GREMLIN Database
GATB - Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
UniProt: Q980Q3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (460)
Sequences: 3085 (1702)
Seq/√Len: 79.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
421_D468_K4.2781.00
53_N56_K3.7291.00
422_E451_K3.6831.00
232_S237_I3.5551.00
396_K404_E3.5161.00
103_A114_I3.4291.00
105_D114_I3.4151.00
201_V230_R3.4021.00
118_R159_E3.3601.00
71_E280_P3.2791.00
174_K295_D3.2251.00
158_T171_F3.0171.00
463_E467_K2.8711.00
108_I111_N2.8531.00
66_N103_A2.8301.00
116_R161_D2.7761.00
292_E300_R2.7551.00
369_E399_G2.7541.00
373_Y402_I2.7081.00
417_E468_K2.6741.00
21_C40_C2.6451.00
23_C37_C2.6411.00
417_E467_K2.6101.00
280_P284_E2.5711.00
62_A99_S2.5601.00
369_E397_T2.5131.00
419_I452_T2.5111.00
328_I338_V2.4881.00
403_K408_T2.4711.00
21_C37_C2.4231.00
23_C40_C2.4061.00
186_D192_A2.3271.00
426_E451_K2.2471.00
390_E405_K2.2181.00
397_T400_Q2.2151.00
448_V461_T2.2011.00
166_K219_E2.1921.00
299_E303_K2.1661.00
165_A222_I2.1571.00
440_V444_L2.1241.00
284_E287_K2.1191.00
172_L218_V2.1001.00
422_E426_E2.0841.00
37_C40_C2.0511.00
165_A223_N2.0481.00
418_R422_E2.0411.00
68_Q101_A2.0261.00
10_V179_L2.0151.00
61_T154_L2.0151.00
201_V233_I2.0131.00
232_S239_I2.0121.00
54_A122_I1.9911.00
105_D112_D1.9871.00
297_R323_D1.9751.00
242_E255_P1.9571.00
246_W251_R1.9371.00
53_N57_Y1.9211.00
61_T184_V1.8861.00
113_K167_E1.8601.00
308_T339_A1.8431.00
400_Q404_E1.8231.00
430_A440_V1.8101.00
302_V309_P1.7921.00
8_V175_L1.7911.00
162_L168_A1.7891.00
87_K124_E1.7771.00
50_L55_V1.7601.00
327_E365_N1.7491.00
245_H256_L1.7361.00
413_E417_E1.7351.00
430_A433_K1.7341.00
30_K35_V1.7261.00
76_D95_D1.7191.00
421_D425_N1.7071.00
390_E394_T1.7031.00
19_L54_A1.6911.00
70_A100_M1.6841.00
13_T57_Y1.6831.00
433_K440_V1.6571.00
230_R234_L1.6551.00
284_E288_R1.6271.00
379_I383_I1.6251.00
8_V172_L1.6221.00
387_L401_L1.6201.00
302_V312_A1.6131.00
445_V462_V1.6131.00
319_K323_D1.6071.00
68_Q100_M1.5901.00
106_G115_I1.5881.00
334_N375_D1.5871.00
116_R159_E1.5841.00
204_G233_I1.5811.00
85_M88_N1.5761.00
10_V185_C1.5691.00
228_R244_R1.5641.00
217_D246_W1.5430.99
71_E283_I1.5370.99
55_V276_Y1.5350.99
415_Y418_R1.5310.99
429_E433_K1.5310.99
328_I371_F1.5070.99
66_N114_I1.5020.99
60_L289_E1.4940.99
129_I144_L1.4860.99
321_L347_M1.4830.99
101_A117_I1.4780.99
428_K432_E1.4690.99
417_E464_I1.4660.99
197_V218_V1.4580.99
