GREMLIN Database
Q980N8 - Proliferating-cell nucleolar antigen p120 homolog
UniProt: Q980N8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (295)
Sequences: 7036 (5106)
Seq/√Len: 297.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_E286_E3.6491.00
248_L282_F3.6131.00
141_D212_K3.2241.00
280_V336_L3.1301.00
33_F58_C3.0141.00
213_I258_L2.9441.00
290_K337_K2.8781.00
263_Y335_L2.8691.00
263_Y337_K2.7411.00
144_L210_F2.7041.00
255_Y289_M2.6561.00
200_L249_S2.5931.00
248_L279_I2.5421.00
211_D259_K2.5161.00
258_L264_I2.4721.00
40_R274_E2.4631.00
292_M337_K2.4151.00
74_D77_K2.3561.00
255_Y283_A2.3391.00
44_M273_P2.2331.00
166_L193_V2.1911.00
184_V192_V2.1851.00
318_C332_F2.1841.00
215_L250_L2.1191.00
168_I210_F2.1191.00
163_N191_N2.1141.00
146_M254_A2.1051.00
92_V126_L2.0901.00
252_E287_L2.0741.00
161_M165_G2.0701.00
222_E270_S2.0041.00
35_D39_E1.9601.00
46_S51_L1.9411.00
73_T78_L1.9351.00
79_E99_Y1.9231.00
265_V335_L1.8851.00
92_V98_G1.8751.00
78_L121_Y1.8641.00
154_T169_A1.8631.00
138_S141_D1.8321.00
81_I120_Y1.8071.00
283_A287_L1.7821.00
292_M335_L1.7591.00
142_F166_L1.7531.00
171_E177_I1.7531.00
283_A289_M1.7451.00
98_G129_M1.7221.00
90_E102_K1.7091.00
268_T276_D1.6791.00
66_I121_Y1.6721.00
282_F286_E1.6671.00
50_E324_H1.6611.00
72_K188_G1.6551.00
277_E320_R1.6471.00
132_A156_Q1.6151.00
137_P141_D1.6141.00
244_A279_I1.6021.00
222_E272_A1.5941.00
114_L118_M1.5871.00
40_R272_A1.5711.00
155_T187_L1.5631.00
177_I194_L1.5581.00
157_L214_L1.5541.00
281_N285_E1.5421.00
79_E89_L1.5391.00
291_A334_C1.5321.00
38_I55_L1.5271.00
158_S189_A1.5111.00
148_A180_L1.4821.00
70_T97_H1.4601.00
70_T159_Q1.4391.00
51_L55_L1.4361.00
42_L51_L1.4281.00
65_S100_V1.4041.00
273_P278_L1.3891.00
251_I283_A1.3811.00
177_I196_K1.3671.00
255_Y264_I1.3511.00
291_A318_C1.3511.00
256_E287_L1.3381.00
278_L281_N1.3311.00
75_C91_K1.3311.00
135_L212_K1.3301.00
127_A328_T1.3291.00
178_R181_L1.3271.00
85_K115_E1.3191.00
33_F55_L1.3181.00
189_A192_V1.3021.00
133_Y160_I1.2791.00
251_I264_I1.2601.00
248_L286_E1.2431.00
135_L157_L1.2421.00
68_C78_L1.2371.00
156_Q160_I1.2351.00
134_V333_L1.2301.00
147_A215_L1.2291.00
73_T120_Y1.2271.00
274_E278_L1.2241.00
245_H249_S1.2071.00
168_I195_I1.1951.00
241_R274_E1.1921.00
65_S126_L1.1891.00
253_I256_E1.1831.00
212_K263_Y1.1741.00
148_A154_T1.1721.00
154_T167_V1.1721.00
56_N60_F1.1701.00
137_P161_M1.1691.00
280_V284_I1.1651.00
142_F168_I1.1621.00
142_F210_F1.1611.00
170_V195_I1.1421.00
248_L252_E1.1381.00
41_Y272_A1.1361.00
293_S317_N1.1331.00
142_F209_Q1.1261.00
45_F322_F1.1201.00
136_N263_Y1.1181.00
154_T184_V1.1101.00
41_Y55_L1.1051.00
318_C334_C1.1051.00
284_I291_A1.1021.00
321_F328_T1.1001.00
203_I253_I1.0981.00
139_Y162_Q1.0951.00
258_L338_K1.0891.00
131_P333_L1.0871.00
199_A250_L1.0851.00
161_M164_K1.0851.00
95_L126_L1.0821.00
52_E56_N1.0691.00
115_E121_Y1.0661.00
131_P156_Q1.0651.00
155_T184_V1.0651.00
155_T183_N1.0631.00
66_I101_V1.0621.00
122_H155_T1.0621.00
240_L244_A1.0601.00
139_Y164_K1.0571.00
90_E100_V1.0561.00
95_L98_G1.0531.00
50_E325_K1.0491.00
79_E91_K1.0421.00
88_V102_K1.0301.00
174_R196_K1.0281.00
80_E83_L1.0271.00
220_S243_F1.0261.00
