Q980P1 - SULSO - GREMLIN Contacts

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Q980P1 - Threonine dehydratase catabolic (Threonine deaminase) (TdcB)

UniProt:	Q980P1	Sequences: MNYLEYFDRIRLAKEKIEKYVHITPIDYSTTFSRIINAKVYLKLENLQKTGSFKVRGAFNKLLSLKEEEKKNGVIAVSAGNHAQGVAYAASTLNIKSTIVMPETAPASKYLATKSYGAEVVLYGKYLHESMKKAEELIQNTGLIFVHPYSDLDVITGQGTIGLELYDIEPDYVIIPIGGGGLISGISIALKYRFPNVKIIGVQSSSSPSMKVSKDLGRLVEIEPSYSIADGILVKSPSELTFSIINELVDDIVLVDDEEIAEAIVLLLERSKTLAEGAGAAALASLISGKVKVNGIDKKVISLVSGGNIDLSLLSTLTEKFLYRQKRVVKVRVIVPDKPGQLNKVLSYVVKIRGNIIDIVHDRHSSDVLPGYTKIYITFELQSSEAITLLLTNLANEGIDVKIVE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	405 (312)
Sequences:	8202 (4616)
Seq/√Len:	261.3

ECOLI - ILVA DPAL TDCB SDHD TRPB CYSK CYSM DCYD
BACSU - ILVA SDHD TRPB CYSM CYSK THRC MCCA
HALSA - Q9HNH6 Q9HRU4 TRPB Q9HMQ7 Q9HNH0 Q9HQ70
SULSO - Q980P1 TRPB2 TRPB1 Q97ZL6 Q980F2 Q97ZT5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
90_A	97_S	4.038	1.00
133_K	136_E	3.682	1.00
39_K	299_K	3.628	1.00
165_L	301_I	3.490	1.00
173_V	190_L	3.282	1.00
66_K	69_E	3.036	1.00
136_E	140_N	2.988	1.00
100_V	137_L	2.985	1.00
259_E	288_S	2.959	1.00
23_I	168_I	2.935	1.00
64_S	153_D	2.933	1.00
211_K	215_D	2.933	1.00
28_Y	39_K	2.884	1.00
194_F	197_V	2.831	1.00
107_A	111_L	2.811	1.00
205_S	256_D	2.723	1.00
187_S	248_L	2.580	1.00
96_K	119_E	2.565	1.00
198_K	251_D	2.561	1.00
208_P	212_V	2.558	1.00
172_Y	200_I	2.470	1.00
183_I	249_V	2.313	1.00
170_P	301_I	2.310	1.00
61_K	151_D	2.245	1.00
23_I	167_D	2.212	1.00
98_T	119_E	2.194	1.00
232_I	281_A	2.064	1.00
216_L	220_V	2.032	1.00
221_E	236_S	2.007	1.00
103_E	124_G	1.991	1.00
162_G	186_I	1.942	1.00
171_D	298_K	1.935	1.00
191_K	250_D	1.921	1.00
282_A	302_S	1.896	1.00
16_K	60_N	1.868	1.00
256_D	259_E	1.816	1.00
26_I	301_I	1.801	1.00
212_V	215_D	1.797	1.00
20_Y	59_F	1.755	1.00
28_Y	41_Y	1.725	1.00
41_Y	299_K	1.711	1.00
28_Y	33_S	1.679	1.00
200_I	251_D	1.647	1.00
174_I	202_V	1.638	1.00
150_S	239_E	1.636	1.00
200_I	253_V	1.634	1.00
275_A	304_V	1.625	1.00
111_L	114_K	1.611	1.00
110_Y	122_L	1.604	1.00
101_M	113_T	1.601	1.00
137_L	141_T	1.598	1.00
131_M	135_E	1.593	1.00
62_L	93_L	1.590	1.00
183_I	245_I	1.586	1.00
267_L	275_A	1.576	1.00
229_A	260_I	1.571	1.00
264_I	309_I	1.569	1.00
171_D	299_K	1.563	1.00
210_M	237_P	1.560	1.00
40_V	286_L	1.553	1.00
173_V	186_I	1.546	1.00
202_V	285_S	1.544	1.00
110_Y	114_K	1.517	1.00
98_T	121_V	1.498	1.00
