.89
202_N205_E1.3070.88
91_K114_F1.2860.87
111_G182_A1.2540.86
65_K68_T1.2480.85
169_Y209_K1.2420.85
216_I220_I1.2390.85
82_L178_Y1.2300.85
191_L194_I1.2220.84
185_Y188_G1.2090.84
62_L65_K1.2090.84
99_I109_Y1.2020.83
127_G145_W1.2020.83
264_I279_I1.2000.83
174_L231_Y1.1970.83
207_L263_L1.1590.81
50_L61_K1.1540.81
88_Y173_P1.1530.81
71_S127_G1.1530.81
150_V179_N1.1420.80
154_K176_V1.1380.80
236_D242_Y1.1370.80
71_S126_V1.1350.79
76_F108_V1.1310.79
101_G246_W1.1140.78
93_L123_F1.0990.77
135_K140_Q1.0980.77
159_A249_A1.0890.77
280_F284_R1.0860.76
234_L248_Q1.0790.76
113_D116_D1.0660.75
124_H247_P1.0650.75
129_D145_W1.0540.74
213_T216_I1.0540.74
159_A223_I1.0530.74
276_T279_I1.0490.74
78_G127_G1.0450.74
211_L260_L1.0330.73
155_R230_P1.0330.73
82_L93_L1.0240.72
49_E52_I1.0240.72
119_I206_I1.0210.72
125_R133_K1.0180.72
168_G213_T1.0060.71
244_I248_Q0.9960.70
87_L180_A0.9940.70
218_Y283_V0.9900.69
52_I56_K0.9890.69
87_L92_I0.9890.69
279_I284_R0.9880.69
139_S155_R0.9870.69
224_T238_N0.9840.69
203_L272_I0.9810.69
155_R223_I0.9800.69
110_Y125_R0.9720.68
260_L279_I0.9570.67
211_L220_I0.9560.67
279_I283_V0.9550.67
205_E209_K0.9510.66
146_L177_E0.9440.66
149_T152_N0.9430.66
80_D101_G0.9410.65
209_K241_P0.9380.65
85_K89_V0.9350.65
93_L143_K0.9330.65
126_V134_V0.9260.64
110_Y185_Y0.9250.64
261_S276_T0.9240.64
209_K213_T0.9230.64
75_T262_N0.9190.64
49_E53_S0.9100.63
84_I181_V0.9080.63
93_L236_D0.9070.63
215_R228_L0.9050.62
119_I182_A0.9050.62
278_K281_D0.8960.62
87_L182_A0.8890.61
207_L211_L0.8810.60
157_F273_D0.8810.60
153_A188_G0.8740.60
258_K262_N0.8720.59
94_N243_L0.8710.59
140_Q151_E0.8700.59
92_I119_I0.8690.59
102_I179_N0.8660.59
152_N159_A0.8650.59
164_S170_V0.8580.58
186_I266_F0.8570.58
97_A110_Y0.8560.58
154_K162_C0.8520.58
178_Y258_K0.8510.58
211_L273_D0.8490.57
108_V254_E0.8420.57
111_G121_V0.8370.56
51_K55_K0.8370.56
134_V251_K0.8330.56
125_R145_W0.8280.55
81_I84_I0.8260.55
224_T255_R0.8250.55
75_T109_Y0.8200.55
147_S150_V0.8150.54
108_V133_K0.8010.53
225_H232_N0.8000.53
52_I187_D0.7930.52
198_N252_S0.7930.52
82_L150_V0.7920.52
54_L57_L0.7890.52
105_E131_Y0.7880.52
113_D278_K0.7870.52
76_F146_L0.7830.51
159_A229_S0.7790.51
167_G271_G0.7770.51
161_T165_N0.7770.51
188_G194_I0.7740.51
54_L63_I0.7700.50
185_Y271_G0.7680.50
193_K243_L0.7630.50
79_L150_V0.7630.50
107_L125_R0.7610.49
164_S184_E0.7600.49
188_G234_L0.7560.49
246_W249_A0.7540.49
127_G130_S0.7510.48
111_G160_L0.7440.48
264_I276_T0.7440.48
124_H152_N0.7400.47
58_S65_K0.7390.47
146_L181_V0.7380.47
214_M261_S0.7300.46
203_L209_K0.7280.46
230_P266_F0.7240.46
154_K218_Y0.7210.46
73_K109_Y0.7210.46
213_T228_L0.7170.45
63_I212_Q0.7150.45
187_D222_H0.7150.45
210_I260_L0.7140.45
107_L128_T0.7110.45
168_G228_L0.7080.44
153_A176_V0.7070.44
124_H177_E0.7060.44
196_V266_F0.7040.44
77_S152_N0.7020.44
93_L121_V0.7020.44
118_K269_K0.7020.44
115_N224_T0.7000.44
76_F154_K0.7000.44
99_I185_Y0.6990.44
74_L128_T0.6980.44
252_S265_I0.6960.43
51_K160_L0.6910.43
228_L262_N0.6880.43
227_D232_N0.6860.42
101_G231_Y0.6860.42
155_R250_T0.6810.42
125_R134_V0.6750.41
