GREMLIN Database
METK - S-adenosylmethionine synthase
UniProt: Q980S9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 404 (392)
Sequences: 268 (203)
Seq/√Len: 10.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_A66_V6.1011.00
292_G307_T5.7611.00
361_V382_V4.4120.99
105_I110_I4.1980.99
205_L346_L4.0100.99
297_T302_M3.9170.99
48_Y105_I3.4310.97
41_A61_L3.3440.96
330_K385_M3.1690.95
200_I343_V3.0700.94
395_L400_K2.9820.93
210_E253_N2.9610.93
36_A118_W2.8490.91
363_V378_I2.8320.91
327_I381_I2.7140.89
331_I341_S2.7040.89
63_K285_M2.6480.88
48_Y52_K2.6080.87
210_E255_R2.5560.86
48_Y110_I2.4680.84
37_V115_V2.3830.81
125_Y223_L2.3380.80
319_L392_L2.3320.80
149_F314_N2.3280.80
38_A286_T2.3220.79
33_I123_F2.2500.77
225_E229_H2.2280.77
209_N252_Y2.2270.76
326_L395_L2.2060.76
298_P302_M2.1900.75
90_G281_G2.1890.75
85_Y135_D2.1830.75
195_E229_H2.1380.73
4_I180_T2.1170.73
232_N236_Q2.0380.70
226_D229_H2.0320.69
339_K366_Y2.0290.69
80_I103_D1.9740.67
26_G181_E1.9700.67
345_V359_A1.9500.66
158_S347_G1.9380.66
226_D380_G1.9290.65
167_F325_N1.8820.63
185_N190_K1.8790.63
34_A285_M1.8710.63
175_K179_E1.8680.63
177_V204_G1.8300.61
172_K249_A1.8060.60
61_L87_I1.7980.59
195_E224_I1.7660.58
359_A382_V1.7560.58
84_I156_P1.7560.58
74_R221_S1.7490.57
148_I261_G1.7330.57
392_L401_A1.7160.56
88_V136_Y1.7110.56
16_K339_K1.7010.55
45_L49_Y1.6960.55
151_A198_E1.6900.55
70_Q82_Q1.6660.53
46_S217_M1.6610.53
52_K103_D1.6560.53
249_A252_Y1.6550.53
93_T343_V1.6320.52
260_T303_S1.6270.52
125_Y198_E1.6240.51
359_A383_D1.6230.51
229_H233_V1.6170.51
26_G270_Y1.6160.51
56_I313_V1.6140.51
67_V85_Y1.5910.50
90_G283_D1.5690.49
195_E233_V1.5640.49
32_Y36_A1.5500.48
162_S279_E1.5450.48
6_V326_L1.5380.48
32_Y118_W1.5240.47
299_M324_A1.5040.46
378_I382_V1.5010.46
181_E185_N1.4850.45
227_V269_L1.4750.45
231_I234_K1.4700.44
13_D16_K1.4690.44
295_L302_M1.4670.44
368_G396_I1.4460.43
38_A90_G1.4440.43
348_Q351_R1.4430.43
124_R198_E1.4370.43
295_L298_P1.4260.42
180_T244_L1.4240.42
65_L87_I1.4230.42
351_R355_D1.4060.41
91_R142_S1.3890.41
82_Q387_S1.3760.40
73_P273_V1.3630.40
118_W131_H1.3620.39
55_V80_I1.3590.39
60_N91_R1.3550.39
203_M277_S1.3500.39
116_K378_I1.3480.39
158_S389_F1.3470.39
73_P218_A1.3470.39
323_L354_D1.3390.38
118_W285_M1.3380.38
37_V41_A1.3340.38
14_I171_T1.3250.38
47_L242_L1.3200.38
327_I331_I1.3180.38
13_D76_K1.3120.37
196_V217_M1.2910.36
164_G304_L1.2890.36
148_I346_L1.2860.36
26_G202_V1.2730.36
219_T224_I1.2700.36