353_N393_L1.4550.99
52_E282_L1.4500.99
285_K289_E1.4390.99
67_C99_S1.4360.99
176_R180_E1.4320.99
430_A444_L1.4290.99
391_M398_P1.4200.99
91_I270_D1.4200.99
19_L50_L1.4140.99
169_R219_E1.4130.99
369_E398_P1.4130.99
370_L391_M1.4110.99
409_N457_D1.4090.99
412_D415_Y1.4060.99
169_R173_E1.4010.99
378_L408_T1.4010.99
460_M463_E1.3980.99
327_E330_N1.3980.99
109_K166_K1.3870.99
12_I154_L1.3840.99
67_C101_A1.3760.99
89_Y270_D1.3740.99
420_I468_K1.3700.99
417_E421_D1.3670.99
423_V448_V1.3620.99
332_Y338_V1.3580.99
420_I464_I1.3530.99
441_V466_K1.3400.98
56_K282_L1.3370.98
11_H188_G1.3360.98
432_E436_R1.3320.98
413_E460_M1.3230.98
61_T65_L1.3220.98
226_I230_R1.3110.98
346_Y360_S1.3090.98
438_P466_K1.3060.98
224_Y253_T1.3030.98
416_L452_T1.2970.98
74_I95_D1.2950.98
56_K285_K1.2920.98
279_T282_L1.2630.98
61_T179_L1.2620.98
101_A159_E1.2600.98
462_V466_K1.2580.98
314_V343_I1.2540.98
399_G403_K1.2470.98
456_A461_T1.2450.97
188_G192_A1.2410.97
219_E223_N1.2360.97
36_T41_L1.2340.97
305_Y329_T1.2310.97
444_L465_I1.2300.97
200_S204_G1.2250.97
158_T162_L1.2190.97
349_W389_P1.2080.97
179_L187_C1.2000.97
341_L384_V1.2000.97
8_V158_T1.1940.97
13_T183_G1.1940.97
224_Y252_V1.1900.97
120_I154_L1.1890.97
12_I15_L1.1880.97
355_I359_Q1.1870.97
3_K163_R1.1800.97
246_W250_R1.1730.96
59_I286_F1.1720.96
240_E255_P1.1710.96
373_Y398_P1.1710.96
308_T343_I1.1690.96
72_K277_S1.1650.96
15_L54_A1.1600.96
217_D248_N1.1570.96
423_V447_M1.1560.96
62_A69_I1.1500.96
389_P393_L1.1480.96
101_A118_R1.1460.96
424_L431_V1.1410.96
363_K366_H1.1400.96
396_K400_Q1.1370.96
104_K117_I1.1370.96
337_K375_D1.1360.96
377_G411_K1.1280.95
280_P283_I1.1280.95
349_W392_I1.1280.95
353_N392_I1.1270.95
61_T182_L1.1240.95
163_R202_K1.1230.95
300_R326_E1.1210.95
205_E241_R1.1130.95
328_I364_A1.1090.95
176_R193_M1.1090.95
63_L287_K1.1050.95
441_V465_I1.1030.95
459_Q463_E1.0970.95
419_I423_V1.0960.95
297_R326_E1.0930.95
247_D254_V1.0930.95
424_L428_K1.0880.94
79_H268_F1.0810.94
440_V443_Y1.0740.94
15_L152_P1.0730.94
59_I282_L1.0730.94
310_Y314_V1.0700.94
301_F305_Y1.0690.94
99_S120_I1.0600.94
331_N365_N1.0570.94
187_C192_A1.0370.93
320_A358_T1.0350.93
423_V444_L1.0320.93
402_I408_T1.0260.93
217_D220_D1.0260.93
310_Y343_I1.0230.92
16_K53_N1.0230.92
418_R421_D1.0230.92
25_S35_V1.0190.92
292_E297_R1.0170.92
437_D440_V1.0160.92
416_L455_R1.0130.92
297_R301_F1.0100.92
8_V171_F1.0050.92
172_L195_A1.0020.92
400_Q403_K1.0020.92
