GREMLIN Database
IF2P - Probable translation initiation factor IF-2
UniProt: Q980Q8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 600 (454)
Sequences: 6136 (2888)
Seq/√Len: 135.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
294_D300_Y5.0851.00
105_I219_L3.9661.00
119_I182_L3.4621.00
239_K261_D3.4351.00
284_R289_P3.3981.00
265_K293_Q3.3931.00
211_G214_D3.0741.00
31_K209_G3.0141.00
111_T141_K2.9911.00
204_V215_L2.9501.00
77_P225_R2.7801.00
200_A218_L2.6781.00
447_K451_N2.6601.00
409_S414_I2.6311.00
268_D317_S2.5821.00
366_A372_L2.5801.00
145_W148_N2.5261.00
501_P512_E2.5121.00
31_K212_V2.3521.00
232_K235_E2.3341.00
313_G316_I2.2971.00
223_T227_L2.2831.00
409_S415_I2.2101.00
399_V402_A2.1951.00
394_I413_G2.1781.00
263_V293_Q2.1761.00
218_L225_R2.1741.00
476_G485_V2.1101.00
375_L442_L2.0961.00
474_L490_E2.0911.00
202_V218_L2.0821.00
139_I210_E2.0551.00
312_A315_K2.0161.00
232_K236_G1.9961.00
468_P500_Y1.9811.00
414_I417_A1.9791.00
336_E340_E1.9441.00
441_Q444_E1.9341.00
135_A204_V1.9251.00
125_L132_F1.9251.00
34_G209_G1.9151.00
327_G331_Y1.9151.00
176_V194_D1.8961.00
275_I307_E1.8881.00
39_K51_A1.8751.00
236_G261_D1.8701.00
410_K414_I1.8411.00
399_V411_E1.8311.00
409_S416_A1.8171.00
482_S485_V1.8051.00
409_S412_Y1.7941.00
353_V356_Y1.7911.00
136_A203_P1.7861.00
100_V241_V1.7761.00
409_S419_R1.7671.00
411_E415_I1.7651.00
266_K292_L1.7371.00
399_V406_A1.7361.00
32_I212_V1.7321.00
329_P332_V1.7231.00
414_I419_R1.7061.00
482_S486_V1.7011.00
355_L358_D1.6921.00
176_V203_P1.6911.00
416_A424_Q1.6851.00
137_N206_A1.6831.00
409_S417_A1.6671.00
346_I349_E1.6551.00
347_E350_I1.6551.00
246_K256_D1.6381.00
123_Q388_L1.6321.00
351_K358_D1.6121.00
48_E368_S1.6071.00
119_I123_Q1.6051.00
286_I289_P1.6001.00
110_I144_G1.6001.00
483_D486_V1.5981.00
291_P294_D1.5741.00
350_I353_V1.5741.00
291_P296_K1.5691.00
285_G289_P1.5611.00
419_R424_Q1.5511.00
284_R287_F1.5441.00
412_Y415_I1.5231.00
320_N323_E1.5221.00
470_K493_G1.5151.00
106_L134_I1.5131.00
54_V72_I1.5061.00
76_I217_A1.5061.00
351_K355_L1.5041.00
417_A420_V1.4911.00
295_M298_S1.4911.00
410_K419_R1.4851.00
353_V358_D1.4741.00
178_Q181_N1.4741.00
352_E358_D1.4691.00
136_A201_I1.4621.00
16_V104_A1.4591.00
444_E447_K1.4551.00
40_K43_G1.4451.00
328_S332_V1.4411.00
514_L517_Q1.4411.00
426_I433_I1.4391.00
398_D406_A1.4361.00
291_P300_Y1.4341.00
399_V405_V1.4201.00
10_L77_P1.4151.00
