Q980T1 - SULSO - GREMLIN Contacts

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Q980T1 - Uncharacterized protein

UniProt:	Q980T1	Sequences: MRLSLAEKASLVRPFDYILLKTIYGLRDKSEFVSFNALKKRLDIKDDEELKISLKKLSELKLISKKPTDLSFKLTFSGLDILGIKLLYVNKILNRLAEIIGIGKESLVYYGYDFNDNKIIVKFHRVGTDSYKKVKFRKSQEKKSWLSITVENAKREFEALTCLSNEGGYVPKPLGVEYNAVAMEYIDGIELYKIPVTNMDLNLDEILEKILQTMRIAYTICHITHGDLSPYNVLIDKNGNPYLIDWPQATKSEERLEKDLSNLIIFFRKKGIDVDTRKIFDYVRGVS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	287 (233)
Sequences:	984 (618)
Seq/√Len:	40.5

HALSA - Q9HSL0 Q9HN65
SULSO - Q980T1 Q97W63

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
233_V	243_L	4.505	1.00
186_I	191_L	4.052	1.00
172_K	184_E	3.800	1.00
211_L	279_I	3.719	1.00
113_D	117_N	3.628	1.00
214_M	283_V	3.225	1.00
209_K	240_N	3.184	1.00
163_L	217_A	2.956	1.00
169_Y	240_N	2.864	1.00
233_V	241_P	2.823	1.00
164_S	172_K	2.797	1.00
210_I	241_P	2.611	1.00
100_I	120_I	2.505	1.00
214_M	260_L	2.481	1.00
186_I	242_Y	2.441	1.00
253_E	257_E	2.317	1.00
213_T	243_L	2.273	1.00
215_R	219_T	2.220	1.00
113_D	119_I	2.173	0.99
133_K	137_R	2.136	0.99
206_I	235_I	2.122	0.99
121_V	182_A	2.104	0.99
164_S	173_P	2.091	0.99
95_R	112_Y	2.072	0.99
206_I	241_P	2.037	0.99
261_S	265_I	2.029	0.99
169_Y	213_T	1.965	0.99
224_T	271_G	1.926	0.99
123_F	180_A	1.913	0.99
215_R	282_Y	1.911	0.99
102_I	107_L	1.911	0.99
90_N	175_G	1.908	0.99
275_D	278_K	1.791	0.98
217_A	246_W	1.779	0.98
119_I	174_L	1.772	0.98
190_E	193_K	1.761	0.97
210_I	233_V	1.734	0.97
88_Y	96_L	1.704	0.97
110_Y	118_K	1.664	0.96
176_V	179_N	1.654	0.96
207_L	264_I	1.628	0.96
229_S	262_N	1.607	0.96
92_I	175_G	1.574	0.95
163_L	246_W	1.569	0.95
96_L	121_V	1.567	0.95
133_K	136_F	1.550	0.95
191_L	236_D	1.517	0.94
124_H	181_V	1.514	0.94
144_S	147_S	1.493	0.94
266_F	270_K	1.493	0.94
234_L	244_I	1.481	0.93
83_G	178_Y	1.458	0.93
163_L	168_G	1.452	0.93
226_G	255_R	1.434	0.92
214_M	228_L	1.434	0.92
155_R	159_A	1.422	0.92
206_I	210_I	1.387	0.91
163_L	252_S	1.387	0.91
96_L	111_G	1.385	0.91
135_K	138_K	1.383	0.91
111_G	119_I	1.355	0.90
212_Q	216_I	1.353	0.90
79_L	178_Y	1.352	0.90
179_N	188_G	1.340	0.89
117_N	172_K	1.325	0.89
157_F	173_P	1.324	0.89
202_N	205_E	1.307	0.88
91_K	114_F	1.286	0.87
111_G	182_A	1.254	0.86
65_K	68_T	1.248	0.85
169_Y	209_K	1.242	0.85
216_I	220_I	1.239	0.85