217_G	246_N	1.490	1.00
206_S	257_D	1.479	1.00
211_K	254_L	1.472	1.00
208_P	254_L	1.470	1.00
83_A	113_T	1.467	1.00
169_E	299_K	1.446	1.00
147_H	151_D	1.428	1.00
177_I	252_I	1.401	1.00
152_L	240_L	1.399	1.00
135_E	139_Q	1.388	1.00
210_M	245_I	1.368	1.00
155_I	244_I	1.367	1.00
266_L	270_R	1.363	1.00
165_L	170_P	1.361	1.00
26_I	165_L	1.354	1.00
14_K	167_D	1.349	1.00
91_S	97_S	1.348	1.00
70_K	95_I	1.345	1.00
98_T	143_L	1.341	1.00
227_S	233_L	1.341	1.00
172_Y	298_K	1.338	1.00
204_S	232_I	1.330	1.00
212_V	216_L	1.321	1.00
162_G	190_L	1.303	1.00
172_Y	198_K	1.302	1.00
114_K	119_E	1.300	1.00
236_S	239_E	1.291	1.00
161_I	182_L	1.288	1.00
76_A	99_I	1.280	1.00
166_Y	190_L	1.277	1.00
214_K	252_I	1.276	1.00
177_I	183_I	1.266	1.00
268_L	274_L	1.255	1.00
163_L	189_A	1.255	1.00
119_E	141_T	1.244	1.00
101_M	122_L	1.242	1.00
267_L	283_L	1.241	1.00
133_K	137_L	1.238	1.00
174_I	286_L	1.235	1.00
161_I	186_I	1.233	1.00
232_I	278_A	1.229	1.00
201_G	252_I	1.217	1.00
174_I	289_G	1.213	1.00
190_L	197_V	1.212	1.00
266_L	287_I	1.210	1.00
245_I	249_V	1.201	1.00
215_D	251_D	1.201	1.00
15_E	18_E	1.196	1.00
210_M	252_I	1.183	1.00
67_E	70_K	1.182	1.00
75_I	134_A	1.180	1.00
25_P	47_L	1.180	1.00
126_Y	129_E	1.179	1.00
177_I	201_G	1.175	1.00
86_V	97_S	1.169	1.00
289_G	292_K	1.166	1.00
198_K	250_D	1.155	1.00
67_E	71_K	1.148	1.00
240_L	243_S	1.144	1.00
66_K	70_K	1.141	1.00
35_I	266_L	1.138	1.00
187_S	199_I	1.137	1.00
172_Y	300_V	1.135	1.00
176_P	305_S	1.135	1.00
243_S	247_E	1.133	1.00
96_K	143_L	1.125	1.00
103_E	125_K	1.122	1.00
62_L	74_V	1.117	1.00
290_K	293_V	1.109	1.00
208_P	211_K	1.103	1.00
88_Y	92_T	1.103	1.00
198_K	298_K	1.101	1.00
155_I	240_L	1.099	1.00
161_I	303_L	1.094	1.00
175_I	186_I	1.089	1.00
243_S	246_N	1.086	1.00
30_T	34_R	1.079	1.00
135_E	138_I	1.079	1.00
110_Y	120_V	1.072	1.00
132_K	136_E	1.072	1.00
211_K	252_I	1.068	1.00
212_V	220_V	1.065	1.00
186_I	303_L	1.063	1.00
129_E	132_K	1.062	1.00
177_I	210_M	1.052	1.00
38_A	300_V	1.051	1.00
46_N	273_T	1.042	1.00
123_Y	133_K	1.030	1.00
163_L	167_D	1.029	1.00
11_R	193_R	1.027	1.00
228_I	261_A	1.026	1.00
16_K	63_L	1.021	1.00
134_A	138_I	1.015	1.00
279_G	305_S	1.014	1.00
63_L	93_L	1.014	1.00
263_A	284_A	1.012	1.00
166_Y	194_F	1.008	1.00
267_L	304_V	1.004	1.00
105_A	230_D	1.002	1.00
100_V	133_K	0.997	1.00
253_V	285_S	0.995	1.00
111_L	115_S	0.994	1.00
264_I	280_A	0.993	1.00
261_A	317_L	0.992	1.00
31_T	270_R	0.991	1.00
21_V	55_V	0.988	1.00
