GREMLIN Database
Q980Q0 - Uncharacterized protein
UniProt: Q980Q0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 582 (458)
Sequences: 285 (184)
Seq/√Len: 8.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_K86_E4.4980.99
175_D209_N3.9420.98
357_S410_K3.9060.98
174_V206_L3.6860.96
302_V345_I3.5390.95
51_T64_A3.3890.94
199_I237_Y3.2660.93
119_P123_N3.2600.93
252_S265_H3.1670.92
363_T506_D3.0740.91
502_V521_T2.9780.89
91_A340_E2.9660.89
200_I237_Y2.8330.86
166_T169_Q2.8150.86
501_R520_C2.7790.85
300_N303_K2.7720.85
505_C520_C2.7710.85
198_D201_E2.7650.85
289_V298_L2.6700.83
497_Y502_V2.6570.82
284_V507_I2.6030.81
90_Y339_P2.6030.81
120_C124_C2.5300.79
231_P277_R2.5230.79
257_T296_N2.5160.79
120_C127_C2.5040.78
124_C127_C2.4560.77
150_W265_H2.4320.76
171_K205_M2.4210.76
388_C520_C2.3920.75
239_R243_E2.3730.74
54_L486_L2.3660.74
121_P124_C2.3050.72
54_L497_Y2.2430.70
171_K209_N2.1870.68
501_R505_C2.1690.67
141_I188_V2.1660.67
230_D236_K2.1430.66
150_W266_W2.1390.66
189_T252_S2.1010.65
303_K352_E2.0790.64
238_A278_A2.0770.64
88_L297_D2.0640.63
261_N265_H2.0260.62
121_P130_H2.0240.62
92_D407_P2.0170.61
134_S137_V1.9850.60
388_C505_C1.9820.60
276_R310_D1.9690.59
132_Q506_D1.9470.58
119_P128_P1.9470.58
252_S325_M1.9330.58
99_F390_A1.9190.57
236_K239_R1.8920.56
188_V217_N1.8850.56
154_F189_T1.8760.55
358_W486_L1.8650.55
297_D300_N1.8480.54
124_C130_H1.8300.54
205_M209_N1.8140.53
306_A405_F1.8130.53
121_P127_C1.7730.51
188_V206_L1.7490.50
196_R199_I1.7420.50
142_T198_D1.7260.49
167_L201_E1.7210.49
305_A484_L1.7110.49
114_V128_P1.7080.48
511_V517_I1.7020.48
102_W296_N1.6980.48
339_P346_E1.6970.48
344_N347_E1.6890.48
357_S486_L1.6830.47
189_T341_V1.6820.47
76_R84_E1.6800.47
146_D289_V1.6800.47
137_V177_L1.6500.46
189_T265_H1.6470.46
92_D250_Y1.6440.46
57_A85_F1.6070.44
81_E249_V1.6040.44
157_E252_S1.6030.44
76_R86_E1.6020.44
292_T295_D1.5900.43
150_W252_S1.5880.43
179_K300_N1.5630.42
111_V177_L1.5630.42
140_V217_N1.5570.42
392_T395_Y1.5550.42
290_I320_V1.5530.42
56_P85_F1.5460.42
52_H61_L1.5460.42
249_V271_T1.5370.41
361_I487_G1.5260.41
312_V419_E1.4980.40
222_T230_D1.4970.40
141_I170_I1.4910.39
223_F274_V1.4890.39
301_I315_V1.4890.39
336_I344_N1.4870.39
129_M503_M1.4770.39
131_H503_M1.4620.38
120_C130_H1.4540.38
411_F455_P1.4530.38
170_I272_L1.4520.38
154_F265_H1.4520.38
150_W497_Y1.4420.37
109_P132_Q1.4390.37
78_I84_E1.4380.37
144_R489_M1.4370.37
