GREMLIN Database
Q980P8 - Adenylosuccinate lyase
UniProt: Q980P8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 474 (412)
Sequences: 11042 (5662)
Seq/√Len: 279.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_T69_V3.9161.00
68_D112_Y3.5461.00
52_I77_L3.4121.00
367_N370_K3.2811.00
56_K73_E3.2461.00
136_R197_E3.1341.00
408_K412_T3.1041.00
431_S434_E2.8721.00
46_R133_D2.8221.00
143_V190_L2.8061.00
280_S362_R2.7661.00
258_A311_L2.7631.00
369_E373_N2.7121.00
146_L187_S2.7001.00
148_M359_R2.6441.00
139_K194_N2.6131.00
135_I250_L2.6121.00
175_L363_V2.5321.00
280_S364_N2.5031.00
144_E355_I2.4771.00
199_R249_E2.4711.00
139_K190_L2.3891.00
42_E345_L2.3551.00
310_V338_I2.3141.00
152_L155_K2.3091.00
307_L349_E2.3091.00
255_A315_V2.3051.00
158_D365_F2.2691.00
132_R201_V2.2671.00
59_T66_E2.2641.00
60_K225_N2.2201.00
314_L343_E2.2011.00
65_K68_D2.1241.00
143_V194_N2.0641.00
370_K374_L2.0621.00
225_N228_K2.0111.00
282_G360_N2.0091.00
146_L190_L1.9951.00
367_N371_N1.9911.00
83_E86_E1.9761.00
393_M401_Y1.9701.00
78_T102_M1.9541.00
151_S359_R1.9371.00
259_S312_R1.9301.00
414_K422_E1.9161.00
369_E442_K1.9111.00
151_S155_K1.9101.00
66_E70_Q1.9021.00
190_L194_N1.8891.00
195_E199_R1.8841.00
148_M358_L1.8841.00
417_L436_E1.8771.00
60_K222_I1.8561.00
142_V257_L1.8461.00
265_A304_I1.8301.00
195_E198_K1.7971.00
56_K229_F1.7931.00
192_R249_E1.7921.00
408_K427_L1.7901.00
70_Q74_K1.7601.00
52_I73_E1.7331.00
78_T105_R1.7171.00
49_Q133_D1.7161.00
156_Y159_L1.7081.00
432_K436_E1.7071.00
440_N443_N1.6911.00
189_S260_Q1.6811.00
150_V187_S1.6811.00
224_E228_K1.6781.00
28_R105_R1.6651.00
365_F369_E1.6501.00
261_C304_I1.6481.00
146_L183_I1.6411.00
421_L432_K1.6351.00
221_E225_N1.6011.00
401_Y404_K1.5891.00
69_V73_E1.5871.00
83_E104_E1.5821.00
221_E224_E1.5701.00
414_K419_V1.5641.00
24_P27_W1.5461.00
434_E437_N1.5431.00
148_M355_I1.5271.00
317_A334_S1.5201.00
355_I359_R1.5061.00
153_A183_I1.5021.00
141_K352_D1.4961.00
222_I226_V1.4791.00
205_M222_I1.4471.00
188_R245_D1.4191.00
207_G240_Q1.4161.00
152_L156_Y1.4071.00
28_R31_S1.4061.00
45_K49_Q1.4001.00
71_K107_G1.3961.00
146_L186_F1.3931.00
201_V230_L1.3771.00
196_V253_D1.3751.00
415_T418_E1.3681.00
401_Y429_Y1.3671.00
414_K418_E1.3631.00
319_L322_I1.3521.00
354_M359_R1.3441.00
301_S357_L1.3371.00
57_A225_N1.3361.00
191_E199_R1.3361.00
95_V99_V1.3311.00
141_K351_L1.3291.00
244_R332_N1.3251.00
408_K419_V1.3211.00
227_M233_R1.3211.00
364_N367_N1.3161.00
141_K348_D1.3111.00
252_S256_I1.3091.00
277_N367_N1.3081.00
24_P31_S1.3041.00
134_A348_D1.3001.00
248_A256_I1.2911.00
421_L436_E1.2901.00