135_K142_K0.6730.41
174_L216_I0.6730.41
229_S256_L0.6690.41
87_L175_G0.6670.41
190_E234_L0.6620.40
215_R283_V0.6600.40
168_G256_L0.6580.40
96_L130_S0.6570.40
198_N238_N0.6550.40
138_K247_P0.6550.40
56_K174_L0.6550.40
67_P283_V0.6510.39
79_L127_G0.6500.39
130_S145_W0.6470.39
126_V246_W0.6460.39
74_L78_G0.6460.39
229_S246_W0.6450.39
152_N191_L0.6440.39
208_E274_V0.6430.39
149_T179_N0.6430.39
145_W247_P0.6410.38
69_D127_G0.6390.38
139_S224_T0.6390.38
198_N283_V0.6380.38
87_L114_F0.6380.38
127_G247_P0.6370.38
128_T145_W0.6330.38
209_K212_Q0.6320.38
79_L147_S0.6310.38
168_G221_C0.6300.38
121_V231_Y0.6300.38
136_F255_R0.6280.37
100_I205_E0.6280.37
57_L263_L0.6260.37
93_L261_S0.6260.37
158_E251_K0.6230.37
229_S249_A0.6220.37
98_E109_Y0.6190.37
58_S90_N0.6180.36
55_K271_G0.6170.36
84_I123_F0.6160.36
210_I263_L0.6130.36
136_F152_N0.6120.36
170_V184_E0.6120.36
113_D184_E0.6110.36
140_Q177_E0.6110.36
97_A188_G0.6070.36
109_Y196_V0.6070.36
50_L54_L0.6040.35
50_L56_K0.6010.35
86_L147_S0.6010.35
64_S67_P0.5970.35
208_E269_K0.5970.35
204_D208_E0.5970.35
157_F161_T0.5960.35
92_I182_A0.5920.34
148_I214_M0.5890.34
223_I249_A0.5870.34
87_L181_V0.5860.34
237_K272_I0.5850.34
85_K88_Y0.5840.34
74_L146_L0.5840.34
69_D153_A0.5840.34
167_G209_K0.5810.33
189_I237_K0.5800.33
93_L254_E0.5790.33
145_W148_I0.5790.33
166_E173_P0.5790.33
150_V170_V0.5750.33
94_N113_D0.5750.33
77_S136_F0.5720.33
93_L263_L0.5720.33
183_M249_A0.5710.33
93_L183_M0.5660.32
58_S263_L0.5640.32
202_N206_I0.5640.32
92_I205_E0.5630.32
74_L125_R0.5630.32
59_E266_F0.5620.32
82_L283_V0.5620.32
61_K243_L0.5570.31
74_L247_P0.5560.31
211_L214_M0.5530.31
100_I185_Y0.5510.31
106_S162_C0.5490.31
218_Y243_L0.5490.31
159_A246_W0.5480.31
219_T283_V0.5480.31
114_F272_I0.5470.31
252_S258_K0.5460.31
87_L95_R0.5430.30
134_V139_S0.5430.30
80_D179_N0.5410.30
129_D148_I0.5400.30
141_E231_Y0.5370.30
257_E282_Y0.5350.30
116_D269_K0.5290.29
223_I246_W0.5270.29
196_V240_N0.5250.29
186_I197_T0.5230.29
109_Y207_L0.5230.29
160_L180_A0.5210.29
76_F128_T0.5190.29
121_V174_L0.5190.29
254_E271_G0.5180.28
212_Q254_E0.5150.28
158_E162_C0.5150.28
201_L208_E0.5140.28
191_L240_N0.5130.28
257_E261_S0.5130.28
186_I209_K0.5110.28
241_P263_L0.5110.28
192_Y197_T0.5110.28
174_L184_E0.5110.28
68_T109_Y0.5090.28
219_T224_T0.5090.28
224_T254_E0.5090.28
49_E56_K0.5070.28
106_S251_K0.5070.28
184_E265_I0.5060.28
159_A256_L0.5060.28
235_I238_N0.5060.28
153_A251_K0.5040.27
67_P120_I0.5040.27
204_D273_D0.5040.27
91_K186_I0.5030.27
250_T279_I0.5010.27
109_Y133_K0.5010.27
108_V252_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zarA 1 0.9059 100 0.495 Contact Map
4gyiA 1 0.9721 100 0.513 Contact Map
1zthA 1 0.7909 100 0.671 Contact Map
4otpA 1 0.6446 100 0.709 Contact Map
4pedA 1 0.9129 99.7 0.822 Contact Map
4h05A 1 0.6411 99.5 0.84 Contact Map
3w0oA 1 0.6098 99.5 0.845 Contact Map
2zmdA 2 0.5958 99.5 0.846 Contact Map
2y7jA 3 0.6551 99.5 0.847 Contact Map
3atsA 1 0.6655 99.4 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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