GREMLIN Database
Q980S1 - Phosphomannomutase (PmM)
UniProt: Q980S1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (438)
Sequences: 10917 (6810)
Seq/√Len: 325.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
315_M318_K4.0891.00
228_V232_L4.0701.00
184_G244_A3.6701.00
176_L234_V3.5871.00
252_S361_A3.2561.00
227_K231_Q3.2531.00
174_K198_K2.8731.00
160_L194_E2.8461.00
48_A209_L2.7981.00
28_K64_S2.7601.00
292_E304_W2.7011.00
437_E441_K2.7001.00
303_K315_M2.6861.00
85_A154_T2.6761.00
39_R67_L2.6421.00
228_V231_Q2.5671.00
190_I194_E2.5461.00
32_T127_I2.4961.00
54_L70_E2.3991.00
226_A230_K2.3291.00
268_Y298_Y2.3241.00
240_H346_F2.3111.00
153_E157_R2.3111.00
27_G57_V2.2071.00
40_I61_L2.1921.00
174_K200_F2.1671.00
390_D394_N2.1631.00
20_P52_M2.1571.00
249_F349_M2.1471.00
61_L92_V2.1351.00
36_K127_I2.1241.00
280_R301_E2.1051.00
57_V92_V2.0841.00
293_E296_K2.0791.00
43_G79_F2.0781.00
201_T204_G2.0761.00
31_G61_L2.0541.00
223_T227_K2.0461.00
42_I58_E2.0451.00
30_I90_G2.0331.00
44_R54_L1.9801.00
13_V102_E1.9531.00
41_L88_Y1.9481.00
51_D55_K1.9321.00
445_K449_K1.9321.00
127_I130_N1.9161.00
44_R50_G1.9091.00
358_E362_E1.9051.00
126_D130_N1.8981.00
441_K445_K1.8861.00
31_G64_S1.8771.00
268_Y272_V1.8531.00
123_K126_D1.8511.00
271_S300_I1.8391.00
176_L228_V1.8301.00
436_D439_K1.8141.00
153_E190_I1.8011.00
268_Y366_R1.7891.00
292_E296_K1.7811.00
200_F232_L1.7681.00
32_T64_S1.7661.00
81_Y85_A1.7581.00
39_R69_Y1.7321.00
315_M319_E1.7211.00
30_I108_V1.6961.00
116_I124_I1.6951.00
238_V346_F1.6921.00
203_N224_E1.6851.00
156_L191_V1.6841.00
13_V103_Y1.6631.00
265_L352_M1.6631.00
440_S444_A1.6581.00
28_K32_T1.6421.00
439_K442_E1.6311.00
157_R194_E1.6131.00
24_L56_A1.6101.00
36_K123_K1.6081.00
295_L300_I1.5921.00
442_E446_E1.5761.00
227_K230_K1.5641.00
362_E365_N1.5611.00
255_R365_N1.5431.00
432_V444_A1.5351.00
190_I193_R1.5161.00
273_K355_S1.5081.00
359_S362_E1.4951.00
125_E129_F1.4821.00
189_P193_R1.4761.00
269_W355_S1.4751.00
179_P204_G1.4681.00
391_E395_K1.4481.00
314_H318_K1.4421.00
23_A106_I1.4371.00
39_R89_D1.4341.00
406_D409_K1.4221.00
293_E435_K1.4161.00
24_L59_S1.4091.00
46_V73_M1.4041.00
229_A237_A1.4001.00
189_P204_G1.3991.00
283_T302_V1.3961.00
438_N442_E1.3911.00
37_G67_L1.3891.00
38_A89_D1.3871.00
61_L66_V1.3831.00
208_P211_S1.3761.00
390_D393_M1.3751.00
381_E384_D1.3741.00
24_L63_S1.3731.00
33_Y120_D1.3631.00
374_K379_V1.3611.00
305_T315_M1.3601.00
266_L333_Y1.3601.00
224_E227_K1.3521.00
312_I324_G1.3481.00
252_S359_S1.3461.00
133_F136_V1.3451.00
153_E194_E1.3431.00
41_L82_G1.3391.00
4_L129_F1.3361.00
223_T226_A1.3341.00
81_Y158_G1.3291.00
44_R51_D1.3221.00
272_V356_E1.3171.00
23_A53_L1.3131.00
367_L370_Y1.3131.00
387_K391_E1.3121.00
175_V236_L1.3071.00
