Q980P2 - SULSO - GREMLIN Contacts

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Q980P2 - Probable chorismate mutase (CM)/prephenate dehydratase (PDT) (PheA)

UniProt:	Q980P2	Sequences: MVDADGIYYLGPEGSFTHEAASLFKGKDLKAESTISLVFKRVYERESSIGIVPIENSLEGPVNETLDNLYNYDNIYVIGEIEKKIELVLAARSDNLSQIKRIYSHPHAFNEAREKLKELGFNEYIPVESTSKAAKIVSQDSEAAAICSNFAAKLYNLKVLITISSHNNYTRFIVLSKEMNSNGNKSMILFTVPHKPGALYKVLQVFYEYNINISMIYSRPLKSIPWQYYFYLEYEGGISNREFIEKLVKSTSVLKIKGSFSKLNNDPGF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (257)
Sequences:	3567 (2401)
Seq/√Len:	149.8

ECOLI - PHEA
BACSU - PHEA
HALSA - Q9HN73
SULSO - Q980P2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
149_N	162_T	3.441	1.00
8_Y	47_S	3.238	1.00
104_S	130_T	2.899	1.00
135_K	139_Q	2.880	1.00
38_V	50_G	2.720	1.00
90_A	147_C	2.658	1.00
93_S	158_K	2.622	1.00
99_I	144_A	2.557	1.00
146_I	163_I	2.535	1.00
16_F	87_L	2.533	1.00
95_N	98_Q	2.523	1.00
90_A	134_A	2.444	1.00
152_A	159_V	2.435	1.00
101_R	123_E	2.426	1.00
190_F	232_L	2.407	1.00
134_A	157_L	2.158	1.00
186_S	259_S	2.089	1.00
32_E	41_R	2.084	1.00
132_K	135_K	2.070	1.00
67_D	219_R	2.069	1.00
119_L	122_N	2.060	1.00
8_Y	32_E	2.054	1.00
200_Y	204_Q	2.023	1.00
209_Y	242_E	2.021	1.00
188_I	234_Y	2.001	1.00
108_A	130_T	1.991	1.00
6_G	28_D	1.949	1.00
115_K	161_I	1.939	1.00
101_R	125_I	1.936	1.00
21_A	29_L	1.929	1.00
204_Q	208_E	1.922	1.00
9_Y	31_A	1.878	1.00
187_M	233_E	1.868	1.00
202_V	247_L	1.851	1.00
77_V	173_I	1.846	1.00
245_E	248_V	1.841	1.00
113_R	164_S	1.833	1.00
208_E	246_K	1.814	1.00
78_I	176_S	1.769	1.00
195_K	201_K	1.753	1.00
18_H	150_F	1.742	1.00
206_F	213_I	1.737	1.00
112_A	146_I	1.717	1.00
212_N	235_E	1.716	1.00
187_M	260_F	1.698	1.00
91_A	94_D	1.691	1.00
104_S	109_F	1.656	1.00
54_I	173_I	1.640	1.00
87_L	107_H	1.639	1.00
10_L	129_S	1.637	1.00
9_Y	13_E	1.636	1.00
102_I	122_N	1.623	1.00
102_I	119_L	1.610	1.00
42_V	75_I	1.570	1.00
103_Y	143_A	1.569	1.00
91_A	160_L	1.539	1.00
91_A	158_K	1.528	1.00
90_A	152_A	1.499	1.00
19_E	150_F	1.498	1.00
233_E	260_F	1.472	1.00
45_R	177_K	1.464	1.00
209_Y	246_K	1.458	1.00
18_H	22_S	1.449	1.00
10_L	17_T	1.442	1.00
15_S	131_S	1.435	1.00
109_F	124_Y	1.406	1.00
42_V	50_G	1.404	1.00
25_K	174_V	1.388	1.00
149_N	153_K	1.370	1.00
39_F	175_L	1.368	1.00
52_V	65_T	1.361	1.00
19_E	23_L	1.355	1.00
6_G	30_K	1.349	1.00
43_Y	72_Y	1.343	1.00
114_E	164_S	1.342	1.00
13_E	154_L	1.334	1.00
103_Y	125_I	1.331	1.00
109_F	126_P	1.318	1.00
220_P	228_Y	1.299	1.00
100_K	142_E	1.295	1.00
