GREMLIN Database
Q980P9 - Thiamine monophosphate kinase, putative (ThiL)
UniProt: Q980P9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (270)
Sequences: 14887 (9657)
Seq/√Len: 587.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_L293_I3.3771.00
232_N296_Q2.9401.00
232_N298_I2.9321.00
276_P279_E2.6641.00
150_D299_H2.6541.00
271_I280_M2.6341.00
152_D207_K2.5721.00
205_F276_P2.4601.00
153_L296_Q2.4131.00
60_Y108_D2.3451.00
153_L277_V2.3191.00
60_Y101_E2.2881.00
154_L270_I2.2731.00
207_K272_D2.2671.00
155_V293_I2.2401.00
101_E104_G2.2221.00
42_G79_V2.1681.00
224_V231_I2.1661.00
155_V281_L2.1331.00
229_L297_V2.1171.00
107_S111_H2.0961.00
272_D276_P2.0651.00
277_V293_I2.0471.00
281_L291_P1.9421.00
153_L273_K1.9391.00
230_G298_I1.9221.00
277_V281_L1.8761.00
155_V271_I1.8651.00
60_Y104_G1.8301.00
82_E138_E1.8191.00
220_L231_I1.8171.00
196_L200_K1.8121.00
155_V291_P1.8041.00
70_S135_V1.7941.00
220_L233_I1.7831.00
207_K270_I1.7801.00
223_I270_I1.7741.00
64_W109_A1.7601.00
273_K296_Q1.7571.00
74_I79_V1.7081.00
44_K135_V1.7061.00
38_N141_C1.6631.00
194_S197_F1.6541.00
155_V277_V1.6541.00
230_G300_E1.6491.00
43_Y85_L1.6201.00
150_D229_L1.6071.00
22_Y26_Y1.5831.00
293_I296_Q1.5821.00
203_C283_E1.5761.00
108_D111_H1.5591.00
278_K282_A1.5581.00
279_E282_A1.5501.00
154_L231_I1.5361.00
40_K141_C1.5171.00
95_D98_K1.5131.00
148_I297_V1.5101.00
108_D112_Y1.4771.00
209_S269_L1.4721.00
104_G108_D1.4711.00
39_E138_E1.4681.00
149_D272_D1.4471.00
220_L268_L1.4441.00
39_E140_L1.4361.00
152_D272_D1.4311.00
197_F200_K1.4301.00
282_A286_Y1.4301.00
22_Y27_M1.4261.00
148_I270_I1.4261.00
37_I42_G1.4191.00
284_L291_P1.4061.00
80_K197_F1.4021.00
208_Y223_I1.4001.00
186_V189_P1.3951.00
148_I208_Y1.3891.00
162_Y170_Y1.3691.00
152_D297_V1.3651.00
85_L119_G1.3611.00
149_D207_K1.3521.00
109_A112_Y1.3481.00
61_D105_G1.3311.00
231_I297_V1.3291.00
270_I297_V1.3191.00
278_K281_L1.3181.00
89_G125_S1.3001.00
281_L293_I1.2991.00
283_E287_L1.2981.00
43_Y136_E1.2951.00
86_I106_I1.2841.00
76_A209_S1.2821.00
45_V87_S1.2811.00
88_L99_A1.2651.00
281_L285_Q1.2641.00
212_I268_L1.2451.00
61_D64_W1.2421.00
83_F118_V1.2411.00
74_I135_V1.2411.00
47_G132_D1.2401.00
67_I106_I1.2371.00
144_S147_V1.2361.00
67_I84_Y1.2361.00
185_K188_H1.2351.00
56_F183_L1.2311.00
155_V280_M1.2291.00
209_S267_P1.2271.00
162_Y239_D1.2211.00
279_E283_E1.2171.00
66_A131_V1.2131.00
192_K266_L1.2041.00
143_I209_S1.1961.00
61_D188_H1.1801.00
154_L268_L1.1791.00
45_V134_F1.1781.00
195_L284_L1.1751.00
64_W112_Y1.1651.00
212_I219_S1.1611.00
230_G301_N1.1571.00
80_K200_K1.1541.00
35_V77_K1.1531.00
28_D40_K1.1461.00
43_Y134_F1.1131.00
110_I117_Y1.1111.00
182_S186_V1.1071.00
208_Y270_I1.1061.00
183_L186_V1.0951.00
195_L198_F1.0951.00
283_E286_Y1.0941.00
153_L271_I1.0851.00
23_I26_Y1.0851.00
36_F118_V1.0841.00
21_R100_E1.0801.00
185_K189_P1.0591.00
195_L199_M1.0511.00
204_K280_M1.0491.00
85_L134_F1.0401.00