312_A316_I1.4061.00
180_A185_S1.4031.00
402_A406_A1.3931.00
410_K415_I1.3891.00
436_N445_D1.3811.00
473_I485_V1.3801.00
416_A419_R1.3791.00
420_V424_Q1.3791.00
146_K203_P1.3701.00
126_R183_G1.3681.00
415_I419_R1.3581.00
109_D112_E1.3581.00
180_A195_F1.3551.00
414_I418_F1.3481.00
352_E355_L1.3431.00
315_K318_A1.3421.00
345_Q350_I1.3381.00
31_K34_G1.3341.00
294_D298_S1.3281.00
113_G178_Q1.3231.00
192_I201_I1.3201.00
513_V517_Q1.3181.00
412_Y419_R1.3171.00
234_A263_V1.3111.00
29_L81_F1.3091.00
419_R422_L1.3061.00
345_Q348_E1.3051.00
410_K417_A1.3041.00
193_K200_A1.2961.00
271_I278_I1.2921.00
53_F80_L1.2891.00
217_A224_Q1.2891.00
352_E356_Y1.2821.00
398_D402_A1.2801.00
334_E338_K1.2751.00
328_S331_Y1.2741.00
335_D339_V1.2681.00
257_V315_K1.2661.00
185_S192_I1.2631.00
132_F184_F1.2631.00
338_K341_R1.2611.00
413_G435_Y1.2601.00
432_K461_T1.2601.00
398_D404_I1.2591.00
203_P210_E1.2511.00
397_R402_A1.2471.00
317_S321_L1.2441.00
409_S424_Q1.2441.00
472_K477_Y1.2391.00
348_E351_K1.2341.00
306_D310_A1.2271.00
71_P78_G1.2241.00
73_K78_G1.2231.00
353_V360_D1.2231.00
133_L219_L1.2211.00
313_G321_L1.2181.00
403_S429_S1.2141.00
35_T213_A1.2141.00
73_K76_I1.2131.00
481_R486_V1.2091.00
346_I350_I1.2061.00
53_F78_G1.2061.00
491_V496_I1.2051.00
421_K424_Q1.2001.00
283_V289_P1.1961.00
28_L212_V1.1931.00
192_I195_F1.1891.00
74_L77_P1.1880.99
356_Y359_I1.1820.99
377_S381_R1.1810.99
397_R406_A1.1800.99
417_A424_Q1.1780.99
414_I420_V1.1750.99
416_A422_L1.1600.99
104_A130_V1.1560.99
504_K509_R1.1440.99
469_G472_K1.1430.99
473_I477_Y1.1390.99
410_K416_A1.1330.99
479_F482_S1.1320.99
9_R234_A1.1310.99
345_Q349_E1.1230.99
313_G322_E1.1230.99
413_G416_A1.1160.99
351_K360_D1.1160.99
184_F199_V1.1140.99
105_I135_A1.1130.99
329_P333_V1.1130.99
348_E352_E1.1060.99
468_P473_I1.1060.99
351_K356_Y1.1050.99
350_I355_L1.1020.99
398_D405_V1.0940.99
415_I420_V1.0910.99
502_L513_V1.0910.99
283_V290_R1.0910.99
314_V317_S1.0890.99
238_A264_L1.0880.99
377_S380_Q1.0870.99
409_S423_L1.0860.99
335_D338_K1.0850.99
398_D401_E1.0830.99
413_G417_A1.0820.99
409_S418_F1.0790.99
356_Y360_D1.0770.99
473_I476_G1.0750.99
355_L360_D1.0740.99
145_W177_S1.0720.99
327_G330_I1.0710.99
409_S413_G1.0710.99
294_D301_D1.0680.99
283_V286_I1.0680.99
328_S333_V1.0650.99
108_V118_S1.0610.99
246_K301_D1.0600.99
330_I333_V1.0560.99
114_L201_I1.0560.99
313_G317_S1.0550.99
350_I358_D1.0540.99
332_V335_D1.0530.99