372_E376_S1.0000.92
21_C38_P0.9990.92
92_S270_D0.9970.91
442_N462_V0.9930.91
174_K177_S0.9870.91
301_F322_A0.9820.91
247_D250_R0.9810.91
278_I282_L0.9810.91
434_A438_P0.9700.90
58_G98_G0.9690.90
176_R187_C0.9660.90
332_Y375_D0.9630.90
189_I193_M0.9570.90
74_I96_G0.9540.90
380_S409_N0.9520.89
447_M450_K0.9490.89
413_E463_E0.9480.89
24_P35_V0.9430.89
443_Y447_M0.9430.89
39_V46_A0.9400.89
411_K416_L0.9300.88
423_V451_K0.9260.88
88_N149_S0.9250.88
356_T359_Q0.9250.88
438_P441_V0.9230.88
373_Y399_G0.9220.88
331_N368_I0.9220.88
311_Q336_A0.9180.88
433_K437_D0.9150.88
241_R262_E0.9140.87
292_E326_E0.9090.87
432_E435_K0.9070.87
321_L342_L0.9050.87
329_T335_Y0.9020.87
382_K386_E0.9020.87
39_V49_V0.9020.87
390_E393_L0.9000.87
66_N296_Q0.8990.87
301_F326_E0.8950.86
333_K372_E0.8930.86
201_V226_I0.8920.86
416_L464_I0.8920.86
449_M454_K0.8910.86
172_L215_P0.8890.86
113_K163_R0.8850.86
56_K59_I0.8840.86
58_G154_L0.8840.86
329_T332_Y0.8830.86
92_S95_D0.8830.86
336_A340_N0.8810.85
220_D251_R0.8800.85
228_R242_E0.8800.85
329_T333_K0.8760.85
209_V212_V0.8740.85
464_I467_K0.8690.85
209_V253_T0.8680.85
350_L360_S0.8670.85
31_D34_T0.8640.84
433_K444_L0.8620.84
344_N347_M0.8620.84
4_I162_L0.8590.84
61_T67_C0.8590.84
181_H297_R0.8560.84
43_L46_A0.8550.84
345_D385_K0.8530.84
398_P402_I0.8530.84
366_H395_G0.8530.84
63_L283_I0.8530.84
115_I162_L0.8510.83
380_S383_I0.8510.83
26_D30_K0.8470.83
391_M394_T0.8470.83
75_F122_I0.8470.83
200_S206_R0.8470.83
429_E432_E0.8440.83
102_I106_G0.8420.83
201_V234_L0.8380.83
431_V435_K0.8380.83
410_I452_T0.8370.82
423_V452_T0.8340.82
420_I448_V0.8340.82
427_E447_M0.8330.82
345_D349_W0.8310.82
3_K202_K0.8300.82
298_A302_V0.8270.82
282_L286_F0.8260.82
52_E56_K0.8240.81
207_V244_R0.8230.81
4_I226_I0.8200.81
286_F289_E0.8200.81
245_H254_V0.8200.81
386_E405_K0.8190.81
228_R232_S0.8190.81
285_K288_R0.8190.81
176_R215_P0.8180.81
442_N445_V0.8120.80
349_W353_N0.8110.80
180_E320_A0.8090.80
129_I142_T0.8080.80
199_I226_I0.8080.80
401_L405_K0.8040.80
396_K401_L0.8010.80
282_L285_K0.7990.79
169_R215_P0.7970.79
74_I92_S0.7950.79
11_H245_H0.7910.79
107_Y112_D0.7840.78
448_V465_I0.7840.78
131_Y142_T0.7820.78
342_L346_Y0.7820.78
216_K220_D0.7820.78
431_V469_L0.7810.78
431_V434_A0.7800.78
106_G113_K0.7800.78
174_K298_A0.7780.78
416_L456_A0.7780.78
23_C38_P0.7760.77
324_L328_I0.7740.77
373_Y378_L0.7730.77
348_R352_E0.7730.77
180_E187_C0.7690.77
