GREMLIN Database
Q980P1 - Threonine dehydratase catabolic (Threonine deaminase) (TdcB)
UniProt: Q980P1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 405 (312)
Sequences: 8202 (4616)
Seq/√Len: 261.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_A97_S4.0381.00
133_K136_E3.6821.00
39_K299_K3.6281.00
165_L301_I3.4901.00
173_V190_L3.2821.00
66_K69_E3.0361.00
136_E140_N2.9881.00
100_V137_L2.9851.00
259_E288_S2.9591.00
23_I168_I2.9351.00
64_S153_D2.9331.00
211_K215_D2.9331.00
28_Y39_K2.8841.00
194_F197_V2.8311.00
107_A111_L2.8111.00
205_S256_D2.7231.00
187_S248_L2.5801.00
96_K119_E2.5651.00
198_K251_D2.5611.00
208_P212_V2.5581.00
172_Y200_I2.4701.00
183_I249_V2.3131.00
170_P301_I2.3101.00
61_K151_D2.2451.00
23_I167_D2.2121.00
98_T119_E2.1941.00
232_I281_A2.0641.00
216_L220_V2.0321.00
221_E236_S2.0071.00
103_E124_G1.9911.00
162_G186_I1.9421.00
171_D298_K1.9351.00
191_K250_D1.9211.00
282_A302_S1.8961.00
16_K60_N1.8681.00
256_D259_E1.8161.00
26_I301_I1.8011.00
212_V215_D1.7971.00
20_Y59_F1.7551.00
28_Y41_Y1.7251.00
41_Y299_K1.7111.00
28_Y33_S1.6791.00
200_I251_D1.6471.00
174_I202_V1.6381.00
150_S239_E1.6361.00
200_I253_V1.6341.00
275_A304_V1.6251.00
111_L114_K1.6111.00
110_Y122_L1.6041.00
101_M113_T1.6011.00
137_L141_T1.5981.00
131_M135_E1.5931.00
62_L93_L1.5901.00
183_I245_I1.5861.00
267_L275_A1.5761.00
229_A260_I1.5711.00
264_I309_I1.5691.00
171_D299_K1.5631.00
210_M237_P1.5601.00
40_V286_L1.5531.00
173_V186_I1.5461.00
202_V285_S1.5441.00
110_Y114_K1.5171.00
98_T121_V1.4981.00
217_G246_N1.4901.00
206_S257_D1.4791.00
211_K254_L1.4721.00
208_P254_L1.4701.00
83_A113_T1.4671.00
169_E299_K1.4461.00
147_H151_D1.4281.00
177_I252_I1.4011.00
152_L240_L1.3991.00
135_E139_Q1.3881.00
210_M245_I1.3681.00
155_I244_I1.3671.00
266_L270_R1.3631.00
165_L170_P1.3611.00
26_I165_L1.3541.00
14_K167_D1.3491.00
91_S97_S1.3481.00
70_K95_I1.3451.00
98_T143_L1.3411.00
227_S233_L1.3411.00
172_Y298_K1.3381.00
204_S232_I1.3301.00
212_V216_L1.3211.00
162_G190_L1.3031.00
172_Y198_K1.3021.00
114_K119_E1.3001.00
236_S239_E1.2911.00
161_I182_L1.2881.00
76_A99_I1.2801.00
166_Y190_L1.2771.00
214_K252_I1.2761.00
177_I183_I1.2661.00
268_L274_L1.2551.00
163_L189_A1.2551.00
119_E141_T1.2441.00
101_M122_L1.2421.00
267_L283_L1.2411.00
133_K137_L1.2381.00
174_I286_L1.2351.00
161_I186_I1.2331.00
232_I278_A1.2291.00
201_G252_I1.2171.00
174_I289_G1.2131.00
190_L197_V1.2121.00
266_L287_I1.2101.00
245_I249_V1.2011.00
215_D251_D1.2011.00
15_E18_E1.1961.00
210_M252_I1.1831.00
