GREMLIN Database
Q980P4 - Uncharacterized protein
UniProt: Q980P4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (449)
Sequences: 629 (337)
Seq/√Len: 15.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
355_S360_I7.5721.00
18_A206_L6.3321.00
107_Y456_I5.2551.00
425_D429_E5.0651.00
37_L175_I4.4281.00
279_Y302_S4.2261.00
243_S277_R3.8911.00
49_C64_C3.8791.00
100_K103_E3.7721.00
377_I412_A3.7361.00
21_E460_R3.7221.00
3_S203_R3.7051.00
9_I207_V3.6251.00
115_F167_Y3.5631.00
183_D223_K3.3850.99
24_G114_K3.2910.99
436_F461_G3.1880.99
42_A178_L3.1860.99
7_V36_L3.1590.99
21_E107_Y3.1320.99
49_C61_C2.8890.98
61_C64_C2.8790.98
50_P61_C2.7250.97
84_R87_I2.6790.96
195_T200_I2.6500.96
7_V200_I2.6420.96
4_Y36_L2.6190.96
429_E436_F2.5890.96
239_V408_T2.5770.95
380_G413_P2.5110.95
189_N193_L2.5080.95
313_I385_V2.5040.95
337_G373_T2.4720.94
36_L176_G2.4220.94
311_T388_N2.4200.94
106_N110_D2.4140.94
227_D423_V2.3430.92
49_C58_C2.3300.92
321_D324_E2.3260.92
58_C64_C2.3070.92
185_E192_F2.3010.92
8_I19_A2.2960.92
3_S201_E2.2880.92
456_I460_R2.2710.91
109_D150_R2.2420.91
14_A209_P2.2190.90
357_W361_N2.1820.89
50_P64_C2.1540.89
87_I145_V2.1390.88
21_E456_I2.1300.88
215_K327_K2.1300.88
220_Q224_L2.1290.88
190_K433_D2.0990.87
107_Y460_R2.0830.87
204_I436_F2.0560.86
38_V176_G2.0510.86
459_A462_I1.9910.84
115_F163_N1.9230.82
11_G37_L1.9140.82
40_K180_E1.9010.82
7_V193_L1.9000.82
241_T403_I1.8920.81
6_V35_I1.8770.81
186_K192_F1.8670.80
191_F205_V1.8510.80
136_R139_K1.8170.78
205_V435_L1.8140.78
220_Q223_K1.7980.78
350_Q394_E1.7910.77
430_T437_A1.7470.76
346_L393_L1.6800.73
33_Y463_A1.6780.72
99_D366_K1.6760.72
81_I449_N1.6620.72
22_L459_A1.6500.71
162_E166_N1.6500.71
45_S166_N1.6490.71
256_P274_V1.6160.70
267_D384_R1.5960.69
438_A458_A1.5930.68
78_S295_E1.5870.68
349_F386_V1.5730.67
202_S205_V1.5570.67
84_R147_I1.5100.64
209_P441_G1.5040.64
18_A458_A1.5040.64
186_K191_F1.5000.64
423_V431_V1.4910.63
70_F177_E1.4840.63
100_K426_N1.4770.62
323_I419_S1.4750.62
184_I207_V1.4650.62
313_I379_M1.4590.61
81_I112_F1.4570.61
113_V150_R1.4330.60
346_L394_E1.4320.60
329_I381_L1.4250.59
87_I147_I1.4180.59
459_A463_A1.3870.57
204_I434_N1.3630.56
427_N461_G1.3500.55
234_D418_Y1.3410.55
383_Y387_D1.3400.55
87_I148_R1.3380.55
195_T198_G1.3360.54
16_L70_F1.3270.54
247_D251_E1.3270.54
255_D315_L1.3240.54
194_K198_G1.3230.54
36_L200_I1.3100.53
83_L145_V1.3070.53
266_D362_R1.2990.52
9_I198_G1.2980.52
103_E107_Y1.2900.52
9_I438_A1.2790.51
132_E196_S1.2740.51
255_D334_T1.2740.51
106_N148_R1.2700.51
197_R434_N1.2700.51
346_L390_I1.2640.50
183_D220_Q1.2540.50
58_C61_C1.2470.49
246_F305_T1.2440.49
91_L428_M1.2370.49
38_V193_L1.2320.48
69_G72_G1.2310.48
96_R101_A1.2250.48
9_I38_V1.2140.47
32_N182_I1.2130.47
315_L319_L1.2120.47
330_A415_I1.1920.46
74_G80_I1.1910.46