82_L	178_Y	1.230	0.85
191_L	194_I	1.222	0.84
185_Y	188_G	1.209	0.84
62_L	65_K	1.209	0.84
99_I	109_Y	1.202	0.83
127_G	145_W	1.202	0.83
264_I	279_I	1.200	0.83
174_L	231_Y	1.197	0.83
207_L	263_L	1.159	0.81
50_L	61_K	1.154	0.81
88_Y	173_P	1.153	0.81
71_S	127_G	1.153	0.81
150_V	179_N	1.142	0.80
154_K	176_V	1.138	0.80
236_D	242_Y	1.137	0.80
71_S	126_V	1.135	0.79
76_F	108_V	1.131	0.79
101_G	246_W	1.114	0.78
93_L	123_F	1.099	0.77
135_K	140_Q	1.098	0.77
159_A	249_A	1.089	0.77
280_F	284_R	1.086	0.76
234_L	248_Q	1.079	0.76
113_D	116_D	1.066	0.75
124_H	247_P	1.065	0.75
129_D	145_W	1.054	0.74
213_T	216_I	1.054	0.74
159_A	223_I	1.053	0.74
276_T	279_I	1.049	0.74
78_G	127_G	1.045	0.74
211_L	260_L	1.033	0.73
155_R	230_P	1.033	0.73
82_L	93_L	1.024	0.72
49_E	52_I	1.024	0.72
119_I	206_I	1.021	0.72
125_R	133_K	1.018	0.72
168_G	213_T	1.006	0.71
244_I	248_Q	0.996	0.70
87_L	180_A	0.994	0.70
218_Y	283_V	0.990	0.69
52_I	56_K	0.989	0.69
87_L	92_I	0.989	0.69
279_I	284_R	0.988	0.69
139_S	155_R	0.987	0.69
224_T	238_N	0.984	0.69
203_L	272_I	0.981	0.69
155_R	223_I	0.980	0.69
110_Y	125_R	0.972	0.68
260_L	279_I	0.957	0.67
211_L	220_I	0.956	0.67
279_I	283_V	0.955	0.67
205_E	209_K	0.951	0.66
146_L	177_E	0.944	0.66
149_T	152_N	0.943	0.66
80_D	101_G	0.941	0.65
209_K	241_P	0.938	0.65
85_K	89_V	0.935	0.65
93_L	143_K	0.933	0.65
126_V	134_V	0.926	0.64
110_Y	185_Y	0.925	0.64
261_S	276_T	0.924	0.64
209_K	213_T	0.923	0.64
75_T	262_N	0.919	0.64
49_E	53_S	0.910	0.63
84_I	181_V	0.908	0.63
93_L	236_D	0.907	0.63
215_R	228_L	0.905	0.62
119_I	182_A	0.905	0.62
278_K	281_D	0.896	0.62
87_L	182_A	0.889	0.61
207_L	211_L	0.881	0.60
157_F	273_D	0.881	0.60
153_A	188_G	0.874	0.60
258_K	262_N	0.872	0.59
94_N	243_L	0.871	0.59
140_Q	151_E	0.870	0.59
92_I	119_I	0.869	0.59
102_I	179_N	0.866	0.59
152_N	159_A	0.865	0.59
164_S	170_V	0.858	0.58
186_I	266_F	0.857	0.58
97_A	110_Y	0.856	0.58
154_K	162_C	0.852	0.58
178_Y	258_K	0.851	0.58
211_L	273_D	0.849	0.57
108_V	254_E	0.842	0.57
111_G	121_V	0.837	0.56
51_K	55_K	0.837	0.56
134_V	251_K	0.833	0.56
125_R	145_W	0.828	0.55
81_I	84_I	0.826	0.55
224_T	255_R	0.825	0.55
75_T	109_Y	0.820	0.55
147_S	150_V	0.815	0.54
108_V	133_K	0.801	0.53
225_H	232_N	0.800	0.53
52_I	187_D	0.793	0.52
198_N	252_S	0.793	0.52
82_L	150_V	0.792	0.52
54_L	57_L	0.789	0.52
