GREMLIN Database
Q980Q2 - Uncharacterized protein
UniProt: Q980Q2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (211)
Sequences: 601 (386)
Seq/√Len: 26.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_K215_S5.7511.00
185_K213_N5.0721.00
126_V150_S4.3821.00
126_V205_L3.0401.00
123_T187_D2.5280.99
34_T41_F2.5070.99
166_I169_S2.4070.99
112_Y220_L2.3260.98
116_L220_L2.3000.98
231_D234_I2.2500.98
35_Y41_F2.2250.98
137_T147_L2.2120.98
122_V145_K2.1350.97
192_V220_L2.0740.97
187_D214_A2.0710.97
121_D188_K2.0560.96
106_K141_S2.0370.96
191_I205_L2.0120.96
56_R66_E1.9490.95
48_L52_Y1.9050.94
34_T38_L1.8910.94
126_V209_I1.8770.94
239_N242_V1.7790.92
150_S205_L1.7600.92
237_D240_L1.7320.91
45_Q50_C1.7090.90
34_T42_F1.7030.90
155_D203_L1.6720.89
35_Y38_L1.6720.89
35_Y50_C1.6670.89
209_I216_V1.6560.89
35_Y45_Q1.6470.89
37_E41_F1.6100.87
190_L218_G1.6050.87
35_Y53_V1.5930.87
99_L201_T1.5860.87
50_C53_V1.5790.86
188_K217_V1.5770.86
112_Y116_L1.5650.86
229_W233_F1.5530.85
30_K34_T1.5490.85
209_I214_A1.5370.85
128_I152_K1.5210.84
152_K174_S1.5190.84
34_T50_C1.4870.83
38_L52_Y1.4680.82
62_R68_V1.4480.81
47_S50_C1.4420.81
96_S148_I1.4300.80
38_L41_F1.4280.80
45_Q52_Y1.4190.80
171_G175_T1.3890.78
38_L42_F1.3850.78
225_N228_T1.3820.78
35_Y47_S1.3780.78
39_S42_F1.3750.78
33_Y37_E1.3550.76
34_T39_S1.3170.74
177_Y207_N1.3140.74
76_F101_Y1.2830.72
60_S64_A1.2830.72
197_R219_A1.2780.72
47_S51_R1.2660.71
60_S63_Q1.2600.71
31_N35_Y1.2570.71
112_Y139_V1.2550.71
132_G193_D1.2400.70
79_N82_I1.2400.70
33_Y38_L1.2330.69
42_F52_Y1.2320.69
38_L45_Q1.2310.69
202_L229_W1.2230.69
116_L192_V1.2210.69
135_F222_I1.2180.68
224_T228_T1.2160.68
38_L53_V1.2090.68
76_F121_D1.2040.67
76_F107_T1.1970.67
31_N37_E1.1960.67
101_Y104_L1.1880.66
30_K35_Y1.1870.66
129_A182_Y1.1830.66
189_I214_A1.1790.66
38_L47_S1.1660.65
36_K40_K1.1660.65
171_G198_S1.1650.65
35_Y42_F1.1600.64
139_V161_Y1.1580.64
34_T47_S1.1570.64
47_S52_Y1.1530.64
32_I38_L1.1510.64
105_L222_I1.1370.63
186_K214_A1.1320.63
35_Y39_S1.1300.62
128_I153_H1.1230.62
164_E174_S1.1210.62
34_T37_E1.1160.61
30_K39_S1.1090.61
30_K38_L1.1020.60
30_K45_Q1.0990.60
123_T186_K1.0980.60
62_R191_I1.0910.60
111_L163_E1.0740.58
154_K177_Y1.0680.58
165_N178_I1.0590.57
70_R117_N1.0540.57
33_Y41_F1.0380.56
34_T45_Q1.0270.55
105_L137_T1.0250.55
156_S223_A1.0170.54
35_Y49_I1.0150.54
100_F147_L1.0130.54
182_Y200_K1.0120.54
31_N38_L1.0050.53
35_Y44_I0.9860.52
42_F55_G0.9840.52
32_I47_S0.9780.51
56_R192_V0.9770.51
227_D232_K0.9720.51
131_N151_K0.9660.50
112_Y192_V0.9640.50
92_F126_V0.9630.50
52_Y190_L0.9580.50
188_K191_I0.9530.49
124_K183_I0.9490.49
144_E175_T0.9490.49
93_I112_Y0.9490.49
203_L207_N0.9440.49
80_F101_Y0.9380.48
130_S133_I0.9330.48
45_Q48_L0.9260.47
148_I155_D0.9190.47
135_F174_S0.9180.47
96_S222_I0.9130.46
41_F44_I0.9070.46
155_D241_M0.9070.46
143_L212_A0.9060.46
155_D177_Y0.9040.46
88_Y146_P0.8890.45
157_T197_R0.8840.44
36_K41_F0.8830.44
34_T53_V0.8650.43
72_K235_N0.8640.43
101_Y135_F0.8630.43
41_F50_C0.8620.43
41_F45_Q0.8520.42
81_F202_L0.8420.41
33_Y36_K0.8360.41
42_F53_V0.8360.41
30_K52_Y0.8350.41
238_I241_M0.8340.41
128_I209_I0.8340.41
108_F189_I0.8300.40
91_D140_A0.8270.40
183_I209_I0.8260.40
95_V174_S0.8230.40
95_V177_Y0.8210.40
95_V227_D0.8200.40
57_T63_Q0.8200.40
36_K43_N0.8160.39
228_T231_D0.8130.39
72_K75_E0.8080.39
31_N34_T0.8070.39
145_K197_R0.8050.39
59_P75_E0.8040.39
113_L143_L0.8020.38