92_R	158_K	1.291	1.00
128_E	132_K	1.287	1.00
96_L	119_L	1.265	1.00
201_K	207_Y	1.265	1.00
39_F	52_V	1.263	1.00
12_P	129_S	1.257	1.00
40_K	44_E	1.257	1.00
6_G	48_S	1.252	1.00
59_E	110_N	1.236	1.00
102_I	116_L	1.232	1.00
13_E	18_H	1.231	1.00
191_T	253_V	1.224	1.00
221_L	229_Y	1.214	1.00
88_V	149_N	1.206	1.00
51_I	174_V	1.196	1.00
192_V	198_A	1.193	1.00
101_R	143_A	1.187	1.00
80_E	185_K	1.183	1.00
115_K	118_E	1.182	1.00
213_I	234_Y	1.177	1.00
35_I	65_T	1.169	1.00
190_F	202_V	1.166	1.00
205_V	246_K	1.161	1.00
127_V	133_A	1.160	1.00
100_K	123_E	1.159	1.00
115_K	163_I	1.158	1.00
16_F	148_S	1.152	1.00
23_L	81_I	1.146	1.00
236_G	240_N	1.143	1.00
10_L	15_S	1.142	1.00
140_D	143_A	1.136	1.00
94_D	98_Q	1.125	0.99
24_F	174_V	1.118	0.99
99_I	122_N	1.114	0.99
87_L	108_A	1.112	0.99
88_V	159_V	1.110	0.99
21_A	51_I	1.109	0.99
115_K	119_L	1.106	0.99
22_S	150_F	1.102	0.99
103_Y	127_V	1.100	0.99
117_K	124_Y	1.098	0.99
224_I	227_Q	1.084	0.99
50_G	175_L	1.080	0.99
184_N	237_G	1.075	0.99
41_R	46_E	1.073	0.99
90_A	157_L	1.073	0.99
77_V	260_F	1.065	0.99
30_K	47_S	1.061	0.99
181_S	184_N	1.059	0.99
129_S	132_K	1.048	0.99
82_E	169_Y	1.044	0.99
137_V	145_A	1.042	0.99
90_A	159_V	1.041	0.99
192_V	202_V	1.039	0.99
62_V	107_H	1.027	0.99
41_R	47_S	1.026	0.99
42_V	47_S	1.017	0.99
7_I	25_K	1.002	0.99
206_F	243_F	1.002	0.99
49_I	78_I	0.996	0.99
194_H	212_N	0.994	0.99
59_E	62_V	0.991	0.99
43_Y	74_N	0.989	0.99
197_G	212_N	0.984	0.99
92_R	156_N	0.983	0.99
89_L	163_I	0.975	0.99
24_F	79_G	0.974	0.99
95_N	158_K	0.974	0.99
251_T	254_L	0.968	0.98
87_L	112_A	0.961	0.98
132_K	136_I	0.955	0.98
42_V	175_L	0.955	0.98
61_P	217_Y	0.930	0.98
32_E	46_E	0.930	0.98
205_V	209_Y	0.925	0.98
150_F	153_K	0.924	0.98
194_H	227_Q	0.923	0.98
235_E	262_K	0.917	0.98
206_F	247_L	0.917	0.98
25_K	49_I	0.915	0.98
89_L	144_A	0.914	0.98
88_V	162_T	0.911	0.98
66_L	215_M	0.911	0.98
17_T	53_P	0.901	0.98
48_S	177_K	0.901	0.98
12_P	15_S	0.892	0.97
30_K	41_R	0.892	0.97
18_H	29_L	0.884	0.97
118_E	161_I	0.880	0.97
236_G	259_S	0.880	0.97
9_Y	29_L	0.877	0.97
61_P	215_M	0.877	0.97
127_V	136_I	0.875	0.97
79_G	174_V	0.872	0.97
133_A	145_A	0.871	0.97
34_T	37_L	0.870	0.97
136_I	140_D	0.869	0.97
184_N	259_S	0.869	0.97
36_S	117_K	0.862	0.97
15_S	129_S	0.860	0.97
186_S	236_G	0.859	0.97
39_F	75_I	0.854	0.97
94_D	158_K	0.852	0.97
116_L	122_N	0.848	0.96
36_S	71_N	0.847	0.96
8_Y	38_V	0.840	0.96
96_L	115_K	0.829	0.96
37_L	117_K	0.829	0.96
186_S	256_I	0.824	0.96
201_K	204_Q	0.823	0.96
