GREMLIN Database
Q980S0 - DNA/pantothenate metabolism flavoprotein (Dfp)
UniProt: Q980S0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 413 (377)
Sequences: 3591 (2464)
Seq/√Len: 126.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_L322_Y3.4831.00
199_N239_K3.4321.00
210_Y263_T3.4161.00
224_T375_E2.9081.00
151_D159_I2.8341.00
227_I244_C2.8101.00
24_K51_E2.7971.00
300_T338_V2.7351.00
350_I354_R2.6791.00
194_D236_R2.6221.00
338_V343_E2.5741.00
343_E346_E2.5331.00
379_V399_I2.4671.00
61_A79_T2.3951.00
151_D155_R2.3771.00
30_T106_T2.3591.00
236_R405_D2.3431.00
42_A73_T2.3191.00
233_A404_L2.3111.00
295_K312_E2.2841.00
293_K314_E2.2601.00
199_N241_R2.2531.00
28_A119_I2.2491.00
236_R404_L2.2471.00
265_E269_N2.2061.00
27_L42_A2.1911.00
167_E180_Y2.1871.00
389_R406_I2.1791.00
53_S75_N2.1431.00
345_I382_I2.1091.00
361_V379_V2.0751.00
44_S47_R2.0611.00
98_I185_I2.0571.00
92_E171_D2.0461.00
203_T271_V2.0441.00
200_I282_V1.9911.00
231_N397_T1.9821.00
251_I258_I1.9801.00
110_I135_I1.9691.00
39_L72_A1.9631.00
164_I176_P1.9441.00
257_D274_S1.9421.00
39_L68_M1.9351.00
96_V185_I1.9191.00
202_A229_I1.8681.00
108_V149_V1.8571.00
29_V69_F1.8561.00
55_I122_T1.8541.00
22_D50_A1.8521.00
239_K257_D1.8151.00
201_L280_F1.8011.00
241_R259_V1.7961.00
206_P246_P1.7961.00
272_V322_Y1.7851.00
268_L272_V1.7831.00
51_E75_N1.7581.00
58_K62_K1.7471.00
234_Y256_K1.7341.00
337_T365_V1.7341.00
381_V406_I1.7311.00
293_K316_T1.7271.00
53_S93_D1.7211.00
97_M123_A1.7091.00
97_M129_M1.7031.00
348_A362_A1.6821.00
295_K314_E1.6711.00
210_Y220_P1.6651.00
203_T243_I1.6641.00
232_E401_R1.6631.00
48_N186_T1.6451.00
110_I123_A1.6131.00
153_A163_V1.5841.00
206_P245_G1.5781.00
211_L217_I1.5721.00
308_I312_E1.5651.00
271_V323_I1.5591.00
229_I403_I1.5521.00
251_I260_Y1.5501.00
134_I188_Y1.5491.00
144_Y153_A1.5401.00
32_S103_T1.5341.00
227_I249_S1.5331.00
107_M135_I1.5331.00
154_D158_R1.5321.00
270_E273_K1.5031.00
265_E317_P1.4971.00
282_V407_V1.4971.00
261_V267_M1.4901.00
344_L362_A1.4851.00
376_Y393_K1.4801.00
165_E176_P1.4751.00
359_L383_D1.4731.00
259_V274_S1.4631.00
222_S373_S1.4631.00
198_F281_N1.4551.00
99_V123_A1.4451.00
56_I60_A1.4361.00
64_I69_F1.4331.00
106_T120_T1.3861.00
151_D158_R1.3831.00
106_T117_T1.3751.00
210_Y262_E1.3691.00
227_I247_I1.3601.00
208_R218_S1.3541.00
283_V323_I1.3531.00
200_I233_A1.3471.00
148_Q159_I1.3461.00
307_E315_R1.3441.00
