Q980P5 - SULSO - GREMLIN Contacts

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Q980P5 - Adenylosuccinate synthetase

UniProt:	Q980P5	Sequences: MLELIIGGFFGDEGKGKVAAYLGIKDRPKLSVRTGSINAGHTVTYSGRIWKLRIIPSAFINKSTELALGPGALTSLDALFKEMRETETYDRLYIDSHVGIITEDEIRDEKNDPYLMNVIGSTGQGVGYAESKRILRKLKLAKDYKELEKFIIDVPNKILDYLDNGHNILIEGTQGHYLSLYHGEYPYVTSRNTTASGVLSEAGIGPKYVDHIIITFKSYVTRVGKGPLEGELTEEDAKKLGLTEYGTVTGRLRRVAPFNVKLAREAIRINSATIVAITKLDTLFKDAYRVREYEKLPAEARKWLDELEEELKTPIGLIGTGEDAYDMIDLREEVG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	335 (315)
Sequences:	2774 (1326)
Seq/√Len:	74.7

ECOLI - PURA
BACSU - PURA
HALSA - PURA
SULSO - Q980P5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_R	248_V	7.262	1.00
295_K	314_P	5.576	1.00
51_K	247_T	4.695	1.00
297_P	312_K	3.998	1.00
258_F	263_A	3.785	1.00
211_H	274_I	3.693	1.00
153_D	161_Y	3.538	1.00
241_G	252_L	3.455	1.00
28_P	166_H	3.330	1.00
84_R	88_T	3.329	1.00
75_S	105_E	3.265	1.00
109_E	123_G	3.262	1.00
153_D	162_L	3.228	1.00
238_K	242_L	3.183	1.00
68_L	72_A	2.792	1.00
74_T	98_V	2.732	1.00
31_S	202_A	2.701	1.00
154_V	162_L	2.680	1.00
154_V	161_Y	2.675	1.00
177_Y	262_L	2.603	1.00
296_L	300_A	2.543	1.00
100_I	141_A	2.520	1.00
118_V	225_K	2.504	1.00
242_L	245_Y	2.460	1.00
296_L	312_K	2.246	1.00
8_G	272_A	2.207	1.00
153_D	159_L	2.176	1.00
296_L	309_E	2.152	1.00
37_I	101_I	2.071	1.00
79_L	92_L	2.070	1.00
155_P	159_L	2.031	1.00
296_L	313_T	2.029	1.00
45_Y	60_I	2.012	1.00
170_I	204_I	2.007	1.00
37_I	75_S	1.964	1.00
65_E	93_Y	1.959	1.00
260_V	290_V	1.957	1.00
151_I	155_P	1.956	1.00
7_G	13_E	1.942	1.00
74_T	79_L	1.936	1.00
99_G	138_L	1.886	1.00
84_R	87_E	1.875	1.00
37_I	78_A	1.873	1.00
267_I	272_A	1.849	1.00
216_F	263_A	1.827	1.00
237_A	255_V	1.815	1.00
306_E	309_E	1.792	1.00
131_S	135_L	1.767	1.00
4_L	198_V	1.746	1.00
154_V	157_K	1.716	1.00
70_P	182_H	1.713	1.00
68_L	74_T	1.704	1.00
234_E	237_A	1.702	1.00
207_K	271_S	1.644	1.00
232_L	237_A	1.642	1.00
176_H	270_N	1.639	1.00
241_G	245_Y	1.637	1.00
79_L	83_M	1.622	1.00
291_R	315_I	1.598	0.99
147_L	151_I	1.592	0.99
207_K	273_T	1.592	0.99
291_R	294_E	1.563	0.99
153_D	157_K	1.542	0.99
98_V	141_A	1.533	0.99
74_T	141_A	1.527	0.99
153_D	160_D	1.516	0.99
157_K	161_Y	1.497	0.99
295_K	298_A	1.495	0.99
77_D	81_K	1.492	0.99
30_L	64_T	1.490	0.99
315_I	318_I	1.478	0.99
296_L	299_E	1.465	0.99
154_V	159_L	1.465	0.99
150_F	154_V	1.447	0.99