47_G87_S1.0391.00
68_S109_A1.0311.00
152_D270_I1.0291.00
159_Y162_Y1.0281.00
71_T135_V1.0251.00
20_K23_I1.0201.00
90_L99_A1.0201.00
31_L34_D1.0201.00
35_V42_G1.0181.00
84_Y135_V1.0141.00
23_I27_M1.0141.00
58_S61_D1.0111.00
182_S185_K1.0041.00
164_T261_A1.0041.00
40_K139_V1.0011.00
71_T115_G0.9991.00
203_C279_E0.9941.00
83_F116_R0.9891.00
186_V190_I0.9831.00
113_Y192_K0.9791.00
157_G195_L0.9721.00
258_L263_E0.9701.00
148_I223_I0.9701.00
199_M280_M0.9691.00
216_L268_L0.9601.00
282_A285_Q0.9581.00
230_G303_L0.9551.00
59_L98_K0.9531.00
33_D77_K0.9501.00
58_S184_L0.9491.00
180_P184_L0.9481.00
271_I277_V0.9461.00
280_M283_E0.9451.00
210_T222_K0.9451.00
65_K263_E0.9421.00
67_I110_I0.9411.00
195_L200_K0.9411.00
125_S130_W0.9401.00
44_K74_I0.9391.00
63_G105_G0.9351.00
269_L280_M0.9321.00
40_K142_D0.9291.00
184_L187_K0.9201.00
210_T268_L0.9161.00
64_W108_D0.9151.00
147_V207_K0.9081.00
232_N304_I0.9051.00
204_K283_E0.8961.00
67_I71_T0.8901.00
196_L199_M0.8891.00
150_D153_L0.8881.00
179_L182_S0.8881.00
144_S148_I0.8861.00
64_W68_S0.8801.00
110_I115_G0.8781.00
83_F136_E0.8771.00
24_K27_M0.8741.00
204_K276_P0.8731.00
180_P185_K0.8631.00
150_D298_I0.8541.00
84_Y133_V0.8531.00
253_T256_D0.8491.00
175_N178_I0.8481.00
181_E184_L0.8471.00
157_G269_L0.8461.00
151_G296_Q0.8451.00
66_A133_V0.8431.00
280_M284_L0.8411.00
148_I227_F0.8401.00
22_Y25_N0.8381.00
106_I133_V0.8371.00
63_G102_L0.8311.00
160_I163_T0.8301.00
180_P188_H0.8291.00
300_E304_I0.8251.00
198_F283_E0.8241.00
274_N277_V0.8221.00
94_F98_K0.8191.00
183_L187_K0.8171.00
42_G74_I0.8161.00
259_K262_G0.8141.00
96_V100_E0.8091.00
237_P292_L0.8071.00
220_L224_V0.8051.00
80_K114_G0.8041.00
157_G284_L0.7991.00
167_F170_Y0.7911.00
205_F279_E0.7891.00
71_T109_A0.7871.00
145_D148_I0.7831.00
181_E185_K0.7801.00
168_I171_I0.7771.00
47_G89_G0.7731.00
84_Y110_I0.7701.00
97_N101_E0.7691.00
212_I266_L0.7671.00
224_V297_V0.7621.00
188_H191_V0.7621.00
63_G106_I0.7601.00
216_L220_L0.7561.00
87_S132_D0.7551.00
98_K102_L0.7541.00
194_S198_F0.7531.00
84_Y106_I0.7501.00
157_G267_P0.7411.00
198_F287_L0.7351.00
67_I109_A0.7341.00
219_S268_L0.7331.00
37_I77_K0.7331.00
193_K197_F0.7311.00
28_D38_N0.7281.00
48_F69_A0.7271.00
143_I147_V0.7261.00
154_L297_V0.7251.00
92_P124_D0.7211.00
29_I34_D0.7211.00
112_Y190_I0.7181.00
273_K277_V0.7171.00
80_K138_E0.7151.00
60_Y105_G0.7131.00
51_S128_N0.7111.00
198_F286_Y0.7111.00
189_P192_K0.7101.00
194_S200_K0.7091.00
102_L131_V0.7071.00
100_E104_G0.7051.00
159_Y290_N0.7021.00
88_L131_V0.7011.00
174_F177_Q0.7001.00
70_S133_V0.7001.00
224_V303_L0.6991.00
187_K190_I0.6981.00
163_T186_V0.6961.00
42_G139_V0.6951.00
218_V222_K0.6941.00
75_I197_F0.6911.00
212_I216_L0.6901.00
76_A267_P0.6881.00
163_T262_G0.6851.00
184_L189_P0.6801.00
85_L118_V0.6791.00
79_V139_V0.6781.00
155_V269_L0.6781.00
149_D152_D0.6741.00
224_V227_F0.6741.00
174_F178_I0.6721.00
163_T263_E0.6681.00
102_L106_I0.6661.00