284_I404_L1.3431.00
40_D44_S1.3391.00
135_I161_V1.3381.00
265_E293_K1.3241.00
332_G357_F1.3141.00
402_K405_D1.3101.00
109_K114_I1.3091.00
208_R262_E1.3031.00
41_L182_T1.2861.00
154_D157_K1.2841.00
211_L294_F1.2821.00
27_L38_S1.2801.00
136_V164_I1.2781.00
323_I330_L1.2741.00
111_A155_R1.2691.00
361_V403_I1.2681.00
193_K196_S1.2621.00
204_A227_I1.2611.00
394_N402_K1.2601.00
349_K353_R1.2591.00
55_I119_I1.2581.00
229_I284_I1.2511.00
285_L320_S1.2501.00
213_S300_T1.2501.00
108_V124_L1.2491.00
370_I376_Y1.2461.00
130_K142_Q1.2461.00
346_E350_I1.2441.00
155_R159_I1.2431.00
347_K350_I1.2431.00
140_H169_V1.2351.00
144_Y166_P1.2280.99
39_L64_I1.2260.99
96_V134_I1.2210.99
109_K116_D1.2160.99
262_E266_E1.2140.99
244_C258_I1.1780.99
264_T289_P1.1770.99
167_E176_P1.1760.99
201_L274_S1.1760.99
227_I251_I1.1750.99
105_N116_D1.1700.99
40_D179_E1.1690.99
378_E393_K1.1630.99
243_I271_V1.1600.99
54_V73_T1.1570.99
353_R384_K1.1570.99
265_E268_L1.1540.99
44_S182_T1.1440.99
25_I96_V1.1430.99
234_Y255_V1.1390.99
383_D387_D1.1370.99
57_S119_I1.1270.99
253_P256_K1.1260.99
124_L149_V1.1250.99
275_I283_V1.1210.99
235_F401_R1.1150.99
136_V176_P1.1150.99
320_S332_G1.1140.99
108_V114_I1.1130.99
117_T120_T1.1100.99
142_Q171_D1.1070.99
263_T266_E1.1060.99
270_E274_S1.1050.99
241_R274_S1.0920.99
275_I328_V1.0890.99
110_I161_V1.0880.99
394_N399_I1.0880.99
56_I61_A1.0790.99
112_Y155_R1.0770.99
241_R257_D1.0760.99
42_A69_F1.0750.99
157_K165_E1.0650.99
194_D405_D1.0530.98
167_E177_K1.0390.98
266_E269_N1.0380.98
220_P373_S1.0360.98
201_L243_I1.0340.98
283_V330_L1.0330.98
220_P262_E1.0260.98
265_E316_T1.0240.98
162_E188_Y1.0160.98
267_M319_I1.0120.98
331_V407_V1.0110.98
378_E390_K1.0070.98
58_K80_K1.0060.98
105_N114_I1.0050.98
123_A133_L1.0040.98
379_V403_I1.0020.98
78_V118_P1.0000.98
194_D408_K0.9970.98
136_V175_Y0.9940.98
208_R216_F0.9920.98
308_I315_R0.9910.98
23_K95_D0.9890.98
394_N398_V0.9870.98
59_D105_N0.9860.98
163_V176_P0.9840.98
241_R280_F0.9810.98
211_L311_V0.9800.98
25_I50_A0.9770.97
233_A284_I0.9760.97
268_L317_P0.9760.97
102_S107_M0.9740.97
108_V112_Y0.9700.97
352_M384_K0.9680.97
146_S161_V0.9670.97
176_P180_Y0.9660.97
202_A233_A0.9640.97
236_R401_R0.9620.97
45_L182_T0.9620.97
24_K93_D0.9600.97
294_F311_V0.9570.97
175_Y178_L0.9560.97
164_I184_R0.9560.97
357_F360_I0.9520.97
28_A97_M0.9500.97
23_K50_A0.9470.97
200_I284_I0.9470.97
58_K61_A0.9460.97