127_C130_H1.4220.37
388_C501_R1.4200.36
206_L214_I1.4110.36
252_S290_I1.4060.36
306_A396_V1.3880.35
283_V312_V1.3710.35
246_V292_T1.3460.34
48_V141_I1.3450.34
341_V488_S1.3350.33
299_G349_T1.3290.33
517_I522_Y1.3280.33
140_V189_T1.3270.33
261_N268_I1.3150.32
102_W536_E1.3130.32
86_E151_Y1.3070.32
86_E277_R1.3060.32
203_I464_L1.3030.32
146_D251_M1.2910.32
252_S266_W1.2900.32
265_H325_M1.2800.31
416_G419_E1.2790.31
195_L273_E1.2790.31
52_H63_P1.2760.31
513_D517_I1.2720.31
203_I237_Y1.2720.31
198_D351_G1.2620.31
62_L77_K1.2620.31
81_E208_E1.2610.30
413_D416_G1.2570.30
99_F339_P1.2540.30
87_D331_R1.2510.30
260_T297_D1.2500.30
197_E275_F1.2490.30
142_T288_T1.2430.30
146_D219_W1.2430.30
71_G454_G1.2420.30
134_S508_H1.2400.30
51_T496_N1.2390.30
62_L85_F1.2370.30
135_A252_S1.2250.29
246_V507_I1.2130.29
523_N530_R1.2100.29
169_Q172_F1.2090.29
126_L134_S1.2000.28
169_Q296_N1.1990.28
54_L59_Y1.1940.28
385_H501_R1.1940.28
224_A280_M1.1940.28
136_L361_I1.1920.28
74_F88_L1.1910.28
136_L248_T1.1890.28
261_N272_L1.1840.28
256_T300_N1.1800.28
236_K274_V1.1760.27
111_V332_A1.1720.27
451_K515_R1.1640.27
230_D298_L1.1600.27
490_H496_N1.1500.27
199_I351_G1.1460.26
293_V345_I1.1410.26
180_Q362_G1.1360.26
150_W154_F1.1340.26
297_D362_G1.1290.26
238_A249_V1.1290.26
354_T357_S1.1250.26
261_N290_I1.1210.26
80_P214_I1.1180.26
273_E277_R1.1130.25
107_K504_R1.1130.25
213_H409_S1.1110.25
154_F252_S1.1100.25
261_N266_W1.1070.25
57_A283_V1.1040.25
131_H497_Y1.1030.25
150_W195_L1.0950.25
259_K314_S1.0940.25
213_H473_Y1.0850.25
67_F76_R1.0820.24
68_E73_L1.0800.24
140_V154_F1.0770.24
60_R515_R1.0740.24
112_P181_D1.0710.24
99_F279_G1.0690.24
49_R100_D1.0690.24
77_K325_M1.0680.24
132_Q363_T1.0650.24
166_T267_E1.0630.24
141_I457_D1.0590.24
276_R291_K1.0590.24
81_E315_V1.0550.24
91_A343_K1.0540.24
318_Q491_F1.0540.24
154_F266_W1.0530.24
338_I346_E1.0510.23
274_V510_V1.0490.23
252_S488_S1.0460.23
195_L305_A1.0430.23
277_R439_S1.0400.23
282_S386_P1.0390.23
137_V188_V1.0380.23
153_F315_V1.0360.23
216_L313_R1.0350.23
440_K443_Y1.0310.23
187_Q286_V1.0260.23
204_K221_G1.0240.23
53_S64_A1.0200.23
165_P196_R1.0200.23
224_A402_E1.0180.22
200_I528_L1.0180.22
126_L133_H1.0180.22
295_D508_H1.0110.22
81_E476_L1.0100.22
282_S327_K1.0080.22
410_K486_L1.0070.22
140_V265_H1.0050.22
197_E237_Y1.0040.22
62_L249_V1.0040.22
186_I486_L1.0040.22
164_E490_H0.9980.22
200_I240_A0.9960.22
224_A304_F0.9950.22
