GREMLIN Database
Q980P6 - Uncharacterized protein
UniProt: Q980P6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (334)
Sequences: 198 (132)
Seq/√Len: 7.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
343_L346_K7.6311.00
198_Y262_G4.7900.99
138_V156_A3.9530.96
23_E329_R3.9480.96
6_A72_A3.8830.96
144_E147_R3.8310.95
9_A29_G3.4980.92
129_F136_R3.4290.91
323_K333_L3.3620.91
186_E304_G3.1830.88
325_I333_L3.1790.88
134_I162_F2.7740.79
284_Q304_G2.6170.75
73_I348_L2.5940.74
288_T292_D2.5520.73
121_A268_A2.5490.73
160_E164_A2.5080.72
151_R283_L2.4370.69
90_E104_R2.4290.69
74_I92_M2.4280.69
186_E284_Q2.4150.69
217_Q242_E2.3850.68
127_K187_E2.2200.62
4_K28_I2.2090.61
207_L262_G2.1710.60
50_I53_E2.1480.59
26_Q127_K2.0800.56
195_N304_G1.9600.52
228_A231_Q1.9350.51
250_I293_L1.9070.50
147_R239_K1.9050.50
5_I270_Q1.9020.50
150_E245_H1.8770.49
120_E271_K1.8590.48
313_G326_S1.8330.47
284_Q303_G1.8170.46
186_E195_N1.7980.45
299_A303_G1.7870.45
186_E303_G1.7610.44
271_K347_I1.7590.44
73_I97_F1.7420.43
124_S288_T1.7280.43
195_N284_Q1.7240.43
241_I288_T1.7240.43
184_V188_F1.7030.42
78_R150_E1.6970.42
78_R245_H1.6970.42
341_N346_K1.6950.42
15_D303_G1.6770.41
26_Q48_K1.6500.40
78_R195_N1.6460.40
123_I293_L1.6450.40
306_T313_G1.6410.40
108_R195_N1.6350.39
245_H297_D1.6290.39
150_E297_D1.6290.39
267_D270_Q1.6170.39
41_E263_Y1.6070.38
217_Q282_T1.5780.37
225_R326_S1.5760.37
94_T155_F1.5520.36
195_N303_G1.5440.36
15_D195_N1.5070.35
144_E239_K1.4880.34
213_D221_D1.4850.34
247_P314_S1.4840.34
219_D241_I1.4620.33
9_A137_P1.4560.33
152_G305_G1.4480.33
78_R297_D1.4440.32
152_G307_N1.4370.32
212_V218_S1.4200.32
150_E195_N1.4050.31
195_N245_H1.4050.31
144_E150_E1.4020.31
144_E245_H1.4020.31
147_R150_E1.4000.31
147_R245_H1.4000.31
337_H340_I1.3980.31
153_F297_D1.3790.30
108_R284_Q1.3760.30
287_V291_L1.3740.30
5_I335_I1.3680.30
196_L258_V1.3480.29
152_G306_T1.3440.29
137_P198_Y1.3350.29
259_F287_V1.3320.29
109_I300_P1.3150.28
74_I222_S1.3130.28
188_F325_I1.3080.28
97_F331_I1.3020.28
80_L92_M1.2900.27
94_T158_N1.2840.27
6_A262_G1.2800.27
73_I335_I1.2770.27
117_I211_S1.2710.27
53_E160_E1.2660.27
249_T297_D1.2340.26
108_R304_G1.2260.25
84_V345_E1.2220.25
46_M142_L1.2160.25
77_N299_A1.2000.25
57_E258_V1.1950.25
153_F216_I1.1890.24
67_L72_A1.1850.24
313_G324_P1.1850.24
108_R303_G1.1750.24
309_Y313_G1.1730.24
137_P227_P1.1720.24
78_R144_E1.1640.24
299_A315_Q1.1600.24
78_R147_R1.1580.24
209_L221_D1.1480.23
192_A241_I1.1480.23
335_I345_E1.1460.23
195_N297_D1.1420.23
245_H249_T1.1400.23
150_E249_T1.1400.23
46_M331_I1.1380.23
59_I293_L1.1310.23
92_M222_S1.1300.23
117_I222_S1.1160.22
213_D305_G1.1130.22