232_E235_F0.9420.97
345_I349_K0.9420.97
395_F398_V0.9410.97
135_I163_V0.9320.97
227_I258_I0.9310.97
48_N182_T0.9270.97
217_I313_L0.9260.96
44_S178_L0.9260.96
134_I164_I0.9240.96
329_L359_L0.9200.96
389_R402_K0.9190.96
244_C247_I0.9170.96
321_E354_R0.9160.96
99_V110_I0.9140.96
370_I378_E0.9120.96
136_V181_L0.9120.96
367_R378_E0.9110.96
343_E347_K0.9100.96
71_W85_L0.9010.96
324_R328_V0.8990.96
41_L100_A0.8980.96
383_D386_G0.8940.96
104_A124_L0.8920.96
232_E236_R0.8910.96
259_V270_E0.8900.96
204_A242_V0.8890.96
39_L69_F0.8860.95
42_A54_V0.8840.95
275_I323_I0.8830.95
89_S93_D0.8740.95
359_L381_V0.8710.95
329_L407_V0.8710.95
391_I402_K0.8700.95
141_L145_I0.8600.95
406_I409_E0.8570.95
133_L161_V0.8530.94
285_L323_I0.8510.94
338_V347_K0.8510.94
202_A284_I0.8480.94
40_D178_L0.8450.94
244_C249_S0.8450.94
24_K53_S0.8410.94
41_L98_I0.8400.94
296_N312_E0.8390.94
325_K328_V0.8330.94
350_I353_R0.8300.94
141_L171_D0.8290.94
45_L185_I0.8280.94
26_L94_N0.8220.93
292_Y309_P0.8190.93
227_I260_Y0.8190.93
61_A66_P0.8190.93
46_M74_G0.8180.93
123_A146_S0.8170.93
199_N280_F0.8120.93
51_E93_D0.8080.93
165_E175_Y0.8080.93
44_S48_N0.8050.93
134_I185_I0.8050.93
155_R158_R0.8040.93
109_K120_T0.8040.93
157_K163_V0.8040.93
349_K382_I0.8030.92
269_N273_K0.8030.92
298_S302_I0.8010.92
200_I404_L0.8000.92
28_A99_V0.7980.92
29_V35_I0.7960.92
335_A365_V0.7920.92
334_S348_A0.7920.92
98_I181_L0.7910.92
38_S41_L0.7890.92
92_E142_Q0.7890.92
183_S187_S0.7870.92
204_A226_G0.7830.92
360_I382_I0.7820.91
167_E174_H0.7820.91
194_D401_R0.7820.91
206_P218_S0.7790.91
39_L42_A0.7770.91
229_I400_A0.7740.91
201_L271_V0.7710.91
213_S337_T0.7700.91
303_D336_E0.7680.91
282_V329_L0.7680.91
88_V169_V0.7670.91
123_A161_V0.7660.91
380_I390_K0.7640.90
112_Y152_A0.7630.90
275_I280_F0.7620.90
320_S357_F0.7610.90
132_P162_E0.7550.90
141_L169_V0.7540.90
345_I380_I0.7540.90
236_R408_K0.7540.90
195_L408_K0.7510.90
349_K352_M0.7510.90
370_I393_K0.7510.90
133_L146_S0.7470.89
129_M133_L0.7420.89
107_M153_A0.7390.89
371_G377_N0.7390.89
176_P184_R0.7390.89
370_I374_S0.7360.89
45_L98_I0.7360.89
228_S231_N0.7360.89
82_T86_E0.7290.88
402_K406_I0.7280.88
361_V381_V0.7270.88
404_L407_V0.7260.88
27_L100_A0.7250.88
203_T285_L0.7240.88
235_F397_T0.7220.88
244_C260_Y0.7210.88
111_A151_D0.7200.88
349_K387_D0.7200.88
271_V285_L0.7200.88
246_P249_S0.7190.88
391_I394_N0.7120.87
383_D406_I0.7100.87
81_L118_P0.7070.87
