GREMLIN Database
PURP - 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase
UniProt: Q980P7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (332)
Sequences: 199 (130)
Seq/√Len: 7.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
331_K334_L7.7811.00
187_F251_A4.7650.99
131_V147_A3.9180.96
137_G140_G3.8790.95
21_E317_R3.7230.94
7_G27_V3.3980.91
311_E321_R3.2940.89
175_Q293_A3.2000.88
313_M321_R3.1770.87
121_F129_R3.0830.86
277_T281_D2.6830.76
113_S257_T2.6400.75
273_E293_A2.6050.74
127_V153_V2.5390.72
4_A66_G2.4730.70
84_D98_E2.4360.69
175_Q273_E2.4240.68
68_L86_I2.3950.67
142_K272_L2.3700.66
151_S155_E2.3600.66
206_E231_V2.3310.65
196_T251_A2.2450.62
119_E176_E2.2250.61
2_I26_M2.2090.61
217_F220_M2.1030.57
24_Q119_E1.9700.52
184_Y293_A1.9660.51
239_A282_I1.9050.49
141_G234_N1.9020.49
295_T301_G1.8760.48
140_G228_T1.8760.48
24_Q45_N1.8200.46
175_Q184_Y1.8190.46
67_I91_F1.8110.45
103_Q289_G1.8070.45
273_E292_V1.8040.45
175_Q292_V1.7800.44
112_K260_E1.7560.43
184_Y273_E1.7440.43
288_S292_V1.7430.43
3_I259_K1.7110.42
106_K287_F1.7090.42
72_G141_G1.7050.41
72_G234_N1.7050.41
329_K334_L1.6840.41
115_I282_I1.6790.40
39_N252_N1.6550.40
72_G184_Y1.6510.39
13_Q292_V1.6480.39
102_D184_Y1.6370.39
234_N286_E1.6330.39
141_G286_E1.6330.39
256_R259_K1.6290.39
173_I177_Y1.6260.38
201_I207_T1.6210.38
276_I280_S1.6080.38
184_Y292_V1.5670.36
130_L187_F1.5380.35
13_Q184_Y1.5360.35
47_Y50_A1.5200.35
236_P302_S1.5040.34
206_E271_C1.5020.34
214_R314_S1.4730.33
137_G228_T1.4720.33
202_D210_D1.4690.33
3_I323_I1.4600.33
301_G314_S1.4490.32
260_E335_V1.4480.32
116_K277_T1.4390.32
72_G286_E1.4320.32
141_G184_Y1.4240.31
184_Y234_N1.4240.31
143_G294_G1.4140.31
325_V328_E1.4120.31
137_G234_N1.4110.31
137_G141_G1.4110.31
143_G296_N1.4060.31
125_E169_E1.4000.31
140_G234_N1.3980.31
301_G312_P1.3940.30
143_G295_T1.3800.30
248_L276_I1.3740.30
144_Y286_E1.3740.30
106_K288_S1.3740.30
185_F247_A1.3690.30
4_A251_A1.3670.30
208_N230_V1.3660.30
294_G301_G1.3640.29
43_I319_I1.3630.29
102_D273_E1.3590.29
109_L200_G1.3460.29
230_V277_T1.3390.29
74_L86_I1.3390.29
91_F319_I1.3200.28
88_T146_L1.3150.28
67_I323_I1.3010.27
177_Y313_M1.2830.27
200_G254_F1.2790.27
296_N301_G1.2520.26
88_T149_N1.2450.26
195_R308_Y1.2360.25
238_V286_E1.2300.25
106_K292_V1.2250.25
7_G130_L1.2140.25
323_I333_S1.2120.25
102_D293_A1.2070.25
324_R328_E1.1860.24
64_D69_I1.1810.24
102_D292_V1.1720.24
144_Y205_Y1.1710.24
50_A151_S1.1710.24
72_G137_G1.1610.23
59_I90_I1.1600.23
69_I129_R1.1570.23
181_V230_V1.1500.23
193_I309_W1.1490.23
198_I210_D1.1450.23
72_G140_G1.1440.23
155_E247_A1.1440.23
128_D334_L1.1430.23
78_L333_S1.1390.23