97_H	305_D	1.445	0.99
62_K	91_R	1.434	0.99
205_G	271_S	1.390	0.99
159_L	162_L	1.377	0.98
106_I	109_E	1.353	0.98
33_R	193_T	1.333	0.98
85_E	88_T	1.314	0.98
233_T	236_D	1.303	0.98
260_V	263_A	1.292	0.98
155_P	161_Y	1.291	0.98
238_K	241_G	1.288	0.98
192_N	200_S	1.287	0.98
261_K	293_Y	1.280	0.97
146_E	308_E	1.267	0.97
294_E	304_L	1.263	0.97
239_K	242_L	1.253	0.97
231_E	254_R	1.230	0.97
288_Y	294_E	1.230	0.97
96_S	305_D	1.227	0.97
55_I	86_T	1.213	0.96
24_I	61_N	1.212	0.96
238_K	252_L	1.210	0.96
133_R	181_Y	1.198	0.96
74_T	94_I	1.193	0.96
152_I	161_Y	1.190	0.96
101_I	129_A	1.185	0.96
279_K	282_T	1.177	0.96
177_Y	265_E	1.175	0.96
199_L	206_P	1.166	0.96
211_H	273_T	1.155	0.95
154_V	160_D	1.138	0.95
94_I	141_A	1.126	0.95
153_D	156_N	1.121	0.94
113_P	123_G	1.116	0.94
235_E	238_K	1.110	0.94
153_D	163_D	1.109	0.94
4_L	209_V	1.109	0.94
196_S	200_S	1.104	0.94
311_L	315_I	1.102	0.94
307_L	311_L	1.099	0.94
170_I	202_A	1.094	0.94
220_V	262_L	1.084	0.93
178_L	222_R	1.077	0.93
303_W	310_E	1.077	0.93
139_K	150_F	1.076	0.93
152_I	162_L	1.073	0.93
174_Q	178_L	1.070	0.93
194_T	197_G	1.067	0.93
309_E	312_K	1.067	0.93
176_H	266_A	1.063	0.93
155_P	162_L	1.063	0.93
314_P	318_I	1.060	0.93
76_L	80_F	1.056	0.92
142_K	305_D	1.053	0.92
214_I	272_A	1.045	0.92
104_D	132_K	1.045	0.92
106_I	110_K	1.045	0.92
308_E	311_L	1.044	0.92
314_P	317_L	1.041	0.92
5_I	27_R	1.039	0.92
42_T	49_I	1.037	0.92
221_T	279_K	1.037	0.92
154_V	158_I	1.034	0.92
265_E	268_R	1.022	0.91
3_E	27_R	1.017	0.91
266_A	270_N	1.014	0.91
300_A	309_E	1.011	0.91
294_E	298_A	1.010	0.91
81_K	85_E	1.005	0.91
300_A	313_T	0.991	0.90
134_I	180_L	0.988	0.90
157_K	162_L	0.986	0.90
44_T	49_I	0.982	0.89
159_L	163_D	0.976	0.89
29_K	65_E	0.971	0.89
133_R	140_L	0.967	0.89
80_F	84_R	0.961	0.88
216_F	277_I	0.961	0.88
244_E	253_R	0.953	0.88
213_I	274_I	0.952	0.88
96_S	142_K	0.942	0.87
195_A	199_L	0.937	0.87
29_K	67_A	0.935	0.87
312_K	315_I	0.933	0.87
152_I	159_L	0.933	0.87
232_L	255_V	0.932	0.87
75_S	78_A	0.928	0.87
240_L	278_T	0.927	0.87
28_P	167_N	0.922	0.86
288_Y	291_R	0.916	0.86
152_I	157_K	0.913	0.86
29_K	166_H	0.908	0.85
245_Y	252_L	0.900	0.85
90_D	93_Y	0.894	0.85
53_R	85_E	0.890	0.84
285_K	288_Y	0.888	0.84
216_F	275_V	0.887	0.84
121_S	127_G	0.883	0.84
32_V	173_T	0.882	0.84
153_D	158_I	0.881	0.84
99_G	129_A	0.879	0.84
110_K	123_G	0.874	0.83
293_Y	301_R	0.872	0.83
152_I	156_N	0.871	0.83
70_P	201_E	0.870	0.83
