GREMLIN Database
Q980P3 - Heme biosynthesis nirD related protein (NirD)
UniProt: Q980P3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (313)
Sequences: 292 (210)
Seq/√Len: 11.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_D45_R7.6281.00
146_L255_Q5.7181.00
26_Q197_R3.4900.98
7_S45_R3.4520.98
101_V321_L3.4390.98
83_I109_I3.3300.98
72_A139_I3.2280.97
76_A90_A3.1700.97
101_V319_E3.1480.97
269_H323_P2.9510.95
187_E205_K2.8990.95
274_E285_Y2.7160.92
252_N275_S2.6640.92
7_S10_D2.5430.90
195_S201_E2.5100.89
82_K85_K2.4200.87
72_A125_V2.4080.87
244_G314_I2.3480.85
48_K52_D2.3330.85
290_A296_I2.2420.82
25_P210_E2.2350.82
149_S323_P2.1980.81
150_V269_H2.1430.79
60_M229_Y2.1220.79
181_N216_L2.0790.77
152_Y268_T2.0260.75
236_E320_N1.9950.74
109_I321_L1.9780.73
84_E321_L1.9620.73
249_D275_S1.9540.72
142_S269_H1.9310.72
112_V191_P1.9260.71
26_Q39_E1.9240.71
13_I42_L1.9220.71
235_G271_V1.9080.71
263_N281_K1.8660.69
320_N323_P1.7950.66
97_T269_H1.7840.65
57_R325_I1.7630.64
275_S283_L1.7420.63
77_R106_K1.7340.63
29_N39_E1.7330.63
83_I321_L1.7260.63
81_D211_D1.6750.60
93_I131_H1.6740.60
60_M188_L1.6630.60
97_T325_I1.6420.59
228_D271_V1.6260.58
69_M112_V1.6230.58
101_V290_A1.6230.58
149_S269_H1.6150.57
115_A121_L1.6020.57
112_V145_T1.5880.56
71_G148_L1.5860.56
99_N227_K1.5820.56
78_I86_F1.5780.55
52_D305_K1.5620.55
55_I257_C1.5290.53
80_Q206_Y1.5240.53
97_T323_P1.5190.52
141_Y274_E1.4980.51
51_E263_N1.4720.50
197_R210_E1.4610.50
69_M323_P1.4580.49
32_S48_K1.4510.49
98_H243_N1.4470.49
187_E202_I1.4300.48
189_S285_Y1.4250.48
104_H313_M1.4070.47
228_D235_G1.4000.47
218_K294_E1.3980.46
142_S323_P1.3920.46
91_L99_N1.3920.46
92_G204_E1.3850.46
200_K210_E1.3790.45
97_T114_K1.3680.45
32_S38_S1.3680.45
64_F114_K1.3550.44
61_Y97_T1.3530.44
21_F226_I1.3510.44
67_K185_L1.3480.44
129_L137_Y1.3450.44
32_S173_P1.3440.44
61_Y230_G1.3420.44
83_I101_V1.3310.43
99_N111_F1.3170.42
292_K296_I1.3110.42
150_V323_P1.3110.42
104_H285_Y1.3090.42
78_I90_A1.3050.42
129_L233_L1.2930.41
188_L217_I1.2850.41
69_M320_N1.2780.41
183_Q215_E1.2730.40
33_D80_Q1.2650.40
152_Y230_G1.2640.40
248_L270_V1.2580.40
47_K51_E1.2560.39
97_T149_S1.2560.39
103_D316_F1.2550.39
235_G270_V1.2400.39
84_E319_E1.2140.37
232_T321_L1.2120.37
148_L285_Y1.2110.37
69_M269_H1.2040.37
150_V312_Y1.2040.37
21_F230_G1.2000.37
228_D270_V1.1980.37
65_R153_D1.1980.37
269_H320_N1.1970.37
112_V325_I1.1890.36
56_K320_N1.1880.36
25_P214_V1.1840.36
128_L134_S1.1720.36
187_E218_K1.1690.35