349_W388_L0.7670.77
370_L387_L0.7650.76
464_I468_K0.7650.76
383_I407_M0.7620.76
133_T140_K0.7590.76
427_E443_Y0.7580.76
369_E372_E0.7580.76
244_R255_P0.7570.76
258_T263_E0.7570.76
201_V232_S0.7560.76
391_M401_L0.7560.76
381_I385_K0.7520.75
281_E285_K0.7510.75
341_L371_F0.7500.75
366_H391_M0.7500.75
62_A120_I0.7490.75
126_P129_I0.7460.75
328_I368_I0.7450.74
448_V452_T0.7450.74
414_N417_E0.7440.74
434_A441_V0.7440.74
6_L197_V0.7420.74
328_I342_L0.7410.74
338_V371_F0.7410.74
244_R253_T0.7400.74
229_Q239_I0.7390.74
341_L374_L0.7380.74
24_P30_K0.7370.74
209_V221_A0.7360.74
197_V222_I0.7340.73
200_S205_E0.7330.73
232_S244_R0.7320.73
434_A466_K0.7290.73
65_L117_I0.7270.73
181_H319_K0.7270.73
422_E425_N0.7270.73
321_L357_V0.7250.72
207_V239_I0.7250.72
327_E331_N0.7230.72
50_L54_A0.7210.72
311_Q343_I0.7200.72
72_K96_G0.7200.72
179_L183_G0.7180.72
59_I278_I0.7180.72
434_A469_L0.7180.72
207_V232_S0.7160.72
324_L357_V0.7140.71
154_L184_V0.7140.71
95_D119_R0.7140.71
424_L441_V0.7120.71
240_E258_T0.7120.71
329_T338_V0.7120.71
195_A218_V0.7120.71
179_L182_L0.7110.71
204_G229_Q0.7110.71
399_G402_I0.7110.71
360_S392_I0.7100.71
38_P43_L0.7100.71
427_E430_A0.7090.71
387_L402_I0.7090.71
94_Y119_R0.7080.71
428_K441_V0.7080.71
448_V456_A0.7050.70
430_A443_Y0.7040.70
419_I451_K0.6980.70
390_E395_G0.6980.70
366_H397_T0.6960.69
371_F374_L0.6930.69
94_Y262_E0.6920.69
423_V443_Y0.6920.69
73_L276_Y0.6920.69
369_E400_Q0.6920.69
297_R300_R0.6900.69
333_K338_V0.6860.68
318_E321_L0.6830.68
379_I387_L0.6820.68
334_N337_K0.6810.68
246_W252_V0.6790.67
41_L146_Y0.6780.67
12_I152_P0.6770.67
11_H187_C0.6770.67
133_T139_S0.6760.67
65_L120_I0.6730.67
431_V444_L0.6730.67
332_Y372_E0.6710.67
165_A219_E0.6680.66
414_N418_R0.6680.66
345_D348_R0.6680.66
212_V217_D0.6650.66
188_G245_H0.6650.66
175_L179_L0.6640.66
67_C120_I0.6630.66
415_Y419_I0.6620.66
60_L286_F0.6620.66
337_K374_L0.6590.65
278_I283_I0.6580.65
339_A343_I0.6580.65
59_I69_I0.6550.65
220_D246_W0.6530.64
56_K60_L0.6530.64
207_V228_R0.6520.64
411_K457_D0.6510.64
301_F325_F0.6510.64
166_K170_F0.6500.64
206_R241_R0.6500.64
16_K26_D0.6480.64
424_L468_K0.6480.64
100_M118_R0.6480.64
169_R218_V0.6440.63
59_I62_A0.6430.63
312_A316_V0.6430.63
417_E463_E0.6420.63
25_S151_T0.6420.63
390_E401_L0.6410.63
366_H369_E0.6390.63
116_R160_P0.6380.63
366_H398_P0.6370.63
322_A326_E0.6370.63
10_V156_I0.6350.62
328_I367_I0.6330.62