97_H133_Y1.0261.00
39_E43_N1.0251.00
214_L267_S1.0221.00
40_R237_M1.0191.00
38_I51_L1.0131.00
53_E56_N0.9991.00
75_C99_Y0.9971.00
136_N212_K0.9941.00
115_E120_Y0.9891.00
96_Q133_Y0.9801.00
263_Y292_M0.9751.00
273_P277_E0.9741.00
135_L265_V0.9731.00
146_M199_A0.9681.00
89_L99_Y0.9601.00
132_A157_L0.9521.00
157_L212_K0.9501.00
94_W126_L0.9441.00
68_C75_C0.9391.00
60_F327_G0.9371.00
72_K120_Y0.9321.00
137_P157_L0.9301.00
244_A248_L0.9301.00
236_T239_D0.9261.00
137_P160_I0.9241.00
157_L167_V0.9181.00
148_A169_A0.9161.00
253_I257_L0.9161.00
242_D246_L0.9101.00
131_P267_S0.9071.00
125_G226_Q0.9061.00
239_D242_D0.9051.00
197_T201_N0.9011.00
217_A250_L0.8991.00
122_H183_N0.8991.00
158_S191_N0.8961.00
252_E282_F0.8951.00
42_L47_T0.8911.00
80_E84_E0.8871.00
40_R44_M0.8851.00
255_Y287_L0.8841.00
137_P143_V0.8821.00
146_M215_L0.8811.00
31_Y38_I0.8801.00
197_T202_L0.8751.00
235_T239_D0.8731.00
36_Y237_M0.8711.00
69_N72_K0.8681.00
225_I231_R0.8671.00
75_C79_E0.8621.00
143_V212_K0.8601.00
170_V202_L0.8571.00
162_Q165_G0.8571.00
127_A321_F0.8551.00
144_L170_V0.8541.00
92_V95_L0.8501.00
146_M170_V0.8501.00
71_L189_A0.8481.00
135_L214_L0.8471.00
122_H159_Q0.8411.00
85_K114_L0.8401.00
50_E53_E0.8381.00
128_S331_F0.8381.00
246_L249_S0.8331.00
31_Y55_L0.8311.00
181_L194_L0.8271.00
265_V333_L0.8211.00
289_M338_K0.8191.00
98_G126_L0.8181.00
30_K52_E0.8171.00
279_I282_F0.8131.00
181_L185_N0.8121.00
321_F326_Q0.8101.00
224_L228_D0.8091.00
213_I254_A0.8091.00
143_V165_G0.8081.00
158_S167_V0.8071.00
46_S50_E0.8051.00
146_M213_I0.8051.00
248_L283_A0.8011.00
37_M41_Y0.7991.00
76_K80_E0.7991.00
54_Y271_V0.7940.99
215_L254_A0.7940.99
37_M272_A0.7910.99
41_Y51_L0.7840.99
200_L250_L0.7780.99
29_S32_R0.7780.99
168_I193_V0.7760.99
175_S178_R0.7730.99
220_S240_L0.7640.99
131_P265_V0.7620.99
294_V298_P0.7600.99
32_R59_S0.7600.99
78_L82_M0.7580.99
175_S179_A0.7580.99
136_N160_I0.7560.99
65_S92_V0.7560.99
255_Y258_L0.7550.99
284_I336_L0.7540.99
177_I180_L0.7530.99
144_L213_I0.7520.99
79_E83_L0.7470.99
33_F38_I0.7380.99
143_V161_M0.7330.99
39_E42_L0.7330.99
146_M250_L0.7310.99
78_L81_I0.7310.99
202_L257_L0.7230.99
258_L289_M0.7230.99
313_N316_K0.7220.99
37_M222_E0.7210.99
37_M225_I0.7210.99
182_S186_R0.7210.99
202_L206_N0.7200.99
282_F285_E0.7200.99
67_R159_Q0.7190.99
299_A302_G0.7180.99
170_V197_T0.7150.99
92_V100_V0.7150.99
154_T192_V0.7140.99
59_S232_R0.7140.99
143_V157_L0.7140.99
73_T81_I0.7130.99
125_G227_K0.7120.99
159_Q189_A0.7120.99
67_R155_T0.7100.99
244_A274_E0.7080.99
41_Y46_S0.7040.99
68_C99_Y0.7040.99
130_V321_F0.7030.99
95_L133_Y0.7010.99
182_S185_N0.7000.99
77_K80_E0.6990.99
125_G329_E0.6990.99
215_L251_I0.6980.99
71_L163_N0.6920.99
284_I288_G0.6920.99
114_L117_L0.6920.99
280_V291_A0.6920.99
238_D242_D0.6830.98
54_Y324_H0.6820.98
237_M241_R0.6820.98
289_M336_L0.6810.98
203_I257_L0.6810.98
134_V294_V0.6800.98
241_R244_A0.6780.98
62_L227_K0.6780.98
140_D164_K0.6760.98
323_P330_G0.6750.98
230_T234_K0.6750.98
315_V318_C0.6730.98
87_F113_T0.6730.98
67_R124_Q0.6720.98
141_D211_D0.6720.98
314_D317_N0.6710.98
277_E281_N0.6710.98
258_L262_G0.6660.98
213_I264_I0.6640.98
97_H156_Q0.6620.98
201_N204_N0.6620.98