105_E	131_Y	0.788	0.52
113_D	278_K	0.787	0.52
76_F	146_L	0.783	0.51
159_A	229_S	0.779	0.51
167_G	271_G	0.777	0.51
161_T	165_N	0.777	0.51
188_G	194_I	0.774	0.51
54_L	63_I	0.770	0.50
185_Y	271_G	0.768	0.50
193_K	243_L	0.763	0.50
79_L	150_V	0.763	0.50
107_L	125_R	0.761	0.49
164_S	184_E	0.760	0.49
188_G	234_L	0.756	0.49
246_W	249_A	0.754	0.49
127_G	130_S	0.751	0.48
111_G	160_L	0.744	0.48
264_I	276_T	0.744	0.48
124_H	152_N	0.740	0.47
58_S	65_K	0.739	0.47
146_L	181_V	0.738	0.47
214_M	261_S	0.730	0.46
203_L	209_K	0.728	0.46
230_P	266_F	0.724	0.46
154_K	218_Y	0.721	0.46
73_K	109_Y	0.721	0.46
213_T	228_L	0.717	0.45
63_I	212_Q	0.715	0.45
187_D	222_H	0.715	0.45
210_I	260_L	0.714	0.45
107_L	128_T	0.711	0.45
168_G	228_L	0.708	0.44
153_A	176_V	0.707	0.44
124_H	177_E	0.706	0.44
196_V	266_F	0.704	0.44
77_S	152_N	0.702	0.44
93_L	121_V	0.702	0.44
118_K	269_K	0.702	0.44
115_N	224_T	0.700	0.44
76_F	154_K	0.700	0.44
99_I	185_Y	0.699	0.44
74_L	128_T	0.698	0.44
252_S	265_I	0.696	0.43
51_K	160_L	0.691	0.43
228_L	262_N	0.688	0.43
227_D	232_N	0.686	0.42
101_G	231_Y	0.686	0.42
155_R	250_T	0.681	0.42
125_R	134_V	0.675	0.41
135_K	142_K	0.673	0.41
174_L	216_I	0.673	0.41
229_S	256_L	0.669	0.41
87_L	175_G	0.667	0.41
190_E	234_L	0.662	0.40
215_R	283_V	0.660	0.40
168_G	256_L	0.658	0.40
96_L	130_S	0.657	0.40
198_N	238_N	0.655	0.40
138_K	247_P	0.655	0.40
56_K	174_L	0.655	0.40
67_P	283_V	0.651	0.39
79_L	127_G	0.650	0.39
130_S	145_W	0.647	0.39
126_V	246_W	0.646	0.39
74_L	78_G	0.646	0.39
229_S	246_W	0.645	0.39
152_N	191_L	0.644	0.39
208_E	274_V	0.643	0.39
149_T	179_N	0.643	0.39
145_W	247_P	0.641	0.38
69_D	127_G	0.639	0.38
139_S	224_T	0.639	0.38
198_N	283_V	0.638	0.38
87_L	114_F	0.638	0.38
127_G	247_P	0.637	0.38
128_T	145_W	0.633	0.38
209_K	212_Q	0.632	0.38
79_L	147_S	0.631	0.38
168_G	221_C	0.630	0.38
121_V	231_Y	0.630	0.38
136_F	255_R	0.628	0.37
100_I	205_E	0.628	0.37
57_L	263_L	0.626	0.37
93_L	261_S	0.626	0.37
158_E	251_K	0.623	0.37
229_S	249_A	0.622	0.37
98_E	109_Y	0.619	0.37
58_S	90_N	0.618	0.36
55_K	271_G	0.617	0.36
84_I	123_F	0.616	0.36
210_I	263_L	0.613	0.36
136_F	152_N	0.612	0.36
170_V	184_E	0.612	0.36
113_D	184_E	0.611	0.36
140_Q	177_E	0.611	0.36
97_A	188_G	0.607	0.36
109_Y	196_V	0.607	0.36
50_L	54_L	0.604	0.35
50_L	56_K	0.601	0.35
86_L	147_S	0.601	0.35