67_E70_K1.1821.00
75_I134_A1.1801.00
25_P47_L1.1801.00
126_Y129_E1.1791.00
177_I201_G1.1751.00
86_V97_S1.1691.00
289_G292_K1.1661.00
198_K250_D1.1551.00
67_E71_K1.1481.00
240_L243_S1.1441.00
66_K70_K1.1411.00
35_I266_L1.1381.00
187_S199_I1.1371.00
172_Y300_V1.1351.00
176_P305_S1.1351.00
243_S247_E1.1331.00
96_K143_L1.1251.00
103_E125_K1.1221.00
62_L74_V1.1171.00
290_K293_V1.1091.00
208_P211_K1.1031.00
88_Y92_T1.1031.00
198_K298_K1.1011.00
155_I240_L1.0991.00
161_I303_L1.0941.00
175_I186_I1.0891.00
243_S246_N1.0861.00
30_T34_R1.0791.00
135_E138_I1.0791.00
110_Y120_V1.0721.00
132_K136_E1.0721.00
211_K252_I1.0681.00
212_V220_V1.0651.00
186_I303_L1.0631.00
129_E132_K1.0621.00
177_I210_M1.0521.00
38_A300_V1.0511.00
46_N273_T1.0421.00
123_Y133_K1.0301.00
163_L167_D1.0291.00
11_R193_R1.0271.00
228_I261_A1.0261.00
16_K63_L1.0211.00
134_A138_I1.0151.00
279_G305_S1.0141.00
63_L93_L1.0141.00
263_A284_A1.0121.00
166_Y194_F1.0081.00
267_L304_V1.0041.00
105_A230_D1.0021.00
100_V133_K0.9971.00
253_V285_S0.9951.00
111_L115_S0.9941.00
264_I280_A0.9931.00
261_A317_L0.9921.00
31_T270_R0.9911.00
21_V55_V0.9881.00
50_T88_Y0.9821.00
36_I287_I0.9801.00
183_I201_G0.9781.00
78_S83_A0.9691.00
70_K93_L0.9671.00
75_I137_L0.9601.00
31_T34_R0.9571.00
134_A145_F0.9551.00
156_T159_G0.9551.00
219_L239_E0.9511.00
263_A283_L0.9481.00
32_F283_L0.9461.00
75_I143_L0.9451.00
59_F63_L0.9401.00
251_D292_K0.9401.00
61_K153_D0.9331.00
162_G189_A0.9301.00
155_I188_I0.9281.00
69_E144_I0.9231.00
137_L143_L0.9221.00
159_G163_L0.9181.00
22_H49_K0.9151.00
242_F246_N0.9151.00
113_T118_A0.9101.00
289_G293_V0.9071.00
127_L131_M0.9051.00
260_I281_A0.8971.00
44_L304_V0.8951.00
268_L314_L0.8901.00
55_V88_Y0.8901.00
42_L304_V0.8871.00
61_K146_V0.8851.00
121_V133_K0.8841.00
175_I183_I0.8811.00
231_G278_A0.8791.00
11_R163_L0.8791.00
61_K154_V0.8731.00
206_S226_Y0.8711.00
125_K129_E0.8711.00
209_S213_S0.8671.00
33_S39_K0.8591.00
77_V127_L0.8591.00
174_I285_S0.8521.00
14_K163_L0.8521.00
91_S116_Y0.8460.99
264_I314_L0.8460.99
27_D44_L0.8450.99
171_D297_D0.8430.99
136_E139_Q0.8430.99
205_S254_L0.8380.99
265_V269_E0.8360.99
87_A118_A0.8330.99
42_L267_L0.8270.99
213_S219_L0.8220.99
20_Y63_L0.8210.99
97_S118_A0.8200.99
35_I270_R0.8170.99
183_I199_I0.8170.99
261_A277_G0.8160.99
11_R14_K0.8060.99
127_L148_P0.8040.99
161_I165_L0.8010.99
258_E262_E0.7970.99
61_K64_S0.7940.99
38_A298_K0.7860.99
24_T48_Q0.7860.99
84_Q113_T0.7850.99
239_E243_S0.7850.99
286_L302_S0.7840.99
143_L184_S0.7840.99
