GREMLIN Database
Q980R7 - Uncharacterized protein
UniProt: Q980R7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (287)
Sequences: 123 (112)
Seq/√Len: 6.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_I270_V4.7900.98
194_R227_I3.6440.92
64_I225_A3.4980.90
181_S188_R3.4890.90
227_I253_I3.2970.87
32_V86_I3.2340.86
25_N183_L3.0600.83
12_I81_V2.9770.81
112_L142_I2.5940.71
86_I226_H2.5010.68
221_V276_L2.4630.66
13_I90_L2.4400.66
116_I295_F2.4110.65
37_K199_S2.2800.60
11_I37_K2.1090.54
216_K278_S2.0990.53
95_R98_E2.0950.53
183_L258_G2.0390.51
42_G86_I2.0280.51
264_L270_V2.0270.51
147_Y274_G2.0240.51
187_N262_S1.9450.48
268_R277_M1.9160.47
55_K62_I1.8940.46
19_V205_D1.8780.45
125_I142_I1.8630.45
37_K234_L1.8580.44
272_V285_V1.7990.42
46_W82_L1.7860.42
14_D182_S1.7760.41
199_S259_I1.7540.41
9_R46_W1.7330.40
199_S257_E1.7190.39
193_Y199_S1.7150.39
37_K257_E1.7090.39
44_G52_I1.6900.38
133_L208_W1.6880.38
101_K275_L1.6740.38
37_K263_A1.6490.37
116_I286_I1.6440.37
44_G134_G1.5870.35
108_I196_I1.5670.34
199_S262_S1.5580.34
252_K284_V1.5560.34
169_I172_A1.5530.34
125_I144_I1.5470.34
143_D237_P1.5340.33
141_D237_P1.5340.33
259_I262_S1.5240.33
190_R201_L1.5230.33
115_F142_I1.5090.32
92_P268_R1.5090.32
222_K271_E1.4900.32
21_T198_I1.4800.31
234_L268_R1.4480.30
7_L82_L1.4370.30
32_V112_L1.4340.30
287_I296_I1.4300.30
99_I116_I1.4240.30
187_N199_S1.4210.29
264_L268_R1.4210.29
13_I88_R1.4070.29
158_S181_S1.4050.29
257_E262_S1.3960.29
229_G240_A1.3850.28
21_T35_Y1.3800.28
17_G133_L1.3530.27
21_T37_K1.3440.27
135_N183_L1.3380.27
199_S235_I1.3340.27
199_S263_A1.3340.27
196_I272_V1.3280.27
88_R138_S1.3250.27
198_I263_A1.3220.26
259_I277_M1.3210.26
99_I180_F1.3200.26
205_D256_Y1.3090.26
120_V158_S1.3070.26
111_A276_L1.3020.26
32_V223_F1.2910.26
57_G62_I1.2900.26
79_P292_V1.2860.25
108_I146_I1.2860.25
144_I273_E1.2800.25
21_T257_E1.2750.25
187_N277_M1.2750.25
140_S143_D1.2640.25
140_S237_P1.2640.25
285_V296_I1.2540.25
254_V272_V1.2490.24
151_S205_D1.2480.24
149_R217_K1.2390.24
116_I193_Y1.2380.24
104_V253_I1.2300.24
17_G270_V1.2280.24
71_E74_Y1.2200.24
40_Y45_I1.2150.23
126_G148_G1.2110.23
40_Y44_G1.2080.23
225_A242_V1.1970.23
147_Y263_A1.1940.23
14_D20_Y1.1930.23
27_N91_K1.1870.23
99_I226_H1.1840.23
199_S258_G1.1840.23
19_V206_K1.1840.23
187_N235_I1.1810.23
38_Y126_G1.1670.22
189_R262_S1.1670.22
142_I226_H1.1620.22
13_I17_G1.1590.22
115_F194_R1.1540.22
152_A186_D1.1510.22
196_I258_G1.1490.22
16_E133_L1.1440.22
96_L113_I1.1420.22
20_Y96_L1.1400.22
90_L118_E1.1370.21
28_P202_F1.1240.21
168_W294_G1.1230.21
37_K187_N1.1230.21
186_D199_S1.1220.21
111_A227_I1.1180.21
128_T271_E1.1100.21
96_L109_I1.1060.21
150_K242_V1.1040.21
257_E268_R1.1020.21
75_D100_L1.1020.21
91_K296_I1.0970.20
55_K272_V1.0940.20
186_D263_A1.0920.20
57_G159_F1.0920.20
139_N181_S1.0910.20
286_I292_V1.0910.20
92_P129_G1.0870.20
128_T132_L1.0820.20
37_K259_I1.0780.20
89_H282_E1.0700.20
125_I200_V1.0650.20
44_G132_L1.0650.20
40_Y82_L1.0630.20
6_F41_T1.0600.20
94_E157_E1.0530.19
9_R201_L1.0440.19
8_D12_I1.0420.19
