GREMLIN Database
Q980R8 - Uncharacterized protein
UniProt: Q980R8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (259)
Sequences: 1073 (848)
Seq/√Len: 52.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_G230_A3.3601.00
183_N186_S3.3101.00
59_Y81_L3.2591.00
222_I234_A3.2181.00
42_V263_N3.1751.00
39_Q256_N3.0391.00
29_I38_S3.0211.00
66_R77_T3.0191.00
245_D248_S2.9421.00
74_I106_Y2.9051.00
226_Y230_A2.6851.00
29_I36_S2.6781.00
234_A259_L2.6431.00
196_K283_D2.6301.00
199_L205_D2.5471.00
222_I264_F2.5331.00
214_L234_A2.5231.00
23_S97_T2.4591.00
164_F224_K2.4521.00
255_L259_L2.4131.00
226_Y264_F2.4111.00
15_V105_A2.4061.00
237_V258_Y2.3821.00
199_L280_Y2.3411.00
206_V277_L2.3201.00
105_A109_A2.2651.00
29_I37_R2.2221.00
67_G109_A2.2131.00
28_Y50_V2.1991.00
164_F168_M2.1851.00
180_N187_I2.0631.00
241_V248_S2.0021.00
213_I217_Y1.9961.00
174_Y223_Y1.9831.00
267_G271_D1.9671.00
28_Y46_Y1.9531.00
194_V198_G1.9250.99
17_Y57_S1.9150.99
108_A282_L1.9060.99
175_D179_L1.8950.99
210_F214_L1.8900.99
187_I217_Y1.8210.99
28_Y37_R1.7250.99
139_A143_L1.7200.99
208_R248_S1.7100.99
86_N95_F1.6840.99
192_Y276_A1.6740.99
194_V212_Y1.6290.98
24_I53_A1.6020.98
100_L177_V1.6010.98
15_V109_A1.5520.98
19_L101_I1.5500.98
256_N260_I1.5410.98
19_L278_A1.5200.97
16_S20_S1.5110.97
52_S85_S1.5110.97
67_G106_Y1.5000.97
92_Y271_D1.5000.97
62_E80_E1.4980.97
44_V49_I1.4830.97
237_V255_L1.4620.97
36_S39_Q1.4280.96
143_L147_Y1.4280.96
29_I39_Q1.4280.96
232_L235_S1.3910.95
56_S81_L1.3890.95
181_M185_Y1.3820.95
256_N259_L1.3810.95
44_V93_Q1.3740.95
209_A276_A1.3740.95
25_I281_Y1.3410.94
140_L146_K1.3280.94
25_I51_K1.2900.93
223_Y231_A1.2810.93
168_M224_K1.2660.93
230_A264_F1.2540.92
217_Y269_T1.2490.92
233_E237_V1.2450.92
252_L256_N1.2370.92
92_Y267_G1.2320.91
52_S94_L1.2290.91
19_L56_S1.2280.91
65_I69_R1.2210.91
144_N147_Y1.2200.91
141_K145_L1.2200.91
101_I274_A1.2150.91
131_L134_R1.2140.91
218_P235_S1.2050.91
64_C105_A1.2050.91
191_A216_N1.2040.91
36_S256_N1.2010.90
211_L252_L1.1550.89
21_Q281_Y1.1530.89
146_K182_V1.1460.88
41_L221_L1.1350.88
56_S60_Y1.1340.88
85_S89_G1.1280.87
103_P181_M1.1190.87
97_T177_V1.1170.87
104_F279_I1.1110.87
20_S57_S1.1020.86
58_T84_R1.0970.86
30_F36_S1.0950.86
35_A92_Y1.0930.86
37_R46_Y1.0870.85
62_E77_T1.0850.85
75_Y99_L1.0820.85
24_I28_Y1.0800.85
99_L221_L1.0730.85
194_V208_R1.0550.84
213_I269_T1.0540.84
260_I263_N1.0430.83
85_S93_Q1.0400.83
230_A233_E1.0400.83
49_I92_Y1.0320.82
231_A235_S1.0320.82
100_L275_S1.0310.82
179_L183_N1.0250.82
140_L143_L1.0200.81
223_Y228_A1.0190.81
71_I99_L1.0160.81
214_L238_A1.0140.81
133_T136_F1.0090.81
20_S53_A1.0060.81
71_I75_Y0.9950.80
187_I269_T0.9950.80
140_L147_Y0.9900.80
30_F207_Q0.9900.80
39_Q260_I0.9860.79
27_S49_I0.9840.79
52_S93_Q0.9780.79