50_T	88_Y	0.982	1.00
36_I	287_I	0.980	1.00
183_I	201_G	0.978	1.00
78_S	83_A	0.969	1.00
70_K	93_L	0.967	1.00
75_I	137_L	0.960	1.00
31_T	34_R	0.957	1.00
134_A	145_F	0.955	1.00
156_T	159_G	0.955	1.00
219_L	239_E	0.951	1.00
263_A	283_L	0.948	1.00
32_F	283_L	0.946	1.00
75_I	143_L	0.945	1.00
59_F	63_L	0.940	1.00
251_D	292_K	0.940	1.00
61_K	153_D	0.933	1.00
162_G	189_A	0.930	1.00
155_I	188_I	0.928	1.00
69_E	144_I	0.923	1.00
137_L	143_L	0.922	1.00
159_G	163_L	0.918	1.00
22_H	49_K	0.915	1.00
242_F	246_N	0.915	1.00
113_T	118_A	0.910	1.00
289_G	293_V	0.907	1.00
127_L	131_M	0.905	1.00
260_I	281_A	0.897	1.00
44_L	304_V	0.895	1.00
268_L	314_L	0.890	1.00
55_V	88_Y	0.890	1.00
42_L	304_V	0.887	1.00
61_K	146_V	0.885	1.00
121_V	133_K	0.884	1.00
175_I	183_I	0.881	1.00
231_G	278_A	0.879	1.00
11_R	163_L	0.879	1.00
61_K	154_V	0.873	1.00
206_S	226_Y	0.871	1.00
125_K	129_E	0.871	1.00
209_S	213_S	0.867	1.00
33_S	39_K	0.859	1.00
77_V	127_L	0.859	1.00
174_I	285_S	0.852	1.00
14_K	163_L	0.852	1.00
91_S	116_Y	0.846	0.99
264_I	314_L	0.846	0.99
27_D	44_L	0.845	0.99
171_D	297_D	0.843	0.99
136_E	139_Q	0.843	0.99
205_S	254_L	0.838	0.99
265_V	269_E	0.836	0.99
87_A	118_A	0.833	0.99
42_L	267_L	0.827	0.99
213_S	219_L	0.822	0.99
20_Y	63_L	0.821	0.99
97_S	118_A	0.820	0.99
35_I	270_R	0.817	0.99
183_I	199_I	0.817	0.99
261_A	277_G	0.816	0.99
11_R	14_K	0.806	0.99
127_L	148_P	0.804	0.99
161_I	165_L	0.801	0.99
258_E	262_E	0.797	0.99
61_K	64_S	0.794	0.99
38_A	298_K	0.786	0.99
24_T	48_Q	0.786	0.99
84_Q	113_T	0.785	0.99
239_E	243_S	0.785	0.99
286_L	302_S	0.784	0.99
143_L	184_S	0.784	0.99
206_S	225_S	0.781	0.99
74_V	95_I	0.779	0.99
66_K	95_I	0.774	0.99
283_L	302_S	0.773	0.99
73_G	143_L	0.772	0.99
262_E	266_L	0.767	0.99
79_A	231_G	0.765	0.99
86_V	99_I	0.764	0.99
77_V	145_F	0.764	0.99
201_G	249_V	0.760	0.99
17_I	20_Y	0.755	0.99
62_L	86_V	0.755	0.99
69_E	72_N	0.753	0.99
170_P	197_V	0.752	0.99
16_K	64_S	0.752	0.99
11_R	15_E	0.750	0.99
39_K	297_D	0.749	0.99
259_E	290_K	0.749	0.99
255_V	284_A	0.748	0.99
154_V	158_Q	0.748	0.99
294_N	298_K	0.746	0.99
259_E	262_E	0.746	0.99
77_V	134_A	0.744	0.99
213_S	220_V	0.743	0.99
14_K	18_E	0.737	0.99
68_E	72_N	0.735	0.99
21_V	48_Q	0.735	0.99
213_S	217_G	0.734	0.99
191_K	248_L	0.732	0.98
112_A	115_S	0.731	0.98
100_V	123_Y	0.728	0.98
313_L	316_T	0.727	0.98
109_K	230_D	0.727	0.98
176_P	282_A	0.723	0.98
98_T	141_T	0.722	0.98
72_N	142_G	0.721	0.98
32_F	42_L	0.721	0.98