187_N257_E1.0340.19
190_R288_G1.0320.19
186_D277_M1.0260.19
17_G112_L1.0260.19
201_L258_G1.0240.19
262_S291_D1.0190.19
42_G269_Q1.0170.19
37_K268_R1.0130.19
111_A170_I1.0120.18
87_S101_K1.0110.18
191_G236_Y1.0100.18
27_N206_K1.0050.18
10_D36_L1.0020.18
25_N135_N0.9980.18
276_L285_V0.9960.18
111_A194_R0.9960.18
28_P256_Y0.9950.18
176_Y183_L0.9920.18
49_Y99_I0.9900.18
25_N258_G0.9900.18
24_T203_A0.9890.18
90_L216_K0.9730.18
99_I222_K0.9670.18
78_F250_V0.9620.17
92_P257_E0.9620.17
183_L199_S0.9590.17
88_R293_R0.9580.17
86_I119_Y0.9490.17
92_P190_R0.9400.17
13_I19_V0.9340.17
50_E185_Y0.9270.17
86_I89_H0.9270.17
21_T199_S0.9240.17
13_I16_E0.9220.17
240_A268_R0.9210.17
54_K80_I0.9190.16
233_A294_G0.9180.16
142_I292_V0.9080.16
187_N268_R0.9070.16
98_E104_V0.9070.16
19_V42_G0.9050.16
86_I223_F0.9040.16
11_I277_M0.8960.16
58_V62_I0.8930.16
100_L264_L0.8900.16
40_Y272_V0.8890.16
226_H269_Q0.8890.16
132_L274_G0.8890.16
79_P286_I0.8870.16
79_P197_K0.8860.16
201_L272_V0.8840.16
129_G141_D0.8790.16
129_G143_D0.8790.16
129_G237_P0.8790.16
260_F274_G0.8730.16
259_I263_A0.8730.16
119_Y157_E0.8670.15
168_W202_F0.8660.15
65_N185_Y0.8660.15
128_T174_E0.8630.15
35_Y219_G0.8620.15
6_F64_I0.8590.15
81_V179_N0.8570.15
109_I220_K0.8550.15
120_V150_K0.8540.15
130_S143_D0.8540.15
130_S237_P0.8540.15
130_S141_D0.8540.15
12_I269_Q0.8520.15
31_Y196_I0.8520.15
126_G143_D0.8500.15
126_G141_D0.8500.15
126_G237_P0.8500.15
18_N68_F0.8500.15
199_S268_R0.8490.15
52_I61_L0.8490.15
259_I268_R0.8470.15
161_G233_A0.8460.15
152_A172_A0.8460.15
92_P287_I0.8440.15
183_L187_N0.8400.15
92_P168_W0.8380.15
9_R272_V0.8360.15
99_I296_I0.8340.15
15_K216_K0.8280.15
69_N86_I0.8270.15
98_E101_K0.8270.15
97_R166_S0.8260.15
241_Y283_N0.8220.15
223_F250_V0.8220.15
19_V127_V0.8220.15
221_V272_V0.8210.15
199_S234_L0.8180.15
143_D274_G0.8170.15
141_D274_G0.8170.15
237_P274_G0.8170.15
37_K68_F0.8160.14
72_S87_S0.8150.14
96_L189_R0.8150.14
37_K277_M0.8110.14
187_N290_K0.7980.14
116_I195_G0.7920.14
186_D268_R0.7870.14
259_I290_K0.7870.14
263_A296_I0.7860.14
10_D290_K0.7860.14
46_W135_N0.7860.14
196_I285_V0.7850.14
17_G292_V0.7810.14
200_V230_D0.7780.14
221_V282_E0.7750.14
227_I282_E0.7730.14
166_S225_A0.7710.14
36_L235_I0.7700.14
98_E169_I0.7680.14
80_I142_I0.7670.14
190_R289_D0.7640.14
100_L104_V0.7620.14
92_P140_S0.7600.13
63_K248_Y0.7590.13
181_S203_A0.7580.13
137_H142_I0.7540.13
148_G274_G0.7530.13
73_C279_C0.7530.13
6_F256_Y0.7490.13
219_G295_F0.7480.13
15_K181_S0.7460.13
182_S250_V0.7430.13
113_I216_K0.7400.13
192_I282_E0.7390.13
21_T268_R0.7390.13
130_S189_R0.7380.13
8_D199_S0.7370.13
20_Y282_E0.7360.13
238_S260_F0.7350.13
11_I290_K0.7300.13
42_G226_H0.7290.13
143_D147_Y0.7230.13
141_D147_Y0.7230.13
147_Y237_P0.7230.13
155_F191_G0.7230.13
75_D78_F0.7210.13
157_E188_R0.7090.13
168_W200_V0.7090.13
142_I195_G0.7070.13
20_Y268_R0.7040.13
50_E132_L0.7020.13
37_K258_G0.7010.12
257_E263_A0.7000.12
190_R255_S0.7000.12
257_E277_M0.7000.12
11_I259_I0.6980.12
75_D95_R0.6970.12
36_L198_I0.6960.12
46_W51_R0.6910.12
53_F227_I0.6890.12