71_T113_Y0.6631.00
48_F66_A0.6611.00
90_L98_K0.6611.00
185_K190_I0.6601.00
198_F203_C0.6601.00
38_N142_D0.6571.00
45_V132_D0.6541.00
184_L190_I0.6541.00
228_N300_E0.6531.00
29_I144_S0.6501.00
20_K24_K0.6461.00
143_I206_I0.6421.00
28_D31_L0.6391.00
34_D38_N0.6391.00
162_Y167_F0.6371.00
89_G130_W0.6361.00
254_E258_L0.6351.00
86_I103_I0.6331.00
257_I261_A0.6301.00
125_S128_N0.6291.00
29_I32_L0.6281.00
34_D210_T0.6271.00
158_D290_N0.6241.00
43_Y83_F0.6211.00
191_V289_F0.6191.00
166_V169_S0.6191.00
204_K279_E0.6171.00
25_N104_G0.6171.00
230_G302_R0.6161.00
167_F171_I0.6151.00
278_K293_I0.6151.00
75_I193_K0.6141.00
58_S101_E0.6131.00
89_G123_N0.6121.00
156_I160_I0.6111.00
33_D145_D0.6091.00
143_I200_K0.6081.00
205_F272_D0.6071.00
210_T223_I0.6011.00
28_D34_D0.6001.00
164_T257_I0.5991.00
182_S190_I0.5981.00
173_N252_L0.5971.00
20_K26_Y0.5961.00
298_I301_N0.5951.00
221_Y225_D0.5951.00
211_D222_K0.5941.00
153_L274_N0.5911.00
44_K70_S0.5911.00
162_Y185_K0.5901.00
73_D211_D0.5901.00
105_G109_A0.5891.00
235_E292_L0.5881.00
68_S113_Y0.5821.00
256_D260_Y0.5821.00
152_D273_K0.5791.00
57_M98_K0.5781.00
182_S189_P0.5781.00
86_I89_G0.5761.00
106_I131_V0.5651.00
258_L261_A0.5651.00
37_I40_K0.5641.00
146_K226_N0.5641.00
98_K101_E0.5641.00
52_Y102_L0.5620.99
62_I102_L0.5620.99
148_I229_L0.5570.99
218_V221_Y0.5570.99
104_G107_S0.5540.99
300_E303_L0.5540.99
164_T168_I0.5530.99
88_L102_L0.5530.99
78_G81_P0.5530.99
46_D73_D0.5520.99
230_G304_I0.5520.99
84_Y117_Y0.5500.99
156_I237_P0.5480.99
147_V154_L0.5480.99
99_A124_D0.5470.99
31_L35_V0.5450.99
106_I109_A0.5420.99
217_M255_L0.5410.99
21_R25_N0.5410.99
145_D226_N0.5410.99
207_K276_P0.5410.99
252_L256_D0.5380.99
191_V194_S0.5370.99
229_L299_H0.5370.99
97_N100_E0.5340.99
153_L156_I0.5340.99
148_I207_K0.5320.99
158_D292_L0.5310.99
234_T237_P0.5300.99
47_G130_W0.5270.99
151_G273_K0.5240.99
164_T167_F0.5200.99
110_I133_V0.5190.99
198_F284_L0.5190.99
193_K196_L0.5180.99
179_L183_L0.5180.99
45_V85_L0.5170.99
258_L262_G0.5150.99
277_V291_P0.5150.99
73_D213_S0.5140.99
96_V99_A0.5140.99
85_L136_E0.5120.99
190_I193_K0.5110.99
181_E188_H0.5110.99
61_D101_E0.5100.99
205_F283_E0.5090.99
165_N182_S0.5090.99
252_L257_I0.5080.99
196_L267_P0.5080.99
261_A264_E0.5070.99
238_I254_E0.5070.99
280_M291_P0.5060.99
278_K285_Q0.5060.99
156_I212_I0.5050.99
84_Y115_G0.5020.99
237_P240_K0.5010.99
217_M259_K0.5000.99
290_N293_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yxzA 2 0.9133 100 0.223 Contact Map
3c9uA 2 0.9226 100 0.233 Contact Map
3mcqA 2 0.8793 100 0.263 Contact Map
2z01A 2 0.87 100 0.337 Contact Map
3m84A 2 0.935 100 0.343 Contact Map
3p4eA 2 0.8731 100 0.344 Contact Map
2btuA 2 0.8885 100 0.354 Contact Map
3vtiC 2 0.8824 100 0.357 Contact Map
2zodA 2 0.8824 100 0.364 Contact Map
3fd5A 2 0.9412 100 0.381 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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