211_S265_F1.1080.22
67_L121_A1.1050.22
104_R203_I1.1030.22
17_F45_I1.1000.22
280_P283_L1.0960.22
78_R153_F1.0930.22
261_I293_L1.0910.22
144_E297_D1.0880.22
75_V229_D1.0840.22
64_Q96_V1.0820.21
147_R297_D1.0810.21
87_D156_A1.0730.21
137_P155_F1.0730.21
145_A238_P1.0720.21
77_N249_T1.0720.21
336_K340_I1.0710.21
243_V291_L1.0640.21
123_I166_L1.0590.21
164_A258_V1.0570.21
204_F321_F1.0570.21
15_D313_G1.0550.21
182_N264_R1.0520.21
124_S292_D1.0430.20
115_Y298_V1.0430.20
115_Y300_P1.0390.20
150_E197_N1.0380.20
197_N245_H1.0380.20
251_R305_G1.0380.20
161_D214_R1.0380.20
305_G313_G1.0380.20
195_N298_V1.0330.20
85_G123_I1.0260.20
32_K54_D1.0240.20
153_F245_H1.0220.20
150_E153_F1.0220.20
8_L30_L1.0220.20
87_D151_R1.0220.20
108_R297_D1.0190.20
107_E153_F1.0110.20
53_E57_E1.0070.20
217_Q297_D1.0060.20
108_R245_H1.0040.19
108_R150_E1.0040.19
129_F139_I1.0030.19
37_R41_E1.0030.19
16_V337_H1.0000.19
57_E101_Y0.9970.19
213_D307_N0.9950.19
201_S225_R0.9900.19
108_R186_E0.9900.19
130_K133_E0.9880.19
175_I227_P0.9870.19
260_E264_R0.9860.19
35_R117_I0.9850.19
5_I281_F0.9820.19
219_D288_T0.9780.19
200_Y326_S0.9740.19
75_V136_R0.9740.19
284_Q297_D0.9730.19
144_E217_Q0.9710.19
307_N313_G0.9710.19
57_E134_I0.9590.18
303_G306_T0.9520.18
10_S79_S0.9470.18
82_V226_L0.9440.18
4_K70_E0.9420.18
115_Y297_D0.9420.18
109_I115_Y0.9420.18
96_V161_D0.9390.18
78_R115_Y0.9360.18
251_R307_N0.9300.18
69_S75_V0.9270.18
31_C36_E0.9220.18
297_D303_G0.9210.18
15_D284_Q0.9120.17
99_N288_T0.9100.17
135_D346_K0.9080.17
243_V290_D0.9060.17
21_K139_I0.9050.17
94_T173_N0.9000.17
78_R249_T0.8990.17
107_E297_D0.8900.17
77_N174_V0.8850.17
65_S181_K0.8850.17
82_V242_E0.8830.17
170_L181_K0.8820.17
188_F238_P0.8810.17
217_Q241_I0.8730.16
112_K240_L0.8720.16
35_R275_P0.8670.16
46_M112_K0.8660.16
159_K260_E0.8650.16
83_Y100_R0.8640.16
132_E345_E0.8630.16
132_E159_K0.8620.16
74_I263_Y0.8600.16
152_G217_Q0.8590.16
150_E303_G0.8570.16
245_H303_G0.8570.16
265_F298_V0.8570.16
213_D225_R0.8550.16
212_V287_V0.8540.16
81_A197_N0.8510.16
42_F247_P0.8490.16
18_D153_F0.8480.16
107_E245_H0.8470.16
107_E150_E0.8470.16
255_L316_Y0.8370.16
275_P278_I0.8360.16
196_L285_V0.8360.16
81_A254_L0.8340.16
31_C65_S0.8330.16
54_D132_E0.8320.16
221_D225_R0.8310.16
80_L103_L0.8300.16
193_H216_I0.8300.16
78_R256_E0.8270.16
15_D197_N0.8220.15
15_D150_E0.8200.15
15_D245_H0.8200.15
159_K163_E0.8190.15
22_D100_R0.8180.15
144_E152_G0.8170.15
283_L295_V0.8170.15
201_S208_E0.8160.15
229_D233_K0.8160.15
25_F339_I0.8110.15
198_Y258_V0.8100.15
29_G121_A0.8100.15
153_F249_T0.8080.15
115_Y245_H0.8060.15
115_Y150_E0.8060.15
123_I288_T0.8060.15
197_N265_F0.8030.15
209_L218_S0.8010.15