316_V397_L1.2660.35
165_V299_M1.2590.35
118_W304_L1.2500.35
257_Y260_T1.2390.34
170_L313_V1.2370.34
137_K224_I1.2330.34
283_D297_T1.2320.34
42_S59_H1.2250.34
48_Y68_G1.2170.33
38_A87_I1.2160.33
332_A341_S1.2150.33
37_V88_V1.2140.33
63_K308_A1.2080.33
68_G319_L1.1930.32
332_A338_V1.1910.32
167_F170_L1.1770.32
274_T283_D1.1740.32
21_L357_L1.1680.31
376_N379_S1.1660.31
164_G279_E1.1610.31
53_Y103_D1.1470.30
338_V378_I1.1460.30
61_L65_L1.1460.30
231_I264_I1.1460.30
12_S364_I1.1440.30
41_A111_I1.1420.30
237_V304_L1.1350.30
157_L382_V1.1330.30
61_L285_M1.1290.30
283_D298_P1.1250.30
314_N319_L1.1240.30
326_L329_N1.1220.29
9_N362_D1.1200.29
242_L246_S1.1120.29
330_K334_E1.1110.29
90_G297_T1.1090.29
157_L324_A1.1020.29
18_Q208_G1.0960.28
164_G297_T1.0890.28
285_M344_Q1.0840.28
49_Y145_L1.0800.28
51_K367_D1.0710.28
330_K384_E1.0660.27
135_D139_G1.0650.27
14_I17_L1.0630.27
164_G298_P1.0580.27
33_I122_N1.0570.27
49_Y349_I1.0530.27
21_L207_R1.0500.27
105_I361_V1.0470.27
172_K252_Y1.0470.27
167_F316_V1.0460.27
301_P342_Q1.0430.27
179_E248_I1.0420.27
170_L402_T1.0400.26
167_F186_S1.0400.26
168_A328_A1.0320.26
33_I392_L1.0310.26
319_L401_A1.0300.26
127_D363_V1.0260.26
96_V185_N1.0190.26
261_G283_D1.0180.26
58_H69_G1.0150.26
49_Y277_S1.0130.25
34_A167_F1.0110.25
238_R242_L1.0080.25
60_N145_L1.0070.25
108_G240_Q1.0060.25
45_L349_I1.0040.25
145_L349_I0.9990.25
147_G151_A0.9970.25
226_D245_A0.9930.25
180_T190_K0.9920.25
118_W397_L0.9920.25
73_P316_V0.9920.25
66_V285_M0.9870.25
322_V392_L0.9800.24
33_I278_A0.9790.24
63_K89_A0.9790.24
45_L145_L0.9780.24
81_I384_E0.9780.24
322_V401_A0.9780.24
67_V348_Q0.9770.24
90_G298_P0.9760.24
127_D243_D0.9740.24
391_K394_E0.9730.24
181_E190_K0.9730.24
41_A87_I0.9730.24
60_N349_I0.9730.24
11_L170_L0.9710.24
375_K379_S0.9660.24
323_L328_A0.9630.24
219_T233_V0.9620.24
49_Y279_E0.9610.24
61_L346_L0.9540.23
335_V363_V0.9480.23
61_L344_Q0.9460.23
33_I276_T0.9430.23
63_K118_W0.9420.23
68_G89_A0.9380.23
188_Q337_D0.9380.23
189_F196_V0.9360.23
200_I270_Y0.9350.23
63_K68_G0.9350.23
142_S149_F0.9310.23
56_I389_F0.9280.23
7_Q105_I0.9260.23
111_I286_T0.9230.22
65_L308_A0.9220.22
91_R162_S0.9200.22
190_K198_E0.9170.22
285_M314_N0.9170.22
27_L387_S0.9150.22
291_R297_T0.9120.22
67_V144_D0.9120.22
164_G295_L0.9110.22
345_V366_Y0.9100.22
86_I155_V0.9070.22
88_V111_I0.9070.22
164_G283_D0.9050.22
220_I366_Y0.9010.22
258_V292_G0.9010.22
4_I133_I0.9010.22
304_L390_N0.9010.22
167_F297_T0.9000.22