65_L	69_E	0.719	0.98
191_K	199_I	0.718	0.98
174_I	200_I	0.717	0.98
70_K	73_G	0.715	0.98
98_T	137_L	0.713	0.98
105_A	110_Y	0.713	0.98
112_A	270_R	0.708	0.98
34_R	37_N	0.707	0.98
108_S	311_L	0.705	0.98
49_K	88_Y	0.704	0.98
214_K	219_L	0.704	0.98
82_H	158_Q	0.700	0.98
73_G	98_T	0.698	0.98
259_E	284_A	0.698	0.98
285_S	289_G	0.698	0.98
44_L	273_T	0.697	0.98
169_E	194_F	0.696	0.98
12_L	16_K	0.696	0.98
244_I	248_L	0.694	0.98
60_N	64_S	0.692	0.98
264_I	317_L	0.692	0.98
128_H	235_K	0.690	0.98
222_I	225_S	0.688	0.98
219_L	242_F	0.684	0.98
293_V	298_K	0.681	0.98
219_L	236_S	0.681	0.98
167_D	193_R	0.679	0.98
218_R	242_F	0.675	0.97
257_D	260_I	0.675	0.97
61_K	69_E	0.672	0.97
58_A	85_G	0.671	0.97
63_L	67_E	0.670	0.97
55_V	92_T	0.669	0.97
188_I	244_I	0.668	0.97
60_N	63_L	0.664	0.97
124_G	129_E	0.662	0.97
36_I	286_L	0.662	0.97
26_I	41_Y	0.662	0.97
128_H	132_K	0.661	0.97
76_A	86_V	0.660	0.97
18_E	23_I	0.660	0.97
73_G	96_K	0.660	0.97
184_S	244_I	0.659	0.97
96_K	141_T	0.657	0.97
17_I	59_F	0.657	0.97
256_D	288_S	0.656	0.97
101_M	120_V	0.656	0.97
12_L	15_E	0.653	0.97
260_I	280_A	0.653	0.97
312_S	316_T	0.653	0.97
66_K	144_I	0.651	0.97
166_Y	189_A	0.650	0.97
190_L	194_F	0.649	0.97
66_K	73_G	0.648	0.97
137_L	140_N	0.648	0.97
188_I	192_Y	0.647	0.97
209_S	237_P	0.640	0.97
184_S	241_T	0.639	0.96
13_A	60_N	0.639	0.96
31_T	271_S	0.635	0.96
214_K	245_I	0.634	0.96
72_N	96_K	0.628	0.96
286_L	290_K	0.628	0.96
83_A	99_I	0.627	0.96
278_A	281_A	0.627	0.96
35_I	287_I	0.627	0.96
66_K	71_K	0.626	0.96
279_G	304_V	0.624	0.96
61_K	144_I	0.622	0.96
103_E	122_L	0.619	0.96
21_V	59_F	0.618	0.96
189_A	193_R	0.617	0.96
11_R	167_D	0.617	0.96
22_H	48_Q	0.612	0.96
152_L	156_T	0.612	0.96
214_K	246_N	0.611	0.95
10_I	189_A	0.610	0.95
61_K	147_H	0.607	0.95
59_F	92_T	0.607	0.95
213_S	216_L	0.606	0.95
38_A	297_D	0.606	0.95
29_S	271_S	0.605	0.95
210_M	214_K	0.604	0.95
275_A	279_G	0.602	0.95
15_E	19_K	0.602	0.95
172_Y	293_V	0.599	0.95
129_E	133_K	0.598	0.95
79_A	127_L	0.597	0.95
203_Q	211_K	0.597	0.95
131_M	149_Y	0.589	0.94
121_V	137_L	0.588	0.94
12_L	64_S	0.588	0.94
186_I	199_I	0.588	0.94
46_N	307_G	0.585	0.94
312_S	315_S	0.582	0.94
202_V	253_V	0.582	0.94
213_S	237_P	0.581	0.94
203_Q	209_S	0.581	0.94
207_S	225_S	0.581	0.94
47_L	273_T	0.580	0.94
127_L	130_S	0.580	0.94
162_G	166_Y	0.579	0.94
62_L	95_I	0.578	0.94
86_V	146_V	0.578	0.94
132_K	135_E	0.577	0.94
207_S	222_I	0.577	0.94
60_N	156_T	0.576	0.94