372_L376_K1.3011.00
27_G106_I1.2991.00
174_K232_L1.2991.00
253_M361_A1.2981.00
48_A208_P1.2931.00
14_T49_G1.2881.00
393_M404_T1.2851.00
434_A440_S1.2841.00
10_I26_I1.2841.00
375_T445_K1.2721.00
263_G325_F1.2681.00
31_G66_V1.2671.00
58_E62_L1.2651.00
236_L350_L1.2641.00
293_E370_Y1.2521.00
173_Y235_D1.2421.00
159_I344_M1.2411.00
364_F367_L1.2241.00
351_D355_S1.2241.00
236_L353_M1.2231.00
33_Y127_I1.2231.00
74_A78_A1.2161.00
33_Y123_K1.2131.00
444_A448_E1.2101.00
126_D129_F1.2071.00
301_E319_E1.2061.00
441_K444_A1.1921.00
158_G161_S1.1891.00
67_L145_V1.1791.00
61_L68_V1.1731.00
154_T157_R1.1731.00
44_R70_E1.1711.00
364_F368_P1.1681.00
27_G61_L1.1681.00
373_V441_K1.1671.00
353_M363_L1.1561.00
40_I90_G1.1551.00
230_K253_M1.1541.00
267_S281_I1.1511.00
225_S239_A1.1511.00
159_I347_A1.1511.00
174_K233_G1.1501.00
439_K443_L1.1481.00
264_T290_L1.1451.00
162_H348_L1.1441.00
38_A66_V1.1421.00
225_S250_I1.1341.00
195_L347_A1.1261.00
150_K153_E1.1231.00
238_V249_F1.1181.00
303_K319_E1.1161.00
42_I57_V1.1131.00
58_E70_E1.1131.00
283_T287_S1.1111.00
391_E394_N1.1101.00
290_L370_Y1.1081.00
269_W273_K1.1041.00
123_K127_I1.0991.00
62_L146_K1.0911.00
54_L58_E1.0901.00
152_I187_V1.0851.00
89_D111_P1.0841.00
376_K379_V1.0801.00
283_T304_W1.0781.00
157_R161_S1.0771.00
386_K390_D1.0761.00
192_A346_F1.0721.00
294_Y298_Y1.0661.00
30_I92_V1.0631.00
367_L371_Y1.0621.00
20_P56_A1.0601.00
287_S291_V1.0591.00
86_L151_V1.0581.00
10_I108_V1.0571.00
384_D387_K1.0551.00
83_V91_G1.0551.00
35_G66_V1.0521.00
57_V94_I1.0491.00
120_D123_K1.0481.00
358_E366_R1.0481.00
220_E223_T1.0461.00
271_S279_R1.0451.00
152_I190_I1.0451.00
193_R201_T1.0411.00
200_F228_V1.0401.00
184_G240_H1.0401.00
224_E228_V1.0401.00
13_V16_T1.0381.00
92_V106_I1.0361.00
166_E170_S1.0351.00
156_L187_V1.0351.00
79_F91_G1.0341.00
85_A158_G1.0311.00
56_A60_G1.0311.00
156_L194_E1.0211.00
43_G93_I1.0201.00
164_D351_D1.0181.00
202_I228_V1.0151.00
57_V61_L1.0141.00
264_T294_Y1.0131.00
251_D255_R1.0111.00
75_P78_A1.0111.00
385_I389_Y1.0091.00
79_F93_I1.0051.00
177_I192_A1.0011.00
134_H137_E1.0011.00
229_A250_I1.0011.00
226_A256_V1.0001.00
185_T189_P0.9991.00
28_K63_S0.9981.00
251_D361_A0.9961.00
200_F234_V0.9941.00
225_S229_A0.9941.00
316_L321_G0.9921.00
375_T379_V0.9891.00
406_D410_I0.9871.00
29_A127_I0.9871.00
119_E123_K0.9851.00
110_S120_D0.9811.00
157_R160_L0.9791.00
389_Y392_V0.9781.00
192_A350_L0.9781.00
311_D314_H0.9761.00
408_V443_L0.9761.00
117_S120_D0.9751.00
49_G52_M0.9741.00
176_L200_F0.9731.00
383_S387_K0.9731.00
271_S298_Y0.9711.00
203_N215_P0.9671.00
410_I417_L0.9661.00
46_V206_L0.9631.00
352_M356_E0.9611.00
71_A74_A0.9601.00
292_E302_V0.9591.00
81_Y154_T0.9581.00
55_K59_S0.9571.00
333_Y348_L0.9561.00
185_T204_G0.9551.00
