GREMLIN Database
Q980P5 - Adenylosuccinate synthetase
UniProt: Q980P5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (315)
Sequences: 2774 (1326)
Seq/√Len: 74.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_R248_V7.2621.00
295_K314_P5.5761.00
51_K247_T4.6951.00
297_P312_K3.9981.00
258_F263_A3.7851.00
211_H274_I3.6931.00
153_D161_Y3.5381.00
241_G252_L3.4551.00
28_P166_H3.3301.00
84_R88_T3.3291.00
75_S105_E3.2651.00
109_E123_G3.2621.00
153_D162_L3.2281.00
238_K242_L3.1831.00
68_L72_A2.7921.00
74_T98_V2.7321.00
31_S202_A2.7011.00
154_V162_L2.6801.00
154_V161_Y2.6751.00
177_Y262_L2.6031.00
296_L300_A2.5431.00
100_I141_A2.5201.00
118_V225_K2.5041.00
242_L245_Y2.4601.00
296_L312_K2.2461.00
8_G272_A2.2071.00
153_D159_L2.1761.00
296_L309_E2.1521.00
37_I101_I2.0711.00
79_L92_L2.0701.00
155_P159_L2.0311.00
296_L313_T2.0291.00
45_Y60_I2.0121.00
170_I204_I2.0071.00
37_I75_S1.9641.00
65_E93_Y1.9591.00
260_V290_V1.9571.00
151_I155_P1.9561.00
7_G13_E1.9421.00
74_T79_L1.9361.00
99_G138_L1.8861.00
84_R87_E1.8751.00
37_I78_A1.8731.00
267_I272_A1.8491.00
216_F263_A1.8271.00
237_A255_V1.8151.00
306_E309_E1.7921.00
131_S135_L1.7671.00
4_L198_V1.7461.00
154_V157_K1.7161.00
70_P182_H1.7131.00
68_L74_T1.7041.00
234_E237_A1.7021.00
207_K271_S1.6441.00
232_L237_A1.6421.00
176_H270_N1.6391.00
241_G245_Y1.6371.00
79_L83_M1.6221.00
291_R315_I1.5980.99
147_L151_I1.5920.99
207_K273_T1.5920.99
291_R294_E1.5630.99
153_D157_K1.5420.99
98_V141_A1.5330.99
74_T141_A1.5270.99
153_D160_D1.5160.99
157_K161_Y1.4970.99
295_K298_A1.4950.99
77_D81_K1.4920.99
30_L64_T1.4900.99
315_I318_I1.4780.99
296_L299_E1.4650.99
154_V159_L1.4650.99
150_F154_V1.4470.99
97_H305_D1.4450.99
62_K91_R1.4340.99
205_G271_S1.3900.99
159_L162_L1.3770.98
106_I109_E1.3530.98
33_R193_T1.3330.98
85_E88_T1.3140.98
233_T236_D1.3030.98
260_V263_A1.2920.98
155_P161_Y1.2910.98
238_K241_G1.2880.98
192_N200_S1.2870.98
261_K293_Y1.2800.97
146_E308_E1.2670.97
294_E304_L1.2630.97
239_K242_L1.2530.97
231_E254_R1.2300.97
288_Y294_E1.2300.97
96_S305_D1.2270.97
55_I86_T1.2130.96
24_I61_N1.2120.96
238_K252_L1.2100.96
133_R181_Y1.1980.96
74_T94_I1.1930.96
152_I161_Y1.1900.96
101_I129_A1.1850.96
279_K282_T1.1770.96
177_Y265_E1.1750.96
199_L206_P1.1660.96
211_H273_T1.1550.95
154_V160_D1.1380.95
94_I141_A1.1260.95
153_D156_N1.1210.94
113_P123_G1.1160.94
235_E238_K1.1100.94
153_D163_D1.1090.94
4_L209_V1.1090.94
196_S200_S1.1040.94
311_L315_I1.1020.94
307_L311_L1.0990.94
170_I202_A1.0940.94
220_V262_L1.0840.93