322_T419_S1.1910.46
411_Y416_K1.1730.45
4_Y174_K1.1710.45
80_I254_W1.1680.45
104_L453_A1.1640.45
226_V427_N1.1580.44
36_L174_K1.1510.44
84_R145_V1.1480.44
187_K433_D1.1460.43
261_Y363_S1.1440.43
166_N169_E1.1440.43
111_I423_V1.1410.43
11_G15_G1.1390.43
129_K251_E1.1380.43
377_I380_G1.1290.43
424_V454_T1.1260.42
48_T53_S1.1160.42
360_I363_S1.1130.42
226_V431_V1.1090.41
445_S448_I1.1060.41
309_F392_G1.1050.41
312_T452_A1.1050.41
185_E205_V1.0960.41
74_G77_S1.0950.41
377_I413_P1.0950.41
234_D445_S1.0840.40
176_G200_I1.0830.40
39_D175_I1.0830.40
250_T274_V1.0810.40
99_D103_E1.0780.40
16_L161_I1.0780.40
14_A438_A1.0750.39
150_R418_Y1.0700.39
114_K167_Y1.0690.39
211_R352_G1.0690.39
21_E24_G1.0630.39
184_I427_N1.0620.39
302_S320_E1.0610.39
37_L434_N1.0590.39
280_I389_L1.0570.39
180_E225_G1.0550.38
322_T446_R1.0540.38
132_E187_K1.0520.38
259_I268_K1.0470.38
293_N414_E1.0470.38
275_N416_K1.0450.38
356_T360_I1.0450.38
345_R410_L1.0430.38
326_G415_I1.0400.38
105_I388_N1.0200.36
349_F378_S1.0170.36
111_I201_E1.0160.36
3_S188_G1.0160.36
106_N227_D1.0160.36
104_L370_R1.0150.36
109_D418_Y1.0100.36
334_T412_A1.0090.36
261_Y405_S1.0090.36
232_P421_R1.0060.36
428_M454_T1.0010.35
31_S34_K0.9970.35
209_P442_T0.9950.35
203_R426_N0.9900.35
137_A258_V0.9870.35
132_E219_E0.9840.35
316_S362_R0.9810.34
117_A155_D0.9810.34
353_R359_R0.9790.34
419_S446_R0.9770.34
196_S229_I0.9740.34
418_Y445_S0.9740.34
149_Q255_D0.9720.34
424_V428_M0.9700.34
11_G39_D0.9690.34
344_Q375_G0.9620.33
189_N366_K0.9580.33
141_G217_F0.9580.33
255_D448_I0.9580.33
170_K219_E0.9570.33
319_L322_T0.9540.33
8_I457_L0.9490.33
3_S48_T0.9480.33
149_Q289_T0.9450.33
175_I180_E0.9410.32
274_V385_V0.9400.32
109_D372_V0.9370.32
132_E136_R0.9360.32
70_F155_D0.9340.32
153_G411_Y0.9290.32
309_F389_L0.9270.32
255_D392_G0.9270.32
344_Q348_D0.9250.32
262_S267_D0.9240.32
23_A35_I0.9210.31
187_K192_F0.9200.31
346_L404_F0.9180.31
226_V290_I0.9120.31
247_D389_L0.9120.31
182_I433_D0.9100.31
179_T201_E0.9060.31
267_D388_N0.9030.30
321_D360_I0.9010.30
255_D341_P0.9000.30
272_F414_E0.8950.30
183_D224_L0.8950.30
75_T112_F0.8920.30
222_K464_I0.8920.30
335_R386_V0.8920.30
111_I462_I0.8910.30
393_L403_I0.8910.30
164_I406_S0.8880.30
94_I231_G0.8850.30
37_L296_T0.8820.29
443_G451_A0.8800.29
85_P437_A0.8790.29
183_D366_K0.8760.29
211_R354_R0.8740.29
326_G417_Y0.8730.29
338_G349_F0.8720.29
74_G79_G0.8720.29
229_I423_V0.8690.29
76_F262_S0.8670.29
100_K203_R0.8640.29
197_R219_E0.8640.29
80_I84_R0.8600.28
169_E174_K0.8560.28
36_L202_S0.8560.28
60_F185_E0.8550.28
383_Y407_N0.8540.28
42_A46_K0.8530.28
154_T255_D0.8520.28
171_R188_G0.8500.28
192_F435_L0.8500.28
428_M444_L0.8490.28
12_G41_G0.8450.28
269_V311_T0.8450.28
424_V444_L0.8430.28
7_V202_S0.8390.27
207_V220_Q0.8390.27
151_H411_Y0.8380.27
82_N145_V0.8360.27
184_I224_L0.8350.27