60_S86_R0.7960.38
192_V240_L0.7920.38
38_L48_L0.7880.37
33_Y50_C0.7870.37
149_I182_Y0.7860.37
35_Y52_Y0.7860.37
150_S209_I0.7830.37
156_S181_D0.7780.37
52_Y59_P0.7770.37
140_A154_K0.7720.36
38_L50_C0.7710.36
30_K50_C0.7690.36
75_E223_A0.7630.36
63_Q69_T0.7600.35
68_V190_L0.7590.35
81_F152_K0.7580.35
35_Y43_N0.7560.35
125_I145_K0.7510.35
50_C106_K0.7430.34
192_V227_D0.7420.34
68_V74_K0.7410.34
176_L212_A0.7400.34
55_G235_N0.7400.34
164_E207_N0.7390.34
55_G197_R0.7280.33
183_I189_I0.7250.33
95_V173_I0.7220.33
34_T44_I0.7080.32
117_N209_I0.7040.32
192_V213_N0.7020.32
98_L107_T0.7010.32
33_Y47_S0.6940.31
190_L209_I0.6920.31
33_Y49_I0.6900.31
142_I231_D0.6900.31
76_F125_I0.6870.31
111_L187_D0.6850.31
168_E204_S0.6840.30
123_T184_S0.6750.30
184_S187_D0.6720.30
127_G133_I0.6710.30
101_Y119_V0.6690.30
165_N200_K0.6670.29
67_I85_I0.6650.29
99_L190_L0.6600.29
193_D199_G0.6600.29
196_I225_N0.6540.29
41_F53_V0.6540.29
54_N68_V0.6520.28
104_L222_I0.6510.28
41_F47_S0.6480.28
31_N41_F0.6470.28
230_K242_V0.6450.28
63_Q67_I0.6420.28
97_N176_L0.6380.28
41_F52_Y0.6380.28
84_K214_A0.6350.27
95_V149_I0.6350.27
108_F144_E0.6300.27
81_F128_I0.6280.27
81_F177_Y0.6250.27
51_R213_N0.6230.27
30_K41_F0.6220.27
46_E176_L0.6220.27
32_I36_K0.6190.26
229_W234_I0.6160.26
92_F129_A0.6160.26
71_I187_D0.6130.26
189_I205_L0.6120.26
30_K44_I0.6090.26
124_K187_D0.6090.26
217_V226_T0.6060.26
80_F98_L0.6050.26
115_K124_K0.6030.26
95_V152_K0.6020.26
130_S158_Q0.5960.25
148_I182_Y0.5950.25
124_K148_I0.5950.25
129_A207_N0.5930.25
97_N200_K0.5920.25
80_F83_R0.5920.25
106_K185_K0.5850.25
94_D131_N0.5850.25
130_S178_I0.5850.25
119_V149_I0.5830.24
30_K42_F0.5830.24
184_S232_K0.5810.24
32_I35_Y0.5810.24
46_E50_C0.5760.24
62_R148_I0.5750.24
144_E189_I0.5730.24
192_V218_G0.5720.24
98_L219_A0.5720.24
113_L142_I0.5710.24
93_I125_I0.5670.24
87_V177_Y0.5650.23
162_I212_A0.5630.23
76_F79_N0.5630.23
145_K191_I0.5610.23
129_A225_N0.5610.23
32_I43_N0.5600.23
39_S50_C0.5590.23
71_I110_E0.5580.23
129_A139_V0.5580.23
150_S172_V0.5580.23
45_Q53_V0.5550.23
45_Q51_R0.5550.23
157_T173_I0.5540.23
38_L51_R0.5540.23
77_L108_F0.5510.23
59_P104_L0.5490.23
37_E40_K0.5480.23
86_R212_A0.5470.23
36_K53_V0.5470.23
72_K119_V0.5440.22
109_L195_V0.5440.22
196_I221_I0.5410.22
94_D158_Q0.5410.22
86_R133_I0.5400.22
113_L125_I0.5400.22
96_S105_L0.5390.22
59_P129_A0.5330.22
155_D161_Y0.5320.22
139_V192_V0.5300.22
77_L104_L0.5300.22
32_I45_Q0.5290.22
113_L212_A0.5290.22
33_Y53_V0.5280.22
106_K120_S0.5280.22
79_N184_S0.5190.21
45_Q107_T0.5190.21
70_R111_L0.5190.21
34_T43_N0.5180.21
201_T221_I0.5170.21
60_S211_K0.5160.21
131_N200_K0.5140.21
43_N54_N0.5130.21
178_I198_S0.5130.21
189_I209_I0.5120.21
94_D97_N0.5110.21
74_K103_N0.5100.21
45_Q49_I0.5090.21
213_N229_W0.5090.21
75_E210_G0.5060.20
51_R59_P0.5060.20
229_W232_K0.5060.20
177_Y220_L0.5050.20
228_T233_F0.5010.20
128_I167_R0.5000.20
129_A153_H0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o57A 2 0.9309 100 0.527 Contact Map
4m0kA 2 0.6951 100 0.598 Contact Map
4lzaA 2 0.687 100 0.6 Contact Map
1qb7A 2 0.7642 99.9 0.646 Contact Map
2dy0A 2 0.7154 99.9 0.648 Contact Map
1y0bA 2 0.7114 99.9 0.668 Contact Map
1l1qA 2 0.7073 99.9 0.67 Contact Map
1zn8A 2 0.6992 99.9 0.674 Contact Map
1g2qA 2 0.6951 99.9 0.681 Contact Map
2wnsA 2 0.6382 99.9 0.691 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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