298_L344_N0.9910.22
297_D506_D0.9880.22
166_T443_Y0.9870.22
358_W410_K0.9850.22
298_L347_E0.9840.21
135_A140_V0.9840.21
90_Y246_V0.9830.21
207_R441_V0.9830.21
214_I243_E0.9810.21
136_L504_R0.9780.21
256_T297_D0.9750.21
195_L267_E0.9740.21
316_N487_G0.9710.21
172_F515_R0.9700.21
156_A284_V0.9690.21
241_L492_M0.9680.21
101_Y343_K0.9670.21
350_D470_H0.9660.21
53_S77_K0.9660.21
301_I313_R0.9630.21
184_L506_D0.9610.21
331_R416_G0.9600.21
275_F283_V0.9570.21
296_N300_N0.9540.21
272_L304_F0.9510.21
203_I432_A0.9480.20
221_G239_R0.9480.20
146_D517_I0.9480.20
301_I304_F0.9440.20
388_C411_F0.9430.20
146_D298_L0.9430.20
178_K182_I0.9400.20
196_R237_Y0.9390.20
151_Y486_L0.9390.20
53_S317_F0.9340.20
277_R454_G0.9330.20
154_F219_W0.9310.20
262_P266_W0.9300.20
166_T174_V0.9270.20
141_I241_L0.9270.20
167_L205_M0.9220.20
140_V252_S0.9170.20
171_K208_E0.9160.20
77_K85_F0.9150.20
261_N269_P0.9140.20
394_V405_F0.9140.20
155_Y189_T0.9100.19
289_V513_D0.9100.19
305_A311_V0.9080.19
161_Y531_D0.9070.19
153_F164_E0.9070.19
258_R275_F0.9030.19
286_V491_F0.9030.19
362_G393_Y0.9010.19
451_K500_Q0.9010.19
287_P346_E0.9000.19
314_S537_Y0.8990.19
357_S434_K0.8940.19
206_L211_V0.8930.19
524_V531_D0.8860.19
295_D423_E0.8850.19
60_R80_P0.8850.19
137_V494_L0.8830.19
155_Y217_N0.8830.19
289_V344_N0.8820.19
59_Y213_H0.8750.19
116_L119_P0.8730.18
236_K516_V0.8720.18
215_Q501_R0.8700.18
213_H250_Y0.8700.18
219_W271_T0.8690.18
54_L502_V0.8690.18
361_I513_D0.8660.18
189_T264_N0.8640.18
140_V322_L0.8600.18
141_I199_I0.8580.18
346_E351_G0.8580.18
230_D446_R0.8580.18
151_Y497_Y0.8570.18
140_V524_V0.8550.18
146_D262_P0.8540.18
289_V320_V0.8510.18
268_I312_V0.8510.18
198_D202_I0.8460.18
271_T325_M0.8450.18
247_N476_L0.8450.18
312_V403_P0.8450.18
284_V476_L0.8440.18
110_K182_I0.8410.18
223_F275_F0.8380.18
350_D357_S0.8380.18
231_P278_A0.8370.18
472_N475_A0.8360.18
201_E422_K0.8350.18
287_P301_I0.8320.17
151_Y534_L0.8320.17
437_V442_L0.8290.17
504_R507_I0.8270.17
140_V188_V0.8240.17
111_V181_D0.8240.17
250_Y390_A0.8220.17
114_V119_P0.8210.17
133_H363_T0.8210.17
362_G504_R0.8180.17
385_H504_R0.8180.17
354_T410_K0.8180.17
170_I196_R0.8170.17
293_V499_V0.8170.17
237_Y247_N0.8160.17
196_R351_G0.8150.17
298_L352_E0.8140.17
89_Y214_I0.8130.17
51_T260_T0.8130.17
150_W386_P0.8090.17
178_K211_V0.8060.17
82_H285_L0.8000.17
120_C529_Y0.7990.17
219_W265_H0.7950.17
224_A271_T0.7930.17
168_E353_I0.7920.16