274_A279_R0.9551.00
409_K416_W0.9551.00
122_D125_E0.9461.00
177_I240_H0.9461.00
177_I184_G0.9451.00
29_A128_Y0.9441.00
270_A348_L0.9421.00
295_L302_V0.9421.00
396_Y400_G0.9421.00
389_Y393_M0.9421.00
22_F26_I0.9311.00
377_V448_E0.9201.00
59_S63_S0.9181.00
297_K366_R0.9181.00
392_V419_V0.9141.00
54_L94_I0.9051.00
160_L195_L0.9051.00
122_D126_D0.9041.00
173_Y353_M0.8931.00
50_G104_N0.8901.00
280_R303_K0.8891.00
181_N203_N0.8881.00
262_S331_F0.8831.00
188_T240_H0.8831.00
118_R311_D0.8801.00
392_V395_K0.8791.00
293_E297_K0.8791.00
445_K448_E0.8781.00
166_E171_K0.8751.00
158_G162_H0.8751.00
262_S349_M0.8741.00
67_L147_R0.8701.00
44_R73_M0.8691.00
263_G291_V0.8671.00
26_I128_Y0.8661.00
20_P24_L0.8661.00
35_G38_A0.8641.00
225_S237_A0.8641.00
294_Y297_K0.8631.00
281_I295_L0.8631.00
82_G151_V0.8601.00
27_G60_G0.8601.00
348_L351_D0.8571.00
430_I448_E0.8571.00
175_V197_C0.8541.00
255_R364_F0.8531.00
247_A345_S0.8521.00
41_L71_A0.8501.00
72_G186_L0.8491.00
323_A331_F0.8481.00
362_E370_Y0.8481.00
187_V343_A0.8461.00
174_K235_D0.8441.00
152_I186_L0.8401.00
261_R369_V0.8401.00
43_G74_A0.8361.00
151_V154_T0.8351.00
176_L232_L0.8341.00
381_E385_I0.8321.00
132_R135_V0.8291.00
175_V350_L0.8271.00
281_I291_V0.8241.00
434_A439_K0.8191.00
272_V298_Y0.8191.00
238_V247_A0.8171.00
306_K311_D0.8171.00
141_L144_D0.8161.00
255_R261_R0.8161.00
374_K378_R0.8141.00
373_V444_A0.8131.00
403_V411_I0.8131.00
263_G281_I0.8131.00
188_T343_A0.8111.00
361_A369_V0.8091.00
411_I446_E0.8081.00
249_F262_S0.8071.00
230_K233_G0.8061.00
283_T292_E0.8051.00
269_W352_M0.8041.00
27_G31_G0.8021.00
69_Y88_Y0.8021.00
265_L364_F0.8021.00
116_I120_D0.8021.00
226_A250_I0.8021.00
74_A93_I0.8001.00
261_R364_F0.7971.00
350_L353_M0.7971.00
375_T448_E0.7971.00
438_N441_K0.7961.00
39_R88_Y0.7911.00
262_S266_L0.7901.00
379_V384_D0.7871.00
85_A151_V0.7861.00
21_E25_K0.7841.00
389_Y395_K0.7831.00
69_Y149_D0.7821.00
240_H342_G0.7791.00
222_L256_V0.7791.00
73_M183_V0.7781.00
383_S386_K0.7781.00
362_E368_P0.7781.00
331_F345_S0.7771.00
268_Y294_Y0.7771.00
248_I256_V0.7751.00
238_V350_L0.7731.00
156_L190_I0.7711.00
368_P371_Y0.7691.00
282_F324_G0.7681.00
131_S135_V0.7661.00
280_R321_G0.7621.00
56_A59_S0.7611.00
417_L447_L0.7611.00
432_V440_S0.7600.99
296_K302_V0.7590.99
443_L446_E0.7580.99
35_G64_S0.7580.99
376_K380_T0.7560.99
288_S325_F0.7540.99
43_G71_A0.7540.99
8_D284_A0.7520.99
282_F315_M0.7490.99
202_I224_E0.7460.99
46_V183_V0.7440.99
82_G86_L0.7430.99
173_Y236_L0.7420.99
192_A197_C0.7410.99
163_V347_A0.7380.99
229_A234_V0.7370.99
313_A332_M0.7360.99
158_G337_Q0.7350.99
158_G336_H0.7340.99
401_N411_I0.7340.99
78_A152_I0.7330.99
235_D357_N0.7310.99
131_S134_H0.7300.99
322_V335_P0.7300.99
156_L160_L0.7290.99
289_S433_E0.7260.99