165_A169_R0.6320.62
206_R239_I0.6310.62
379_I402_I0.6310.62
46_A149_S0.6310.62
64_A182_L0.6300.62
344_N348_R0.6290.62
370_L388_L0.6280.61
26_D35_V0.6280.61
383_I405_K0.6270.61
63_L290_M0.6250.61
5_G9_H0.6240.61
58_G122_I0.6230.61
206_R212_V0.6200.60
66_N101_A0.6200.60
3_K166_K0.6180.60
325_F329_T0.6180.60
185_C189_I0.6180.60
233_I239_I0.6170.60
174_K178_I0.6160.60
50_L273_L0.6140.60
88_N246_W0.6130.60
362_A391_M0.6130.60
374_L383_I0.6120.59
307_V339_A0.6120.59
66_N105_D0.6090.59
108_I166_K0.6080.59
21_C46_A0.6070.59
276_Y282_L0.6070.59
173_E176_R0.6070.59
181_H322_A0.6060.59
419_I448_V0.6060.59
204_G241_R0.6060.59
116_R158_T0.6050.59
57_Y60_L0.6040.58
207_V240_E0.6040.58
59_I283_I0.6030.58
279_T284_E0.6020.58
371_F381_I0.6020.58
332_Y371_F0.6010.58
11_H88_N0.6010.58
326_E330_N0.5990.58
101_A116_R0.5990.58
204_G239_I0.5990.58
374_L384_V0.5980.58
177_S317_N0.5970.58
207_V242_E0.5970.58
411_K414_N0.5960.57
169_R172_L0.5960.57
452_T456_A0.5950.57
460_M467_K0.5940.57
421_D467_K0.5940.57
365_N369_E0.5920.57
76_D94_Y0.5920.57
11_H151_T0.5890.57
22_S37_C0.5890.57
57_Y184_V0.5890.57
430_A437_D0.5880.56
434_A444_L0.5880.56
68_Q71_E0.5860.56
297_R322_A0.5850.56
374_L381_I0.5850.56
79_H267_Y0.5850.56
266_R272_D0.5840.56
378_L399_G0.5830.56
70_A73_L0.5830.56
166_K223_N0.5830.56
310_Y313_Q0.5820.56
40_C46_A0.5810.56
410_I414_N0.5810.56
415_Y455_R0.5800.55
107_Y298_A0.5780.55
214_S217_D0.5780.55
92_S154_L0.5770.55
20_F75_F0.5770.55
13_T185_C0.5750.55
57_Y182_L0.5740.55
21_C39_V0.5730.55
332_Y368_I0.5730.55
343_I347_M0.5730.55
19_L87_K0.5730.55
433_K436_R0.5730.55
305_Y325_F0.5720.54
173_E193_M0.5710.54
260_E266_R0.5690.54
76_D247_D0.5690.54
181_H316_V0.5680.54
70_A96_G0.5680.54
308_T311_Q0.5670.54
79_H270_D0.5670.54
374_L379_I0.5670.54
361_K395_G0.5660.54
107_Y110_L0.5660.54
41_L87_K0.5650.54
298_A313_Q0.5630.53
15_L154_L0.5610.53
305_Y330_N0.5610.53
39_V87_K0.5610.53
182_L293_L0.5610.53
71_E278_I0.5610.53
323_D327_E0.5610.53
417_E420_I0.5600.53
206_R258_T0.5600.53
434_A443_Y0.5590.53
94_Y267_Y0.5590.53
172_L193_M0.5590.53
352_E389_P0.5580.53
19_L124_E0.5580.53
298_A309_P0.5580.53
369_E373_Y0.5570.53
76_D245_H0.5570.53
118_R158_T0.5570.53
212_V244_R0.5570.53
447_M451_K0.5560.52
41_L152_P0.5560.52
200_S239_I0.5540.52
80_Y84_D0.5530.52
220_D248_N0.5530.52
99_S122_I0.5520.52
396_K405_K0.5510.52
297_R319_K0.5510.52
73_L278_I0.5510.52
59_I154_L0.5510.52
197_V212_V0.5500.52