56_P520_C0.7910.16
532_K536_E0.7910.16
73_L183_T0.7900.16
385_H388_C0.7890.16
132_Q135_A0.7890.16
162_V481_Y0.7880.16
325_M491_F0.7880.16
52_H73_L0.7860.16
489_M507_I0.7860.16
141_I195_L0.7850.16
155_Y267_E0.7830.16
238_A332_A0.7810.16
73_L222_T0.7790.16
259_K271_T0.7780.16
127_C529_Y0.7770.16
90_Y99_F0.7760.16
392_T414_L0.7760.16
185_V476_L0.7740.16
164_E509_Y0.7730.16
464_L521_T0.7700.16
291_K503_M0.7690.16
215_Q244_A0.7680.16
187_Q489_M0.7670.16
195_L198_D0.7640.16
252_S534_L0.7630.16
187_Q491_F0.7590.16
319_P491_F0.7550.16
279_G533_V0.7540.16
55_C58_C0.7530.16
338_I351_G0.7520.16
288_T496_N0.7510.16
135_A189_T0.7490.16
312_V459_D0.7470.15
247_N328_R0.7450.15
413_D419_E0.7440.15
217_N534_L0.7430.15
73_L461_Y0.7420.15
106_G487_G0.7410.15
265_H488_S0.7410.15
170_I205_M0.7380.15
72_K486_L0.7380.15
442_L449_I0.7380.15
137_V500_Q0.7370.15
188_V203_I0.7370.15
252_S261_N0.7360.15
199_I216_L0.7360.15
142_T489_M0.7360.15
185_V248_T0.7350.15
189_T488_S0.7350.15
108_G112_P0.7330.15
297_D304_F0.7310.15
103_E492_M0.7300.15
360_P523_N0.7290.15
74_F114_V0.7270.15
196_R480_H0.7260.15
203_I240_A0.7220.15
75_I476_L0.7210.15
333_K517_I0.7200.15
119_P132_Q0.7200.15
230_D238_A0.7190.15
336_I449_I0.7180.15
146_D265_H0.7170.15
418_L452_E0.7170.15
154_F326_M0.7130.15
68_E93_S0.7130.15
340_E414_L0.7120.15
92_D131_H0.7100.15
81_E343_K0.7090.15
358_W388_C0.7090.15
187_Q213_H0.7080.15
166_T460_V0.7080.15
271_T292_T0.7050.15
86_E106_G0.7050.15
434_K459_D0.7040.15
296_N345_I0.7040.15
135_A325_M0.7030.15
82_H320_V0.7030.15
151_Y252_S0.7020.14
136_L250_Y0.7020.14
288_T508_H0.7010.14
291_K496_N0.7000.14
118_S123_N0.6990.14
120_C518_P0.6990.14
48_V73_L0.6960.14
132_Q364_S0.6960.14
436_W439_S0.6950.14
273_E296_N0.6940.14
279_G511_V0.6930.14
249_V404_H0.6920.14
214_I346_E0.6910.14
282_S313_R0.6880.14
62_L433_N0.6880.14
189_T219_W0.6860.14
136_L362_G0.6850.14
336_I430_E0.6850.14
144_R244_A0.6840.14
140_V155_Y0.6840.14
196_R202_I0.6840.14
436_W440_K0.6820.14
361_I364_S0.6800.14
238_A274_V0.6790.14
127_C518_P0.6770.14
312_V416_G0.6760.14
147_L410_K0.6760.14
307_Y440_K0.6750.14
168_E535_R0.6750.14
176_Q221_G0.6740.14
201_E237_Y0.6740.14
173_M407_P0.6730.14
151_Y290_I0.6710.14
153_F244_A0.6680.14
158_K507_I0.6660.14
138_N323_T0.6660.14
168_E186_I0.6650.14
222_T236_K0.6630.14
174_V188_V0.6630.14
293_V300_N0.6620.14
386_P393_Y0.6610.14
169_Q176_Q0.6610.14
258_R449_I0.6600.14
172_F214_I0.6600.14