178_L222_R1.0770.93
303_W310_E1.0770.93
139_K150_F1.0760.93
152_I162_L1.0730.93
174_Q178_L1.0700.93
194_T197_G1.0670.93
309_E312_K1.0670.93
176_H266_A1.0630.93
155_P162_L1.0630.93
314_P318_I1.0600.93
76_L80_F1.0560.92
142_K305_D1.0530.92
214_I272_A1.0450.92
104_D132_K1.0450.92
106_I110_K1.0450.92
308_E311_L1.0440.92
314_P317_L1.0410.92
5_I27_R1.0390.92
42_T49_I1.0370.92
221_T279_K1.0370.92
154_V158_I1.0340.92
265_E268_R1.0220.91
3_E27_R1.0170.91
266_A270_N1.0140.91
300_A309_E1.0110.91
294_E298_A1.0100.91
81_K85_E1.0050.91
300_A313_T0.9910.90
134_I180_L0.9880.90
157_K162_L0.9860.90
44_T49_I0.9820.89
159_L163_D0.9760.89
29_K65_E0.9710.89
133_R140_L0.9670.89
80_F84_R0.9610.88
216_F277_I0.9610.88
244_E253_R0.9530.88
213_I274_I0.9520.88
96_S142_K0.9420.87
195_A199_L0.9370.87
29_K67_A0.9350.87
312_K315_I0.9330.87
152_I159_L0.9330.87
232_L255_V0.9320.87
75_S78_A0.9280.87
240_L278_T0.9270.87
28_P167_N0.9220.86
288_Y291_R0.9160.86
152_I157_K0.9130.86
29_K166_H0.9080.85
245_Y252_L0.9000.85
90_D93_Y0.8940.85
53_R85_E0.8900.84
285_K288_Y0.8880.84
216_F275_V0.8870.84
121_S127_G0.8830.84
32_V173_T0.8820.84
153_D158_I0.8810.84
99_G129_A0.8790.84
110_K123_G0.8740.83
293_Y301_R0.8720.83
152_I156_N0.8710.83
70_P201_E0.8700.83
176_H269_I0.8690.83
59_F66_L0.8640.82
75_S103_E0.8630.82
148_E151_I0.8560.82
240_L279_K0.8560.82
168_I204_I0.8550.82
294_E297_P0.8550.82
52_L59_F0.8520.82
131_S137_K0.8510.82
235_E239_K0.8470.81
307_L315_I0.8460.81
197_G201_E0.8430.81
260_V318_I0.8430.81
232_L236_D0.8420.81
236_D239_K0.8390.81
177_Y303_W0.8390.81
297_P300_A0.8390.81
8_G216_F0.8380.81
33_R197_G0.8340.80
154_V163_D0.8340.80
127_G136_R0.8310.80
106_I123_G0.8300.80
78_A101_I0.8280.80
138_L185_Y0.8270.80
70_P192_N0.8250.79
239_K285_K0.8210.79
31_S69_G0.8200.79
34_T175_G0.8190.79
215_T278_T0.8170.79
291_R304_L0.8150.79
194_T200_S0.8140.79
118_V123_G0.8060.78
311_L314_P0.8060.78
55_I59_F0.8040.78
173_T178_L0.8020.78
6_I195_A0.8000.77
246_G253_R0.8000.77
170_I198_V0.7960.77
105_E109_E0.7950.77
156_N159_L0.7940.77
221_T255_V0.7930.77
146_E306_E0.7930.77
307_L310_E0.7900.76
174_Q222_R0.7890.76
308_E312_K0.7870.76
181_Y192_N0.7740.75
54_I72_A0.7730.75
67_A93_Y0.7710.75
27_R167_N0.7710.75
49_I247_T0.7700.75
288_Y304_L0.7690.75
184_E222_R0.7680.74
29_K168_I0.7660.74
306_E315_I0.7650.74
295_K299_E0.7650.74
66_L247_T0.7630.74
219_Y282_T0.7630.74
37_I284_F0.7620.74
310_E313_T0.7610.74
45_Y48_R0.7580.73
73_L130_E0.7530.73
80_F83_M0.7520.73
196_S205_G0.7510.73
307_L312_K0.7500.73
