GREMLIN Database
Q980S5 - D-arabino 3-hexulose 6-phosphate formaldehyde lyase (HpS-2)
UniProt: Q980S5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (206)
Sequences: 3248 (2086)
Seq/√Len: 145.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_N63_L3.7541.00
23_D26_D3.4961.00
210_E213_N3.3841.00
98_G120_Q3.3401.00
61_K92_H3.1161.00
100_M104_T2.4541.00
128_N131_E2.3591.00
212_K216_K2.2941.00
55_E58_R2.2911.00
128_N183_L2.2761.00
189_L221_I2.2411.00
167_I171_S2.2171.00
28_I59_K2.2151.00
102_D106_Y2.2001.00
213_N217_E2.1621.00
102_D135_E2.1321.00
208_S214_V2.0941.00
164_K186_D2.0761.00
109_V113_R2.0351.00
15_L201_V2.0151.00
105_I157_G1.9341.00
24_I59_K1.9301.00
189_L193_D1.9281.00
46_T50_K1.9261.00
103_S183_L1.9161.00
168_R171_S1.8921.00
167_I172_E1.8151.00
37_L216_K1.7651.00
130_Y141_V1.7051.00
186_D194_L1.6811.00
140_G143_I1.6481.00
83_V86_A1.6371.00
21_F30_V1.6271.00
130_Y134_K1.5861.00
168_R172_E1.5771.00
24_I56_G1.5581.00
171_S197_S1.5431.00
190_E193_D1.5311.00
196_V199_Y1.5061.00
16_Q41_I1.5011.00
30_V34_V1.4971.00
29_K33_E1.4801.00
24_I52_F1.4781.00
68_I92_H1.4471.00
75_T86_A1.4471.00
26_D29_K1.4421.00
84_E114_E1.4361.00
44_I60_I1.4351.00
15_L215_S1.4311.00
50_K75_T1.4261.00
103_S106_Y1.3881.00
15_L222_L1.3521.00
33_E211_P1.3481.00
102_D155_S1.3411.00
171_S177_I1.3361.00
59_K62_S1.3181.00
102_D151_D1.3071.00
102_D154_K1.2951.00
139_L147_H1.2941.00
190_E194_L1.2881.00
106_Y110_K1.2841.00
18_A202_G1.2811.00
42_I67_K1.2671.00
31_V42_I1.2611.00
48_L52_F1.2571.00
177_I197_S1.2551.00
27_A48_L1.2551.00
33_E210_E1.2451.00
58_R62_S1.2411.00
150_L173_L1.2361.00
139_L143_I1.2161.00
213_N216_K1.1931.00
39_N215_S1.1901.00
179_I196_V1.1831.00
24_I28_I1.1771.00
17_I206_T1.1741.00
95_T119_V1.1741.00
111_K115_L1.1731.00
16_Q198_I1.1711.00
216_K220_N1.1691.00
217_E220_N1.1681.00
17_I39_N1.1440.99
169_K173_L1.1440.99
51_S85_I1.1350.99
48_L56_G1.1320.99
82_E108_A1.1280.99
82_E104_T1.1280.99
217_E221_I1.1250.99
170_V177_I1.1170.99
123_L144_I1.1170.99
33_E212_K1.0970.99
117_I176_I1.0950.99
119_V157_G1.0900.99
22_I26_D1.0830.99
40_E67_K1.0810.99
176_I197_S1.0810.99
146_F173_L1.0790.99
41_I68_I1.0790.99
83_V94_M1.0790.99
214_V217_E1.0720.99
79_G104_T1.0620.99
95_T121_A1.0390.99
160_V175_L1.0360.99
192_I222_L1.0360.99
75_T82_E1.0280.99
36_D212_K1.0200.99
107_S110_K1.0140.99
132_R136_L1.0070.99
192_I199_Y1.0040.99
123_L127_K0.9970.99
57_I89_G0.9930.99
133_S139_L0.9880.98
144_I148_V0.9840.98
131_E135_E0.9820.98
93_I117_I0.9580.98
117_I158_I0.9560.98
28_I32_N0.9540.98
71_A91_A0.9530.98
103_S107_S0.9480.98
99_I148_V0.9470.98
15_L219_V0.9330.98
88_L115_L0.9330.98
54_I57_I0.9320.98
99_I144_I0.9230.98
159_S162_D0.9210.98
51_S88_L0.9180.98
85_I88_L0.9060.97
96_V118_L0.9040.97
28_I31_V0.9000.97
168_R173_L0.8930.97
52_F55_E0.8890.97
82_E100_M0.8840.97
94_M112_A0.8800.97
41_I93_I0.8790.97
119_V178_S0.8770.97
139_L144_I0.8720.97
84_E111_K0.8710.97
34_V212_K0.8630.96
146_F150_L0.8530.96
130_Y140_G0.8520.96
113_R116_D0.8520.96
49_L73_T0.8510.96
109_V118_L0.8490.96
169_K172_E0.8470.96
205_I215_S0.8460.96
168_R194_L0.8330.96
127_K132_R0.8330.96
96_V105_I0.8330.96
137_K147_H0.8280.96
107_S111_K0.8210.95
99_I123_L0.8210.95
186_D190_E0.8210.95
215_S219_V0.8210.95
159_S163_L0.8180.95
132_R137_K0.8120.95
95_T105_I0.8100.95
204_A218_I0.8100.95
83_V112_A0.8080.95
105_I155_S0.8070.95
120_Q152_V0.8070.95
