GREMLIN Database
Q980P2 - Probable chorismate mutase (CM)/prephenate dehydratase (PDT) (PheA)
UniProt: Q980P2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (257)
Sequences: 3567 (2401)
Seq/√Len: 149.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_N162_T3.4411.00
8_Y47_S3.2381.00
104_S130_T2.8991.00
135_K139_Q2.8801.00
38_V50_G2.7201.00
90_A147_C2.6581.00
93_S158_K2.6221.00
99_I144_A2.5571.00
146_I163_I2.5351.00
16_F87_L2.5331.00
95_N98_Q2.5231.00
90_A134_A2.4441.00
152_A159_V2.4351.00
101_R123_E2.4261.00
190_F232_L2.4071.00
134_A157_L2.1581.00
186_S259_S2.0891.00
32_E41_R2.0841.00
132_K135_K2.0701.00
67_D219_R2.0691.00
119_L122_N2.0601.00
8_Y32_E2.0541.00
200_Y204_Q2.0231.00
209_Y242_E2.0211.00
188_I234_Y2.0011.00
108_A130_T1.9911.00
6_G28_D1.9491.00
115_K161_I1.9391.00
101_R125_I1.9361.00
21_A29_L1.9291.00
204_Q208_E1.9221.00
9_Y31_A1.8781.00
187_M233_E1.8681.00
202_V247_L1.8511.00
77_V173_I1.8461.00
245_E248_V1.8411.00
113_R164_S1.8331.00
208_E246_K1.8141.00
78_I176_S1.7691.00
195_K201_K1.7531.00
18_H150_F1.7421.00
206_F213_I1.7371.00
112_A146_I1.7171.00
212_N235_E1.7161.00
187_M260_F1.6981.00
91_A94_D1.6911.00
104_S109_F1.6561.00
54_I173_I1.6401.00
87_L107_H1.6391.00
10_L129_S1.6371.00
9_Y13_E1.6361.00
102_I122_N1.6231.00
102_I119_L1.6101.00
42_V75_I1.5701.00
103_Y143_A1.5691.00
91_A160_L1.5391.00
91_A158_K1.5281.00
90_A152_A1.4991.00
19_E150_F1.4981.00
233_E260_F1.4721.00
45_R177_K1.4641.00
209_Y246_K1.4581.00
18_H22_S1.4491.00
10_L17_T1.4421.00
15_S131_S1.4351.00
109_F124_Y1.4061.00
42_V50_G1.4041.00
25_K174_V1.3881.00
149_N153_K1.3701.00
39_F175_L1.3681.00
52_V65_T1.3611.00
19_E23_L1.3551.00
6_G30_K1.3491.00
43_Y72_Y1.3431.00
114_E164_S1.3421.00
13_E154_L1.3341.00
103_Y125_I1.3311.00
109_F126_P1.3181.00
220_P228_Y1.2991.00
100_K142_E1.2951.00
92_R158_K1.2911.00
128_E132_K1.2871.00
96_L119_L1.2651.00
201_K207_Y1.2651.00
39_F52_V1.2631.00
12_P129_S1.2571.00
40_K44_E1.2571.00
6_G48_S1.2521.00
59_E110_N1.2361.00
102_I116_L1.2321.00
13_E18_H1.2311.00
191_T253_V1.2241.00
221_L229_Y1.2141.00
88_V149_N1.2061.00
51_I174_V1.1961.00
192_V198_A1.1931.00
101_R143_A1.1871.00
80_E185_K1.1831.00
115_K118_E1.1821.00
213_I234_Y1.1771.00
35_I65_T1.1691.00
190_F202_V1.1661.00
205_V246_K1.1611.00
127_V133_A1.1601.00
100_K123_E1.1591.00
115_K163_I1.1581.00
16_F148_S1.1521.00
23_L81_I1.1461.00
236_G240_N1.1431.00
10_L15_S1.1421.00
140_D143_A1.1361.00
94_D98_Q1.1250.99
24_F174_V1.1180.99
99_I122_N1.1140.99
87_L108_A1.1120.99
88_V159_V1.1100.99
21_A51_I1.1090.99
115_K119_L1.1060.99
22_S150_F1.1020.99
103_Y127_V1.1000.99
117_K124_Y1.0980.99
224_I227_Q1.0840.99
50_G175_L1.0800.99
184_N237_G1.0750.99
41_R46_E1.0730.99
90_A157_L1.0730.99
77_V260_F1.0650.99
30_K47_S1.0610.99