64_T285_M0.9000.22
55_V215_I0.9000.22
241_I258_V0.8990.22
348_Q353_I0.8980.22
282_D320_Y0.8970.22
198_E276_T0.8940.22
186_S190_K0.8920.21
68_G90_G0.8810.21
66_V402_T0.8800.21
90_G274_T0.8800.21
113_E130_R0.8780.21
90_G163_F0.8650.21
87_I308_A0.8650.21
61_L111_I0.8640.21
66_V165_V0.8610.20
64_T139_G0.8610.20
7_Q360_N0.8550.20
131_H276_T0.8490.20
52_K105_I0.8490.20
68_G280_H0.8460.20
41_A114_S0.8390.20
148_I223_L0.8370.20
46_S343_V0.8370.20
200_I400_K0.8360.20
243_D338_V0.8350.20
217_M258_V0.8350.20
173_L216_A0.8300.20
291_R302_M0.8290.20
57_L91_R0.8290.20
110_I134_V0.8270.19
163_F298_P0.8250.19
56_I256_V0.8240.19
323_L389_F0.8240.19
372_D400_K0.8240.19
21_L185_N0.8220.19
216_A349_I0.8210.19
225_E247_K0.8210.19
60_N316_V0.8190.19
94_T108_G0.8170.19
22_V181_E0.8170.19
237_V241_I0.8160.19
92_A277_S0.8160.19
48_Y70_Q0.8110.19
45_L277_S0.8110.19
172_K209_N0.8110.19
147_G269_L0.8090.19
215_I388_S0.8080.19
292_G397_L0.8030.19
116_K129_E0.8020.19
45_L218_A0.8020.19
7_Q110_I0.8010.19
202_V232_N0.8000.19
119_I128_A0.7990.19
263_K266_K0.7950.19
163_F283_D0.7950.19
264_I397_L0.7940.19
36_A119_I0.7920.18
229_H395_L0.7900.18
327_I382_V0.7860.18
90_G261_G0.7810.18
185_N200_I0.7810.18
68_G299_M0.7810.18
34_A140_K0.7810.18
80_I132_V0.7800.18
65_L285_M0.7770.18
60_N162_S0.7760.18
354_D383_D0.7700.18
125_Y222_E0.7700.18
282_D291_R0.7690.18
74_R224_I0.7690.18
286_T306_A0.7690.18
65_L89_A0.7680.18
147_G261_G0.7660.18
45_L216_A0.7650.18
279_E321_N0.7640.18
204_G298_P0.7610.18
335_V378_I0.7600.18
119_I387_S0.7600.18
68_G173_L0.7570.18
281_G297_T0.7570.18
368_G399_G0.7550.17
103_D258_V0.7520.17
212_D255_R0.7470.17
34_A64_T0.7470.17
230_Y282_D0.7470.17
266_K400_K0.7460.17
79_D112_I0.7450.17
212_D357_L0.7420.17
148_I241_I0.7380.17
158_S163_F0.7380.17
327_I387_S0.7350.17
291_R295_L0.7330.17
235_E333_Q0.7320.17
36_A280_H0.7310.17
291_R303_S0.7300.17
65_L68_G0.7300.17
315_H318_K0.7300.17
90_G392_L0.7280.17
158_S170_L0.7270.17
328_A345_V0.7270.17
77_G349_I0.7220.17
65_L118_W0.7220.17
319_L337_D0.7210.17
162_S277_S0.7180.17
149_F319_L0.7180.17
172_K211_V0.7180.17
179_E239_N0.7180.17
38_A281_G0.7160.16
189_F240_Q0.7160.16
37_V226_D0.7140.16
85_Y133_I0.7140.16
224_I231_I0.7120.16
325_N345_V0.7110.16
262_D282_D0.7110.16
63_K344_Q0.7110.16
67_V135_D0.7110.16
61_L173_L0.7070.16
351_R364_I0.7060.16
12_S389_F0.7060.16
85_Y139_G0.7050.16
343_V361_V0.7040.16
368_G372_D0.7040.16
46_S397_L0.7030.16
104_Q225_E0.6990.16