190_F	251_T	0.820	0.96
201_K	250_S	0.819	0.96
182_N	261_S	0.818	0.96
16_F	88_V	0.818	0.96
137_V	140_D	0.817	0.96
6_G	46_E	0.815	0.96
75_I	175_L	0.812	0.95
237_G	259_S	0.811	0.95
91_A	144_A	0.806	0.95
209_Y	243_F	0.806	0.95
240_N	259_S	0.803	0.95
39_F	50_G	0.803	0.95
197_G	230_F	0.801	0.95
114_E	117_K	0.798	0.95
134_A	147_C	0.797	0.95
69_L	173_I	0.797	0.95
147_C	151_A	0.793	0.95
217_Y	233_E	0.792	0.95
149_N	159_V	0.780	0.94
87_L	168_N	0.776	0.94
96_L	161_I	0.766	0.94
197_G	218_S	0.766	0.94
36_S	40_K	0.764	0.94
32_E	47_S	0.763	0.94
223_S	227_Q	0.758	0.93
191_T	229_Y	0.753	0.93
87_L	146_I	0.752	0.93
205_V	250_S	0.745	0.93
87_L	148_S	0.745	0.93
135_K	155_Y	0.742	0.93
215_M	233_E	0.742	0.93
181_S	237_G	0.742	0.93
96_L	160_L	0.739	0.93
16_F	107_H	0.738	0.93
184_N	261_S	0.730	0.92
182_N	237_G	0.730	0.92
36_S	64_E	0.729	0.92
102_I	109_F	0.729	0.92
59_E	107_H	0.725	0.92
238_I	256_I	0.724	0.92
53_P	130_T	0.723	0.92
39_F	72_Y	0.722	0.92
116_L	124_Y	0.722	0.92
74_N	255_K	0.719	0.92
238_I	259_S	0.715	0.91
76_Y	178_E	0.712	0.91
187_M	231_Y	0.712	0.91
93_S	98_Q	0.708	0.91
70_Y	189_L	0.707	0.91
134_A	138_S	0.707	0.91
62_V	110_N	0.704	0.91
70_Y	229_Y	0.703	0.91
211_I	234_Y	0.700	0.90
35_I	68_N	0.698	0.90
49_I	174_V	0.695	0.90
183_G	262_K	0.693	0.90
106_P	126_P	0.689	0.90
92_R	141_S	0.688	0.90
8_Y	41_R	0.686	0.90
40_K	43_Y	0.686	0.90
189_L	229_Y	0.683	0.89
61_P	233_E	0.682	0.89
24_F	81_I	0.678	0.89
5_D	48_S	0.678	0.89
94_D	142_E	0.672	0.89
220_P	226_W	0.670	0.88
71_N	114_E	0.667	0.88
17_T	129_S	0.666	0.88
55_E	228_Y	0.664	0.88
80_E	171_R	0.659	0.88
103_Y	136_I	0.658	0.87
241_R	245_E	0.656	0.87
192_V	216_I	0.656	0.87
25_K	79_G	0.653	0.87
77_V	187_M	0.650	0.87
180_N	239_S	0.646	0.87
98_Q	141_S	0.644	0.86
84_K	169_Y	0.644	0.86
85_I	148_S	0.641	0.86
186_S	237_G	0.640	0.86
238_I	244_I	0.640	0.86
116_L	120_G	0.639	0.86
131_S	134_A	0.638	0.86
14_G	154_L	0.638	0.86
77_V	257_K	0.637	0.86
234_Y	243_F	0.636	0.86
56_N	111_E	0.633	0.85
35_I	64_E	0.633	0.85
150_F	154_L	0.632	0.85
67_D	220_P	0.631	0.85
115_K	120_G	0.631	0.85
96_L	99_I	0.629	0.85
72_Y	75_I	0.628	0.85
136_I	139_Q	0.628	0.85
128_E	135_K	0.627	0.85
199_L	212_N	0.626	0.85
35_I	52_V	0.622	0.84
98_Q	101_R	0.622	0.84
237_G	240_N	0.618	0.84
10_L	131_S	0.617	0.84
37_L	40_K	0.612	0.83
213_I	232_L	0.612	0.83
10_L	35_I	0.609	0.83
138_S	157_L	0.604	0.83
130_T	148_S	0.599	0.82
12_P	135_K	0.598	0.82
203_L	213_I	0.598	0.82
13_E	135_K	0.596	0.82
10_L	132_K	0.596	0.82
86_E	149_N	0.594	0.82