261_K303_W0.7480.72
121_S188_V0.7440.72
289_R294_E0.7420.72
230_G256_A0.7400.72
3_E213_I0.7400.72
18_V21_Y0.7330.71
294_E300_A0.7320.71
289_R317_L0.7310.71
158_I162_L0.7300.71
6_I198_V0.7280.70
99_G140_L0.7270.70
49_I243_T0.7260.70
115_L137_K0.7250.70
53_R78_A0.7250.70
249_T253_R0.7240.70
236_D240_L0.7230.70
126_V130_E0.7220.70
18_V276_A0.7140.69
55_I175_G0.7110.69
256_A259_N0.7100.69
204_I208_Y0.7090.68
155_P160_D0.7080.68
306_E311_L0.7080.68
221_T278_T0.7070.68
111_N131_S0.7060.68
70_P95_D0.7040.68
68_L79_L0.7000.67
142_K145_K0.7000.67
35_G126_V0.6990.67
147_L150_F0.6970.67
258_F290_V0.6950.67
81_K88_T0.6920.67
160_D163_D0.6890.66
236_D287_A0.6870.66
181_Y219_Y0.6810.65
279_K283_L0.6810.65
67_A142_K0.6800.65
81_K84_R0.6790.65
158_I161_Y0.6790.65
37_I105_E0.6780.65
298_A304_L0.6770.65
194_T266_A0.6760.65
212_I272_A0.6740.64
173_T222_R0.6730.64
306_E314_P0.6730.64
244_E249_T0.6720.64
293_Y298_A0.6720.64
223_V249_T0.6720.64
117_N187_Y0.6670.64
89_Y93_Y0.6640.63
8_G263_A0.6630.63
43_V50_W0.6610.63
37_I241_G0.6600.63
51_K66_L0.6600.63
10_F184_E0.6590.63
33_R170_I0.6570.63
206_P212_I0.6560.62
311_L318_I0.6550.62
61_N64_T0.6520.62
70_P181_Y0.6520.62
152_I163_D0.6500.62
244_E251_R0.6470.61
152_I155_P0.6460.61
293_Y304_L0.6460.61
104_D128_Y0.6460.61
110_K113_P0.6450.61
8_G214_I0.6430.61
309_E313_T0.6430.61
265_E302_K0.6420.61
122_T125_G0.6400.60
134_I137_K0.6390.60
88_T167_N0.6390.60
50_W247_T0.6380.60
11_G15_K0.6380.60
306_E310_E0.6370.60
96_S145_K0.6370.60
34_T52_L0.6370.60
24_I27_R0.6370.60
214_I275_V0.6350.60
113_P118_V0.6340.60
311_L317_L0.6320.60
195_A205_G0.6280.59
178_L184_E0.6280.59
43_V52_L0.6240.59
34_T172_G0.6230.58
69_G201_E0.6200.58
34_T193_T0.6160.58
277_I284_F0.6160.58
265_E269_I0.6150.57
4_L195_A0.6150.57
199_L202_A0.6140.57
292_E318_I0.6140.57
19_A216_F0.6120.57
77_D105_E0.6100.57
293_Y316_G0.6100.57
97_H142_K0.6070.56
287_A294_E0.6030.56
72_A141_A0.6020.56
31_S170_I0.6020.56
14_G267_I0.6020.56
76_L174_Q0.6020.56
301_R304_L0.6010.56
115_L225_K0.6010.56
11_G14_G0.5980.55
179_S201_E0.5980.55
118_V208_Y0.5980.55
47_G50_W0.5960.55
184_E220_V0.5950.55
80_F94_I0.5950.55
10_F262_L0.5920.55
139_K143_D0.5920.55
38_N56_P0.5920.55
60_I86_T0.5910.54
290_V318_I0.5910.54
10_F228_L0.5890.54
26_D167_N0.5890.54
195_A206_P0.5890.54
131_S134_I0.5890.54
74_T227_P0.5880.54
77_D103_E0.5850.54
290_V294_E0.5840.54
255_V279_K0.5830.54
140_L143_D0.5820.53
93_Y152_I0.5820.53
23_G27_R0.5810.53
207_K269_I0.5810.53
150_F157_K0.5780.53