59_H190_K0.6990.16
47_L246_S0.6940.16
380_G384_E0.6940.16
383_D387_S0.6930.16
90_G302_M0.6920.16
335_V390_N0.6900.16
162_S203_M0.6900.16
203_M349_I0.6900.16
283_D302_M0.6890.16
311_N317_G0.6880.16
193_L236_Q0.6870.16
285_M308_A0.6830.16
301_P362_D0.6830.16
96_V143_S0.6820.16
209_N322_V0.6800.16
205_L213_L0.6780.16
253_N329_N0.6780.16
16_K71_A0.6780.16
32_Y285_M0.6770.15
333_Q345_V0.6760.15
192_K256_V0.6760.15
170_L175_K0.6750.15
68_G361_V0.6740.15
200_I235_E0.6740.15
48_Y106_P0.6720.15
162_S349_I0.6720.15
218_A283_D0.6710.15
277_S349_I0.6700.15
329_N333_Q0.6700.15
144_D261_G0.6690.15
67_V132_V0.6680.15
339_K373_E0.6660.15
37_V361_V0.6640.15
61_L68_G0.6640.15
46_S204_G0.6610.15
6_V245_A0.6600.15
73_P283_D0.6600.15
108_G249_A0.6590.15
145_L162_S0.6590.15
110_I270_Y0.6580.15
36_A131_H0.6550.15
220_I274_T0.6550.15
70_Q81_I0.6550.15
347_G350_G0.6540.15
29_H35_D0.6510.15
30_P35_D0.6510.15
25_K29_H0.6510.15
23_E30_P0.6510.15
23_E31_D0.6510.15
23_E29_H0.6510.15
25_K30_P0.6510.15
23_E35_D0.6510.15
31_D35_D0.6510.15
25_K35_D0.6510.15
25_K31_D0.6510.15
9_N380_G0.6510.15
235_E384_E0.6490.15
49_Y216_A0.6480.15
17_L146_V0.6470.15
242_L363_V0.6460.15
45_L73_P0.6450.15
192_K384_E0.6440.15
164_G218_A0.6430.15
164_G277_S0.6430.15
88_V345_V0.6430.15
105_I192_K0.6420.15
281_G302_M0.6410.15
274_T297_T0.6400.15
272_T283_D0.6370.15
84_I261_G0.6350.14
142_S145_L0.6350.14
242_L379_S0.6350.14
14_I82_Q0.6330.14
343_V393_T0.6330.14
11_L212_D0.6330.14
179_E182_R0.6290.14
162_S347_G0.6290.14
57_L142_S0.6290.14
378_I393_T0.6290.14
189_F193_L0.6260.14
57_L279_E0.6250.14
147_G286_T0.6250.14
176_L299_M0.6250.14
293_V347_G0.6240.14
69_G272_T0.6230.14
64_T89_A0.6230.14
196_V328_A0.6220.14
45_L279_E0.6220.14
73_P164_G0.6210.14
157_L186_S0.6200.14
88_V196_V0.6190.14
90_G135_D0.6190.14
70_Q273_V0.6190.14
164_G291_R0.6180.14
63_K66_V0.6170.14
104_Q247_K0.6160.14
104_Q355_D0.6160.14
73_P281_G0.6160.14
39_E281_G0.6160.14
148_I303_S0.6130.14
295_L352_P0.6120.14
183_H240_Q0.6110.14
226_D255_R0.6110.14
145_L283_D0.6100.14
239_N243_D0.6100.14
14_I120_R0.6090.14
85_Y137_K0.6090.14
354_D359_A0.6070.14
10_P237_V0.6070.14
192_K228_N0.6070.14
12_S53_Y0.6020.14
49_Y162_S0.6020.14
162_S321_N0.6010.14
52_K170_L0.6000.14
342_Q362_D0.6000.14
34_A192_K0.5980.14
63_K131_H0.5980.14
209_N249_A0.5970.14
260_T347_G0.5970.14
376_N394_E0.5970.14
261_G314_N0.5960.14
118_W148_I0.5950.14
68_G281_G0.5950.14
84_I126_L0.5930.14
134_V383_D0.5910.14