303_T310_A1.0510.99
504_K507_G1.0500.99
419_R425_G1.0490.99
481_R485_V1.0480.99
347_E351_K1.0440.99
412_Y425_G1.0410.99
506_D509_R1.0400.99
209_G212_V1.0400.99
282_K289_P1.0390.99
139_I146_K1.0380.99
291_P298_S1.0380.99
35_T212_V1.0370.99
376_V389_A1.0310.99
352_E359_I1.0240.98
512_E515_Q1.0210.98
32_I216_L1.0200.98
349_E353_V1.0200.98
420_V423_L1.0180.98
414_I425_G1.0160.98
15_V79_L1.0160.98
393_P507_G1.0140.98
232_K261_D1.0130.98
147_S203_P1.0110.98
294_D299_K1.0090.98
316_I322_E1.0090.98
312_A321_L1.0090.98
376_V380_Q1.0090.98
352_E360_D1.0070.98
468_P472_K1.0060.98
208_T212_V0.9980.98
410_K424_Q0.9980.98
8_R11_R0.9940.98
474_L477_Y0.9910.98
468_P475_P0.9910.98
411_E414_I0.9900.98
412_Y417_A0.9830.98
402_A405_V0.9830.98
469_G473_I0.9770.98
471_I489_I0.9750.98
450_I454_R0.9740.98
204_V211_G0.9740.98
347_E353_V0.9730.98
414_I424_Q0.9720.98
413_G418_F0.9620.98
317_S325_L0.9610.98
441_Q448_K0.9600.98
88_E381_R0.9560.98
121_S124_I0.9530.98
414_I421_K0.9520.98
412_Y416_A0.9510.98
488_G491_V0.9470.97
414_I422_L0.9440.97
445_D449_H0.9420.97
500_Y504_K0.9320.97
411_E417_A0.9270.97
119_I122_I0.9220.97
416_A420_V0.9210.97
380_Q385_P0.9210.97
110_I136_A0.9150.97
318_A321_L0.9140.97
493_G499_K0.9130.97
47_Q50_G0.9130.97
135_A206_A0.9120.97
315_K322_E0.9110.97
414_I423_L0.9070.97
412_Y420_V0.9070.97
437_E441_Q0.9060.97
234_A295_M0.9040.97
497_R500_Y0.9010.97
270_I305_I0.8980.97
317_S322_E0.8970.97
251_L283_V0.8970.97
253_H308_V0.8960.97
424_Q428_T0.8950.96
469_G474_L0.8930.96
417_A422_L0.8920.96
425_G429_S0.8900.96
31_K208_T0.8890.96
355_L359_I0.8890.96
79_L219_L0.8890.96
9_R235_E0.8870.96
74_L217_A0.8870.96
269_T278_I0.8860.96
78_G298_S0.8860.96
294_D297_L0.8840.96
231_L234_A0.8780.96
198_T201_I0.8780.96
12_Q298_S0.8770.96
424_Q427_D0.8770.96
512_E517_Q0.8750.96
211_G215_L0.8720.96
401_E406_A0.8700.96
409_S425_G0.8690.96
415_I418_F0.8690.96
315_K321_L0.8650.96
468_P477_Y0.8630.96
37_V40_K0.8600.96
409_S422_L0.8590.96
53_F298_S0.8570.95
342_Y346_I0.8550.95
347_E352_E0.8550.95
397_R405_V0.8500.95
283_V301_D0.8500.95
282_K287_F0.8480.95
346_I351_K0.8480.95
423_L427_D0.8390.95
200_A223_T0.8300.95
419_R423_L0.8270.95
243_L256_D0.8260.95
253_H348_E0.8250.94
472_K475_P0.8240.94
349_E355_L0.8240.94
34_G41_E0.8230.94
12_Q78_G0.8210.94
18_L106_L0.8210.94
27_T207_K0.8210.94
401_E405_V0.8200.94
92_N377_S0.8200.94
43_G46_T0.8190.94
342_Y350_I0.8180.94