31_C134_I0.7990.15
188_F217_Q0.7970.15
271_K339_I0.7960.15
69_S160_E0.7940.15
299_A314_S0.7890.15
78_R108_R0.7880.15
144_E195_N0.7830.15
78_R197_N0.7800.15
250_I288_T0.7800.15
147_R217_Q0.7780.15
39_Y334_E0.7740.14
17_F153_F0.7730.14
71_N162_F0.7730.14
94_T160_E0.7690.14
147_R195_N0.7690.14
131_P134_I0.7670.14
203_I343_L0.7660.14
239_K299_A0.7650.14
92_M96_V0.7610.14
30_L138_V0.7580.14
147_R152_G0.7550.14
217_Q306_T0.7490.14
13_A155_F0.7490.14
16_V323_K0.7490.14
187_E314_S0.7470.14
221_D305_G0.7470.14
197_N297_D0.7440.14
297_D304_G0.7430.14
53_E128_L0.7420.14
15_D326_S0.7340.14
242_E304_G0.7320.14
3_V176_D0.7270.14
64_Q94_T0.7250.14
112_K298_V0.7240.14
144_E242_E0.7230.14
242_E303_G0.7230.14
66_I210_I0.7220.13
87_D278_I0.7220.13
18_D22_D0.7210.13
117_I265_F0.7210.13
13_A256_E0.7210.13
22_D123_I0.7190.13
15_D108_R0.7180.13
339_I343_L0.7180.13
164_A189_V0.7150.13
206_R320_Y0.7140.13
174_V257_K0.7140.13
105_W272_L0.7140.13
123_I295_V0.7120.13
196_L218_S0.7120.13
86_Y217_Q0.7110.13
336_K343_L0.7110.13
80_L175_I0.7110.13
42_F314_S0.7070.13
112_K269_T0.7050.13
28_I207_L0.7040.13
147_R303_G0.7020.13
9_A336_K0.6990.13
48_K70_E0.6980.13
28_I70_E0.6970.13
129_F347_I0.6970.13
89_I270_Q0.6950.13
153_F195_N0.6930.13
94_T274_P0.6910.13
282_T305_G0.6890.13
261_I321_F0.6880.13
147_R197_N0.6840.13
136_R234_L0.6830.13
7_A17_F0.6790.13
195_N242_E0.6780.13
258_V293_L0.6780.13
221_D307_N0.6760.13
168_E342_N0.6730.13
274_P345_E0.6730.13
144_E303_G0.6720.13
242_E282_T0.6710.13
77_N150_E0.6700.13
77_N245_H0.6700.13
87_D160_E0.6670.13
305_G314_S0.6640.12
131_P135_D0.6610.12
34_G158_N0.6600.12
119_N315_Q0.6590.12
119_N125_I0.6560.12
152_G303_G0.6550.12
201_S334_E0.6550.12
65_S69_S0.6530.12
38_P284_Q0.6520.12
127_K130_K0.6510.12
73_I99_N0.6510.12
254_L280_P0.6500.12
15_D193_H0.6460.12
65_S331_I0.6450.12
132_E135_D0.6450.12
96_V331_I0.6450.12
189_V202_P0.6440.12
193_H322_G0.6410.12
109_I297_D0.6410.12
214_R314_S0.6400.12
3_V71_N0.6390.12
66_I293_L0.6380.12
86_Y242_E0.6380.12
147_R289_P0.6370.12
152_G313_G0.6360.12
170_L177_N0.6310.12
264_R342_N0.6290.12
77_N303_G0.6290.12
203_I335_I0.6270.12
216_I249_T0.6270.12
78_R107_E0.6270.12
303_G307_N0.6230.12
42_F97_F0.6230.12
277_I347_I0.6220.12
251_R314_S0.6210.12
247_P309_Y0.6200.12
109_I261_I0.6200.12
78_R303_G0.6180.12
271_K336_K0.6180.12
64_Q347_I0.6180.12
239_K289_P0.6180.12
126_P141_K0.6150.12
50_I71_N0.6140.12
203_I269_T0.6130.12
165_K267_D0.6130.12
132_E232_I0.6120.12
50_I342_N0.6120.12
82_V249_T0.6100.12
241_I292_D0.6090.12
167_N347_I0.6060.12
288_T291_L0.6060.12
239_K286_M0.6060.12
262_G348_L0.6060.12
62_K198_Y0.6050.11
115_Y195_N0.6010.11