176_H	269_I	0.869	0.83
59_F	66_L	0.864	0.82
75_S	103_E	0.863	0.82
148_E	151_I	0.856	0.82
240_L	279_K	0.856	0.82
168_I	204_I	0.855	0.82
294_E	297_P	0.855	0.82
52_L	59_F	0.852	0.82
131_S	137_K	0.851	0.82
235_E	239_K	0.847	0.81
307_L	315_I	0.846	0.81
197_G	201_E	0.843	0.81
260_V	318_I	0.843	0.81
232_L	236_D	0.842	0.81
236_D	239_K	0.839	0.81
177_Y	303_W	0.839	0.81
297_P	300_A	0.839	0.81
8_G	216_F	0.838	0.81
33_R	197_G	0.834	0.80
154_V	163_D	0.834	0.80
127_G	136_R	0.831	0.80
106_I	123_G	0.830	0.80
78_A	101_I	0.828	0.80
138_L	185_Y	0.827	0.80
70_P	192_N	0.825	0.79
239_K	285_K	0.821	0.79
31_S	69_G	0.820	0.79
34_T	175_G	0.819	0.79
215_T	278_T	0.817	0.79
291_R	304_L	0.815	0.79
194_T	200_S	0.814	0.79
118_V	123_G	0.806	0.78
311_L	314_P	0.806	0.78
55_I	59_F	0.804	0.78
173_T	178_L	0.802	0.78
6_I	195_A	0.800	0.77
246_G	253_R	0.800	0.77
170_I	198_V	0.796	0.77
105_E	109_E	0.795	0.77
156_N	159_L	0.794	0.77
221_T	255_V	0.793	0.77
146_E	306_E	0.793	0.77
307_L	310_E	0.790	0.76
174_Q	222_R	0.789	0.76
308_E	312_K	0.787	0.76
181_Y	192_N	0.774	0.75
54_I	72_A	0.773	0.75
67_A	93_Y	0.771	0.75
27_R	167_N	0.771	0.75
49_I	247_T	0.770	0.75
288_Y	304_L	0.769	0.75
184_E	222_R	0.768	0.74
29_K	168_I	0.766	0.74
306_E	315_I	0.765	0.74
295_K	299_E	0.765	0.74
66_L	247_T	0.763	0.74
219_Y	282_T	0.763	0.74
37_I	284_F	0.762	0.74
310_E	313_T	0.761	0.74
45_Y	48_R	0.758	0.73
73_L	130_E	0.753	0.73
80_F	83_M	0.752	0.73
196_S	205_G	0.751	0.73
307_L	312_K	0.750	0.73
261_K	303_W	0.748	0.72
121_S	188_V	0.744	0.72
289_R	294_E	0.742	0.72
230_G	256_A	0.740	0.72
3_E	213_I	0.740	0.72
18_V	21_Y	0.733	0.71
294_E	300_A	0.732	0.71
289_R	317_L	0.731	0.71
158_I	162_L	0.730	0.71
6_I	198_V	0.728	0.70
99_G	140_L	0.727	0.70
49_I	243_T	0.726	0.70
115_L	137_K	0.725	0.70
53_R	78_A	0.725	0.70
249_T	253_R	0.724	0.70
236_D	240_L	0.723	0.70
126_V	130_E	0.722	0.70
18_V	276_A	0.714	0.69
55_I	175_G	0.711	0.69
256_A	259_N	0.710	0.69
204_I	208_Y	0.709	0.68
155_P	160_D	0.708	0.68
306_E	311_L	0.708	0.68
221_T	278_T	0.707	0.68
111_N	131_S	0.706	0.68
70_P	95_D	0.704	0.68
68_L	79_L	0.700	0.67
142_K	145_K	0.700	0.67
35_G	126_V	0.699	0.67
147_L	150_F	0.697	0.67
258_F	290_V	0.695	0.67
81_K	88_T	0.692	0.67
160_D	163_D	0.689	0.66
236_D	287_A	0.687	0.66
181_Y	219_Y	0.681	0.65
279_K	283_L	0.681	0.65
67_A	142_K	0.680	0.65
81_K	84_R	0.679	0.65
158_I	161_Y	0.679	0.65
37_I	105_E	0.678	0.65
298_A	304_L	0.677	0.65