177_L510_V0.6590.14
168_E474_E0.6590.14
356_D486_L0.6570.14
297_D407_P0.6570.14
361_I504_R0.6530.13
60_R240_A0.6530.13
221_G349_T0.6520.13
256_T409_S0.6510.13
342_I362_G0.6490.13
68_E71_G0.6480.13
188_V524_V0.6460.13
246_V305_A0.6450.13
449_I453_Q0.6450.13
156_A210_G0.6440.13
151_Y265_H0.6440.13
393_Y396_V0.6430.13
301_I320_V0.6430.13
219_W252_S0.6430.13
299_G517_I0.6430.13
315_V507_I0.6430.13
475_A515_R0.6420.13
491_F519_F0.6420.13
173_M409_S0.6410.13
128_P451_K0.6400.13
447_K503_M0.6400.13
265_H497_Y0.6380.13
56_P255_G0.6380.13
179_K429_R0.6380.13
121_P518_P0.6380.13
173_M250_Y0.6350.13
209_N496_N0.6350.13
136_L173_M0.6340.13
220_G360_P0.6340.13
223_F436_W0.6320.13
433_N438_A0.6310.13
136_L184_L0.6310.13
199_I202_I0.6290.13
92_D362_G0.6290.13
220_G251_M0.6250.13
186_I296_N0.6240.13
195_L237_Y0.6230.13
98_K502_V0.6200.13
207_R315_V0.6190.13
385_H520_C0.6170.13
240_A306_A0.6170.13
444_S447_K0.6170.13
150_W261_N0.6170.13
395_Y398_W0.6150.13
97_Y298_L0.6150.13
70_E405_F0.6140.13
320_V333_K0.6140.13
179_K275_F0.6140.13
362_G506_D0.6110.13
328_R522_Y0.6110.13
279_G283_V0.6090.13
222_T268_I0.6090.13
135_A506_D0.6090.13
280_M441_V0.6070.13
174_V335_R0.6070.13
208_E344_N0.6050.13
77_K534_L0.6050.13
435_V438_A0.6030.13
140_V178_K0.6020.13
187_Q215_Q0.6020.13
195_L240_A0.6010.12
169_Q474_E0.6000.12
250_Y407_P0.5990.12
285_L313_R0.5990.12
426_E504_R0.5980.12
62_L325_M0.5960.12
121_P529_Y0.5960.12
50_V61_L0.5960.12
249_V312_V0.5960.12
168_E277_R0.5950.12
223_F528_L0.5950.12
179_K456_K0.5940.12
123_N533_V0.5930.12
187_Q507_I0.5930.12
155_Y310_D0.5930.12
240_A398_W0.5920.12
325_M534_L0.5920.12
132_Q353_I0.5910.12
169_Q413_D0.5880.12
112_P501_R0.5860.12
201_E448_F0.5850.12
251_M516_V0.5850.12
433_N499_V0.5850.12
252_S262_P0.5850.12
326_M492_M0.5830.12
434_K437_V0.5820.12
143_N164_E0.5820.12
250_Y491_F0.5790.12
169_Q495_Y0.5780.12
217_N341_V0.5780.12
199_I282_S0.5780.12
90_Y185_V0.5780.12
142_T508_H0.5770.12
138_N157_E0.5770.12
98_K258_R0.5760.12
138_N495_Y0.5760.12
243_E394_V0.5760.12
287_P321_S0.5740.12
81_E225_K0.5730.12
207_R486_L0.5720.12
184_L211_V0.5720.12
173_M345_I0.5720.12
56_P511_V0.5720.12
276_R308_N0.5720.12
48_V241_L0.5710.12
124_C529_Y0.5710.12
442_L445_I0.5690.12
277_R515_R0.5680.12
260_T534_L0.5680.12
252_S264_N0.5670.12
67_F471_H0.5660.12
451_K454_G0.5660.12
186_I301_I0.5660.12
45_E275_F0.5650.12
212_K249_V0.5650.12
201_E452_E0.5640.12