276_P336_L0.8350.27
89_G234_D0.8320.27
119_K129_K0.8310.27
261_Y362_R0.8300.27
173_I463_A0.8300.27
173_I423_V0.8300.27
32_N35_I0.8270.27
257_K447_G0.8270.27
47_R77_S0.8230.27
328_S331_R0.8220.27
81_I285_Y0.8220.27
354_R402_G0.8190.27
164_I186_K0.8190.27
397_D404_F0.8190.27
89_G109_D0.8190.27
255_D450_V0.8180.26
131_R134_Q0.8170.26
189_N194_K0.8170.26
393_L410_L0.8120.26
75_T322_T0.8120.26
24_G434_N0.8110.26
144_F253_V0.8100.26
242_E415_I0.8080.26
263_K362_R0.8080.26
217_F327_K0.8080.26
4_Y433_D0.8070.26
100_K189_N0.8070.26
146_P232_P0.8030.26
191_F432_V0.7980.26
187_K219_E0.7970.26
154_T341_P0.7960.25
31_S463_A0.7960.25
142_A372_V0.7950.25
227_D366_K0.7950.25
155_D297_Y0.7950.25
30_V33_Y0.7930.25
424_V437_A0.7910.25
304_N409_L0.7890.25
428_M438_A0.7880.25
206_L429_E0.7870.25
187_K194_K0.7860.25
187_K464_I0.7860.25
75_T448_I0.7860.25
293_N318_P0.7840.25
73_A270_R0.7790.25
259_I447_G0.7770.25
255_D445_S0.7740.25
370_R463_A0.7730.25
283_E308_A0.7690.24
180_E196_S0.7670.24
44_A160_I0.7650.24
90_E101_A0.7650.24
184_I197_R0.7640.24
266_D353_R0.7620.24
35_I207_V0.7610.24
234_D257_K0.7610.24
55_K299_D0.7590.24
285_Y449_N0.7590.24
255_D319_L0.7580.24
138_A143_E0.7570.24
354_R414_E0.7530.24
254_W293_N0.7520.24
204_I235_I0.7520.24
30_V167_Y0.7490.23
442_T446_R0.7490.23
38_V197_R0.7480.23
185_E224_L0.7450.23
318_P402_G0.7440.23
283_E293_N0.7420.23
153_G416_K0.7380.23
227_D431_V0.7380.23
79_G88_G0.7360.23
7_V226_V0.7320.23
250_T276_P0.7320.23
141_G263_K0.7320.23
5_D34_K0.7310.23
276_P417_Y0.7310.23
318_P354_R0.7290.23
135_R248_E0.7290.23
176_G193_L0.7280.23
41_G72_G0.7280.23
55_K59_T0.7280.23
376_D384_R0.7260.23
95_T296_T0.7260.23
266_D356_T0.7260.23
3_S9_I0.7260.23
85_P98_W0.7240.22
83_L109_D0.7240.22
190_K426_N0.7240.22
326_G381_L0.7240.22
14_A38_V0.7240.22
182_I199_E0.7210.22
267_D326_G0.7210.22
112_F452_A0.7200.22
458_A462_I0.7190.22
217_F437_A0.7180.22
32_N46_K0.7180.22
142_A284_V0.7180.22
283_E414_E0.7160.22
147_I291_G0.7160.22
58_C63_P0.7160.22
341_P392_G0.7150.22
269_V336_L0.7140.22
412_A450_V0.7140.22
283_E354_R0.7130.22
162_E225_G0.7120.22
256_P365_V0.7110.22
99_D202_S0.7090.22
77_S89_G0.7080.22
13_P112_F0.7080.22
255_D413_P0.7070.22
180_E463_A0.7050.22
34_K217_F0.7040.22
447_G450_V0.7020.22
101_A322_T0.7020.22
279_Y415_I0.6990.21
206_L331_R0.6970.21
389_L410_L0.6950.21
62_D433_D0.6940.21
185_E201_E0.6940.21
9_I220_Q0.6910.21
413_P450_V0.6900.21
151_H416_K0.6890.21
354_R384_R0.6890.21
187_K201_E0.6880.21
329_I391_D0.6880.21
363_S390_I0.6870.21
166_N170_K0.6870.21
135_R247_D0.6860.21
100_K425_D0.6850.21
90_E93_E0.6840.21
310_L414_E0.6840.21
78_S254_W0.6830.21
334_T377_I0.6800.21
186_K199_E0.6800.21
131_R247_D0.6780.21
114_K433_D0.6780.21
51_L364_T0.6780.21
320_E388_N0.6770.21
228_T302_S0.6770.21
37_L200_I0.6770.21
204_I462_I0.6770.21
