Q980N8 - SULSO - GREMLIN Contacts

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Q980N8 - Proliferating-cell nucleolar antigen p120 homolog

UniProt:	Q980N8	Sequences: MENRIAKYLSAHYNLFQISPSYKAKRLASKYRFLDYMIERYLNMFSTEEELEEYLNSCSFPLKKSIRCNTLKTDCKKLEEIMLEKGFVLEKVKWLQHGYVVKRTPPKPSLGSTLEYLMGYYHIQGLASMVPAYVLNPSYDDFVLDMAAAPGGKTTQLSQIMQNKGLVIAVEKKRSRIRALLSNVNRLGAENVVLIKTDALNLININKSQFDKILLDAPCSGEGLIQKDPTRRYKTTMDDLRDFAHLQLSLIEIAYELLKKGGYIVYSTCSVAPEEDELIVNFAIEELGMKAMSVEGYPASNGYIEYYTTRFSNDVKNCLRFFPHKQGTEGFFLCLLKKE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	339 (295)
Sequences:	7036 (5106)
Seq/√Len:	297.3

ECOLI - RSMF RSMB
BACSU - RSMB
HALSA - Q9HRX7
SULSO - Q980N8 Q980Z5 Q980E2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
252_E	286_E	3.649	1.00
248_L	282_F	3.613	1.00
141_D	212_K	3.224	1.00
280_V	336_L	3.130	1.00
33_F	58_C	3.014	1.00
213_I	258_L	2.944	1.00
290_K	337_K	2.878	1.00
263_Y	335_L	2.869	1.00
263_Y	337_K	2.741	1.00
144_L	210_F	2.704	1.00
255_Y	289_M	2.656	1.00
200_L	249_S	2.593	1.00
248_L	279_I	2.542	1.00
211_D	259_K	2.516	1.00
258_L	264_I	2.472	1.00
40_R	274_E	2.463	1.00
292_M	337_K	2.415	1.00
74_D	77_K	2.356	1.00
255_Y	283_A	2.339	1.00
44_M	273_P	2.233	1.00
166_L	193_V	2.191	1.00
184_V	192_V	2.185	1.00
318_C	332_F	2.184	1.00
215_L	250_L	2.119	1.00
168_I	210_F	2.119	1.00
163_N	191_N	2.114	1.00
146_M	254_A	2.105	1.00
92_V	126_L	2.090	1.00
252_E	287_L	2.074	1.00
161_M	165_G	2.070	1.00
222_E	270_S	2.004	1.00
35_D	39_E	1.960	1.00
46_S	51_L	1.941	1.00
73_T	78_L	1.935	1.00
79_E	99_Y	1.923	1.00
265_V	335_L	1.885	1.00
92_V	98_G	1.875	1.00
78_L	121_Y	1.864	1.00
154_T	169_A	1.863	1.00
138_S	141_D	1.832	1.00
81_I	120_Y	1.807	1.00
283_A	287_L	1.782	1.00
292_M	335_L	1.759	1.00
142_F	166_L	1.753	1.00
171_E	177_I	1.753	1.00
283_A	289_M	1.745	1.00
98_G	129_M	1.722	1.00
90_E	102_K	1.709	1.00
268_T	276_D	1.679	1.00
66_I	121_Y	1.672	1.00
282_F	286_E	1.667	1.00
50_E	324_H	1.661	1.00
72_K	188_G	1.655	1.00
277_E	320_R	1.647	1.00
132_A	156_Q	1.615	1.00
137_P	141_D	1.614	1.00
244_A	279_I	1.602	1.00
222_E	272_A	1.594	1.00
114_L	118_M	1.587	1.00
40_R	272_A	1.571	1.00
155_T	187_L	1.563	1.00
177_I	194_L	1.558	1.00
157_L	214_L	1.554	1.00
281_N	285_E	1.542	1.00
79_E	89_L	1.539	1.00
291_A	334_C	1.532	1.00