291_P295_M0.8150.94
54_V73_K0.8140.94
327_G333_V0.8130.94
473_I479_F0.8120.94
400_I403_S0.8090.94
468_P479_F0.8090.94
353_V359_I0.8070.94
468_P471_I0.8060.94
282_K285_G0.8060.94
397_R401_E0.8040.94
410_K413_G0.8040.94
282_K286_I0.8040.94
511_G517_Q0.8010.94
204_V208_T0.7970.93
399_V404_I0.7950.93
108_V134_I0.7930.93
351_K354_R0.7920.93
346_I352_E0.7920.93
224_Q227_L0.7900.93
109_D141_K0.7890.93
124_I128_R0.7890.93
272_L315_K0.7850.93
207_K210_E0.7850.93
305_I308_V0.7830.93
239_K260_Y0.7810.93
16_V130_V0.7810.93
410_K421_K0.7800.93
349_E352_E0.7800.93
265_K268_D0.7800.93
409_S420_V0.7790.93
312_A322_E0.7770.93
273_G322_E0.7750.92
259_I300_Y0.7720.92
468_P495_I0.7720.92
411_E424_Q0.7710.92
475_P519_N0.7700.92
32_I72_I0.7700.92
259_I294_D0.7680.92
378_A443_I0.7680.92
314_V322_E0.7660.92
412_Y418_F0.7660.92
36_T39_K0.7640.92
416_A425_G0.7640.92
344_Q347_E0.7630.92
177_S181_N0.7620.92
316_I321_L0.7620.92
413_G425_G0.7610.92
38_V72_I0.7600.92
42_P45_M0.7600.92
505_E509_R0.7580.92
8_R232_K0.7560.91
420_V425_G0.7550.91
314_V321_L0.7530.91
33_R38_V0.7530.91
471_I496_I0.7520.91
317_S320_N0.7510.91
477_Y480_R0.7430.91
17_V29_L0.7430.91
14_I258_I0.7420.91
263_V295_M0.7410.91
418_F425_G0.7410.91
296_K299_K0.7410.91
203_P211_G0.7410.91
303_T306_D0.7400.91
281_T303_T0.7400.91
122_I126_R0.7380.90
341_R344_Q0.7380.90
447_K458_K0.7360.90
103_I133_L0.7350.90
247_E253_H0.7330.90
418_F424_Q0.7320.90
506_D510_V0.7310.90
16_V101_A0.7280.90
203_P214_D0.7280.90
399_V403_S0.7250.90
347_E355_L0.7240.90
32_I79_L0.7240.90
422_L425_G0.7240.90
176_V201_I0.7230.90
350_I360_D0.7190.89
139_I203_P0.7190.89
340_E343_K0.7170.89
283_V287_F0.7170.89
237_P319_P0.7130.89
476_G480_R0.7100.89
379_L384_I0.7100.89
45_M50_G0.7100.89
471_I478_V0.7090.89
272_L275_I0.7090.89
350_I356_Y0.7070.89
27_T31_K0.7070.89
344_Q348_E0.7060.88
494_G499_K0.7030.88
44_E47_Q0.7000.88
271_I318_A0.6990.88
231_L236_G0.6980.88
513_V516_I0.6970.88
413_G420_V0.6960.88
411_E425_G0.6920.87
340_E344_Q0.6900.87
418_F422_L0.6900.87
296_K300_Y0.6880.87
314_V318_A0.6880.87
475_P480_R0.6850.87
223_T226_Y0.6850.87
327_G336_E0.6830.87
451_N458_K0.6820.87
513_V519_N0.6810.87
467_L475_P0.6810.87
184_F192_I0.6810.87
77_P220_A0.6810.87
472_K492_I0.6800.87
473_I480_R0.6790.86
354_R358_D0.6780.86
238_A259_I0.6780.86
496_I513_V0.6770.86
513_V518_D0.6760.86
496_I502_L0.6740.86
108_V114_L0.6740.86
282_K290_R0.6730.86