201_S213_D0.6010.11
7_A201_S0.6000.11
186_E297_D0.5980.11
8_L341_N0.5970.11
104_R268_A0.5960.11
156_A189_V0.5940.11
209_L213_D0.5920.11
11_H14_L0.5910.11
78_R304_G0.5900.11
4_K69_S0.5900.11
118_L283_L0.5890.11
123_I265_F0.5880.11
30_L84_V0.5870.11
144_E197_N0.5840.11
62_K336_K0.5840.11
15_D304_G0.5840.11
226_L344_T0.5830.11
133_E185_I0.5830.11
249_T296_Y0.5820.11
78_R242_E0.5800.11
12_S83_Y0.5800.11
213_D326_S0.5790.11
139_I345_E0.5770.11
95_K222_S0.5770.11
274_P343_L0.5760.11
143_P223_L0.5760.11
93_K170_L0.5720.11
33_K36_E0.5690.11
181_K260_E0.5660.11
66_I70_E0.5660.11
28_I198_Y0.5650.11
15_D78_R0.5640.11
99_N214_R0.5640.11
206_R261_I0.5640.11
9_A13_A0.5630.11
152_G333_L0.5630.11
76_P251_R0.5620.11
247_P305_G0.5620.11
108_R121_A0.5610.11
182_N336_K0.5610.11
167_N258_V0.5590.11
93_K260_E0.5570.11
115_Y265_F0.5560.11
212_V288_T0.5540.11
62_K122_K0.5530.11
135_D343_L0.5530.11
33_K53_E0.5520.11
213_D302_I0.5510.11
59_I137_P0.5500.11
152_G326_S0.5490.11
82_V217_Q0.5490.11
51_I160_E0.5480.11
196_L293_L0.5470.11
42_F320_Y0.5470.11
85_G196_L0.5460.11
158_N211_S0.5460.11
15_D299_A0.5460.11
137_P235_G0.5450.11
150_E284_Q0.5450.11
245_H284_Q0.5450.11
103_L194_F0.5450.11
140_V292_D0.5380.10
10_S76_P0.5380.10
152_G242_E0.5370.10
267_D271_K0.5370.10
70_E348_L0.5360.10
240_L285_V0.5350.10
197_N298_V0.5350.10
21_K47_D0.5330.10
262_G265_F0.5330.10
162_F211_S0.5330.10
190_F295_V0.5330.10
186_E242_E0.5320.10
305_G310_M0.5310.10
278_I347_I0.5300.10
72_A262_G0.5290.10
21_K27_T0.5280.10
292_D340_I0.5280.10
282_T307_N0.5270.10
147_R242_E0.5270.10
251_R291_L0.5260.10
95_K100_R0.5260.10
261_I348_L0.5250.10
195_N249_T0.5230.10
188_F207_L0.5230.10
132_E323_K0.5210.10
93_K122_K0.5190.10
73_I134_I0.5190.10
159_K337_H0.5170.10
286_M304_G0.5170.10
31_C118_L0.5160.10
122_K233_K0.5160.10
216_I222_S0.5150.10
133_E340_I0.5150.10
197_N217_Q0.5150.10
85_G251_R0.5140.10
104_R151_R0.5130.10
225_R305_G0.5130.10
15_D297_D0.5120.10
6_A28_I0.5110.10
133_E278_I0.5100.10
13_A231_Q0.5090.10
165_K290_D0.5080.10
16_V331_I0.5070.10
140_V317_S0.5060.10
177_N190_F0.5020.10
89_I142_L0.5020.10
211_S298_V0.5010.10
137_P188_F0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r7kA 5 0.9742 100 0.683 Contact Map
2pbzA 3 0.8338 100 0.703 Contact Map
2r85A 3 0.9427 100 0.706 Contact Map
3ln6A 2 0.8625 99.9 0.861 Contact Map
3e5nA 2 0.8453 99.9 0.865 Contact Map
2i87A 2 0.8625 99.9 0.866 Contact Map
3i12A 2 0.8854 99.9 0.868 Contact Map
3k3pA 2 0.808 99.9 0.869 Contact Map
1ehiA 2 0.8854 99.8 0.872 Contact Map
3tqtA 2 0.8481 99.8 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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