366_E370_K1.2751.00
101_L105_R1.2751.00
314_L342_H1.2751.00
179_I182_Y1.2741.00
144_E359_R1.2681.00
48_I95_V1.2621.00
225_N229_F1.2591.00
42_E134_A1.2521.00
52_I56_K1.2511.00
150_V154_I1.2511.00
131_F250_L1.2501.00
47_R122_I1.2461.00
201_V233_R1.2391.00
154_I157_K1.2341.00
148_M151_S1.2331.00
139_K197_E1.2251.00
270_E325_W1.2161.00
145_I355_I1.2161.00
175_L179_I1.2121.00
27_W31_S1.2091.00
28_R32_N1.2071.00
24_P28_R1.2051.00
56_K225_N1.2051.00
250_L344_F1.2001.00
63_L115_F1.2001.00
101_L104_E1.1971.00
142_V186_F1.1961.00
264_F354_M1.1921.00
159_L365_F1.1871.00
24_P30_G1.1861.00
60_K221_E1.1841.00
103_A110_G1.1831.00
156_Y365_F1.1801.00
56_K226_V1.1771.00
52_I80_R1.1741.00
313_S317_A1.1721.00
182_Y327_E1.1691.00
71_K74_K1.1601.00
412_T419_V1.1531.00
48_I80_R1.1511.00
55_L64_V1.1471.00
116_G215_W1.1451.00
257_L347_I1.1441.00
24_P32_N1.1441.00
34_M37_F1.1421.00
203_G227_M1.1381.00
318_S339_I1.1321.00
70_Q73_E1.1301.00
77_L81_P1.1221.00
169_H275_E1.1161.00
175_L368_I1.1111.00
102_M106_S1.1101.00
145_I186_F1.1091.00
279_I361_L1.1061.00
270_E276_I1.1031.00
25_L28_R1.0961.00
157_K176_G1.0941.00
116_G218_I1.0931.00
158_D176_G1.0871.00
149_M264_F1.0851.00
193_L257_L1.0831.00
150_V183_I1.0781.00
251_T318_S1.0721.00
82_E86_E1.0711.00
308_A312_R1.0681.00
191_E198_K1.0681.00
139_K143_V1.0621.00
268_V301_S1.0611.00
304_I354_M1.0601.00
235_H239_T1.0591.00
34_M38_F1.0541.00
143_V147_E1.0441.00
169_H274_P1.0421.00
127_Y336_E1.0401.00
73_E77_L1.0401.00
48_I79_I1.0341.00
141_K144_E1.0341.00
50_V122_I1.0331.00
172_P372_L1.0291.00
262_D305_G1.0291.00
45_K80_R1.0281.00
261_C350_I1.0281.00
144_E354_M1.0261.00
125_T203_G1.0251.00
45_K133_D1.0221.00
36_K39_S1.0201.00
208_A291_T1.0171.00
227_M232_L1.0131.00
182_Y264_F1.0121.00
161_M368_I1.0111.00
71_K75_A1.0111.00
127_Y247_F1.0101.00
392_G438_V1.0061.00
152_L179_I1.0031.00
251_T343_E1.0031.00
49_Q229_F1.0021.00
142_V190_L1.0021.00
53_A229_F1.0001.00
152_L358_L0.9991.00
253_D257_L0.9991.00
277_N364_N0.9971.00
184_Y188_R0.9971.00
145_I358_L0.9941.00
148_M354_M0.9921.00
233_R240_Q0.9891.00
45_K85_D0.9851.00
134_A137_L0.9831.00
33_E36_K0.9831.00
188_R238_S0.9781.00
49_Q226_V0.9761.00
160_A445_L0.9741.00
84_V102_M0.9731.00
77_L80_R0.9701.00
159_L368_I0.9691.00
285_G356_S0.9691.00
174_T445_L0.9691.00
46_R129_L0.9671.00
135_I197_E0.9661.00
393_M402_V0.9651.00
59_T70_Q0.9641.00
157_K174_T0.9631.00
195_E249_E0.9611.00
408_K411_Q0.9591.00
132_R197_E0.9571.00
138_V347_I0.9561.00
23_C27_W0.9561.00
407_S411_Q0.9561.00
63_L215_W0.9541.00
248_A319_L0.9531.00
66_E69_V0.9491.00
197_E201_V0.9491.00
265_A354_M0.9441.00