33_I190_K0.5900.13
84_I396_I0.5890.13
163_F281_G0.5870.13
26_G177_V0.5870.13
163_F266_K0.5840.13
203_M300_R0.5840.13
237_V263_K0.5840.13
41_A334_E0.5830.13
37_V86_I0.5810.13
37_V143_S0.5800.13
192_K208_G0.5790.13
190_K331_I0.5780.13
316_V325_N0.5780.13
371_T391_K0.5770.13
90_G144_D0.5760.13
358_I383_D0.5760.13
32_Y138_I0.5760.13
121_N267_N0.5750.13
8_L251_G0.5730.13
73_P221_S0.5720.13
6_V209_N0.5720.13
145_L214_T0.5710.13
156_P390_N0.5690.13
202_V236_Q0.5690.13
88_V332_A0.5680.13
125_Y128_A0.5670.13
354_D387_S0.5670.13
71_A273_V0.5650.13
125_Y151_A0.5640.13
128_A332_A0.5640.13
6_V158_S0.5630.13
334_E398_E0.5620.13
369_K372_D0.5620.13
230_Y262_D0.5620.13
213_L229_H0.5570.13
5_N400_K0.5560.13
168_A334_E0.5560.13
283_D295_L0.5520.13
45_L60_N0.5510.13
229_H245_A0.5510.13
96_V248_I0.5510.13
91_R314_N0.5490.13
280_H314_N0.5490.13
6_V182_R0.5480.13
7_Q71_A0.5470.13
91_R118_W0.5460.13
232_N266_K0.5460.13
21_L135_D0.5460.13
186_S213_L0.5440.13
335_V377_E0.5420.12
339_K342_Q0.5410.12
218_A272_T0.5410.12
95_E225_E0.5400.12
196_V224_I0.5400.12
236_Q239_N0.5380.12
117_E267_N0.5380.12
145_L166_G0.5350.12
16_K340_F0.5350.12
307_T313_V0.5340.12
166_G216_A0.5340.12
45_L162_S0.5340.12
8_L129_E0.5330.12
46_S189_F0.5330.12
32_Y63_K0.5320.12
175_K255_R0.5320.12
92_A158_S0.5300.12
221_S337_D0.5300.12
34_A228_N0.5280.12
106_P111_I0.5280.12
189_F326_L0.5270.12
57_L162_S0.5270.12
390_N396_I0.5260.12
33_I319_L0.5260.12
120_R247_K0.5230.12
230_Y320_Y0.5230.12
56_I152_S0.5210.12
38_A64_T0.5210.12
163_F297_T0.5200.12
10_P363_V0.5180.12
15_E367_D0.5180.12
5_N255_R0.5170.12
236_Q246_S0.5160.12
395_L401_A0.5160.12
14_I385_M0.5130.12
327_I378_I0.5110.12
222_E264_I0.5100.12
41_A93_T0.5090.12
80_I127_D0.5060.12
235_E382_V0.5060.12
216_A277_S0.5060.12
104_Q130_R0.5050.12
252_Y322_V0.5040.12
184_L200_I0.5030.12
53_Y68_G0.5020.12
49_Y60_N0.5020.12
53_Y105_I0.5020.12
303_S353_I0.5020.12
92_A111_I0.5020.12
139_G285_M0.5010.12
303_S321_N0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4qA 3 0.9876 100 0.003 Contact Map
4l7iA 3 0.995 100 0.3 Contact Map
4odjA 2 0.8168 100 0.668 Contact Map
4le5A 2 0.8243 100 0.669 Contact Map
2p02A 2 0.8243 100 0.68 Contact Map
1p7lA 4 0.8267 100 0.681 Contact Map
3imlA 2 0.7797 100 0.683 Contact Map
3s82A 4 0.8069 100 0.687 Contact Map
3so4A 4 0.8069 100 0.693 Contact Map
4idhA 1 0.1337 38.6 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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