71_G412_I0.5640.12
432_A438_A0.5640.12
60_R81_E0.5630.12
164_E489_M0.5630.12
188_V534_L0.5620.12
77_K252_S0.5610.12
420_Y424_K0.5610.12
111_V179_K0.5580.12
146_D476_L0.5560.12
51_T498_D0.5560.12
62_L431_G0.5550.12
339_P349_T0.5550.12
297_D467_I0.5540.12
391_G417_L0.5540.12
324_G518_P0.5540.12
62_L268_I0.5540.12
403_P419_E0.5530.12
124_C518_P0.5530.12
121_P312_V0.5510.12
217_N323_T0.5500.12
90_Y498_D0.5500.12
66_I96_Y0.5490.12
167_L499_V0.5490.12
326_M534_L0.5490.12
88_L96_Y0.5450.11
135_A265_H0.5430.11
163_Y169_Q0.5430.11
137_V271_T0.5420.11
492_M520_C0.5420.11
137_V237_Y0.5420.11
135_A217_N0.5420.11
196_R200_I0.5400.11
217_N524_V0.5390.11
130_H529_Y0.5380.11
219_W266_W0.5380.11
271_T275_F0.5380.11
385_H393_Y0.5360.11
155_Y270_Y0.5360.11
439_S462_K0.5350.11
180_Q412_I0.5350.11
291_K405_F0.5340.11
97_Y249_V0.5320.11
257_T298_L0.5310.11
109_P302_V0.5310.11
481_Y507_I0.5310.11
195_L199_I0.5310.11
150_W290_I0.5310.11
389_G394_V0.5310.11
430_E499_V0.5300.11
62_L283_V0.5290.11
151_Y388_C0.5290.11
459_D462_K0.5290.11
275_F357_S0.5280.11
171_K175_D0.5280.11
240_A302_V0.5270.11
194_T199_I0.5260.11
243_E296_N0.5250.11
464_L502_V0.5240.11
206_L219_W0.5240.11
146_D387_S0.5240.11
146_D158_K0.5220.11
347_E454_G0.5220.11
250_Y389_G0.5220.11
298_L342_I0.5200.11
70_E300_N0.5200.11
404_H413_D0.5190.11
56_P495_Y0.5190.11
130_H286_V0.5180.11
170_I173_M0.5170.11
216_L448_F0.5170.11
46_K312_V0.5160.11
150_W289_V0.5160.11
490_H509_Y0.5160.11
243_E259_K0.5160.11
140_V150_W0.5150.11
102_W136_L0.5150.11
406_I412_I0.5140.11
166_T306_A0.5130.11
154_F264_N0.5130.11
250_Y393_Y0.5110.11
123_N494_L0.5100.11
158_K243_E0.5090.11
284_V339_P0.5090.11
456_K459_D0.5070.11
72_K303_K0.5060.11
132_Q185_V0.5040.11
67_F434_K0.5040.11
123_N266_W0.5040.11
246_V322_L0.5030.11
237_Y307_Y0.5030.11
438_A453_Q0.5020.11
207_R283_V0.5010.11
205_M441_V0.5010.11
59_Y141_I0.5000.11
58_C219_W0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tv8A 2 0.5309 100 0.871 Contact Map
4k36A 1 0.6134 100 0.885 Contact Map
3c8fA 1 0.3918 100 0.886 Contact Map
2a5hA 4 0.6392 99.9 0.892 Contact Map
2yx0A 1 0.4777 99.9 0.895 Contact Map
4m7tA 1 0.4141 99.9 0.896 Contact Map
2z2uA 1 0.4003 99.9 0.897 Contact Map
3rfaA 1 0.5601 99.9 0.908 Contact Map
4rtbA 2 0.6289 99.8 0.91 Contact Map
4njhA 2 0.3265 99.8 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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