135_I193_L0.9431.00
41_E45_K0.9411.00
50_V125_T0.9401.00
418_E422_E0.9351.00
47_R50_V0.9331.00
191_E195_E0.9311.00
173_I209_V0.9281.00
405_L427_L0.9281.00
27_W32_N0.9241.00
405_L419_V0.9221.00
410_R413_G0.9221.00
80_R105_R0.9181.00
132_R136_R0.9181.00
92_G97_A0.9171.00
127_Y340_I0.9151.00
252_S315_V0.9141.00
268_V361_L0.9131.00
27_W30_G0.9071.00
392_G434_E0.9051.00
236_E239_T0.9031.00
408_K422_E0.9001.00
65_K112_Y0.8981.00
164_R169_H0.8911.00
166_H302_E0.8881.00
202_K231_G0.8851.00
258_A347_I0.8841.00
163_G173_I0.8771.00
251_T315_V0.8771.00
42_E133_D0.8741.00
254_L347_I0.8691.00
46_R130_V0.8671.00
71_K109_S0.8671.00
144_E351_L0.8661.00
311_L347_I0.8661.00
41_E85_D0.8661.00
57_A61_Y0.8661.00
384_L420_C0.8621.00
201_V232_L0.8611.00
149_M358_L0.8591.00
251_T339_I0.8531.00
78_T83_E0.8531.00
67_E71_K0.8521.00
167_G270_E0.8521.00
417_L432_K0.8501.00
373_N417_L0.8501.00
28_R84_V0.8491.00
409_V419_V0.8481.00
418_E432_K0.8461.00
132_R232_L0.8451.00
178_K327_E0.8431.00
243_P260_Q0.8421.00
270_E326_H0.8401.00
159_L363_V0.8391.00
227_M230_L0.8371.00
146_L150_V0.8371.00
155_K362_R0.8361.00
23_C31_S0.8351.00
75_A78_T0.8341.00
30_G35_R0.8331.00
372_L441_P0.8301.00
131_F339_I0.8291.00
316_V320_E0.8281.00
203_G223_E0.8281.00
408_K414_K0.8251.00
60_K229_F0.8251.00
67_E70_Q0.8231.00
235_H238_S0.8220.99
203_G224_E0.8200.99
149_M179_I0.8200.99
31_S282_G0.8190.99
83_E87_L0.8190.99
147_E151_S0.8170.99
153_A180_A0.8160.99
310_V342_H0.8140.99
337_R341_S0.8100.99
183_I187_S0.8090.99
108_D111_R0.8040.99
149_M183_I0.8040.99
310_V341_S0.7980.99
47_R95_V0.7950.99
100_V104_E0.7940.99
405_L420_C0.7920.99
25_L30_G0.7910.99
435_L439_L0.7900.99
59_T64_V0.7860.99
405_L416_L0.7860.99
160_A372_L0.7850.99
433_Q437_N0.7840.99
74_K106_S0.7830.99
155_K365_F0.7830.99
261_C354_M0.7830.99
158_D442_K0.7830.99
60_K66_E0.7810.99
134_A344_F0.7800.99
188_R202_K0.7800.99
52_I229_F0.7790.99
354_M358_L0.7780.99
56_K60_K0.7730.99
29_Y32_N0.7730.99
92_G100_V0.7720.99
339_I343_E0.7650.99
351_L355_I0.7640.99
131_F340_I0.7630.99
387_N390_L0.7630.99
148_M152_L0.7620.99
180_A239_T0.7620.99
25_L31_S0.7590.99
202_K246_A0.7570.99
23_C32_N0.7570.99
178_K271_L0.7560.99
55_L69_V0.7540.99
156_Y363_V0.7510.99
247_F340_I0.7470.99
201_V227_M0.7460.99
265_A353_S0.7430.99
245_D260_Q0.7430.99
249_E252_S0.7410.99
54_L117_A0.7400.99
310_V314_L0.7400.99
250_L339_I0.7360.99
417_L421_L0.7340.99
141_K355_I0.7290.99
164_R275_E0.7260.99
84_V87_L0.7250.99
27_W87_L0.7230.99
177_F236_E0.7200.99
311_L346_V0.7190.99
56_K69_V0.7190.99
357_L361_L0.7140.99
99_V113_V0.7130.99
57_A222_I0.7110.99
