GREMLIN Database
UPP - Uracil phosphoribosyltransferase
UniProt: Q980Q4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (202)
Sequences: 3062 (1572)
Seq/√Len: 110.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_K55_E4.0411.00
117_M201_G3.9581.00
177_N181_S3.7831.00
171_S190_T3.4181.00
51_I63_K3.0331.00
16_T64_G2.9551.00
149_M166_I2.7731.00
33_V91_K2.7671.00
176_V193_I2.7151.00
150_L182_K2.5061.00
150_L178_K2.4861.00
59_G195_P2.4601.00
153_L179_I2.4451.00
53_E60_V2.4221.00
26_I30_K2.4031.00
53_E63_K2.2581.00
51_I65_V2.1891.00
50_E66_D2.1611.00
75_I139_A2.1451.00
154_E158_K2.1431.00
173_E177_N2.1421.00
178_K182_K2.0921.00
40_G89_L2.0611.00
104_S120_Y1.9491.00
52_V66_D1.9141.00
89_L167_V1.8871.00
24_D27_N1.8381.00
157_V183_Y1.8141.00
58_L204_L1.8081.00
18_L32_L1.7941.00
12_L65_V1.7941.00
166_I179_I1.7671.00
154_E182_K1.7441.00
33_V87_E1.7381.00
106_V120_Y1.7351.00
59_G204_L1.6991.00
198_N204_L1.6841.00
50_E68_T1.6561.00
135_N163_R1.6551.00
11_T35_L1.6541.00
55_E60_V1.6041.00
59_G62_T1.5701.00
177_N180_L1.5601.00
173_E195_P1.5491.00
42_E45_N1.5391.00
46_T165_Y1.5381.00
76_I99_G1.5371.00
176_V188_L1.5341.00
119_V147_S1.5001.00
77_N83_V1.4761.00
36_G85_L1.4621.00
156_V161_P1.4601.00
14_I34_R1.4401.00
54_V62_T1.4011.00
151_K154_E1.3951.00
15_L191_V1.3931.00
37_R91_K1.3891.00
90_L98_Q1.3791.00
5_V193_I1.3521.00
43_I167_V1.3351.00
195_P204_L1.3191.00
150_L154_E1.2840.99
32_L169_I1.2830.99
107_E115_K1.2820.99
168_S190_T1.2690.99
75_I89_L1.2620.99
155_E159_A1.2460.99
153_L164_I1.2440.99
47_L73_I1.2390.99
157_V185_F1.2360.99
165_Y187_Y1.2260.99
44_S93_F1.2220.99
196_E204_L1.2100.99
72_N134_D1.1950.99
99_G126_I1.1940.99
107_E200_K1.1720.99
136_V161_P1.1630.99
29_R90_L1.1610.99
39_L43_I1.1600.99
124_K159_A1.1570.99
154_E183_Y1.1450.99
124_K155_E1.1420.99
23_T213_R1.1410.99
18_L31_N1.1380.99
39_L167_V1.1320.98
101_I152_V1.1300.98
155_E158_K1.1090.98
179_I188_L1.1030.98
99_G127_P1.0890.98
103_A148_T1.0780.98
74_V130_R1.0730.98
118_D178_K1.0500.97
6_I11_T1.0500.97
48_D68_T1.0430.97
35_L191_V1.0410.97
162_K185_F1.0390.97
73_I134_D1.0280.97
194_D203_I1.0240.97
106_V115_K1.0090.97
174_Y196_E1.0070.97
74_V136_V1.0060.97
44_S47_L0.9960.97
76_I126_I0.9940.96
27_N30_K0.9890.96
18_L35_L0.9770.96
17_Q66_D0.9640.96
40_G88_G0.9630.96
173_E196_E0.9610.96
129_I134_D0.9530.96
121_I155_E0.9420.95
138_I156_V0.9370.95
40_G75_I0.9370.95
20_D54_V0.9280.95
11_T38_I0.9280.95
135_N165_Y0.9260.95
49_Y65_V0.9240.95
196_E199_N0.9220.95
7_D12_L0.9180.95
83_V100_V0.9060.94
75_I93_F0.8860.93
130_R161_P0.8730.93
14_I31_N0.8690.93
165_Y189_F0.8680.93
37_R92_A0.8660.93
163_R187_Y0.8590.92
151_K155_E0.8590.92
60_V63_K0.8580.92
84_P214_A0.8540.92
16_T66_D0.8530.92
52_V64_G0.8520.92
4_Y189_F0.8370.91
43_I137_I0.8220.91
40_G92_A0.8210.91
15_L170_I0.8190.90
130_R136_V0.8190.90
137_I165_Y0.8100.90
86_V100_V0.8080.90
153_L186_I0.8070.90
116_D119_V0.8030.90
174_Y177_N0.8030.90
17_Q27_N0.8020.89
180_L187_Y0.7930.89
150_L179_I0.7890.89
138_I153_L0.7760.88
33_V37_R0.7750.88
137_I167_V0.7610.87
6_I39_L0.7590.87
178_K181_S0.7530.86
7_D45_N0.7500.86
142_M203_I0.7490.86
190_T193_I0.7470.86
86_V98_Q0.7470.86
175_G197_L0.7450.86
19_R194_D0.7410.85
40_G43_I0.7410.85
138_I152_V0.7390.85
170_I192_A0.7340.85
15_L192_A0.7280.84
81_A142_M0.7270.84