184_Y286_E1.1380.23
234_N238_V1.1380.23
141_G238_V1.1380.23
68_L211_G1.1350.23
24_Q123_R1.1290.22
76_E220_M1.1260.22
71_H288_S1.1150.22
50_A54_E1.1070.22
33_R109_L1.0970.22
202_D294_G1.0920.21
72_G144_Y1.0880.21
30_D51_S1.0860.21
137_G286_E1.0710.21
93_N277_T1.0580.21
250_Y282_I1.0580.21
140_G286_E1.0540.21
141_G186_Q1.0530.20
186_Q234_N1.0530.20
106_K295_T1.0490.20
71_H238_V1.0460.20
14_I325_V1.0430.20
138_A227_P1.0420.20
269_P272_L1.0410.20
98_E192_I1.0370.20
86_I211_G1.0370.20
184_Y287_F1.0340.20
107_M287_F1.0330.20
115_I157_I1.0290.20
144_Y234_N1.0160.20
141_G144_Y1.0160.20
123_R126_D1.0160.20
240_R294_G1.0140.20
189_Y314_S1.0090.19
130_L216_P1.0070.19
54_E127_V1.0060.19
288_S303_P1.0030.19
206_E286_E1.0030.19
101_A144_Y0.9950.19
190_S214_R0.9930.19
102_D286_E0.9920.19
166_I216_P0.9900.19
69_I218_E0.9830.19
102_D234_N0.9820.19
102_D141_G0.9820.19
107_M289_G0.9800.19
85_K158_Q0.9800.19
102_D175_Q0.9800.19
101_A106_K0.9780.19
65_Y327_N0.9770.19
202_D296_N0.9760.19
47_Y330_D0.9700.18
23_F327_N0.9620.18
116_K281_D0.9610.18
74_L97_F0.9560.18
137_G206_E0.9560.18
72_G107_M0.9540.18
8_S73_S0.9540.18
273_E286_E0.9520.18
109_L211_G0.9500.18
15_L42_F0.9480.18
35_N39_N0.9450.18
90_I152_E0.9440.18
292_V295_T0.9410.18
121_F132_I0.9400.18
225_I333_S0.9400.18
152_E203_I0.9390.18
3_I270_F0.9370.18
171_E253_N0.9360.18
79_G115_I0.9340.18
115_I277_T0.9330.18
4_A62_I0.9320.18
41_S196_T0.9300.18
6_I28_I0.9290.18
109_L254_F0.9280.18
62_I113_S0.9250.17
232_V280_S0.9240.17
85_K335_V0.9240.17
76_E215_L0.9240.17
187_F247_A0.9150.17
143_G206_E0.9140.17
254_F287_F0.9130.17
103_Q107_M0.9120.17
240_R296_N0.9100.17
81_E142_K0.9090.17
81_E147_A0.9080.17
286_E292_V0.9070.17
190_S197_E0.9020.17
107_M286_E0.8990.17
125_E128_D0.8950.17
13_Q273_E0.8910.17
124_P127_V0.8880.17
68_L252_N0.8880.17
33_R264_P0.8870.17
43_I135_L0.8870.17
72_G238_V0.8830.17
249_E253_N0.8810.16
98_E164_K0.8800.16
56_V282_I0.8770.16
69_I124_P0.8750.16
228_T288_S0.8730.16
218_E222_E0.8720.16
106_K301_G0.8710.16
234_N292_V0.8680.16
141_G292_V0.8680.16
101_A286_E0.8670.16
75_V186_Q0.8660.16
11_A146_L0.8650.16
264_P267_I0.8640.16
29_T34_E0.8610.16
75_V243_L0.8550.16
88_T151_S0.8470.16
185_F274_S0.8450.16
16_H144_Y0.8390.16
202_D214_R0.8390.16
106_K298_Y0.8360.16
101_A234_N0.8350.16
101_A141_G0.8350.16
137_G143_G0.8340.16
206_E230_V0.8340.16
54_E57_S0.8340.16
150_K154_K0.8330.15
28_I131_V0.8330.15
71_H165_M0.8320.15
107_M234_N0.8290.15
107_M141_G0.8290.15
54_E95_K0.8280.15
130_L146_L0.8280.15
74_L166_I0.8260.15
72_G245_P0.8260.15
20_K115_I0.8250.15
210_D214_R0.8240.15
186_Q254_F0.8230.15
20_K94_K0.8190.15
60_N319_I0.8190.15