89_G418_Y0.6760.21
319_L419_S0.6750.21
94_I380_G0.6730.20
39_D110_D0.6730.20
219_E227_D0.6720.20
3_S166_N0.6700.20
46_K176_G0.6680.20
206_L438_A0.6650.20
179_T195_T0.6650.20
24_G107_Y0.6630.20
345_R372_V0.6630.20
110_D169_E0.6600.20
62_D130_V0.6600.20
42_A432_V0.6600.20
30_V43_R0.6590.20
10_G41_G0.6580.20
81_I309_F0.6580.20
51_L59_T0.6570.20
220_Q346_L0.6560.20
18_A207_V0.6540.20
185_E222_K0.6540.20
171_R229_I0.6540.20
255_D274_V0.6530.20
292_V326_G0.6530.20
193_L202_S0.6520.20
202_S435_L0.6520.20
136_R140_V0.6510.20
186_K190_K0.6510.20
24_G115_F0.6510.20
219_E222_K0.6440.19
304_N416_K0.6420.19
84_R334_T0.6410.19
136_R225_G0.6390.19
184_I193_L0.6390.19
78_S272_F0.6380.19
24_G163_N0.6380.19
439_G455_G0.6380.19
266_D407_N0.6350.19
91_L181_V0.6340.19
265_Y384_R0.6330.19
219_E223_K0.6320.19
46_K188_G0.6320.19
333_M336_L0.6310.19
62_D193_L0.6300.19
152_M445_S0.6280.19
170_K199_E0.6260.19
43_R165_V0.6250.19
78_S81_I0.6250.19
293_N354_R0.6250.19
76_F202_S0.6240.19
190_K219_E0.6240.19
258_V399_I0.6220.19
270_R401_P0.6220.19
34_K174_K0.6200.19
48_T425_D0.6200.19
144_F373_T0.6200.19
84_R454_T0.6190.19
159_L222_K0.6190.19
315_L322_T0.6190.19
134_Q407_N0.6190.19
272_F310_L0.6180.18
147_I335_R0.6170.18
308_A414_E0.6170.18
77_S80_I0.6160.18
35_I156_K0.6160.18
293_N416_K0.6130.18
67_M242_E0.6130.18
334_T450_V0.6130.18
160_I249_L0.6120.18
166_N425_D0.6110.18
109_D113_V0.6090.18
30_V48_T0.6090.18
93_E187_K0.6080.18
274_V392_G0.6080.18
47_R79_G0.6070.18
242_E316_S0.6060.18
83_L150_R0.6060.18
234_D446_R0.6060.18
9_I458_A0.6050.18
442_T447_G0.6040.18
226_V381_L0.6040.18
34_K398_S0.6040.18
284_V337_G0.6040.18
22_L168_V0.6030.18
182_I196_S0.6000.18
142_A412_A0.5990.18
41_G69_G0.5980.18
39_D48_T0.5980.18
201_E222_K0.5980.18
296_T389_L0.5940.18
12_G72_G0.5940.18
93_E207_V0.5910.18
3_S32_N0.5910.18
284_V363_S0.5910.18
184_I432_V0.5910.18
44_A302_S0.5880.17
141_G180_E0.5860.17
358_E461_G0.5850.17
429_E433_D0.5830.17
37_L102_Q0.5830.17
75_T152_M0.5790.17
174_K464_I0.5780.17
115_F279_Y0.5780.17
159_L197_R0.5780.17
397_D402_G0.5780.17
32_N136_R0.5760.17
135_R219_E0.5760.17
123_F250_T0.5760.17
432_V435_L0.5760.17
254_W283_E0.5750.17
418_Y446_R0.5750.17
194_K200_I0.5750.17
151_H154_T0.5740.17
223_K357_W0.5720.17
19_A382_P0.5720.17
62_D427_N0.5710.17
7_V37_L0.5710.17
156_K159_L0.5710.17
155_D448_I0.5700.17
129_K184_I0.5680.17
255_D322_T0.5680.17
261_Y407_N0.5680.17
343_L372_V0.5660.17
318_P348_D0.5660.17
457_L461_G0.5640.17
35_I167_Y0.5630.17
281_M297_Y0.5620.17
78_S310_L0.5620.17
47_R74_G0.5620.17
43_R46_K0.5610.17
194_K201_E0.5610.17
185_E189_N0.5610.17
42_A65_H0.5610.17
37_L229_I0.5590.17
254_W414_E0.5590.17
166_N182_I0.5590.17
75_T419_S0.5580.16
254_W322_T0.5580.16
50_P58_C0.5570.16
422_A437_A0.5550.16
126_N129_K0.5550.16
24_G167_Y0.5550.16