64_S	67_P	0.597	0.35
208_E	269_K	0.597	0.35
204_D	208_E	0.597	0.35
157_F	161_T	0.596	0.35
92_I	182_A	0.592	0.34
148_I	214_M	0.589	0.34
223_I	249_A	0.587	0.34
87_L	181_V	0.586	0.34
237_K	272_I	0.585	0.34
85_K	88_Y	0.584	0.34
74_L	146_L	0.584	0.34
69_D	153_A	0.584	0.34
167_G	209_K	0.581	0.33
189_I	237_K	0.580	0.33
93_L	254_E	0.579	0.33
145_W	148_I	0.579	0.33
166_E	173_P	0.579	0.33
150_V	170_V	0.575	0.33
94_N	113_D	0.575	0.33
77_S	136_F	0.572	0.33
93_L	263_L	0.572	0.33
183_M	249_A	0.571	0.33
93_L	183_M	0.566	0.32
58_S	263_L	0.564	0.32
202_N	206_I	0.564	0.32
92_I	205_E	0.563	0.32
74_L	125_R	0.563	0.32
59_E	266_F	0.562	0.32
82_L	283_V	0.562	0.32
61_K	243_L	0.557	0.31
74_L	247_P	0.556	0.31
211_L	214_M	0.553	0.31
100_I	185_Y	0.551	0.31
106_S	162_C	0.549	0.31
218_Y	243_L	0.549	0.31
159_A	246_W	0.548	0.31
219_T	283_V	0.548	0.31
114_F	272_I	0.547	0.31
252_S	258_K	0.546	0.31
87_L	95_R	0.543	0.30
134_V	139_S	0.543	0.30
80_D	179_N	0.541	0.30
129_D	148_I	0.540	0.30
141_E	231_Y	0.537	0.30
257_E	282_Y	0.535	0.30
116_D	269_K	0.529	0.29
223_I	246_W	0.527	0.29
196_V	240_N	0.525	0.29
186_I	197_T	0.523	0.29
109_Y	207_L	0.523	0.29
160_L	180_A	0.521	0.29
76_F	128_T	0.519	0.29
121_V	174_L	0.519	0.29
254_E	271_G	0.518	0.28
212_Q	254_E	0.515	0.28
158_E	162_C	0.515	0.28
201_L	208_E	0.514	0.28
191_L	240_N	0.513	0.28
257_E	261_S	0.513	0.28
186_I	209_K	0.511	0.28
241_P	263_L	0.511	0.28
192_Y	197_T	0.511	0.28
174_L	184_E	0.511	0.28
68_T	109_Y	0.509	0.28
219_T	224_T	0.509	0.28
224_T	254_E	0.509	0.28
49_E	56_K	0.507	0.28
106_S	251_K	0.507	0.28
184_E	265_I	0.506	0.28
159_A	256_L	0.506	0.28
235_I	238_N	0.506	0.28
153_A	251_K	0.504	0.27
67_P	120_I	0.504	0.27
204_D	273_D	0.504	0.27
91_K	186_I	0.503	0.27
250_T	279_I	0.501	0.27
109_Y	133_K	0.501	0.27
108_V	252_S	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zarA	1	0.9059	100	0.495	Contact Map
4gyiA	1	0.9721	100	0.513	Contact Map
1zthA	1	0.7909	100	0.671	Contact Map
4otpA	1	0.6446	100	0.709	Contact Map
4pedA	1	0.9129	99.7	0.822	Contact Map
4h05A	1	0.6411	99.5	0.84	Contact Map
3w0oA	1	0.6098	99.5	0.845	Contact Map
2zmdA	2	0.5958	99.5	0.846	Contact Map
2y7jA	3	0.6551	99.5	0.847	Contact Map
3atsA	1	0.6655	99.4	0.849	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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