38_I	55_L	1.527	1.00
158_S	189_A	1.511	1.00
148_A	180_L	1.482	1.00
70_T	97_H	1.460	1.00
70_T	159_Q	1.439	1.00
51_L	55_L	1.436	1.00
42_L	51_L	1.428	1.00
65_S	100_V	1.404	1.00
273_P	278_L	1.389	1.00
251_I	283_A	1.381	1.00
177_I	196_K	1.367	1.00
255_Y	264_I	1.351	1.00
291_A	318_C	1.351	1.00
256_E	287_L	1.338	1.00
278_L	281_N	1.331	1.00
75_C	91_K	1.331	1.00
135_L	212_K	1.330	1.00
127_A	328_T	1.329	1.00
178_R	181_L	1.327	1.00
85_K	115_E	1.319	1.00
33_F	55_L	1.318	1.00
189_A	192_V	1.302	1.00
133_Y	160_I	1.279	1.00
251_I	264_I	1.260	1.00
248_L	286_E	1.243	1.00
135_L	157_L	1.242	1.00
68_C	78_L	1.237	1.00
156_Q	160_I	1.235	1.00
134_V	333_L	1.230	1.00
147_A	215_L	1.229	1.00
73_T	120_Y	1.227	1.00
274_E	278_L	1.224	1.00
245_H	249_S	1.207	1.00
168_I	195_I	1.195	1.00
241_R	274_E	1.192	1.00
65_S	126_L	1.189	1.00
253_I	256_E	1.183	1.00
212_K	263_Y	1.174	1.00
148_A	154_T	1.172	1.00
154_T	167_V	1.172	1.00
56_N	60_F	1.170	1.00
137_P	161_M	1.169	1.00
280_V	284_I	1.165	1.00
142_F	168_I	1.162	1.00
142_F	210_F	1.161	1.00
170_V	195_I	1.142	1.00
248_L	252_E	1.138	1.00
41_Y	272_A	1.136	1.00
293_S	317_N	1.133	1.00
142_F	209_Q	1.126	1.00
45_F	322_F	1.120	1.00
136_N	263_Y	1.118	1.00
154_T	184_V	1.110	1.00
41_Y	55_L	1.105	1.00
318_C	334_C	1.105	1.00
284_I	291_A	1.102	1.00
321_F	328_T	1.100	1.00
203_I	253_I	1.098	1.00
139_Y	162_Q	1.095	1.00
258_L	338_K	1.089	1.00
131_P	333_L	1.087	1.00
199_A	250_L	1.085	1.00
161_M	164_K	1.085	1.00
95_L	126_L	1.082	1.00
52_E	56_N	1.069	1.00
115_E	121_Y	1.066	1.00
131_P	156_Q	1.065	1.00
155_T	184_V	1.065	1.00
155_T	183_N	1.063	1.00
66_I	101_V	1.062	1.00
122_H	155_T	1.062	1.00
240_L	244_A	1.060	1.00
139_Y	164_K	1.057	1.00
90_E	100_V	1.056	1.00
95_L	98_G	1.053	1.00
50_E	325_K	1.049	1.00
79_E	91_K	1.042	1.00
88_V	102_K	1.030	1.00
174_R	196_K	1.028	1.00
80_E	83_L	1.027	1.00
220_S	243_F	1.026	1.00
97_H	133_Y	1.026	1.00
39_E	43_N	1.025	1.00
214_L	267_S	1.022	1.00
40_R	237_M	1.019	1.00
38_I	51_L	1.013	1.00
53_E	56_N	0.999	1.00
75_C	99_Y	0.997	1.00
136_N	212_K	0.994	1.00
115_E	120_Y	0.989	1.00
96_Q	133_Y	0.980	1.00
263_Y	292_M	0.975	1.00
273_P	277_E	0.974	1.00
135_L	265_V	0.973	1.00
146_M	199_A	0.968	1.00
89_L	99_Y	0.960	1.00
132_A	157_L	0.952	1.00
157_L	212_K	0.950	1.00
94_W	126_L	0.944	1.00
68_C	75_C	0.939	1.00