39_E196_Q1.1690.35
44_N86_F1.1650.35
114_K325_I1.1600.35
267_A270_V1.1590.35
57_R128_L1.1580.35
112_V150_V1.1530.35
191_P325_I1.1500.35
40_E222_D1.1450.34
25_P200_K1.1400.34
87_R109_I1.1360.34
249_D252_N1.1280.34
114_K323_P1.1280.34
239_G280_W1.1130.33
266_E321_L1.1120.33
78_I146_L1.1110.33
118_R122_N1.1080.33
22_P198_P1.1060.33
56_K147_K1.1030.32
64_F74_I1.0990.32
117_D325_I1.0930.32
151_K269_H1.0840.32
62_V185_L1.0820.32
97_T233_L1.0810.31
55_I233_L1.0790.31
107_F301_K1.0770.31
228_D258_E1.0580.30
253_V256_A1.0550.30
80_Q203_A1.0530.30
24_D81_D1.0530.30
30_I194_I1.0440.30
63_S321_L1.0430.30
21_F184_L1.0430.30
43_L261_A1.0360.30
150_V191_P1.0340.29
250_T258_E1.0290.29
258_E271_V1.0250.29
43_L194_I1.0230.29
232_T305_K1.0210.29
61_Y142_S1.0190.29
31_I50_L1.0180.29
250_T285_Y1.0140.29
220_L223_K1.0100.28
258_E267_A1.0080.28
114_K149_S1.0000.28
189_S322_K1.0000.28
56_K112_V0.9870.28
146_L272_L0.9820.27
112_V320_N0.9780.27
45_R291_S0.9710.27
46_V63_S0.9650.27
65_R121_L0.9530.26
64_F71_G0.9520.26
151_K323_P0.9490.26
57_R97_T0.9470.26
24_D30_I0.9430.26
37_I208_M0.9430.26
57_R117_D0.9420.26
199_F229_Y0.9420.26
74_I150_V0.9420.26
257_C308_N0.9400.26
31_I302_E0.9380.26
61_Y148_L0.9320.25
209_K212_E0.9300.25
40_E205_K0.9290.25
91_L311_S0.9270.25
112_V230_G0.9260.25
144_K255_Q0.9250.25
23_F154_V0.9150.25
248_L271_V0.9150.25
64_F269_H0.9140.25
247_L317_S0.9140.25
97_T148_L0.9100.25
30_I33_D0.9090.25
239_G287_M0.9090.25
86_F90_A0.9060.24
100_Y239_G0.8980.24
128_L137_Y0.8980.24
83_I244_G0.8970.24
17_L97_T0.8970.24
142_S150_V0.8940.24
20_E295_T0.8920.24
278_E303_I0.8920.24
185_L308_N0.8790.23
44_N305_K0.8770.23
40_E48_K0.8740.23
125_V128_L0.8740.23
189_S270_V0.8700.23
96_L213_L0.8700.23
87_R247_L0.8670.23
28_F43_L0.8660.23
145_T227_K0.8590.23
150_V153_D0.8580.23
98_H287_M0.8560.23
243_N287_M0.8560.23
265_P292_K0.8560.23
38_S217_I0.8550.23
177_E267_A0.8520.23
228_D248_L0.8500.22
95_E227_K0.8490.22
220_L246_V0.8460.22
55_I324_G0.8350.22
198_P239_G0.8340.22
55_I85_K0.8340.22
64_F142_S0.8340.22
43_L104_H0.8280.22
147_K320_N0.8270.22
33_D205_K0.8240.22
243_N289_H0.8220.21
98_H289_H0.8220.21
185_L189_S0.8190.21
232_T308_N0.8140.21
246_V286_S0.8140.21
77_R220_L0.8130.21
140_L288_I0.8120.21
126_K196_Q0.8110.21
231_A268_T0.8070.21
23_F197_R0.8060.21
141_Y228_D0.8040.21
76_A86_F0.7930.21
141_Y284_C0.7930.21
52_D215_E0.7920.20
97_T150_V0.7900.20
35_L126_K0.7850.20
125_V139_I0.7840.20
114_K269_H0.7830.20
200_K204_E0.7800.20
42_L232_T0.7770.20