144_L257_L0.6580.98
200_L246_L0.6580.98
38_I42_L0.6570.98
50_E54_Y0.6570.98
299_A319_L0.6570.98
119_G186_R0.6560.98
136_N141_D0.6530.98
142_F259_K0.6520.98
243_F246_L0.6490.98
170_V199_A0.6480.98
33_F59_S0.6460.98
83_L88_V0.6450.98
81_I115_E0.6420.98
264_I283_A0.6410.98
78_L115_E0.6390.98
139_Y161_M0.6380.98
127_A131_P0.6380.98
138_S212_K0.6370.98
122_H187_L0.6340.98
77_K81_I0.6320.97
109_S112_S0.6320.97
225_I232_R0.6270.97
141_D263_Y0.6260.97
179_A182_S0.6250.97
291_A336_L0.6240.97
251_I282_F0.6220.97
207_K256_E0.6170.97
171_E231_R0.6170.97
150_P176_R0.6160.97
73_T77_K0.6160.97
284_I287_L0.6160.97
313_N317_N0.6130.97
42_L46_S0.6120.97
66_I123_I0.6090.97
163_N190_E0.6080.97
63_K100_V0.6050.97
85_K113_T0.6050.97
171_E180_L0.6040.97
184_V187_L0.6030.97
164_K191_N0.6000.97
157_L165_G0.5980.96
71_L162_Q0.5980.96
271_V330_G0.5950.96
75_C98_G0.5940.96
134_V137_P0.5940.96
36_Y39_E0.5910.96
244_A272_A0.5890.96
282_F287_L0.5860.96
71_L159_Q0.5860.96
242_D245_H0.5860.96
66_I99_Y0.5850.96
44_M274_E0.5830.96
75_C78_L0.5830.96
202_L207_K0.5820.96
81_I85_K0.5820.96
169_A192_V0.5800.96
227_K329_E0.5790.96
216_D269_C0.5780.96
83_L87_F0.5770.96
256_E260_K0.5750.96
180_L194_L0.5720.95
116_Y119_G0.5710.95
144_L168_I0.5700.95
178_R182_S0.5700.95
202_L253_I0.5680.95
134_V319_L0.5660.95
207_K257_L0.5660.95
291_A332_F0.5650.95
31_Y52_E0.5630.95
291_A294_V0.5620.95
83_L89_L0.5620.95
174_R178_R0.5600.95
172_K246_L0.5600.95
320_R323_P0.5600.95
313_N318_C0.5580.95
183_N186_R0.5570.95
241_R245_H0.5570.95
57_S60_F0.5570.95
294_V297_Y0.5570.95
247_Q266_Y0.5560.95
239_D243_F0.5560.95
278_L282_F0.5540.95
322_F325_K0.5530.95
252_E256_E0.5520.95
70_T75_C0.5510.94
295_E298_P0.5500.94
184_V189_A0.5480.94
132_A160_I0.5460.94
126_L328_T0.5450.94
170_V194_L0.5440.94
161_M191_N0.5430.94
116_Y186_R0.5420.94
317_N332_F0.5410.94
76_K91_K0.5400.94
97_H160_I0.5400.94
167_V189_A0.5400.94
254_A264_I0.5400.94
62_L226_Q0.5380.94
184_V194_L0.5370.94
51_L54_Y0.5370.94
91_K99_Y0.5360.94
276_D320_R0.5360.94
240_L272_A0.5330.93
324_H328_T0.5330.93
41_Y45_F0.5310.93
161_M167_V0.5310.93
47_T50_E0.5300.93
32_R233_Y0.5300.93
170_V196_K0.5280.93
276_D322_F0.5260.93
153_K216_D0.5250.93
89_L101_V0.5210.93
281_N318_C0.5190.93
40_R43_N0.5190.93
54_Y58_C0.5160.92
280_V332_F0.5160.92
294_V319_L0.5160.92
222_E225_I0.5150.92
65_S98_G0.5150.92
47_T52_E0.5150.92
197_T203_I0.5150.92
319_L323_P0.5090.92
319_L333_L0.5090.92
171_E184_V0.5080.92
291_A317_N0.5050.92
216_D219_C0.5050.92
67_R156_Q0.5050.92
294_V335_L0.5050.92
159_Q187_L0.5040.91
132_A135_L0.5030.91
244_A282_F0.5030.91
58_C271_V0.5020.91
198_D253_I0.5020.91
93_K126_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2frxA 1 0.8496 100 0.277 Contact Map
2yxlA 1 0.9322 100 0.284 Contact Map
1ixkA 1 0.8997 100 0.285 Contact Map
3m4xA 1 0.8614 100 0.307 Contact Map
3m6wA 2 0.8761 100 0.313 Contact Map
1sqgA 1 0.9115 100 0.321 Contact Map
2b9eA 1 0.7463 100 0.351 Contact Map
3ajdA 1 0.7375 100 0.426 Contact Map
4fzvA 1 0.8968 100 0.454 Contact Map
2vdvE 2 0.5752 99.9 0.749 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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