181_S184_N1.0590.99
129_S132_K1.0480.99
82_E169_Y1.0440.99
137_V145_A1.0420.99
90_A159_V1.0410.99
192_V202_V1.0390.99
62_V107_H1.0270.99
41_R47_S1.0260.99
42_V47_S1.0170.99
7_I25_K1.0020.99
206_F243_F1.0020.99
49_I78_I0.9960.99
194_H212_N0.9940.99
59_E62_V0.9910.99
43_Y74_N0.9890.99
197_G212_N0.9840.99
92_R156_N0.9830.99
89_L163_I0.9750.99
24_F79_G0.9740.99
95_N158_K0.9740.99
251_T254_L0.9680.98
87_L112_A0.9610.98
132_K136_I0.9550.98
42_V175_L0.9550.98
61_P217_Y0.9300.98
32_E46_E0.9300.98
205_V209_Y0.9250.98
150_F153_K0.9240.98
194_H227_Q0.9230.98
235_E262_K0.9170.98
206_F247_L0.9170.98
25_K49_I0.9150.98
89_L144_A0.9140.98
88_V162_T0.9110.98
66_L215_M0.9110.98
17_T53_P0.9010.98
48_S177_K0.9010.98
12_P15_S0.8920.97
30_K41_R0.8920.97
18_H29_L0.8840.97
118_E161_I0.8800.97
236_G259_S0.8800.97
9_Y29_L0.8770.97
61_P215_M0.8770.97
127_V136_I0.8750.97
79_G174_V0.8720.97
133_A145_A0.8710.97
34_T37_L0.8700.97
136_I140_D0.8690.97
184_N259_S0.8690.97
36_S117_K0.8620.97
15_S129_S0.8600.97
186_S236_G0.8590.97
39_F75_I0.8540.97
94_D158_K0.8520.97
116_L122_N0.8480.96
36_S71_N0.8470.96
8_Y38_V0.8400.96
96_L115_K0.8290.96
37_L117_K0.8290.96
186_S256_I0.8240.96
201_K204_Q0.8230.96
190_F251_T0.8200.96
201_K250_S0.8190.96
182_N261_S0.8180.96
16_F88_V0.8180.96
137_V140_D0.8170.96
6_G46_E0.8150.96
75_I175_L0.8120.95
237_G259_S0.8110.95
91_A144_A0.8060.95
209_Y243_F0.8060.95
240_N259_S0.8030.95
39_F50_G0.8030.95
197_G230_F0.8010.95
114_E117_K0.7980.95
134_A147_C0.7970.95
69_L173_I0.7970.95
147_C151_A0.7930.95
217_Y233_E0.7920.95
149_N159_V0.7800.94
87_L168_N0.7760.94
96_L161_I0.7660.94
197_G218_S0.7660.94
36_S40_K0.7640.94
32_E47_S0.7630.94
223_S227_Q0.7580.93
191_T229_Y0.7530.93
87_L146_I0.7520.93
205_V250_S0.7450.93
87_L148_S0.7450.93
135_K155_Y0.7420.93
215_M233_E0.7420.93
181_S237_G0.7420.93
96_L160_L0.7390.93
16_F107_H0.7380.93
184_N261_S0.7300.92
182_N237_G0.7300.92
36_S64_E0.7290.92
102_I109_F0.7290.92
59_E107_H0.7250.92
238_I256_I0.7240.92
53_P130_T0.7230.92
39_F72_Y0.7220.92
116_L124_Y0.7220.92
74_N255_K0.7190.92
238_I259_S0.7150.91
76_Y178_E0.7120.91
187_M231_Y0.7120.91
93_S98_Q0.7080.91
70_Y189_L0.7070.91
134_A138_S0.7070.91
62_V110_N0.7040.91
70_Y229_Y0.7030.91
211_I234_Y0.7000.90
35_I68_N0.6980.90
49_I174_V0.6950.90
183_G262_K0.6930.90
106_P126_P0.6890.90
92_R141_S0.6880.90
8_Y41_R0.6860.90
40_K43_Y0.6860.90
189_L229_Y0.6830.89
61_P233_E0.6820.89
24_F81_I0.6780.89
5_D48_S0.6780.89
94_D142_E0.6720.89
220_P226_W0.6700.88
71_N114_E0.6670.88
17_T129_S0.6660.88
55_E228_Y0.6640.88
80_E171_R0.6590.88
103_Y136_I0.6580.87
241_R245_E0.6560.87
192_V216_I0.6560.87
25_K79_G0.6530.87
77_V187_M0.6500.87
180_N239_S0.6460.87
98_Q141_S0.6440.86
84_K169_Y0.6440.86
85_I148_S0.6410.86