300_A304_L0.5760.53
199_L209_V0.5730.52
23_G61_N0.5730.52
306_E316_G0.5730.52
112_D191_R0.5720.52
288_Y292_E0.5700.52
78_A81_K0.5690.52
223_V251_R0.5680.52
54_I73_L0.5680.52
149_K153_D0.5680.52
7_G11_G0.5680.52
18_V173_T0.5660.51
155_P163_D0.5640.51
142_K307_L0.5640.51
230_G257_P0.5630.51
292_E295_K0.5620.51
173_T191_R0.5620.51
83_M89_Y0.5610.51
59_F92_L0.5610.51
148_E152_I0.5600.51
308_E316_G0.5590.51
115_L156_N0.5580.50
121_S125_G0.5570.50
96_S309_E0.5540.50
128_Y191_R0.5530.50
276_A280_L0.5520.50
208_Y271_S0.5510.49
262_L303_W0.5510.49
280_L284_F0.5490.49
128_Y132_K0.5470.49
34_T192_N0.5470.49
197_G200_S0.5460.49
310_E315_I0.5440.49
59_F79_L0.5430.48
205_G210_D0.5430.48
121_S136_R0.5430.48
311_L316_G0.5420.48
229_E313_T0.5420.48
66_L193_T0.5420.48
115_L119_I0.5420.48
5_I96_S0.5410.48
65_E166_H0.5410.48
226_G231_E0.5400.48
34_T57_S0.5400.48
154_V167_N0.5400.48
140_L181_Y0.5390.48
205_G212_I0.5380.48
187_Y190_S0.5380.48
293_Y296_L0.5360.48
37_I54_I0.5360.48
263_A266_A0.5350.47
158_I202_A0.5330.47
30_L280_L0.5310.47
174_Q184_E0.5310.47
24_I45_Y0.5300.47
155_P158_I0.5300.47
37_I129_A0.5300.47
120_G125_G0.5290.47
235_E286_D0.5280.47
164_N308_E0.5270.46
299_E314_P0.5270.46
23_G123_G0.5260.46
188_V222_R0.5240.46
242_L252_L0.5240.46
119_I136_R0.5220.46
295_K316_G0.5220.46
308_E315_I0.5220.46
151_I211_H0.5200.46
145_K150_F0.5200.46
239_K290_V0.5200.46
300_A303_W0.5190.45
19_A30_L0.5180.45
103_E174_Q0.5170.45
5_I115_L0.5160.45
187_Y225_K0.5150.45
3_E211_H0.5140.45
8_G262_L0.5120.45
5_I22_L0.5120.45
53_R124_Q0.5110.45
119_I127_G0.5110.45
264_R289_R0.5110.45
141_A145_K0.5100.44
288_Y300_A0.5100.44
187_Y227_P0.5100.44
30_L58_A0.5090.44
127_G222_R0.5080.44
53_R247_T0.5080.44
65_E91_R0.5070.44
50_W121_S0.5060.44
56_P71_G0.5050.44
259_N281_D0.5050.44
76_L100_I0.5050.44
5_I139_K0.5040.44
143_D153_D0.5030.44
26_D84_R0.5030.44
309_E316_G0.5030.44
313_T316_G0.5020.43
104_D172_G0.5020.43
117_N152_I0.5020.43
126_V228_L0.5010.43
232_L257_P0.5000.43
68_L92_L0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hidA 2 0.9731 100 0.019 Contact Map
3ue9A 2 0.9672 100 0.022 Contact Map
4m9dA 2 0.997 100 0.024 Contact Map
3r7tA 4 0.9582 100 0.025 Contact Map
2v40A 2 0.9612 100 0.026 Contact Map
1dj2A 2 0.9821 100 0.027 Contact Map
1p9bA 2 0.9851 100 0.029 Contact Map
2d7uA 2 0.9373 100 0.058 Contact Map
4cgkA 3 0.2597 11.3 0.979 Contact Map
1axnA 1 0.4537 7.6 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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