133_S137_K0.8060.95
49_L54_I0.8000.95
98_G152_V0.7960.94
19_L44_I0.7930.94
84_E115_L0.7930.94
84_E88_L0.7880.94
31_V60_I0.7880.94
212_K215_S0.7870.94
19_L60_I0.7840.94
26_D33_E0.7820.94
131_E134_K0.7800.94
57_I69_I0.7800.94
35_K42_I0.7800.94
37_L212_K0.7760.94
87_K116_D0.7760.94
128_N132_R0.7690.93
13_K40_E0.7680.93
162_D177_I0.7640.93
42_I60_I0.7620.93
28_I63_L0.7600.93
30_V33_E0.7570.93
47_P206_T0.7560.93
14_F68_I0.7560.93
109_V158_I0.7550.93
24_I55_E0.7540.93
103_S132_R0.7540.93
22_I85_I0.7530.93
21_F27_A0.7530.93
13_K68_I0.7500.93
165_N186_D0.7420.92
40_E215_S0.7350.92
156_R159_S0.7290.91
95_T175_L0.7290.91
102_D105_I0.7280.91
167_I177_I0.7260.91
201_V218_I0.7250.91
132_R141_V0.7240.91
25_N28_I0.7220.91
21_F206_T0.7220.91
210_E214_V0.7160.91
97_L180_A0.7140.91
52_F56_G0.7130.91
70_V95_T0.7100.90
99_I127_K0.7090.90
69_I91_A0.7070.90
57_I61_K0.7020.90
147_H151_D0.7020.90
167_I170_V0.6980.90
160_V177_I0.6980.90
76_A99_I0.6960.89
41_I92_H0.6960.89
59_K63_L0.6840.89
60_I67_K0.6820.89
55_E59_K0.6760.88
35_K39_N0.6760.88
29_K32_N0.6760.88
17_I205_I0.6730.88
142_D169_K0.6730.88
36_D67_K0.6680.87
150_L153_Q0.6660.87
19_L31_V0.6630.87
17_I34_V0.6580.87
16_Q178_S0.6570.87
218_I221_I0.6560.87
87_K115_L0.6550.86
25_N29_K0.6540.86
93_I198_I0.6520.86
17_I30_V0.6490.86
188_I199_Y0.6430.85
134_K138_Q0.6430.85
149_G153_Q0.6410.85
31_V34_V0.6400.85
136_L144_I0.6370.85
214_V218_I0.6350.85
163_L166_E0.6330.85
152_V157_G0.6330.85
170_V173_L0.6320.84
214_V221_I0.6310.84
31_V52_F0.6300.84
46_T75_T0.6290.84
34_V215_S0.6280.84
55_E62_S0.6260.84
74_K77_D0.6230.84
44_I56_G0.6230.84
120_Q157_G0.6220.84
178_S200_V0.6200.83
142_D165_N0.6180.83
44_I48_L0.6170.83
39_N219_V0.6150.83
35_K67_K0.6120.83
188_I195_P0.6100.82
110_K114_E0.6080.82
50_K86_A0.6070.82
188_I218_I0.6050.82
150_L154_K0.6010.81
61_K64_V0.6000.81
39_N67_K0.5990.81
83_V108_A0.5970.81
14_F192_I0.5960.81
118_L157_G0.5960.81
167_I173_L0.5910.80
30_V211_P0.5850.80
58_R89_G0.5740.78
212_K220_N0.5710.78
133_S141_V0.5710.78
76_A97_L0.5700.78
146_F170_V0.5700.78
176_I179_I0.5690.78
108_A111_K0.5690.78
19_L27_A0.5660.77
56_G59_K0.5650.77
111_K114_E0.5650.77
87_K94_M0.5630.77
123_L148_V0.5620.77
98_G145_G0.5620.77
177_I198_I0.5610.77
41_I67_K0.5600.77
47_P81_V0.5600.77
130_Y138_Q0.5590.77
71_A86_A0.5590.77
199_Y222_L0.5570.76
176_I198_I0.5540.76
61_K69_I0.5540.76
158_I161_A0.5520.76
122_D160_V0.5500.75
97_L124_I0.5470.75
48_L51_S0.5440.75
93_I119_V0.5410.74
70_V125_N0.5360.74
32_N35_K0.5320.73
37_L219_V0.5320.73
18_A206_T0.5290.73
96_V108_A0.5270.72
153_Q174_N0.5270.72
47_P84_E0.5260.72
121_A124_I0.5260.72
103_S110_K0.5230.72
105_I152_V0.5220.72
135_E151_D0.5180.71
78_A180_A0.5170.71
41_I198_I0.5150.71
36_D39_N0.5130.70
70_V93_I0.5100.70
44_I49_L0.5080.70
101_D148_V0.5060.69
177_I196_V0.5050.69
144_I147_H0.5040.69
42_I205_I0.5040.69
50_K73_T0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qw4B 4 0.9689 100 0.306 Contact Map
3gdmA 2 0.96 100 0.315 Contact Map
3qw3A 2 0.9644 100 0.323 Contact Map
4mjzA 2 0.9822 100 0.348 Contact Map
3r89A 2 0.9956 100 0.36 Contact Map
3tr2A 2 0.9244 100 0.364 Contact Map
2ffcA 2 0.9822 100 0.369 Contact Map
3n3mA 2 0.9911 100 0.383 Contact Map
3ldvA 2 0.9289 100 0.386 Contact Map
3g3dA 2 0.9556 100 0.386 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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