194_T	266_A	0.676	0.65
212_I	272_A	0.674	0.64
173_T	222_R	0.673	0.64
306_E	314_P	0.673	0.64
244_E	249_T	0.672	0.64
293_Y	298_A	0.672	0.64
223_V	249_T	0.672	0.64
117_N	187_Y	0.667	0.64
89_Y	93_Y	0.664	0.63
8_G	263_A	0.663	0.63
43_V	50_W	0.661	0.63
37_I	241_G	0.660	0.63
51_K	66_L	0.660	0.63
10_F	184_E	0.659	0.63
33_R	170_I	0.657	0.63
206_P	212_I	0.656	0.62
311_L	318_I	0.655	0.62
61_N	64_T	0.652	0.62
70_P	181_Y	0.652	0.62
152_I	163_D	0.650	0.62
244_E	251_R	0.647	0.61
152_I	155_P	0.646	0.61
293_Y	304_L	0.646	0.61
104_D	128_Y	0.646	0.61
110_K	113_P	0.645	0.61
8_G	214_I	0.643	0.61
309_E	313_T	0.643	0.61
265_E	302_K	0.642	0.61
122_T	125_G	0.640	0.60
134_I	137_K	0.639	0.60
88_T	167_N	0.639	0.60
50_W	247_T	0.638	0.60
11_G	15_K	0.638	0.60
306_E	310_E	0.637	0.60
96_S	145_K	0.637	0.60
34_T	52_L	0.637	0.60
24_I	27_R	0.637	0.60
214_I	275_V	0.635	0.60
113_P	118_V	0.634	0.60
311_L	317_L	0.632	0.60
195_A	205_G	0.628	0.59
178_L	184_E	0.628	0.59
43_V	52_L	0.624	0.59
34_T	172_G	0.623	0.58
69_G	201_E	0.620	0.58
34_T	193_T	0.616	0.58
277_I	284_F	0.616	0.58
265_E	269_I	0.615	0.57
4_L	195_A	0.615	0.57
199_L	202_A	0.614	0.57
292_E	318_I	0.614	0.57
19_A	216_F	0.612	0.57
77_D	105_E	0.610	0.57
293_Y	316_G	0.610	0.57
97_H	142_K	0.607	0.56
287_A	294_E	0.603	0.56
72_A	141_A	0.602	0.56
31_S	170_I	0.602	0.56
14_G	267_I	0.602	0.56
76_L	174_Q	0.602	0.56
301_R	304_L	0.601	0.56
115_L	225_K	0.601	0.56
11_G	14_G	0.598	0.55
179_S	201_E	0.598	0.55
118_V	208_Y	0.598	0.55
47_G	50_W	0.596	0.55
184_E	220_V	0.595	0.55
80_F	94_I	0.595	0.55
10_F	262_L	0.592	0.55
139_K	143_D	0.592	0.55
38_N	56_P	0.592	0.55
60_I	86_T	0.591	0.54
290_V	318_I	0.591	0.54
10_F	228_L	0.589	0.54
26_D	167_N	0.589	0.54
195_A	206_P	0.589	0.54
131_S	134_I	0.589	0.54
74_T	227_P	0.588	0.54
77_D	103_E	0.585	0.54
290_V	294_E	0.584	0.54
255_V	279_K	0.583	0.54
140_L	143_D	0.582	0.53
93_Y	152_I	0.582	0.53
23_G	27_R	0.581	0.53
207_K	269_I	0.581	0.53
150_F	157_K	0.578	0.53
300_A	304_L	0.576	0.53
199_L	209_V	0.573	0.52
23_G	61_N	0.573	0.52
306_E	316_G	0.573	0.52
112_D	191_R	0.572	0.52
288_Y	292_E	0.570	0.52
78_A	81_K	0.569	0.52
223_V	251_R	0.568	0.52
54_I	73_L	0.568	0.52
149_K	153_D	0.568	0.52
7_G	11_G	0.568	0.52
18_V	173_T	0.566	0.51
155_P	163_D	0.564	0.51
142_K	307_L	0.564	0.51
230_G	257_P	0.563	0.51
292_E	295_K	0.562	0.51
173_T	191_R	0.562	0.51
83_M	89_Y	0.561	0.51
59_F	92_L	0.561	0.51