141_K347_I0.7110.99
71_K106_S0.7100.99
161_M178_K0.7090.99
247_F339_I0.7070.98
43_I123_V0.7070.98
102_M105_R0.7050.98
76_S99_V0.7040.98
400_Q404_K0.7020.98
192_R245_D0.7020.98
242_A327_E0.7010.98
363_V368_I0.6990.98
223_E227_M0.6980.98
49_Q80_R0.6980.98
198_K230_L0.6980.98
434_E438_V0.6970.98
23_C28_R0.6970.98
75_A106_S0.6950.98
135_I196_V0.6940.98
317_A335_S0.6920.98
80_R83_E0.6900.98
78_T84_V0.6890.98
259_S322_I0.6860.98
149_M186_F0.6860.98
304_I349_E0.6840.98
128_A246_A0.6840.98
196_V200_I0.6830.98
137_L141_K0.6820.98
143_V146_L0.6810.98
63_L116_G0.6800.98
185_E260_Q0.6770.98
68_D109_S0.6740.98
367_N374_L0.6710.98
147_E150_V0.6700.98
320_E334_S0.6690.98
137_L348_D0.6690.98
55_L72_V0.6680.98
64_V115_F0.6680.98
250_L254_L0.6680.98
156_Y175_L0.6650.98
186_F189_S0.6650.98
223_E226_V0.6650.98
265_A301_S0.6650.98
198_K201_V0.6640.98
76_S79_I0.6610.98
383_S444_Y0.6600.98
181_N263_R0.6590.98
159_L369_E0.6590.98
404_K408_K0.6590.98
202_K233_R0.6560.98
366_E369_E0.6550.98
189_S256_I0.6550.98
159_L174_T0.6530.97
61_Y221_E0.6520.97
257_L350_I0.6510.97
102_M113_V0.6510.97
179_I368_I0.6500.97
81_P84_V0.6480.97
53_A56_K0.6480.97
52_I69_V0.6480.97
142_V350_I0.6450.97
141_K354_M0.6450.97
151_S154_I0.6440.97
414_K420_C0.6440.97
255_A259_S0.6430.97
25_L32_N0.6430.97
202_K235_H0.6410.97
224_E232_L0.6390.97
143_V187_S0.6380.97
271_L326_H0.6370.97
109_S112_Y0.6370.97
338_I342_H0.6360.97
204_K240_Q0.6350.97
108_D400_Q0.6330.97
29_Y34_M0.6330.97
222_I225_N0.6330.97
82_E105_R0.6330.97
55_L73_E0.6330.97
252_S319_L0.6320.97
266_L305_G0.6320.97
310_V346_V0.6300.97
185_E242_A0.6300.97
106_S109_S0.6270.97
430_F438_V0.6260.97
404_K427_L0.6260.97
192_R195_E0.6240.97
393_M430_F0.6220.97
33_E39_S0.6220.97
191_E194_N0.6210.97
415_T419_V0.6200.97
72_V109_S0.6190.97
61_Y215_W0.6190.97
32_N287_V0.6180.96
80_R84_V0.6180.96
419_V422_E0.6170.96
185_E243_P0.6130.96
278_E371_N0.6130.96
150_V153_A0.6090.96
264_F358_L0.6080.96
68_D71_K0.6080.96
248_A252_S0.6070.96
300_T353_S0.6060.96
144_E148_M0.6050.96
316_V319_L0.6050.96
154_I158_D0.6040.96
162_V372_L0.6020.96
55_L113_V0.6000.96
35_R38_F0.5990.96
135_I139_K0.5990.96
153_A157_K0.5990.96
175_L279_I0.5960.96
164_R276_I0.5950.96
138_V254_L0.5950.96
189_S192_R0.5920.96
161_M173_I0.5920.96
174_T446_G0.5890.95
136_R194_N0.5850.95
402_V406_T0.5840.95
387_N434_E0.5840.95
136_R232_L0.5830.95
380_M444_Y0.5810.95
371_N374_L0.5810.95
437_N443_N0.5800.95
372_L379_I0.5800.95
203_G232_L0.5790.95
219_G222_I0.5770.95
338_I341_S0.5770.95
38_F134_A0.5760.95
112_Y115_F0.5750.95
145_I354_M0.5750.95
60_K219_G0.5750.95
23_C30_G0.5740.95