81_V153_L0.6850.12
87_S253_I0.6830.12
75_D127_V0.6830.12
230_D265_F0.6780.12
11_I199_S0.6770.12
134_G296_I0.6750.12
227_I232_E0.6750.12
71_E289_D0.6730.12
92_P235_I0.6670.12
262_S290_K0.6660.12
222_K296_I0.6660.12
30_G72_S0.6660.12
90_L133_L0.6650.12
82_L267_K0.6630.12
116_I124_D0.6610.12
125_I164_K0.6600.12
170_I296_I0.6600.12
216_K233_A0.6580.12
199_S264_L0.6560.12
103_S209_R0.6550.12
168_W236_Y0.6520.12
34_A184_L0.6500.12
172_A259_I0.6470.12
51_R56_Y0.6440.12
52_I86_I0.6410.12
87_S153_L0.6400.12
45_I265_F0.6400.12
21_T277_M0.6400.12
73_C214_I0.6380.11
69_N146_I0.6380.11
235_I268_R0.6370.11
15_K194_R0.6350.11
36_L277_M0.6280.11
15_K218_I0.6280.11
180_F187_N0.6270.11
112_L292_V0.6220.11
111_A180_F0.6200.11
178_I273_E0.6200.11
44_G109_I0.6190.11
29_P102_K0.6170.11
136_Y233_A0.6150.11
55_K58_V0.6140.11
260_F294_G0.6140.11
174_E234_L0.6130.11
45_I75_D0.6070.11
277_M289_D0.6060.11
228_S243_L0.6050.11
255_S279_C0.6020.11
29_P84_S0.6010.11
159_F233_A0.5970.11
152_A199_S0.5960.11
91_K241_Y0.5940.11
234_L257_E0.5940.11
94_E192_I0.5900.11
132_L260_F0.5880.11
224_K280_E0.5880.11
78_F186_D0.5870.11
37_K264_L0.5870.11
235_I259_I0.5830.11
21_T79_P0.5820.11
6_F89_H0.5800.11
94_E110_Y0.5800.11
135_N227_I0.5770.11
103_S184_L0.5760.11
77_S227_I0.5760.11
127_V230_D0.5760.11
86_I266_G0.5690.10
177_G285_V0.5680.10
42_G248_Y0.5680.10
97_R118_E0.5670.10
187_N263_A0.5660.10
37_K186_D0.5650.10
168_W174_E0.5640.10
242_V286_I0.5640.10
153_L182_S0.5630.10
128_T267_K0.5620.10
118_E241_Y0.5610.10
36_L289_D0.5600.10
19_V230_D0.5570.10
129_G140_S0.5560.10
63_K83_L0.5540.10
179_N289_D0.5500.10
135_N257_E0.5490.10
58_V254_V0.5490.10
9_R258_G0.5480.10
191_G261_S0.5480.10
104_V256_Y0.5460.10
76_A145_I0.5450.10
75_D186_D0.5450.10
183_L235_I0.5440.10
36_L259_I0.5440.10
102_K281_K0.5410.10
104_V116_I0.5410.10
130_S140_S0.5380.10
38_Y237_P0.5350.10
38_Y143_D0.5350.10
38_Y141_D0.5350.10
104_V283_N0.5340.10
126_G140_S0.5320.10
28_P71_E0.5310.10
194_R285_V0.5310.10
86_I281_K0.5300.10
8_D37_K0.5290.10
117_E122_V0.5280.10
108_I174_E0.5270.10
94_E100_L0.5250.10
28_P275_L0.5240.10
14_D18_N0.5240.10
223_F260_F0.5230.10
196_I296_I0.5220.10
81_V217_K0.5210.10
252_K281_K0.5200.10
142_I181_S0.5180.10
160_D203_A0.5180.10
292_V296_I0.5170.10
249_N278_S0.5170.10
98_E154_D0.5160.10
159_F265_F0.5130.10
96_L203_A0.5120.10
20_Y144_I0.5110.10
32_V256_Y0.5100.10
90_L191_G0.5090.10
37_K290_K0.5080.10
33_F171_E0.5070.10
33_F202_F0.5060.10
83_L114_S0.5040.10
112_L239_V0.5010.10
13_I170_I0.5000.10
128_T247_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jz0A 2 0.6187 94.4 0.943 Contact Map
1no5A 4 0.3077 94 0.944 Contact Map
1ylqA 2 0.301 93.5 0.945 Contact Map
1wotA 1 0.3278 91.4 0.948 Contact Map
1knyA 2 0.6087 88.9 0.951 Contact Map
2rffA 1 0.3512 88.6 0.951 Contact Map
2pbeA 1 0.5619 85.7 0.953 Contact Map
3nybA 1 0.612 82.5 0.955 Contact Map
2hhpA 1 0.6321 81.9 0.955 Contact Map
4ud4A 1 0.5518 81.6 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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