60_F	327_G	0.937	1.00
72_K	120_Y	0.932	1.00
137_P	157_L	0.930	1.00
244_A	248_L	0.930	1.00
236_T	239_D	0.926	1.00
137_P	160_I	0.924	1.00
157_L	167_V	0.918	1.00
148_A	169_A	0.916	1.00
253_I	257_L	0.916	1.00
242_D	246_L	0.910	1.00
131_P	267_S	0.907	1.00
125_G	226_Q	0.906	1.00
239_D	242_D	0.905	1.00
197_T	201_N	0.901	1.00
217_A	250_L	0.899	1.00
122_H	183_N	0.899	1.00
158_S	191_N	0.896	1.00
252_E	282_F	0.895	1.00
42_L	47_T	0.891	1.00
80_E	84_E	0.887	1.00
40_R	44_M	0.885	1.00
255_Y	287_L	0.884	1.00
137_P	143_V	0.882	1.00
146_M	215_L	0.881	1.00
31_Y	38_I	0.880	1.00
197_T	202_L	0.875	1.00
235_T	239_D	0.873	1.00
36_Y	237_M	0.871	1.00
69_N	72_K	0.868	1.00
225_I	231_R	0.867	1.00
75_C	79_E	0.862	1.00
143_V	212_K	0.860	1.00
170_V	202_L	0.857	1.00
162_Q	165_G	0.857	1.00
127_A	321_F	0.855	1.00
144_L	170_V	0.854	1.00
92_V	95_L	0.850	1.00
146_M	170_V	0.850	1.00
71_L	189_A	0.848	1.00
135_L	214_L	0.847	1.00
122_H	159_Q	0.841	1.00
85_K	114_L	0.840	1.00
50_E	53_E	0.838	1.00
128_S	331_F	0.838	1.00
246_L	249_S	0.833	1.00
31_Y	55_L	0.831	1.00
181_L	194_L	0.827	1.00
265_V	333_L	0.821	1.00
289_M	338_K	0.819	1.00
98_G	126_L	0.818	1.00
30_K	52_E	0.817	1.00
279_I	282_F	0.813	1.00
181_L	185_N	0.812	1.00
321_F	326_Q	0.810	1.00
224_L	228_D	0.809	1.00
213_I	254_A	0.809	1.00
143_V	165_G	0.808	1.00
158_S	167_V	0.807	1.00
46_S	50_E	0.805	1.00
146_M	213_I	0.805	1.00
248_L	283_A	0.801	1.00
37_M	41_Y	0.799	1.00
76_K	80_E	0.799	1.00
54_Y	271_V	0.794	0.99
215_L	254_A	0.794	0.99
37_M	272_A	0.791	0.99
41_Y	51_L	0.784	0.99
200_L	250_L	0.778	0.99
29_S	32_R	0.778	0.99
168_I	193_V	0.776	0.99
175_S	178_R	0.773	0.99
220_S	240_L	0.764	0.99
131_P	265_V	0.762	0.99
294_V	298_P	0.760	0.99
32_R	59_S	0.760	0.99
78_L	82_M	0.758	0.99
175_S	179_A	0.758	0.99
136_N	160_I	0.756	0.99
65_S	92_V	0.756	0.99
255_Y	258_L	0.755	0.99
284_I	336_L	0.754	0.99
177_I	180_L	0.753	0.99
144_L	213_I	0.752	0.99
79_E	83_L	0.747	0.99
33_F	38_I	0.738	0.99
143_V	161_M	0.733	0.99
39_E	42_L	0.733	0.99
146_M	250_L	0.731	0.99
78_L	81_I	0.731	0.99
202_L	257_L	0.723	0.99
258_L	289_M	0.723	0.99
313_N	316_K	0.722	0.99
37_M	222_E	0.721	0.99
37_M	225_I	0.721	0.99
182_S	186_R	0.721	0.99
202_L	206_N	0.720	0.99
282_F	285_E	0.720	0.99
67_R	159_Q	0.719	0.99
299_A	302_G	0.718	0.99
170_V	197_T	0.715	0.99