173_I211_T0.5730.95
59_T73_E0.5720.95
52_I76_S0.5710.95
304_I308_A0.5710.95
179_I361_L0.5690.94
380_M439_L0.5680.94
205_M226_V0.5670.94
196_V250_L0.5660.94
285_G360_N0.5640.94
78_T82_E0.5630.94
135_I200_I0.5610.94
312_R317_A0.5600.94
203_G226_V0.5600.94
437_N440_N0.5600.94
145_I351_L0.5600.94
33_E38_F0.5590.94
192_R199_R0.5580.94
307_L346_V0.5580.94
186_F354_M0.5580.94
373_N415_T0.5570.94
442_K446_G0.5570.94
187_S191_E0.5570.94
57_A221_E0.5560.94
430_F434_E0.5550.94
152_L361_L0.5540.94
191_E202_K0.5530.94
182_Y185_E0.5510.93
140_T144_E0.5500.93
82_E101_L0.5500.93
223_E236_E0.5490.93
184_Y187_S0.5480.93
205_M219_G0.5480.93
162_V379_I0.5470.93
274_P277_N0.5470.93
365_F368_I0.5450.93
265_A305_G0.5450.93
48_I85_D0.5450.93
421_L435_L0.5440.93
198_K202_K0.5440.93
64_V68_D0.5440.93
193_L253_D0.5430.93
249_E256_I0.5430.93
405_L408_K0.5430.93
268_V353_S0.5410.93
224_E227_M0.5400.93
196_V249_E0.5390.93
160_A441_P0.5390.93
300_T357_L0.5370.93
74_K78_T0.5360.93
188_R199_R0.5350.92
34_M328_R0.5340.92
304_I357_L0.5340.92
237_I325_W0.5330.92
119_S204_K0.5320.92
378_Q409_V0.5320.92
72_V102_M0.5320.92
139_K253_D0.5310.92
273_R276_I0.5310.92
186_F257_L0.5300.92
49_Q53_A0.5290.92
229_F232_L0.5290.92
107_G110_G0.5270.92
305_G331_T0.5260.92
184_Y234_P0.5260.92
382_E385_M0.5250.92
50_V126_A0.5250.92
88_E96_M0.5250.92
68_D72_V0.5240.92
178_K267_E0.5240.92
314_L341_S0.5240.92
171_L209_V0.5230.92
268_V358_L0.5220.92
262_D319_L0.5210.91
284_E411_Q0.5210.91
169_H379_I0.5210.91
272_M279_I0.5200.91
198_K233_R0.5180.91
312_R320_E0.5180.91
350_I354_M0.5180.91
166_H330_L0.5170.91
200_I232_L0.5170.91
161_M271_L0.5150.91
173_I177_F0.5140.91
79_I85_D0.5140.91
26_E30_G0.5140.91
156_Y176_G0.5130.91
186_F261_C0.5120.91
248_A321_N0.5120.91
23_C26_E0.5120.91
278_E368_I0.5110.91
443_N446_G0.5110.91
385_M406_T0.5100.91
46_R49_Q0.5090.91
188_R249_E0.5070.90
129_L226_V0.5060.90
95_V126_A0.5060.90
349_E353_S0.5050.90
204_K241_V0.5040.90
286_R299_V0.5030.90
311_L343_E0.5030.90
303_K353_S0.5020.90
409_V414_K0.5020.90
173_I237_I0.5010.90
268_V279_I0.5010.90
133_D136_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1re5A 4 0.9304 100 0.192 Contact Map
1c3cA 4 0.8924 100 0.203 Contact Map
1q5nA 4 0.8924 100 0.204 Contact Map
2pfmA 4 0.9093 100 0.204 Contact Map
3c8tA 4 0.8882 100 0.211 Contact Map
4eeiA 4 0.884 100 0.211 Contact Map
2e9fA 4 0.9177 100 0.212 Contact Map
1k7wA 4 0.9198 100 0.215 Contact Map
1tj7A 4 0.9304 100 0.216 Contact Map
1dofA 4 0.8122 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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