195_L198_F0.7070.87
183_S186_T0.7050.87
38_S175_Y0.7030.86
26_L90_L0.7030.86
371_G374_S0.7000.86
102_S156_L0.6980.86
106_T123_A0.6970.86
38_S69_F0.6950.86
227_I242_V0.6940.86
379_V391_I0.6940.86
59_D62_K0.6930.86
58_K117_T0.6930.86
303_D347_K0.6910.86
176_P181_L0.6910.86
293_K317_P0.6910.86
364_N367_R0.6900.85
397_T401_R0.6840.85
285_L330_L0.6830.85
91_A131_K0.6820.85
274_S277_N0.6790.85
30_T103_T0.6790.85
54_V69_F0.6780.84
134_I162_E0.6780.84
110_I146_S0.6780.84
231_N235_F0.6780.84
330_L357_F0.6770.84
50_A186_T0.6760.84
234_Y251_I0.6760.84
335_A364_N0.6750.84
367_R370_I0.6750.84
345_I390_K0.6740.84
67_E71_W0.6720.84
201_L283_V0.6710.84
44_S179_E0.6690.84
29_V38_S0.6660.83
369_D378_E0.6650.83
261_V266_E0.6640.83
100_A175_Y0.6630.83
380_I387_D0.6620.83
115_A124_L0.6590.83
272_V323_I0.6590.83
42_A46_M0.6570.83
65_S68_M0.6540.82
85_L169_V0.6540.82
398_V401_R0.6530.82
108_V152_A0.6480.82
300_T343_E0.6480.82
272_V324_R0.6470.82
134_I184_R0.6430.81
43_R47_R0.6420.81
318_K355_H0.6420.81
30_T99_V0.6410.81
304_S320_S0.6390.81
46_M51_E0.6390.81
130_K145_I0.6390.81
269_N272_V0.6370.81
243_I267_M0.6370.81
399_I402_K0.6360.80
33_V68_M0.6360.80
348_A360_I0.6340.80
229_I404_L0.6320.80
264_T316_T0.6310.80
83_G89_S0.6310.80
134_I189_V0.6290.80
140_H171_D0.6280.80
91_A142_Q0.6280.80
304_S315_R0.6270.80
23_K189_V0.6260.79
294_F297_K0.6240.79
364_N370_I0.6220.79
150_A154_D0.6180.79
377_N399_I0.6180.79
55_I118_P0.6150.78
144_Y165_E0.6140.78
376_Y395_F0.6140.78
264_T290_A0.6130.78
275_I330_L0.6130.78
208_R246_P0.6130.78
43_R169_V0.6130.78
206_P247_I0.6120.78
65_S69_F0.6120.78
208_R220_P0.6110.78
306_T315_R0.6090.78
296_N299_D0.6080.77
245_G267_M0.6080.77
280_F283_V0.6070.77
244_C251_I0.6070.77
56_I66_P0.6050.77
31_G59_D0.6040.77
45_L50_A0.6020.77
222_S286_A0.6020.77
276_E326_Y0.5990.76
199_N277_N0.5980.76
382_I387_D0.5960.76
184_R187_S0.5950.76
53_S78_V0.5940.76
56_I77_V0.5940.76
195_L404_L0.5930.76
56_I64_I0.5920.76
148_Q155_R0.5920.76
247_I251_I0.5910.75
26_L97_M0.5910.75
242_V249_S0.5900.75
41_L175_Y0.5900.75
213_S298_S0.5890.75
61_A65_S0.5880.75
41_L44_S0.5870.75
381_V403_I0.5860.75
209_E316_T0.5850.75
195_L200_I0.5850.75
344_L347_K0.5840.75
92_E141_L0.5840.75
206_P249_S0.5840.75
28_A57_S0.5830.74
41_L181_L0.5830.74
391_I399_I0.5820.74
140_H168_I0.5810.74
365_V371_G0.5790.74
97_M122_T0.5780.74
153_A157_K0.5770.74
109_K117_T0.5770.74