316_T	319_E	0.574	0.94
114_K	122_L	0.574	0.94
178_G	234_V	0.571	0.94
107_A	110_Y	0.571	0.94
202_V	281_A	0.570	0.93
100_V	130_S	0.569	0.93
264_I	278_A	0.569	0.93
75_I	138_I	0.568	0.93
65_L	70_K	0.566	0.93
166_Y	193_R	0.564	0.93
107_A	114_K	0.564	0.93
213_S	242_F	0.564	0.93
315_S	319_E	0.564	0.93
70_K	144_I	0.562	0.93
162_G	165_L	0.562	0.93
222_I	226_Y	0.562	0.93
91_S	118_A	0.559	0.93
204_S	260_I	0.559	0.93
191_K	196_N	0.559	0.93
149_Y	238_S	0.558	0.93
215_D	218_R	0.557	0.93
42_L	283_L	0.555	0.93
201_G	210_M	0.555	0.93
88_Y	116_Y	0.555	0.93
263_A	287_I	0.553	0.92
65_L	73_G	0.552	0.92
74_V	97_S	0.552	0.92
175_I	199_I	0.551	0.92
42_L	275_A	0.550	0.92
216_L	219_L	0.550	0.92
169_E	196_N	0.549	0.92
32_F	40_V	0.549	0.92
170_P	299_K	0.549	0.92
184_S	245_I	0.549	0.92
169_E	197_V	0.548	0.92
173_V	199_I	0.548	0.92
76_A	145_F	0.547	0.92
165_L	186_I	0.547	0.92
82_H	146_V	0.546	0.92
46_N	304_V	0.545	0.92
155_I	241_T	0.542	0.92
26_I	168_I	0.541	0.92
275_A	280_A	0.541	0.92
200_I	250_D	0.540	0.92
37_N	294_N	0.539	0.91
315_S	318_T	0.536	0.91
100_V	121_V	0.534	0.91
223_E	226_Y	0.534	0.91
276_E	306_G	0.534	0.91
69_E	73_G	0.534	0.91
293_V	300_V	0.533	0.91
84_Q	112_A	0.533	0.91
108_S	312_S	0.530	0.91
49_K	272_K	0.530	0.91
150_S	219_L	0.530	0.91
291_V	294_N	0.529	0.91
255_V	281_A	0.525	0.90
29_S	42_L	0.525	0.90
10_I	188_I	0.525	0.90
284_A	288_S	0.524	0.90
288_S	291_V	0.524	0.90
79_A	149_Y	0.522	0.90
103_E	123_Y	0.521	0.90
255_V	285_S	0.520	0.90
228_I	257_D	0.519	0.90
316_T	321_F	0.519	0.90
34_R	115_S	0.519	0.90
68_E	71_K	0.519	0.90
229_A	232_I	0.518	0.90
261_A	320_K	0.515	0.90
38_A	294_N	0.515	0.90
173_V	197_V	0.514	0.89
36_I	266_L	0.514	0.89
83_A	101_M	0.511	0.89
314_L	318_T	0.509	0.89
262_E	288_S	0.509	0.89
112_A	116_Y	0.508	0.89
186_I	190_L	0.508	0.89
36_I	290_K	0.507	0.89
26_I	170_P	0.505	0.89
262_E	321_F	0.505	0.89
174_I	291_V	0.502	0.88
72_N	144_I	0.500	0.88
78_S	276_E	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1tdjA	2	0.9802	100	0.177	Contact Map
2gn0A	2	0.7877	100	0.337	Contact Map
1v71A	2	0.7802	100	0.344	Contact Map
3ss7X	1	0.7951	100	0.367	Contact Map
3l6bA	2	0.7852	100	0.369	Contact Map
1ve5A	3	0.7432	100	0.37	Contact Map
3iauA	1	0.7901	100	0.375	Contact Map
4h27A	1	0.7531	100	0.385	Contact Map
2rkbA	2	0.7556	100	0.388	Contact Map
4d9iA	2	0.7926	100	0.391	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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