99_W261_L0.8180.15
185_F207_T0.8160.15
76_E231_V0.8110.15
177_Y206_E0.8100.15
13_Q141_G0.8080.15
13_Q234_N0.8080.15
13_Q186_Q0.8070.15
88_T164_K0.8040.15
201_I276_I0.8030.15
182_P205_Y0.7950.15
27_V113_S0.7900.15
144_Y238_V0.7880.15
29_T127_V0.7880.15
137_G184_Y0.7860.15
177_Y227_P0.7850.15
15_L144_Y0.7810.14
250_Y309_W0.7810.14
272_L284_V0.7810.14
192_I258_T0.7800.14
40_F302_S0.7800.14
324_R331_K0.7790.14
14_I311_E0.7770.14
77_Y94_K0.7770.14
72_G186_Q0.7760.14
11_A245_P0.7760.14
129_R176_E0.7750.14
50_A120_I0.7730.14
143_G301_G0.7680.14
57_S247_A0.7680.14
150_K249_E0.7680.14
87_E114_N0.7680.14
37_Y322_E0.7680.14
244_L304_Y0.7650.14
232_V279_N0.7620.14
140_G184_Y0.7620.14
140_G143_G0.7610.14
247_A282_I0.7600.14
40_F236_P0.7590.14
198_I207_T0.7570.14
140_G206_E0.7540.14
72_G102_D0.7510.14
251_A336_V0.7500.14
231_V292_V0.7470.14
165_M246_V0.7460.14
43_I130_L0.7420.14
85_K257_T0.7410.14
111_R117_I0.7340.14
147_A178_V0.7340.14
186_Q286_E0.7320.14
288_S302_S0.7310.14
59_I335_V0.7310.14
59_I88_T0.7300.14
210_D294_G0.7250.13
231_V293_A0.7240.13
86_I90_I0.7230.13
29_T60_N0.7220.13
140_G278_D0.7210.13
260_E324_R0.7170.13
106_K183_M0.7150.13
206_E295_T0.7120.13
103_Q109_L0.7100.13
143_G321_R0.7090.13
130_L257_T0.7070.13
51_S125_E0.7070.13
64_D121_F0.7060.13
63_K94_K0.7060.13
69_I222_E0.7050.13
286_E293_A0.7040.13
137_G231_V0.7030.13
140_G292_V0.7010.13
176_E302_S0.6980.13
49_Y53_D0.6950.13
7_G324_R0.6950.13
16_H20_K0.6890.13
28_I78_L0.6860.13
178_V191_D0.6840.13
137_G292_V0.6830.13
144_Y184_Y0.6820.13
13_Q102_D0.6800.13
61_G64_D0.6740.13
13_Q314_S0.6720.13
5_T15_L0.6710.12
19_K132_I0.6700.12
26_M196_T0.6700.12
71_H234_N0.6700.12
71_H141_G0.6700.12
125_E150_K0.6660.12
263_P333_S0.6660.12
203_I302_S0.6650.12
6_I329_K0.6650.12
156_G256_R0.6640.12
140_G186_Q0.6630.12
184_Y231_V0.6620.12
294_G302_S0.6600.12
143_G292_V0.6600.12
79_G240_R0.6590.12
210_D296_N0.6540.12
115_I284_V0.6540.12
88_T263_P0.6530.12
69_I221_K0.6530.12
98_E257_T0.6510.12
143_G314_S0.6510.12
81_E85_K0.6500.12
190_S322_E0.6450.12
81_E151_S0.6440.12
67_I93_N0.6440.12
36_F273_E0.6420.12
271_C294_G0.6410.12
105_K186_Q0.6390.12
185_F282_I0.6380.12
115_I254_F0.6360.12
76_E298_Y0.6320.12
61_G199_F0.6290.12
13_Q182_P0.6290.12
90_I319_I0.6280.12
107_M184_Y0.6280.12
192_I323_I0.6230.12
6_I212_L0.6220.12
159_K170_N0.6220.12
171_E324_R0.6210.12
29_T110_L0.6200.12
62_I65_Y0.6180.12
72_G292_V0.6180.12
118_P134_K0.6150.12
228_T275_I0.6130.12
200_G287_F0.6110.12
103_Q271_C0.6110.12
109_L287_F0.6110.12
205_Y238_V0.6100.11
231_V271_C0.6070.11
71_H292_V0.6070.11
243_L269_P0.6060.11
215_L332_L0.6050.11
239_A277_T0.6030.11
72_G101_A0.6030.11