114_K142_S0.7750.20
21_F199_F0.7700.20
146_L189_S0.7690.20
179_G196_Q0.7680.20
44_N47_K0.7680.20
18_E148_L0.7680.20
293_K297_R0.7660.20
235_G258_E0.7610.19
64_F323_P0.7590.19
14_L188_L0.7590.19
145_T285_Y0.7570.19
77_R130_S0.7550.19
10_D49_L0.7540.19
236_E321_L0.7530.19
20_E324_G0.7480.19
112_V268_T0.7460.19
36_K195_S0.7460.19
210_E303_I0.7460.19
65_R138_V0.7450.19
281_K324_G0.7440.19
237_K320_N0.7440.19
14_L40_E0.7420.19
226_I229_Y0.7400.19
7_S48_K0.7380.19
112_V269_H0.7340.19
51_E94_R0.7330.19
9_I37_I0.7330.19
62_V281_K0.7290.19
144_K272_L0.7280.18
59_G230_G0.7250.18
244_G321_L0.7240.18
254_E272_L0.7240.18
61_Y64_F0.7240.18
112_V323_P0.7230.18
251_S309_S0.7230.18
141_Y189_S0.7180.18
147_K231_A0.7170.18
76_A129_L0.7160.18
32_S42_L0.7150.18
165_T195_S0.7140.18
261_A264_I0.7130.18
90_A272_L0.7110.18
94_R209_K0.7100.18
99_N280_W0.7080.18
212_E215_E0.7060.18
41_E211_D0.7020.18
36_K40_E0.7010.18
69_M97_T0.6970.18
151_K244_G0.6960.18
32_S37_I0.6960.18
32_S206_Y0.6960.18
30_I34_G0.6950.18
59_G325_I0.6950.18
34_G43_L0.6920.17
48_K106_K0.6910.17
250_T283_L0.6900.17
144_K227_K0.6900.17
19_Y150_V0.6900.17
244_G269_H0.6900.17
211_D301_K0.6880.17
147_K240_I0.6870.17
148_L229_Y0.6840.17
204_E302_E0.6840.17
82_K241_V0.6840.17
45_R220_L0.6790.17
67_K112_V0.6770.17
126_K130_S0.6770.17
138_V256_A0.6770.17
14_L215_E0.6730.17
226_I252_N0.6710.17
31_I297_R0.6670.17
74_I115_A0.6640.17
205_K213_L0.6620.17
68_G275_S0.6610.17
92_G192_L0.6580.16
290_A295_T0.6560.16
97_T142_S0.6540.16
81_D222_D0.6530.16
214_V300_A0.6530.16
31_I292_K0.6460.16
91_L274_E0.6450.16
181_N220_L0.6410.16
97_T320_N0.6410.16
39_E71_G0.6400.16
56_K271_V0.6400.16
38_S44_N0.6360.16
11_K144_K0.6360.16
258_E270_V0.6360.16
46_V53_G0.6340.16
250_T254_E0.6330.16
48_K298_N0.6330.16
74_I114_K0.6330.16
31_I290_A0.6300.16
183_Q212_E0.6290.16
13_I207_K0.6280.16
31_I316_F0.6270.16
177_E285_Y0.6270.16
161_S301_K0.6270.16
89_I222_D0.6270.16
235_G248_L0.6270.16
40_E47_K0.6260.16
30_I119_D0.6260.16
196_Q241_V0.6240.16
203_A214_V0.6200.15
185_L323_P0.6180.15
123_E253_V0.6180.15
218_K222_D0.6170.15
32_S170_S0.6130.15
196_Q219_E0.6120.15
270_V285_Y0.6120.15
74_I113_L0.6090.15
128_L325_I0.6090.15
142_S145_T0.6080.15
297_R301_K0.6070.15
191_P238_I0.6070.15
38_S211_D0.6060.15
101_V229_Y0.6060.15
177_E248_L0.6050.15
28_F84_E0.6050.15
21_F257_C0.6040.15
112_V238_I0.6030.15
55_I88_K0.6010.15
107_F308_N0.6000.15
71_G246_V0.5990.15
57_R61_Y0.5960.15
74_I269_H0.5950.15
112_V264_I0.5950.15