105_A278_A0.9750.78
104_F275_S0.9680.78
197_E201_G0.9670.78
207_Q248_S0.9620.78
41_L44_V0.9600.77
139_A144_N0.9550.77
244_G251_E0.9530.77
155_D158_E0.9490.77
210_F273_I0.9450.76
237_V240_L0.9440.76
215_S238_A0.9440.76
188_T279_I0.9430.76
85_S225_K0.9380.76
275_S279_I0.9310.75
27_S46_Y0.9300.75
137_L189_F0.9200.74
97_T278_A0.9130.74
26_E271_D0.9100.73
43_N92_Y0.8970.72
199_L202_L0.8960.72
27_S53_A0.8900.72
267_G270_A0.8860.71
100_L189_F0.8830.71
176_I225_K0.8750.71
94_L97_T0.8650.70
15_V64_C0.8560.69
36_S95_F0.8540.69
47_I203_E0.8530.69
211_L241_V0.8510.68
70_G110_K0.8500.68
46_Y50_V0.8500.68
53_A58_T0.8450.68
13_N61_K0.8400.67
141_K144_N0.8380.67
94_L98_Y0.8370.67
195_I281_Y0.8340.67
236_K240_L0.8320.67
23_S91_E0.8260.66
24_I54_L0.8250.66
82_V98_Y0.8240.66
74_I222_I0.8200.65
26_E267_G0.8170.65
154_M160_E0.8140.65
168_M220_T0.8120.65
31_K36_S0.8090.64
167_L224_K0.8080.64
212_Y215_S0.8070.64
59_Y84_R0.8070.64
228_A232_L0.8070.64
187_I213_I0.8070.64
248_S251_E0.8040.64
188_T193_K0.8000.64
189_F279_I0.7990.63
211_L238_A0.7990.63
75_Y221_L0.7930.63
180_N218_P0.7910.63
214_L222_I0.7880.62
258_Y262_N0.7880.62
165_F169_E0.7860.62
79_V135_W0.7770.61
31_K185_Y0.7750.61
35_A49_I0.7740.61
176_I179_L0.7700.61
241_V244_G0.7670.60
146_K149_G0.7650.60
71_I79_V0.7600.60
63_L67_G0.7600.60
53_A189_F0.7590.59
46_Y252_L0.7580.59
83_T246_C0.7540.59
75_Y178_A0.7520.59
195_I276_A0.7520.59
162_I170_F0.7490.58
33_G259_L0.7420.58
233_E262_N0.7410.58
35_A44_V0.7390.57
33_G93_Q0.7380.57
18_I282_L0.7380.57
183_N250_N0.7340.57
97_T224_K0.7260.56
241_V255_L0.7240.56
226_Y276_A0.7240.56
33_G266_P0.7220.56
35_A43_N0.7140.55
153_S156_Y0.7130.55
125_L128_L0.7090.54
168_M214_L0.7090.54
253_E257_K0.7090.54
43_N225_K0.7050.54
84_R87_K0.7050.54
64_C108_A0.7010.53
140_L145_L0.6990.53
55_I84_R0.6980.53
188_T272_L0.6970.53
125_L130_A0.6960.53
198_G208_R0.6950.53
256_N263_N0.6940.53
54_L57_S0.6940.53
222_I266_P0.6910.52
76_D80_E0.6910.52
224_K274_A0.6900.52
210_F269_T0.6900.52
177_V220_T0.6880.52
104_F278_A0.6870.52
140_L144_N0.6830.52
43_N89_G0.6830.52
41_L89_G0.6800.51
143_L146_K0.6790.51
78_L273_I0.6780.51
94_L268_S0.6760.51
240_L254_W0.6750.51
26_E35_A0.6740.51
34_N265_N0.6700.50
41_L225_K0.6690.50
169_E178_A0.6680.50
195_I280_Y0.6680.50
266_P274_A0.6660.50
33_G264_F0.6640.50
240_L243_S0.6640.50
222_I259_L0.6640.50
201_G257_K0.6600.49
89_G265_N0.6580.49
16_S53_A0.6570.49
166_T178_A0.6560.49
78_L268_S0.6560.49
174_Y224_K0.6560.49
94_L221_L0.6520.48
66_R70_G0.6500.48
93_Q271_D0.6490.48
187_I223_Y0.6470.48
174_Y220_T0.6440.47
23_S181_M0.6440.47
191_A212_Y0.6420.47
241_V252_L0.6410.47
48_D93_Q0.6390.47
75_Y166_T0.6390.47
95_F163_D0.6370.47
94_L181_M0.6350.47
104_F185_Y0.6350.47
188_T275_S0.6340.46
235_S239_R0.6340.46