260_L313_I0.5540.16
11_G70_F0.5540.16
167_Y324_E0.5520.16
196_S201_E0.5520.16
167_Y174_K0.5510.16
34_K426_N0.5500.16
285_Y289_T0.5500.16
118_P160_I0.5490.16
149_Q309_F0.5480.16
268_K428_M0.5480.16
9_I15_G0.5480.16
182_I197_R0.5470.16
246_F346_L0.5470.16
67_M428_M0.5470.16
107_Y235_I0.5470.16
317_D391_D0.5470.16
59_T175_I0.5460.16
205_V436_F0.5460.16
235_I456_I0.5450.16
236_G306_N0.5450.16
236_G294_G0.5450.16
236_G273_C0.5450.16
210_G306_N0.5450.16
210_G236_G0.5450.16
210_G273_C0.5450.16
273_C306_N0.5450.16
294_G306_N0.5450.16
210_G294_G0.5450.16
273_C294_G0.5450.16
206_L433_D0.5440.16
38_V464_I0.5420.16
165_V177_E0.5420.16
195_T361_N0.5420.16
400_A403_I0.5410.16
110_D187_K0.5410.16
279_Y428_M0.5400.16
89_G416_K0.5400.16
33_Y462_I0.5400.16
154_T392_G0.5390.16
308_A402_G0.5380.16
129_K434_N0.5380.16
270_R305_T0.5380.16
433_D464_I0.5370.16
255_D372_V0.5360.16
187_K432_V0.5360.16
82_N177_E0.5350.16
219_E464_I0.5340.16
144_F213_G0.5340.16
24_G32_N0.5340.16
3_S38_V0.5330.16
46_K197_R0.5330.16
21_E34_K0.5320.16
167_Y171_R0.5320.16
283_E402_G0.5310.16
377_I450_V0.5310.16
119_K174_K0.5310.16
176_G196_S0.5300.16
170_K433_D0.5300.16
425_D461_G0.5280.16
16_L155_D0.5280.16
9_I45_S0.5270.16
98_W464_I0.5270.16
36_L184_I0.5260.15
326_G384_R0.5250.15
166_N191_F0.5250.15
132_E301_K0.5250.15
53_S56_E0.5240.15
45_S162_E0.5240.15
71_G82_N0.5230.15
164_I335_R0.5220.15
71_G161_I0.5210.15
48_T219_E0.5190.15
217_F221_S0.5180.15
45_S425_D0.5180.15
113_V136_R0.5180.15
325_Y336_L0.5180.15
302_S444_L0.5170.15
305_T310_L0.5160.15
274_V313_I0.5160.15
157_T449_N0.5150.15
55_K60_F0.5140.15
241_T463_A0.5130.15
95_T432_V0.5130.15
311_T415_I0.5120.15
308_A318_P0.5120.15
47_R88_G0.5120.15
159_L196_S0.5120.15
225_G427_N0.5110.15
205_V224_L0.5090.15
162_E202_S0.5090.15
112_F192_F0.5090.15
82_N212_A0.5080.15
275_N411_Y0.5080.15
318_P375_G0.5070.15
211_R376_D0.5070.15
23_A114_K0.5070.15
154_T315_L0.5070.15
110_D201_E0.5070.15
183_D190_K0.5060.15
42_A55_K0.5060.15
93_E229_I0.5050.15
111_I135_R0.5050.15
366_K370_R0.5040.15
14_A106_N0.5040.15
101_A337_G0.5040.15
182_I219_E0.5040.15
110_D464_I0.5040.15
321_D422_A0.5030.15
239_V356_T0.5030.15
188_G464_I0.5030.15
161_I448_I0.5020.15
39_D343_L0.5020.15
178_L187_K0.5020.15
34_K249_L0.5010.15
32_N194_K0.5010.15
309_F379_M0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nlcA 1 0.8977 100 0.625 Contact Map
4cnkA 2 0.7868 99.9 0.852 Contact Map
3g5sA 1 0.7335 99.9 0.857 Contact Map
3cp8A 2 0.7655 99.9 0.859 Contact Map
3cesA 2 0.742 99.9 0.86 Contact Map
3v76A 2 0.7569 99.9 0.86 Contact Map
2gqfA 4 0.8017 99.9 0.861 Contact Map
2i0zA 1 0.7953 99.9 0.862 Contact Map
1chuA 2 0.6674 99.9 0.868 Contact Map
1y0pA 1 0.823 99.9 0.87 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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