105_N109_K0.5770.74
401_R405_D0.5750.73
151_D154_D0.5730.73
356_G384_K0.5720.73
261_V270_E0.5720.73
98_I136_V0.5700.73
271_V319_I0.5690.73
56_I69_F0.5670.72
174_H177_K0.5670.72
178_L182_T0.5660.72
259_V273_K0.5660.72
100_A181_L0.5640.72
132_P188_Y0.5640.72
209_E264_T0.5620.72
112_Y151_D0.5620.72
62_K67_E0.5620.72
317_P322_Y0.5610.72
106_T119_I0.5600.72
102_S135_I0.5580.71
123_A135_I0.5580.71
367_R371_G0.5570.71
359_L406_I0.5570.71
293_K297_K0.5550.71
199_N274_S0.5550.71
31_G35_I0.5520.70
232_E404_L0.5500.70
227_I248_S0.5490.70
195_L233_A0.5480.70
206_P244_C0.5470.70
96_V189_V0.5470.70
86_E89_S0.5460.70
180_Y254_Y0.5450.69
110_I124_L0.5440.69
366_R369_D0.5440.69
210_Y297_K0.5430.69
36_Y40_D0.5430.69
85_L92_E0.5430.69
208_R373_S0.5420.69
345_I387_D0.5420.69
91_A122_T0.5400.69
31_G63_L0.5390.69
117_T121_A0.5390.69
29_V42_A0.5380.68
29_V54_V0.5380.68
31_G60_A0.5380.68
231_N256_K0.5370.68
378_E399_I0.5370.68
46_M73_T0.5370.68
232_E397_T0.5370.68
366_R370_I0.5340.68
128_G140_H0.5340.68
147_P159_I0.5340.68
331_V359_L0.5330.68
114_I121_A0.5330.68
284_I407_V0.5300.67
85_L88_V0.5300.67
276_E324_R0.5300.67
200_I229_I0.5290.67
268_L271_V0.5280.67
88_V140_H0.5260.67
136_V163_V0.5260.67
346_E349_K0.5260.67
40_D47_R0.5260.67
334_S351_K0.5260.67
39_L56_I0.5250.67
24_K95_D0.5240.66
74_G78_V0.5220.66
40_D177_K0.5220.66
187_S235_F0.5220.66
104_A139_M0.5200.66
195_L238_A0.5190.66
169_V172_L0.5180.66
46_M75_N0.5160.65
74_G171_D0.5150.65
249_S258_I0.5150.65
271_V274_S0.5140.65
324_R327_N0.5130.65
98_I134_I0.5130.65
361_V399_I0.5130.65
403_I407_V0.5130.65
85_L206_P0.5120.65
302_I309_P0.5120.65
99_V106_T0.5110.65
352_M360_I0.5110.65
71_W77_V0.5090.64
35_I64_I0.5080.64
43_R46_M0.5070.64
35_I69_F0.5070.64
163_V181_L0.5070.64
141_L174_H0.5070.64
145_I150_A0.5060.64
198_F282_V0.5060.64
162_E184_R0.5060.64
100_A136_V0.5060.64
84_D89_S0.5050.64
352_M357_F0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjiA 2 0.4964 100 0.545 Contact Map
1p9oA 2 0.5206 100 0.608 Contact Map
2gk4A 2 0.5036 100 0.641 Contact Map
1u7zA 2 0.5182 100 0.66 Contact Map
1mvlA 3 0.3923 100 0.669 Contact Map
3qjgA 5 0.385 100 0.674 Contact Map
1p3y1 6 0.3995 100 0.68 Contact Map
1g63A 6 0.3947 100 0.68 Contact Map
1qzuA 3 0.3632 100 0.683 Contact Map
3mcuA 5 0.431 100 0.69 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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