85_S94_L0.6330.46
100_L221_L0.6320.46
250_N254_W0.6320.46
63_L98_Y0.6290.46
85_S98_Y0.6270.46
66_R73_R0.6260.46
145_L148_L0.6240.45
23_S60_Y0.6220.45
192_Y196_K0.6210.45
202_L280_Y0.6190.45
43_N271_D0.6190.45
41_L176_I0.6180.45
95_F169_E0.6170.45
176_I268_S0.6150.44
214_L266_P0.6110.44
44_V92_Y0.6110.44
78_L176_I0.6100.44
198_G212_Y0.6080.44
192_Y279_I0.6070.44
213_I272_L0.6060.44
214_L259_L0.6060.44
198_G205_D0.6050.43
36_S252_L0.6040.43
257_K261_N0.6030.43
130_A163_D0.6020.43
236_K239_R0.6020.43
26_E92_Y0.6000.43
81_L97_T0.6000.43
172_S228_A0.5990.43
59_Y63_L0.5990.43
227_G252_L0.5990.43
36_S94_L0.5980.43
34_N225_K0.5960.42
276_A280_Y0.5950.42
40_D45_K0.5950.42
108_A279_I0.5950.42
69_R73_R0.5920.42
44_V221_L0.5910.42
20_S54_L0.5910.42
19_L280_Y0.5910.42
100_L185_Y0.5910.42
47_I51_K0.5900.42
34_N82_V0.5880.42
78_L99_L0.5860.41
82_V89_G0.5830.41
252_L259_L0.5820.41
95_F268_S0.5800.41
67_G256_N0.5790.41
222_I269_T0.5780.41
33_G67_G0.5780.41
31_K221_L0.5780.41
25_I206_V0.5780.41
35_A271_D0.5760.40
99_L178_A0.5760.40
124_L128_L0.5750.40
143_L148_L0.5730.40
88_F235_S0.5730.40
86_N163_D0.5720.40
75_Y79_V0.5700.40
82_V268_S0.5670.40
243_S246_C0.5640.39
15_V40_D0.5610.39
192_Y280_Y0.5600.39
23_S101_I0.5580.39
44_V99_L0.5580.39
99_L268_S0.5580.39
103_P238_A0.5570.39
63_L102_A0.5570.39
96_G271_D0.5560.38
268_S273_I0.5550.38
80_E83_T0.5540.38
214_L269_T0.5540.38
16_S208_R0.5530.38
168_M222_I0.5520.38
195_I209_A0.5510.38
37_R203_E0.5510.38
102_A177_V0.5500.38
255_L264_F0.5480.38
66_R172_S0.5480.38
25_I47_I0.5460.37
36_S207_Q0.5450.37
74_I196_K0.5430.37
207_Q252_L0.5430.37
234_A282_L0.5410.37
110_K211_L0.5400.37
142_E145_L0.5380.37
208_R241_V0.5360.36
35_A267_G0.5360.36
83_T196_K0.5350.36
44_V264_F0.5340.36
24_I27_S0.5330.36
26_E270_A0.5320.36
176_I273_I0.5310.36
85_S92_Y0.5310.36
215_S239_R0.5310.36
85_S268_S0.5290.36
78_L85_S0.5270.36
103_P226_Y0.5260.35
137_L140_L0.5260.35
56_S89_G0.5250.35
195_I277_L0.5240.35
221_L265_N0.5230.35
34_N41_L0.5220.35
89_G225_K0.5200.35
139_A142_E0.5200.35
126_R131_L0.5190.35
44_V271_D0.5130.34
34_N210_F0.5090.34
139_A145_L0.5080.34
96_G267_G0.5080.34
169_E179_L0.5070.34
53_A99_L0.5050.33
123_K126_R0.5040.33
200_C205_D0.5030.33
238_A259_L0.5000.33
75_Y275_S0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h9pA 2 0.7248 100 0.325 Contact Map
4a4zA 1 0.3289 32.1 0.962 Contact Map
4u4cA 1 0.3523 24.3 0.964 Contact Map
4qu4A 1 0.3054 10.9 0.969 Contact Map
3r84A 2 0.2416 6.3 0.972 Contact Map
4bujA 1 0.3523 5 0.974 Contact Map
2cr7A 1 0.2685 4 0.975 Contact Map
4yozA 1 0.3154 3.3 0.976 Contact Map
5al9A 2 0.3826 2.8 0.977 Contact Map
1e91A 1 0.2752 2.5 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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