98_G103_A0.5480.51
130_V133_T0.5480.51
42_G87_K0.5480.51
156_I171_F0.5480.51
384_V388_L0.5480.51
179_L184_V0.5470.51
351_N357_V0.5460.51
115_I158_T0.5450.51
260_E268_F0.5450.51
108_I170_F0.5450.51
87_K184_V0.5450.51
61_T120_I0.5440.51
12_I61_T0.5440.51
387_L391_M0.5440.51
349_W352_E0.5430.51
180_E188_G0.5430.51
325_F342_L0.5430.51
26_D29_G0.5420.51
86_S146_Y0.5400.50
97_P121_N0.5400.50
413_E468_K0.5400.50
76_D185_C0.5390.50
173_E215_P0.5390.50
55_V122_I0.5380.50
421_D424_L0.5370.50
357_V360_S0.5360.50
429_E440_V0.5360.50
377_G459_Q0.5350.50
121_N157_V0.5350.50
459_Q466_K0.5340.50
350_L357_V0.5340.50
41_L124_E0.5330.49
419_I422_E0.5330.49
60_L183_G0.5310.49
177_S298_A0.5300.49
6_L172_L0.5300.49
279_T285_K0.5300.49
71_E277_S0.5290.49
324_L360_S0.5290.49
170_F174_K0.5290.49
379_I384_V0.5290.49
311_Q314_V0.5280.49
367_I371_F0.5260.49
337_K371_F0.5260.49
302_V307_V0.5260.49
337_K381_I0.5240.48
62_A98_G0.5240.48
327_E364_A0.5230.48
281_E284_E0.5220.48
132_P139_S0.5220.48
195_A212_V0.5220.48
428_K433_K0.5210.48
324_L363_K0.5210.48
355_I360_S0.5210.48
368_I372_E0.5190.48
333_K368_I0.5190.48
318_E356_T0.5180.47
361_K392_I0.5170.47
281_E299_E0.5170.47
310_Y336_A0.5170.47
112_D299_E0.5160.47
230_R233_I0.5160.47
307_V340_N0.5160.47
106_G162_L0.5140.47
29_G186_D0.5130.47
241_R261_T0.5130.47
117_I197_V0.5120.47
362_A367_I0.5120.47
444_L447_M0.5110.47
124_E152_P0.5100.46
200_S241_R0.5100.46
162_L171_F0.5090.46
106_G170_F0.5090.46
10_V120_I0.5080.46
83_P272_D0.5080.46
207_V233_I0.5060.46
329_T334_N0.5060.46
376_S399_G0.5050.46
104_K175_L0.5050.46
57_Y61_T0.5040.46
301_F315_L0.5040.46
370_L408_T0.5030.46
104_K178_I0.5030.46
117_I158_T0.5030.46
309_P313_Q0.5030.46
17_T87_K0.5030.46
117_I161_D0.5030.46
70_A274_P0.5020.45
241_R267_Y0.5020.45
87_K149_S0.5020.45
434_A440_V0.5020.45
444_L469_L0.5010.45
225_E228_R0.5010.45
302_V308_T0.5010.45
310_Y339_A0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3al0B 1 0.9958 100 0.018 Contact Map
3ip4B 1 0.9831 100 0.019 Contact Map
3h0lB 1 0.8453 100 0.022 Contact Map
3kfuF 2 0.8093 100 0.084 Contact Map
4wj3B 2 0.8263 100 0.085 Contact Map
2d6fC 1 0.6801 100 0.152 Contact Map
1zq1C 1 0.6928 100 0.157 Contact Map
4n0hB 1 0.5763 100 0.283 Contact Map
2hz7A 1 0.2013 100 0.77 Contact Map
1ng6A 1 0.2966 99.4 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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