206_S225_S0.7810.99
74_V95_I0.7790.99
66_K95_I0.7740.99
283_L302_S0.7730.99
73_G143_L0.7720.99
262_E266_L0.7670.99
79_A231_G0.7650.99
86_V99_I0.7640.99
77_V145_F0.7640.99
201_G249_V0.7600.99
17_I20_Y0.7550.99
62_L86_V0.7550.99
69_E72_N0.7530.99
170_P197_V0.7520.99
16_K64_S0.7520.99
11_R15_E0.7500.99
39_K297_D0.7490.99
259_E290_K0.7490.99
255_V284_A0.7480.99
154_V158_Q0.7480.99
294_N298_K0.7460.99
259_E262_E0.7460.99
77_V134_A0.7440.99
213_S220_V0.7430.99
14_K18_E0.7370.99
68_E72_N0.7350.99
21_V48_Q0.7350.99
213_S217_G0.7340.99
191_K248_L0.7320.98
112_A115_S0.7310.98
100_V123_Y0.7280.98
313_L316_T0.7270.98
109_K230_D0.7270.98
176_P282_A0.7230.98
98_T141_T0.7220.98
72_N142_G0.7210.98
32_F42_L0.7210.98
65_L69_E0.7190.98
191_K199_I0.7180.98
174_I200_I0.7170.98
70_K73_G0.7150.98
98_T137_L0.7130.98
105_A110_Y0.7130.98
112_A270_R0.7080.98
34_R37_N0.7070.98
108_S311_L0.7050.98
49_K88_Y0.7040.98
214_K219_L0.7040.98
82_H158_Q0.7000.98
73_G98_T0.6980.98
259_E284_A0.6980.98
285_S289_G0.6980.98
44_L273_T0.6970.98
169_E194_F0.6960.98
12_L16_K0.6960.98
244_I248_L0.6940.98
60_N64_S0.6920.98
264_I317_L0.6920.98
128_H235_K0.6900.98
222_I225_S0.6880.98
219_L242_F0.6840.98
293_V298_K0.6810.98
219_L236_S0.6810.98
167_D193_R0.6790.98
218_R242_F0.6750.97
257_D260_I0.6750.97
61_K69_E0.6720.97
58_A85_G0.6710.97
63_L67_E0.6700.97
55_V92_T0.6690.97
188_I244_I0.6680.97
60_N63_L0.6640.97
124_G129_E0.6620.97
36_I286_L0.6620.97
26_I41_Y0.6620.97
128_H132_K0.6610.97
76_A86_V0.6600.97
18_E23_I0.6600.97
73_G96_K0.6600.97
184_S244_I0.6590.97
96_K141_T0.6570.97
17_I59_F0.6570.97
256_D288_S0.6560.97
101_M120_V0.6560.97
12_L15_E0.6530.97
260_I280_A0.6530.97
312_S316_T0.6530.97
66_K144_I0.6510.97
166_Y189_A0.6500.97
190_L194_F0.6490.97
66_K73_G0.6480.97
137_L140_N0.6480.97
188_I192_Y0.6470.97
209_S237_P0.6400.97
184_S241_T0.6390.96
13_A60_N0.6390.96
31_T271_S0.6350.96
214_K245_I0.6340.96
72_N96_K0.6280.96
286_L290_K0.6280.96
83_A99_I0.6270.96
278_A281_A0.6270.96
35_I287_I0.6270.96
66_K71_K0.6260.96
279_G304_V0.6240.96
61_K144_I0.6220.96
103_E122_L0.6190.96
21_V59_F0.6180.96
189_A193_R0.6170.96
11_R167_D0.6170.96
22_H48_Q0.6120.96
152_L156_T0.6120.96
214_K246_N0.6110.95
10_I189_A0.6100.95
61_K147_H0.6070.95
59_F92_T0.6070.95
213_S216_L0.6060.95
38_A297_D0.6060.95
29_S271_S0.6050.95
210_M214_K0.6040.95
275_A279_G0.6020.95
15_E19_K0.6020.95
172_Y293_V0.5990.95
129_E133_K0.5980.95
79_A127_L0.5970.95
203_Q211_K0.5970.95
131_M149_Y0.5890.94
121_V137_L0.5880.94