186_S237_G0.6400.86
238_I244_I0.6400.86
116_L120_G0.6390.86
131_S134_A0.6380.86
14_G154_L0.6380.86
77_V257_K0.6370.86
234_Y243_F0.6360.86
56_N111_E0.6330.85
35_I64_E0.6330.85
150_F154_L0.6320.85
67_D220_P0.6310.85
115_K120_G0.6310.85
96_L99_I0.6290.85
72_Y75_I0.6280.85
136_I139_Q0.6280.85
128_E135_K0.6270.85
199_L212_N0.6260.85
35_I52_V0.6220.84
98_Q101_R0.6220.84
237_G240_N0.6180.84
10_L131_S0.6170.84
37_L40_K0.6120.83
213_I232_L0.6120.83
10_L35_I0.6090.83
138_S157_L0.6040.83
130_T148_S0.5990.82
12_P135_K0.5980.82
203_L213_I0.5980.82
13_E135_K0.5960.82
10_L132_K0.5960.82
86_E149_N0.5940.82
33_S37_L0.5940.82
116_L146_I0.5930.82
246_K250_S0.5930.82
101_R140_D0.5910.81
53_P107_H0.5910.81
191_T252_S0.5900.81
138_S156_N0.5900.81
87_L111_E0.5870.81
82_E225_P0.5850.81
23_L83_K0.5850.81
188_I244_I0.5830.80
81_I174_V0.5810.80
31_A129_S0.5800.80
6_G47_S0.5790.80
58_L165_S0.5780.80
197_G213_I0.5780.80
57_S107_H0.5780.80
17_T64_E0.5740.79
13_E31_A0.5730.79
204_Q207_Y0.5720.79
20_A81_I0.5670.79
16_F85_I0.5670.79
212_N230_F0.5650.78
19_E83_K0.5640.78
151_A155_Y0.5640.78
218_S228_Y0.5610.78
127_V132_K0.5600.78
19_E22_S0.5570.77
17_T65_T0.5560.77
199_L230_F0.5550.77
152_A156_N0.5550.77
186_S238_I0.5530.77
64_E113_R0.5520.77
62_V105_H0.5500.76
198_A201_K0.5460.76
248_V254_L0.5460.76
75_I177_K0.5440.76
213_I216_I0.5430.76
39_F231_Y0.5410.75
185_K233_E0.5410.75
186_S234_Y0.5410.75
91_A137_V0.5410.75
191_T221_L0.5390.75
189_L255_K0.5370.75
202_V205_V0.5360.75
18_H64_E0.5340.74
69_L189_L0.5330.74
194_H214_S0.5330.74
111_E172_F0.5320.74
202_V251_T0.5320.74
94_D160_L0.5310.74
62_V108_A0.5310.74
213_I230_F0.5300.74
210_N241_R0.5280.74
32_E37_L0.5270.73
105_H203_L0.5260.73
53_P65_T0.5260.73
237_G261_S0.5250.73
90_A155_Y0.5240.73
199_L216_I0.5240.73
102_I124_Y0.5230.73
200_Y207_Y0.5220.73
95_N160_L0.5210.73
12_P132_K0.5210.73
58_L107_H0.5210.73
208_E249_K0.5190.72
190_F254_L0.5180.72
91_A96_L0.5180.72
94_D137_V0.5180.72
115_K122_N0.5160.72
222_K225_P0.5160.72
58_L65_T0.5150.72
213_I218_S0.5150.72
54_I233_E0.5140.72
193_P252_S0.5110.71
106_P127_V0.5110.71
62_V130_T0.5100.71
54_I169_Y0.5090.71
212_N218_S0.5090.71
218_S230_F0.5080.71
195_K198_A0.5060.70
129_S137_V0.5060.70
221_L227_Q0.5040.70
128_E133_A0.5020.70
209_Y213_I0.5000.70
27_K153_K0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qmxA 3 0.9628 100 0.096 Contact Map
3mwbA 3 0.9851 100 0.107 Contact Map
4lubA 2 0.6766 100 0.113 Contact Map
3luyA 2 0.9777 100 0.129 Contact Map
2qmwA 2 0.9405 100 0.134 Contact Map
1phzA 2 0.3717 99.9 0.734 Contact Map
2mdaA 2 0.3346 99.8 0.774 Contact Map
2ko1A 2 0.3234 97.6 0.911 Contact Map
2lvwA 2 0.3457 96.9 0.92 Contact Map
1zpvA 3 0.3123 96.4 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.