181_N212_A0.7260.99
83_V90_G0.7260.99
173_Y350_L0.7250.99
236_L249_F0.7240.99
264_T288_S0.7230.99
274_A322_V0.7220.99
150_K154_T0.7200.99
6_G9_G0.7200.99
125_E128_Y0.7180.99
71_A78_A0.7170.99
374_K377_V0.7130.99
446_E449_K0.7110.99
32_T35_G0.7100.99
412_G415_F0.7100.99
181_N215_P0.7080.99
186_L190_I0.7070.99
177_I188_T0.7060.99
361_A365_N0.7060.99
266_L352_M0.7060.99
353_M360_S0.7060.99
67_L144_D0.7050.99
250_I256_V0.7050.99
58_E68_V0.7030.99
285_V418_L0.7030.99
32_T130_N0.7030.99
207_D213_R0.7020.99
7_T423_G0.7010.99
414_D435_K0.7000.99
171_K198_K0.6970.99
176_L237_A0.6970.99
178_D225_S0.6950.99
222_L226_A0.6940.99
366_R369_V0.6920.99
275_P279_R0.6910.99
164_D355_S0.6900.99
172_K198_K0.6900.99
50_G54_L0.6900.99
320_K334_P0.6900.99
291_V325_F0.6860.99
173_Y354_A0.6860.99
25_K128_Y0.6850.99
440_S443_L0.6840.99
181_N213_R0.6840.99
443_L447_L0.6830.99
41_L86_L0.6820.99
203_N212_A0.6790.99
247_A342_G0.6780.99
114_I317_F0.6780.99
23_A56_A0.6780.99
296_K301_E0.6780.99
108_V124_I0.6770.99
59_S135_V0.6750.99
237_A250_I0.6740.99
136_V139_N0.6740.99
153_E156_L0.6740.99
98_H107_K0.6730.99
353_M356_E0.6720.99
66_V89_D0.6710.99
409_K418_L0.6710.99
415_F434_A0.6680.99
149_D153_E0.6680.99
372_L378_R0.6660.99
252_S362_E0.6630.99
247_A346_F0.6620.99
27_G92_V0.6620.99
15_N52_M0.6600.99
265_L363_L0.6600.99
376_K427_I0.6570.99
4_L22_F0.6550.99
32_T36_K0.6550.99
222_L250_I0.6530.98
101_A209_L0.6530.98
358_E363_L0.6510.98
222_L225_S0.6500.98
392_V396_Y0.6500.98
408_V411_I0.6500.98
356_E359_S0.6490.98
86_L154_T0.6480.98
15_N19_Q0.6460.98
349_M360_S0.6460.98
389_Y421_K0.6400.98
283_T289_S0.6400.98
446_E450_L0.6390.98
383_S421_K0.6390.98
25_K131_S0.6390.98
436_D440_S0.6380.98
96_A99_N0.6370.98
13_V17_E0.6370.98
362_E367_L0.6360.98
30_I40_I0.6350.98
192_A199_V0.6350.98
382_K386_K0.6320.98
276_N279_R0.6320.98
385_I392_V0.6310.98
185_T206_L0.6300.98
271_S295_L0.6300.98
74_A152_I0.6300.98
71_A79_F0.6270.98
352_M355_S0.6250.98
222_L248_I0.6250.98
330_G340_R0.6240.98
291_V302_V0.6220.98
212_A216_E0.6220.98
263_G323_A0.6220.98
32_T134_H0.6210.98
419_V451_V0.6210.98
37_G89_D0.6210.98
404_T408_V0.6200.98
360_S364_F0.6180.98
387_K390_D0.6170.98
69_Y148_E0.6150.98
24_L60_G0.6130.98
48_A101_A0.6120.98
379_V382_K0.6110.98
447_L450_L0.6100.98
112_H317_F0.6100.98
52_M56_A0.6090.98
216_E219_F0.6080.98
40_I66_V0.6080.98
266_L345_S0.6080.98
34_F90_G0.6080.98
258_W261_R0.6070.98
221_S224_E0.6040.97
19_Q22_F0.6030.97
267_S291_V0.6020.97
59_S62_L0.5990.97
97_S107_K0.5980.97
119_E122_D0.5980.97
323_A333_Y0.5970.97
207_D211_S0.5960.97
51_D72_G0.5960.97
30_I34_F0.5950.97
189_P201_T0.5950.97
254_G361_A0.5940.97
228_V234_V0.5920.97
6_G423_G0.5920.97
408_V412_G0.5910.97
286_S307_V0.5900.97
289_S411_I0.5900.97