92_V	100_V	0.715	0.99
154_T	192_V	0.714	0.99
59_S	232_R	0.714	0.99
143_V	157_L	0.714	0.99
73_T	81_I	0.713	0.99
125_G	227_K	0.712	0.99
159_Q	189_A	0.712	0.99
67_R	155_T	0.710	0.99
244_A	274_E	0.708	0.99
41_Y	46_S	0.704	0.99
68_C	99_Y	0.704	0.99
130_V	321_F	0.703	0.99
95_L	133_Y	0.701	0.99
182_S	185_N	0.700	0.99
77_K	80_E	0.699	0.99
125_G	329_E	0.699	0.99
215_L	251_I	0.698	0.99
71_L	163_N	0.692	0.99
284_I	288_G	0.692	0.99
114_L	117_L	0.692	0.99
280_V	291_A	0.692	0.99
238_D	242_D	0.683	0.98
54_Y	324_H	0.682	0.98
237_M	241_R	0.682	0.98
289_M	336_L	0.681	0.98
203_I	257_L	0.681	0.98
134_V	294_V	0.680	0.98
241_R	244_A	0.678	0.98
62_L	227_K	0.678	0.98
140_D	164_K	0.676	0.98
323_P	330_G	0.675	0.98
230_T	234_K	0.675	0.98
315_V	318_C	0.673	0.98
87_F	113_T	0.673	0.98
67_R	124_Q	0.672	0.98
141_D	211_D	0.672	0.98
314_D	317_N	0.671	0.98
277_E	281_N	0.671	0.98
258_L	262_G	0.666	0.98
213_I	264_I	0.664	0.98
97_H	156_Q	0.662	0.98
201_N	204_N	0.662	0.98
144_L	257_L	0.658	0.98
200_L	246_L	0.658	0.98
38_I	42_L	0.657	0.98
50_E	54_Y	0.657	0.98
299_A	319_L	0.657	0.98
119_G	186_R	0.656	0.98
136_N	141_D	0.653	0.98
142_F	259_K	0.652	0.98
243_F	246_L	0.649	0.98
170_V	199_A	0.648	0.98
33_F	59_S	0.646	0.98
83_L	88_V	0.645	0.98
81_I	115_E	0.642	0.98
264_I	283_A	0.641	0.98
78_L	115_E	0.639	0.98
139_Y	161_M	0.638	0.98
127_A	131_P	0.638	0.98
138_S	212_K	0.637	0.98
122_H	187_L	0.634	0.98
77_K	81_I	0.632	0.97
109_S	112_S	0.632	0.97
225_I	232_R	0.627	0.97
141_D	263_Y	0.626	0.97
179_A	182_S	0.625	0.97
291_A	336_L	0.624	0.97
251_I	282_F	0.622	0.97
207_K	256_E	0.617	0.97
171_E	231_R	0.617	0.97
150_P	176_R	0.616	0.97
73_T	77_K	0.616	0.97
284_I	287_L	0.616	0.97
313_N	317_N	0.613	0.97
42_L	46_S	0.612	0.97
66_I	123_I	0.609	0.97
163_N	190_E	0.608	0.97
63_K	100_V	0.605	0.97
85_K	113_T	0.605	0.97
171_E	180_L	0.604	0.97
184_V	187_L	0.603	0.97
164_K	191_N	0.600	0.97
157_L	165_G	0.598	0.96
71_L	162_Q	0.598	0.96
271_V	330_G	0.595	0.96
75_C	98_G	0.594	0.96
134_V	137_P	0.594	0.96
36_Y	39_E	0.591	0.96
244_A	272_A	0.589	0.96
282_F	287_L	0.586	0.96
71_L	159_Q	0.586	0.96
242_D	245_H	0.586	0.96
66_I	99_Y	0.585	0.96
44_M	274_E	0.583	0.96
75_C	78_L	0.583	0.96
202_L	207_K	0.582	0.96
81_I	85_K	0.582	0.96
169_A	192_V	0.580	0.96
227_K	329_E	0.579	0.96