80_K206_E0.6030.11
170_N249_E0.6020.11
260_E327_N0.6010.11
125_E311_E0.6000.11
292_V296_N0.6000.11
82_R85_K0.6000.11
67_I127_V0.5980.11
124_P333_S0.5940.11
105_K245_P0.5930.11
71_H106_K0.5900.11
89_K94_K0.5900.11
119_E129_R0.5900.11
5_T190_S0.5900.11
281_D328_E0.5880.11
2_I24_Q0.5870.11
182_P310_D0.5870.11
238_V285_F0.5850.11
133_V281_D0.5850.11
89_K211_G0.5850.11
136_N166_I0.5850.11
129_R223_L0.5830.11
190_S202_D0.5820.11
62_I335_V0.5810.11
198_I202_D0.5790.11
54_E172_V0.5770.11
9_H12_L0.5770.11
137_G186_Q0.5760.11
192_I331_K0.5740.11
88_T321_R0.5740.11
106_K135_L0.5710.11
54_E247_A0.5710.11
78_L119_E0.5690.11
52_L109_L0.5680.11
4_A26_M0.5670.11
175_Q286_E0.5670.11
229_F274_S0.5670.11
178_V192_I0.5660.11
240_R301_G0.5660.11
111_R303_P0.5660.11
104_K198_I0.5640.11
60_N170_N0.5630.11
72_G231_V0.5620.11
51_S61_G0.5610.11
32_K149_N0.5610.11
155_E178_V0.5610.11
7_G11_A0.5600.11
72_G105_K0.5600.11
83_V259_K0.5590.11
125_E256_R0.5570.11
70_P240_R0.5570.11
72_G293_A0.5550.11
256_R260_E0.5540.11
121_F207_T0.5540.11
21_E214_R0.5540.11
97_F183_M0.5540.11
13_Q293_A0.5530.11
76_E238_V0.5530.11
230_V281_D0.5520.11
240_R302_S0.5510.11
177_Y298_Y0.5510.11
31_N34_E0.5480.11
158_Q192_I0.5480.11
225_I253_N0.5470.11
121_F335_V0.5470.11
228_T278_D0.5470.11
202_D314_S0.5450.11
205_Y211_G0.5440.10
10_S77_Y0.5420.10
107_M254_F0.5390.10
13_Q72_G0.5380.10
208_N277_T0.5380.10
277_T280_S0.5380.10
8_S70_P0.5370.10
202_D291_I0.5360.10
109_L273_E0.5360.10
81_E267_I0.5350.10
263_P331_K0.5340.10
111_R170_N0.5330.10
143_G231_V0.5320.10
236_P294_G0.5320.10
217_F221_K0.5310.10
14_I319_I0.5300.10
234_N273_E0.5300.10
141_G273_E0.5300.10
178_V334_L0.5290.10
110_L272_L0.5280.10
327_N331_K0.5260.10
179_V284_V0.5250.10
159_K330_D0.5230.10
175_Q231_V0.5220.10
186_Q287_F0.5220.10
195_R305_S0.5210.10
19_K336_V0.5200.10
149_N200_G0.5160.10
158_Q247_A0.5160.10
80_K231_V0.5150.10
19_K44_D0.5140.10
177_Y212_L0.5120.10
251_A254_F0.5100.10
105_K140_G0.5100.10
133_V320_A0.5090.10
259_K336_V0.5080.10
15_L79_G0.5060.10
184_Y238_V0.5050.10
93_N261_L0.5030.10
64_D151_S0.5010.10
191_D194_N0.5010.10
136_N212_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r7kA 5 0.9911 100 0.669 Contact Map
2r85A 3 0.9733 100 0.688 Contact Map
2pbzA 3 0.8635 100 0.692 Contact Map
3ln6A 2 0.8813 99.9 0.851 Contact Map
2i87A 2 0.8843 99.9 0.854 Contact Map
3e5nA 2 0.8605 99.9 0.854 Contact Map
1ehiA 2 0.911 99.9 0.856 Contact Map
3k3pA 2 0.8279 99.9 0.857 Contact Map
3i12A 2 0.9021 99.9 0.861 Contact Map
3tqtA 2 0.8694 99.9 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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