110_I139_I0.6720.86
180_A192_I0.6710.86
336_E348_E0.6690.86
298_S301_D0.6690.86
260_Y297_L0.6670.85
33_R51_A0.6660.85
91_S124_I0.6660.85
412_Y442_L0.6650.85
474_L478_V0.6650.85
478_V485_V0.6650.85
322_E326_A0.6640.85
348_E355_L0.6620.85
339_V343_K0.6620.85
337_S341_R0.6620.85
467_L476_G0.6600.85
471_I475_P0.6590.85
123_Q126_R0.6580.85
48_E51_A0.6560.85
364_L372_L0.6560.85
491_V499_K0.6560.85
136_A146_K0.6530.84
473_I478_V0.6510.84
336_E341_R0.6510.84
336_E344_Q0.6480.84
489_I513_V0.6480.84
469_G475_P0.6450.84
247_E308_V0.6440.83
322_E325_L0.6430.83
335_D350_I0.6430.83
357_S360_D0.6430.83
308_V311_A0.6410.83
344_Q355_L0.6400.83
334_E337_S0.6400.83
176_V180_A0.6400.83
469_G476_G0.6400.83
413_G423_L0.6390.83
269_T280_I0.6390.83
412_Y421_K0.6390.83
272_L305_I0.6390.83
411_E420_V0.6390.83
339_V350_I0.6390.83
177_S180_A0.6380.83
495_I499_K0.6380.83
417_A423_L0.6380.83
26_T29_L0.6380.83
22_D87_H0.6370.83
118_S134_I0.6360.83
410_K420_V0.6340.82
175_L178_Q0.6330.82
285_G290_R0.6320.82
467_L493_G0.6310.82
282_K294_D0.6310.82
475_P479_F0.6310.82
348_E353_V0.6310.82
330_I334_E0.6300.82
469_G477_Y0.6290.82
312_A317_S0.6290.82
336_E339_V0.6290.82
471_I477_Y0.6260.82
255_I308_V0.6240.81
241_V260_Y0.6240.81
194_D203_P0.6230.81
175_L179_L0.6220.81
32_I105_I0.6210.81
468_P476_G0.6210.81
411_E421_K0.6210.81
399_V433_I0.6200.81
453_V458_K0.6200.81
236_G263_V0.6190.81
341_R345_Q0.6190.81
242_I255_I0.6180.81
445_D448_K0.6180.81
313_G318_A0.6120.80
419_R459_R0.6110.80
417_A425_G0.6100.80
318_A322_E0.6100.80
32_I35_T0.6090.80
115_Q141_K0.6080.80
393_P508_R0.6070.80
418_F435_Y0.6070.80
45_M49_V0.6060.80
339_V346_I0.6040.79
492_I495_I0.6030.79
468_P474_L0.6030.79
471_I474_L0.6030.79
472_K478_V0.6020.79
321_L325_L0.6010.79
339_V348_E0.6010.79
183_G192_I0.6000.79
372_L389_A0.6000.79
413_G424_Q0.6000.79
336_E349_E0.6000.79
82_I92_N0.5970.79
480_R485_V0.5970.79
240_G315_K0.5970.79
413_G422_L0.5960.78
95_R127_E0.5950.78
96_R373_E0.5920.78
421_K425_G0.5910.78
235_E263_V0.5910.78
411_E416_A0.5890.78
313_G319_P0.5890.78
482_S502_L0.5890.78
349_E358_D0.5860.77
41_E47_Q0.5860.77
16_V98_G0.5850.77
344_Q350_I0.5850.77
257_V302_L0.5840.77
467_L474_L0.5830.77
492_I499_K0.5810.77
293_Q298_S0.5800.77
200_A225_R0.5800.77
289_P292_L0.5790.76
514_L518_D0.5780.76
126_R129_K0.5770.76
411_E419_R0.5760.76
292_L296_K0.5750.76
323_E326_A0.5740.76
455_E458_K0.5710.75
476_G479_F0.5710.75