148_E	152_I	0.560	0.51
308_E	316_G	0.559	0.51
115_L	156_N	0.558	0.50
121_S	125_G	0.557	0.50
96_S	309_E	0.554	0.50
128_Y	191_R	0.553	0.50
276_A	280_L	0.552	0.50
208_Y	271_S	0.551	0.49
262_L	303_W	0.551	0.49
280_L	284_F	0.549	0.49
128_Y	132_K	0.547	0.49
34_T	192_N	0.547	0.49
197_G	200_S	0.546	0.49
310_E	315_I	0.544	0.49
59_F	79_L	0.543	0.48
205_G	210_D	0.543	0.48
121_S	136_R	0.543	0.48
311_L	316_G	0.542	0.48
229_E	313_T	0.542	0.48
66_L	193_T	0.542	0.48
115_L	119_I	0.542	0.48
5_I	96_S	0.541	0.48
65_E	166_H	0.541	0.48
226_G	231_E	0.540	0.48
34_T	57_S	0.540	0.48
154_V	167_N	0.540	0.48
140_L	181_Y	0.539	0.48
205_G	212_I	0.538	0.48
187_Y	190_S	0.538	0.48
293_Y	296_L	0.536	0.48
37_I	54_I	0.536	0.48
263_A	266_A	0.535	0.47
158_I	202_A	0.533	0.47
30_L	280_L	0.531	0.47
174_Q	184_E	0.531	0.47
24_I	45_Y	0.530	0.47
155_P	158_I	0.530	0.47
37_I	129_A	0.530	0.47
120_G	125_G	0.529	0.47
235_E	286_D	0.528	0.47
164_N	308_E	0.527	0.46
299_E	314_P	0.527	0.46
23_G	123_G	0.526	0.46
188_V	222_R	0.524	0.46
242_L	252_L	0.524	0.46
119_I	136_R	0.522	0.46
295_K	316_G	0.522	0.46
308_E	315_I	0.522	0.46
151_I	211_H	0.520	0.46
145_K	150_F	0.520	0.46
239_K	290_V	0.520	0.46
300_A	303_W	0.519	0.45
19_A	30_L	0.518	0.45
103_E	174_Q	0.517	0.45
5_I	115_L	0.516	0.45
187_Y	225_K	0.515	0.45
3_E	211_H	0.514	0.45
8_G	262_L	0.512	0.45
5_I	22_L	0.512	0.45
53_R	124_Q	0.511	0.45
119_I	127_G	0.511	0.45
264_R	289_R	0.511	0.45
141_A	145_K	0.510	0.44
288_Y	300_A	0.510	0.44
187_Y	227_P	0.510	0.44
30_L	58_A	0.509	0.44
127_G	222_R	0.508	0.44
53_R	247_T	0.508	0.44
65_E	91_R	0.507	0.44
50_W	121_S	0.506	0.44
56_P	71_G	0.505	0.44
259_N	281_D	0.505	0.44
76_L	100_I	0.505	0.44
5_I	139_K	0.504	0.44
143_D	153_D	0.503	0.44
26_D	84_R	0.503	0.44
309_E	316_G	0.503	0.44
313_T	316_G	0.502	0.43
104_D	172_G	0.502	0.43
117_N	152_I	0.502	0.43
126_V	228_L	0.501	0.43
232_L	257_P	0.500	0.43
68_L	92_L	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hidA	2	0.9731	100	0.019	Contact Map
3ue9A	2	0.9672	100	0.022	Contact Map
4m9dA	2	0.997	100	0.024	Contact Map
3r7tA	4	0.9582	100	0.025	Contact Map
2v40A	2	0.9612	100	0.026	Contact Map
1dj2A	2	0.9821	100	0.027	Contact Map
1p9bA	2	0.9851	100	0.029	Contact Map
2d7uA	2	0.9373	100	0.058	Contact Map
4cgkA	3	0.2597	11.3	0.979	Contact Map
1axnA	1	0.4537	7.6	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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