67_K248_L0.5930.15
235_G267_A0.5930.15
67_K303_I0.5910.15
126_K319_E0.5880.15
141_Y258_E0.5870.15
131_H212_E0.5860.15
33_D218_K0.5820.14
30_I215_E0.5820.14
87_R287_M0.5800.14
40_E44_N0.5800.14
121_L125_V0.5800.14
154_V234_N0.5790.14
31_I199_F0.5750.14
46_V232_T0.5750.14
145_T303_I0.5750.14
126_K200_K0.5740.14
228_D284_C0.5730.14
189_S323_P0.5730.14
22_P280_W0.5700.14
71_G245_M0.5700.14
28_F295_T0.5700.14
99_N239_G0.5700.14
78_I268_T0.5690.14
112_V142_S0.5690.14
182_K304_S0.5690.14
184_L207_K0.5680.14
41_E195_S0.5680.14
107_F114_K0.5680.14
57_R191_P0.5670.14
220_L225_V0.5650.14
69_M268_T0.5650.14
53_G314_I0.5640.14
40_E52_D0.5620.14
33_D311_S0.5620.14
33_D209_K0.5620.14
19_Y323_P0.5600.14
142_S236_E0.5570.14
58_I234_N0.5570.14
146_L248_L0.5560.14
153_D197_R0.5560.14
24_D40_E0.5540.14
42_L286_S0.5530.14
261_A296_I0.5510.14
32_S194_I0.5510.14
33_D192_L0.5500.14
200_K211_D0.5490.14
152_Y244_G0.5490.14
141_Y270_V0.5490.14
55_I188_L0.5470.14
231_A269_H0.5460.14
23_F131_H0.5440.14
76_A324_G0.5430.14
63_S71_G0.5420.14
32_S162_P0.5410.13
108_N287_M0.5410.13
48_K130_S0.5400.13
182_K204_E0.5390.13
79_P112_V0.5390.13
110_W273_R0.5390.13
73_L102_R0.5390.13
102_R273_R0.5390.13
73_L273_R0.5390.13
102_R110_W0.5390.13
73_L110_W0.5390.13
111_F282_Y0.5360.13
24_D31_I0.5350.13
103_D306_E0.5340.13
205_K294_E0.5340.13
165_T207_K0.5330.13
14_L54_I0.5320.13
57_R112_V0.5320.13
35_L46_V0.5320.13
72_A288_I0.5290.13
111_F128_L0.5270.13
31_I46_V0.5270.13
95_E238_I0.5260.13
56_K286_S0.5210.13
189_S274_E0.5210.13
71_G248_L0.5200.13
74_I325_I0.5170.13
132_V285_Y0.5170.13
37_I106_K0.5150.13
55_I213_L0.5150.13
181_N223_K0.5150.13
149_S152_Y0.5130.13
290_A313_M0.5130.13
61_Y323_P0.5110.13
146_L308_N0.5110.13
194_I284_C0.5090.13
85_K129_L0.5070.13
21_F322_K0.5070.13
290_A317_S0.5070.13
39_E43_L0.5060.13
71_G140_L0.5060.13
33_D252_N0.5050.13
267_A271_V0.5030.13
190_Y205_K0.5020.13
211_D221_Y0.5010.13
60_M74_I0.5010.13
203_A206_Y0.5000.13
248_L258_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.8807 100 0.507 Contact Map
4un1B 1 0.4709 100 0.77 Contact Map
4un1A 1 0.4434 100 0.783 Contact Map
4pcqA 2 0.4465 99.9 0.822 Contact Map
2ia0A 2 0.4281 99.9 0.823 Contact Map
2e1cA 1 0.4465 99.9 0.825 Contact Map
2p5vA 5 0.4709 99.9 0.828 Contact Map
2cg4A 6 0.4434 99.8 0.83 Contact Map
2pn6A 5 0.4465 99.8 0.836 Contact Map
3i4pA 5 0.4557 99.8 0.839 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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