16_T54_V0.7260.84
74_V126_I0.7250.84
54_V60_V0.7250.84
73_I135_N0.7250.84
23_T27_N0.7230.84
179_I186_I0.7220.84
104_S123_Y0.7220.84
74_V99_G0.7210.84
17_Q23_T0.7190.84
102_G122_Y0.7050.83
32_L35_L0.7050.83
105_R211_G0.7030.82
77_N139_A0.7030.82
105_R142_M0.7010.82
75_I86_V0.7010.82
106_V118_D0.6990.82
33_V36_G0.6950.82
135_N162_K0.6940.82
126_I159_A0.6910.81
38_I41_Y0.6910.81
180_L188_L0.6890.81
97_R134_D0.6880.81
36_G88_G0.6860.81
129_I132_K0.6840.81
194_D205_P0.6800.80
19_R205_P0.6780.80
168_S171_S0.6780.80
105_R209_D0.6750.80
17_Q31_N0.6730.80
4_Y187_Y0.6690.79
121_I159_A0.6690.79
142_M207_L0.6640.79
142_M148_T0.6610.78
83_V86_V0.6580.78
147_S178_K0.6560.78
34_R41_Y0.6550.78
44_S67_I0.6530.77
10_I38_I0.6440.76
32_L210_A0.6430.76
32_L36_G0.6410.76
73_I93_F0.6410.76
136_V156_V0.6400.76
138_I179_I0.6380.76
183_Y186_I0.6370.76
59_G196_E0.6360.76
103_A151_K0.6290.75
202_Y210_A0.6290.75
116_D152_V0.6230.74
154_E157_V0.6170.73
54_V64_G0.6150.73
105_R144_A0.6150.73
38_I92_A0.6140.73
32_L214_A0.6120.73
86_V139_A0.6110.73
20_D52_V0.6100.73
142_M202_Y0.6090.72
107_E147_S0.6090.72
87_E91_K0.6060.72
153_L157_V0.6020.72
6_I190_T0.6010.71
174_Y195_P0.5930.70
103_A155_E0.5910.70
23_T57_P0.5880.70
176_V180_L0.5880.70
119_V151_K0.5880.70
203_I209_D0.5870.70
176_V190_T0.5870.70
105_R141_P0.5870.70
25_Q29_R0.5850.69
48_D71_N0.5820.69
105_R148_T0.5810.69
203_I207_L0.5780.68
106_V116_D0.5770.68
56_T62_T0.5760.68
22_Y55_E0.5750.68
28_F81_A0.5730.68
164_I186_I0.5720.68
24_D95_K0.5720.68
116_D147_S0.5710.68
32_L85_L0.5710.68
81_A202_Y0.5710.68
31_N34_R0.5700.67
92_A95_K0.5690.67
10_I92_A0.5670.67
12_L192_A0.5670.67
81_A210_A0.5660.67
157_V186_I0.5650.67
168_S176_V0.5640.67
187_Y190_T0.5640.67
27_N165_Y0.5630.66
101_I124_K0.5620.66
18_L43_I0.5620.66
11_T191_V0.5600.66
156_V160_N0.5590.66
57_P213_R0.5570.66
30_K91_K0.5570.66
16_T20_D0.5570.66
24_D97_R0.5550.65
19_R206_G0.5550.65
128_D131_A0.5540.65
117_M200_K0.5500.65
85_L169_I0.5470.64
126_I155_E0.5450.64
183_Y188_L0.5450.64
150_L183_Y0.5430.64
149_M188_L0.5430.64
205_P208_G0.5430.64
130_R134_D0.5420.64
14_I38_I0.5410.63
46_T187_Y0.5400.63
81_A211_G0.5390.63
121_I151_K0.5390.63
81_A203_I0.5390.63
194_D206_G0.5390.63
12_L49_Y0.5390.63
86_V89_L0.5350.63
33_V214_A0.5340.62
119_V148_T0.5330.62
37_R40_G0.5330.62
138_I164_I0.5310.62
93_F96_A0.5260.61
169_I191_V0.5260.61
103_A121_I0.5250.61
40_G167_V0.5230.61
13_H34_R0.5230.61
13_H17_Q0.5200.60
4_Y7_D0.5180.60
148_T151_K0.5180.60
45_N92_A0.5180.60
33_V40_G0.5180.60
148_T168_S0.5160.60
21_K60_V0.5160.60
81_A105_R0.5140.60
67_I93_F0.5130.59
118_D151_K0.5120.59
43_I136_V0.5100.59
58_L198_N0.5100.59
78_I169_I0.5080.59
26_I85_L0.5050.58
103_A119_V0.5050.58
46_T189_F0.5050.58
143_I146_A0.5020.58
82_A122_Y0.5020.58
202_Y209_D0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xttA 3 0.963 100 0.227 Contact Map
1bd3D 3 0.9537 100 0.283 Contact Map
3dmpA 4 0.9444 100 0.284 Contact Map
2ehjA 3 0.9537 100 0.289 Contact Map
1o5oA 3 0.9537 100 0.291 Contact Map
1v9sA 3 0.9537 100 0.295 Contact Map
2e55A 3 0.9444 100 0.313 Contact Map
1i5eA 2 0.9537 100 0.367 Contact Map
3s5jB 2 0.875 99.8 0.742 Contact Map
1qb7A 2 0.912 99.7 0.772 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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