361_G385_P0.5700.75
46_T49_V0.5690.75
192_I199_V0.5680.75
409_S421_K0.5670.75
250_G364_L0.5640.75
337_S340_E0.5630.74
140_D205_S0.5620.74
438_I442_L0.5620.74
438_I441_Q0.5600.74
296_K301_D0.5590.74
87_H96_R0.5590.74
306_D311_A0.5590.74
333_V336_E0.5570.74
216_L220_A0.5550.73
342_Y345_Q0.5550.73
42_P437_E0.5530.73
331_Y387_R0.5530.73
363_I411_E0.5520.73
512_E516_I0.5520.73
340_E345_Q0.5510.73
479_F517_Q0.5510.73
349_E360_D0.5500.73
417_A508_R0.5490.73
392_G440_Y0.5470.72
412_Y424_Q0.5460.72
87_H117_Q0.5460.72
340_E357_S0.5460.72
38_V51_A0.5450.72
449_H452_D0.5450.72
122_I182_L0.5440.72
270_I315_K0.5440.72
200_A226_Y0.5440.72
490_E494_G0.5430.72
500_Y513_V0.5370.71
27_T206_A0.5360.71
8_R230_R0.5360.71
444_E448_K0.5360.71
364_L442_L0.5330.70
417_A421_K0.5330.70
331_Y335_D0.5330.70
481_R494_G0.5320.70
396_K406_A0.5320.70
343_K349_E0.5320.70
475_P478_V0.5300.70
343_K347_E0.5290.70
346_I354_R0.5290.70
341_R348_E0.5280.70
348_E358_D0.5280.70
52_S80_L0.5280.70
291_P299_K0.5280.70
470_K492_I0.5270.70
495_I501_P0.5270.70
410_K422_L0.5270.70
331_Y334_E0.5260.69
413_G419_R0.5250.69
346_I358_D0.5240.69
467_L504_K0.5240.69
467_L470_K0.5240.69
316_I325_L0.5240.69
182_L192_I0.5240.69
504_K508_R0.5240.69
472_K479_F0.5220.69
414_I433_I0.5220.69
107_V204_V0.5220.69
346_I353_V0.5180.68
516_I519_N0.5180.68
338_K342_Y0.5160.68
450_I453_V0.5140.68
41_E44_E0.5130.67
17_V133_L0.5130.67
314_V319_P0.5120.67
263_V296_K0.5110.67
212_V216_L0.5110.67
210_E214_D0.5100.67
474_L480_R0.5100.67
339_V344_Q0.5090.67
415_I424_Q0.5070.67
270_I279_I0.5070.67
269_T318_A0.5060.66
240_G258_I0.5050.66
45_M48_E0.5050.66
111_T148_N0.5050.66
271_I276_N0.5050.66
307_E310_A0.5050.66
291_P301_D0.5050.66
202_V215_L0.5040.66
342_Y349_E0.5030.66
310_A313_G0.5030.66
264_L281_T0.5030.66
480_R517_Q0.5020.66
503_I509_R0.5020.66
285_G291_P0.5000.66
102_D258_I0.5000.66
318_A323_E0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g7sA 1 0.9267 100 0.343 Contact Map
4upyB 1 0.9417 100 0.389 Contact Map
3wbiA 1 0.92 100 0.397 Contact Map
4n3nA 2 0.9333 100 0.404 Contact Map
3izyP 1 0.8067 100 0.416 Contact Map
1zo1I 1 0.8167 100 0.421 Contact Map
3j4jA 1 0.825 100 0.435 Contact Map
1darA 1 0.8033 100 0.526 Contact Map
4kiyV 1 0.8933 100 0.53 Contact Map
3j25A 1 0.915 100 0.531 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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