216_D	269_C	0.578	0.96
83_L	87_F	0.577	0.96
256_E	260_K	0.575	0.96
180_L	194_L	0.572	0.95
116_Y	119_G	0.571	0.95
144_L	168_I	0.570	0.95
178_R	182_S	0.570	0.95
202_L	253_I	0.568	0.95
134_V	319_L	0.566	0.95
207_K	257_L	0.566	0.95
291_A	332_F	0.565	0.95
31_Y	52_E	0.563	0.95
291_A	294_V	0.562	0.95
83_L	89_L	0.562	0.95
174_R	178_R	0.560	0.95
172_K	246_L	0.560	0.95
320_R	323_P	0.560	0.95
313_N	318_C	0.558	0.95
183_N	186_R	0.557	0.95
241_R	245_H	0.557	0.95
57_S	60_F	0.557	0.95
294_V	297_Y	0.557	0.95
247_Q	266_Y	0.556	0.95
239_D	243_F	0.556	0.95
278_L	282_F	0.554	0.95
322_F	325_K	0.553	0.95
252_E	256_E	0.552	0.95
70_T	75_C	0.551	0.94
295_E	298_P	0.550	0.94
184_V	189_A	0.548	0.94
132_A	160_I	0.546	0.94
126_L	328_T	0.545	0.94
170_V	194_L	0.544	0.94
161_M	191_N	0.543	0.94
116_Y	186_R	0.542	0.94
317_N	332_F	0.541	0.94
76_K	91_K	0.540	0.94
97_H	160_I	0.540	0.94
167_V	189_A	0.540	0.94
254_A	264_I	0.540	0.94
62_L	226_Q	0.538	0.94
184_V	194_L	0.537	0.94
51_L	54_Y	0.537	0.94
91_K	99_Y	0.536	0.94
276_D	320_R	0.536	0.94
240_L	272_A	0.533	0.93
324_H	328_T	0.533	0.93
41_Y	45_F	0.531	0.93
161_M	167_V	0.531	0.93
47_T	50_E	0.530	0.93
32_R	233_Y	0.530	0.93
170_V	196_K	0.528	0.93
276_D	322_F	0.526	0.93
153_K	216_D	0.525	0.93
89_L	101_V	0.521	0.93
281_N	318_C	0.519	0.93
40_R	43_N	0.519	0.93
54_Y	58_C	0.516	0.92
280_V	332_F	0.516	0.92
294_V	319_L	0.516	0.92
222_E	225_I	0.515	0.92
65_S	98_G	0.515	0.92
47_T	52_E	0.515	0.92
197_T	203_I	0.515	0.92
319_L	323_P	0.509	0.92
319_L	333_L	0.509	0.92
171_E	184_V	0.508	0.92
291_A	317_N	0.505	0.92
216_D	219_C	0.505	0.92
67_R	156_Q	0.505	0.92
294_V	335_L	0.505	0.92
159_Q	187_L	0.504	0.91
132_A	135_L	0.503	0.91
244_A	282_F	0.503	0.91
58_C	271_V	0.502	0.91
198_D	253_I	0.502	0.91
93_K	126_L	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2frxA	1	0.8496	100	0.277	Contact Map
2yxlA	1	0.9322	100	0.284	Contact Map
1ixkA	1	0.8997	100	0.285	Contact Map
3m4xA	1	0.8614	100	0.307	Contact Map
3m6wA	2	0.8761	100	0.313	Contact Map
1sqgA	1	0.9115	100	0.321	Contact Map
2b9eA	1	0.7463	100	0.351	Contact Map
3ajdA	1	0.7375	100	0.426	Contact Map
4fzvA	1	0.8968	100	0.454	Contact Map
2vdvE	2	0.5752	99.9	0.749	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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