33_S	37_L	0.594	0.82
116_L	146_I	0.593	0.82
246_K	250_S	0.593	0.82
101_R	140_D	0.591	0.81
53_P	107_H	0.591	0.81
191_T	252_S	0.590	0.81
138_S	156_N	0.590	0.81
87_L	111_E	0.587	0.81
82_E	225_P	0.585	0.81
23_L	83_K	0.585	0.81
188_I	244_I	0.583	0.80
81_I	174_V	0.581	0.80
31_A	129_S	0.580	0.80
6_G	47_S	0.579	0.80
58_L	165_S	0.578	0.80
197_G	213_I	0.578	0.80
57_S	107_H	0.578	0.80
17_T	64_E	0.574	0.79
13_E	31_A	0.573	0.79
204_Q	207_Y	0.572	0.79
20_A	81_I	0.567	0.79
16_F	85_I	0.567	0.79
212_N	230_F	0.565	0.78
19_E	83_K	0.564	0.78
151_A	155_Y	0.564	0.78
218_S	228_Y	0.561	0.78
127_V	132_K	0.560	0.78
19_E	22_S	0.557	0.77
17_T	65_T	0.556	0.77
199_L	230_F	0.555	0.77
152_A	156_N	0.555	0.77
186_S	238_I	0.553	0.77
64_E	113_R	0.552	0.77
62_V	105_H	0.550	0.76
198_A	201_K	0.546	0.76
248_V	254_L	0.546	0.76
75_I	177_K	0.544	0.76
213_I	216_I	0.543	0.76
39_F	231_Y	0.541	0.75
185_K	233_E	0.541	0.75
186_S	234_Y	0.541	0.75
91_A	137_V	0.541	0.75
191_T	221_L	0.539	0.75
189_L	255_K	0.537	0.75
202_V	205_V	0.536	0.75
18_H	64_E	0.534	0.74
69_L	189_L	0.533	0.74
194_H	214_S	0.533	0.74
111_E	172_F	0.532	0.74
202_V	251_T	0.532	0.74
94_D	160_L	0.531	0.74
62_V	108_A	0.531	0.74
213_I	230_F	0.530	0.74
210_N	241_R	0.528	0.74
32_E	37_L	0.527	0.73
105_H	203_L	0.526	0.73
53_P	65_T	0.526	0.73
237_G	261_S	0.525	0.73
90_A	155_Y	0.524	0.73
199_L	216_I	0.524	0.73
102_I	124_Y	0.523	0.73
200_Y	207_Y	0.522	0.73
95_N	160_L	0.521	0.73
12_P	132_K	0.521	0.73
58_L	107_H	0.521	0.73
208_E	249_K	0.519	0.72
190_F	254_L	0.518	0.72
91_A	96_L	0.518	0.72
94_D	137_V	0.518	0.72
115_K	122_N	0.516	0.72
222_K	225_P	0.516	0.72
58_L	65_T	0.515	0.72
213_I	218_S	0.515	0.72
54_I	233_E	0.514	0.72
193_P	252_S	0.511	0.71
106_P	127_V	0.511	0.71
62_V	130_T	0.510	0.71
54_I	169_Y	0.509	0.71
212_N	218_S	0.509	0.71
218_S	230_F	0.508	0.71
195_K	198_A	0.506	0.70
129_S	137_V	0.506	0.70
221_L	227_Q	0.504	0.70
128_E	133_A	0.502	0.70
209_Y	213_I	0.500	0.70
27_K	153_K	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qmxA	3	0.9628	100	0.096	Contact Map
3mwbA	3	0.9851	100	0.107	Contact Map
4lubA	2	0.6766	100	0.113	Contact Map
3luyA	2	0.9777	100	0.129	Contact Map
2qmwA	2	0.9405	100	0.134	Contact Map
1phzA	2	0.3717	99.9	0.734	Contact Map
2mdaA	2	0.3346	99.8	0.774	Contact Map
2ko1A	2	0.3234	97.6	0.911	Contact Map
2lvwA	2	0.3457	96.9	0.92	Contact Map
1zpvA	3	0.3123	96.4	0.925	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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