62_L145_V0.5850.97
303_K321_G0.5850.97
137_E140_G0.5850.97
23_A27_G0.5850.97
188_T346_F0.5840.97
268_Y356_E0.5840.97
407_G410_I0.5840.97
25_K28_K0.5830.97
289_S293_E0.5820.97
62_L68_V0.5810.97
133_F137_E0.5800.97
414_D439_K0.5790.97
22_F128_Y0.5760.97
99_N424_T0.5760.97
416_W433_E0.5760.97
407_G446_E0.5760.97
188_T192_A0.5750.97
235_D252_S0.5750.97
374_K380_T0.5750.97
118_R121_E0.5740.97
155_Y159_I0.5720.97
415_F443_L0.5720.97
270_A275_P0.5720.97
179_P202_I0.5700.96
379_V421_K0.5680.96
239_A250_I0.5660.96
33_Y124_I0.5650.96
8_D115_E0.5630.96
152_I156_L0.5620.96
375_T444_A0.5620.96
163_V166_E0.5610.96
289_S370_Y0.5610.96
99_N103_Y0.5590.96
70_E148_E0.5560.96
140_G144_D0.5550.96
139_N143_N0.5520.96
26_I108_V0.5510.96
192_A196_G0.5510.96
116_I121_E0.5500.96
176_L225_S0.5490.96
178_D239_A0.5480.96
155_Y341_D0.5480.96
436_D442_E0.5470.96
411_I442_E0.5460.95
83_V88_Y0.5450.95
20_P59_S0.5440.95
279_R300_I0.5430.95
121_E124_I0.5430.95
24_L28_K0.5430.95
282_F312_I0.5420.95
12_G17_E0.5390.95
280_R319_E0.5380.95
266_L349_M0.5380.95
264_T367_L0.5370.95
80_Q338_T0.5360.95
191_V343_A0.5360.95
280_R322_V0.5350.95
442_E445_K0.5340.95
385_I393_M0.5330.95
171_K235_D0.5330.95
264_T268_Y0.5320.95
124_I128_Y0.5320.95
419_V430_I0.5320.95
18_L22_F0.5310.95
435_K439_K0.5310.95
333_Y344_M0.5310.95
382_K385_I0.5300.95
192_A195_L0.5290.95
439_K446_E0.5290.95
404_T407_G0.5290.95
266_L348_L0.5280.95
174_K234_V0.5260.94
273_K276_N0.5260.94
78_A187_V0.5260.94
11_R98_H0.5250.94
372_L375_T0.5250.94
57_V106_I0.5240.94
14_T53_L0.5210.94
25_K129_F0.5200.94
247_A349_M0.5200.94
41_L91_G0.5200.94
39_R86_L0.5200.94
67_L143_N0.5190.94
193_R198_K0.5190.94
283_T291_V0.5190.94
163_V170_S0.5170.94
375_T378_R0.5170.94
282_F305_T0.5160.94
28_K133_F0.5150.94
262_S329_G0.5150.94
356_E363_L0.5130.94
386_K389_Y0.5130.94
132_R136_V0.5130.94
437_E440_S0.5120.94
85_A157_R0.5110.94
206_L210_F0.5090.93
99_N107_K0.5070.93
191_V194_E0.5070.93
421_K428_I0.5070.93
365_N368_P0.5060.93
155_Y342_G0.5050.93
271_S281_I0.5040.93
214_T219_F0.5040.93
74_A79_F0.5030.93
267_S323_A0.5030.93
5_F26_I0.5030.93
22_F25_K0.5020.93
411_I443_L0.5010.93
23_A57_V0.5010.93
193_R196_G0.5010.93
202_I227_K0.5000.93
199_V202_I0.5000.93
219_F222_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f7lA 4 0.9956 100 0.058 Contact Map
1wqaA 3 0.9868 100 0.06 Contact Map
1tuoA 1 0.9231 100 0.103 Contact Map
3pdkA 2 0.9626 100 0.114 Contact Map
3uw2A 1 0.9538 100 0.121 Contact Map
3i3wA 2 0.956 100 0.124 Contact Map
1p5dX 1 0.9692 100 0.127 Contact Map
3na5A 2 0.9868 100 0.144 Contact Map
2z0fA 2 0.9451 100 0.151 Contact Map
3pmgA 1 0.989 100 0.165 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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