12_L64_S0.5880.94
186_I199_I0.5880.94
46_N307_G0.5850.94
312_S315_S0.5820.94
202_V253_V0.5820.94
213_S237_P0.5810.94
203_Q209_S0.5810.94
207_S225_S0.5810.94
47_L273_T0.5800.94
127_L130_S0.5800.94
162_G166_Y0.5790.94
62_L95_I0.5780.94
86_V146_V0.5780.94
132_K135_E0.5770.94
207_S222_I0.5770.94
60_N156_T0.5760.94
316_T319_E0.5740.94
114_K122_L0.5740.94
178_G234_V0.5710.94
107_A110_Y0.5710.94
202_V281_A0.5700.93
100_V130_S0.5690.93
264_I278_A0.5690.93
75_I138_I0.5680.93
65_L70_K0.5660.93
166_Y193_R0.5640.93
107_A114_K0.5640.93
213_S242_F0.5640.93
315_S319_E0.5640.93
70_K144_I0.5620.93
162_G165_L0.5620.93
222_I226_Y0.5620.93
91_S118_A0.5590.93
204_S260_I0.5590.93
191_K196_N0.5590.93
149_Y238_S0.5580.93
215_D218_R0.5570.93
42_L283_L0.5550.93
201_G210_M0.5550.93
88_Y116_Y0.5550.93
263_A287_I0.5530.92
65_L73_G0.5520.92
74_V97_S0.5520.92
175_I199_I0.5510.92
42_L275_A0.5500.92
216_L219_L0.5500.92
169_E196_N0.5490.92
32_F40_V0.5490.92
170_P299_K0.5490.92
184_S245_I0.5490.92
169_E197_V0.5480.92
173_V199_I0.5480.92
76_A145_F0.5470.92
165_L186_I0.5470.92
82_H146_V0.5460.92
46_N304_V0.5450.92
155_I241_T0.5420.92
26_I168_I0.5410.92
275_A280_A0.5410.92
200_I250_D0.5400.92
37_N294_N0.5390.91
315_S318_T0.5360.91
100_V121_V0.5340.91
223_E226_Y0.5340.91
276_E306_G0.5340.91
69_E73_G0.5340.91
293_V300_V0.5330.91
84_Q112_A0.5330.91
108_S312_S0.5300.91
49_K272_K0.5300.91
150_S219_L0.5300.91
291_V294_N0.5290.91
255_V281_A0.5250.90
29_S42_L0.5250.90
10_I188_I0.5250.90
284_A288_S0.5240.90
288_S291_V0.5240.90
79_A149_Y0.5220.90
103_E123_Y0.5210.90
255_V285_S0.5200.90
228_I257_D0.5190.90
316_T321_F0.5190.90
34_R115_S0.5190.90
68_E71_K0.5190.90
229_A232_I0.5180.90
261_A320_K0.5150.90
38_A294_N0.5150.90
173_V197_V0.5140.89
36_I266_L0.5140.89
83_A101_M0.5110.89
314_L318_T0.5090.89
262_E288_S0.5090.89
112_A116_Y0.5080.89
186_I190_L0.5080.89
36_I290_K0.5070.89
26_I170_P0.5050.89
262_E321_F0.5050.89
174_I291_V0.5020.88
72_N144_I0.5000.88
78_S276_E0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tdjA 2 0.9802 100 0.177 Contact Map
2gn0A 2 0.7877 100 0.337 Contact Map
1v71A 2 0.7802 100 0.344 Contact Map
3ss7X 1 0.7951 100 0.367 Contact Map
3l6bA 2 0.7852 100 0.369 Contact Map
1ve5A 3 0.7432 100 0.37 Contact Map
3iauA 1 0.7901 100 0.375 Contact Map
4h27A 1 0.7531 100 0.385 Contact Map
2rkbA 2 0.7556 100 0.388 Contact Map
4d9iA 2 0.7926 100 0.391 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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