GREMLIN Database
Q980N7 - Adenylate cyclase, cyaB-type, putative (CyaB)
UniProt: Q980N7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (170)
Sequences: 628 (507)
Seq/√Len: 38.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_E7_K6.8401.00
19_R111_I5.1091.00
39_F92_I3.2611.00
110_R123_D2.8741.00
107_K126_K2.8181.00
14_S17_E2.6311.00
26_M115_D2.4941.00
61_G84_T2.4211.00
7_K10_V2.2871.00
165_K173_D2.1410.99
22_L120_V2.0300.99
134_I149_T1.9720.99
83_I94_L1.9550.99
35_E107_K1.8880.98
129_G167_Y1.8730.98
124_L130_Q1.8310.98
68_G78_R1.8290.98
3_E9_V1.8230.98
64_L95_L1.8220.98
83_I86_N1.7940.97
81_I90_K1.7680.97
34_Q110_R1.7340.97
8_I153_I1.7180.97
2_I7_K1.6770.96
78_R166_S1.6690.96
41_Y100_F1.6270.95
120_V134_I1.6040.95
52_A168_L1.6010.95
40_N46_F1.5970.95
52_A78_R1.5780.95
153_I158_I1.5570.94
55_I85_V1.5280.94
33_K107_K1.4980.93
120_V132_I1.4840.93
34_Q58_N1.4750.92
15_L122_L1.4660.92
50_D70_K1.4320.91
128_L171_L1.4090.91
34_Q123_D1.4040.90
52_A68_G1.3930.90
3_E10_V1.3530.89
40_N158_I1.3520.89
54_R135_E1.3440.88
123_D166_S1.3290.88
18_L132_I1.3280.88
22_L26_M1.3270.88
87_D90_K1.3250.88
125_V128_L1.3200.87
108_K167_Y1.3050.87
38_Y128_L1.2750.85
76_K123_D1.2690.85
54_R80_E1.2690.85
85_V91_T1.2570.85
20_E24_K1.2570.85
31_V111_I1.2560.85
83_I90_K1.2480.84
36_D108_K1.2460.84
54_R65_T1.2400.84
44_R103_V1.2350.84
40_N45_N1.2340.84
134_I153_I1.2320.83
53_V98_I1.2290.83
36_D125_V1.2260.83
36_D106_I1.2210.83
8_I162_L1.2180.83
54_R82_S1.2030.82
118_F152_F1.1990.82
36_D128_L1.1840.81
46_F49_T1.1800.81
65_T99_G1.1720.80
54_R67_K1.1590.79
38_Y168_L1.0970.76
67_K80_E1.0970.76
92_I96_R1.0930.75
76_K166_S1.0820.75
52_A70_K1.0760.74
106_I171_L1.0690.74
15_L170_L1.0640.73
106_I110_R1.0600.73
108_K129_G1.0550.73
36_D167_Y1.0550.73
34_Q106_I1.0480.72
36_D129_G1.0330.71
65_T82_S1.0320.71
17_E21_S1.0260.71
42_V101_Y1.0220.70
38_Y125_V1.0080.69
52_A76_K1.0070.69
78_R168_L0.9900.68
48_I101_Y0.9900.68
50_D78_R0.9800.67
136_A145_I0.9780.67
16_E151_N0.9700.66
55_I91_T0.9700.66
78_R110_R0.9620.66
78_R123_D0.9470.64
63_E82_S0.9330.63
4_K138_N0.9310.63
25_D107_K0.9290.63
13_P161_K0.9190.62
125_V167_Y0.9120.61
142_D147_N0.9090.61
51_E66_Y0.9070.61
64_L91_T0.8940.60
91_T94_L0.8860.59
31_V109_T0.8810.59
30_D64_L0.8740.58
21_S143_Q0.8630.57
128_L131_F0.8610.57
68_G168_L0.8570.57
5_E67_K0.8540.56
79_E97_K0.8530.56
149_T153_I0.8500.56
34_Q153_I0.8480.56
41_Y46_F0.8340.54
94_L118_F0.8290.54
123_D133_E0.8290.54
50_D68_G0.8280.54
3_E8_I0.8250.54
19_R23_G0.8220.53
118_F148_Y0.8140.53
92_I102_P0.8120.52
52_A166_S0.8030.52
19_R122_L0.8030.52
65_T80_E0.8020.52
6_V9_V0.8000.51
9_V131_F0.8000.51
37_V92_I0.7980.51
19_R26_M0.7930.51
142_D145_I0.7840.50
150_S154_R0.7840.50
38_Y50_D0.7820.50
138_N145_I0.7810.50
34_Q78_R0.7770.49
76_K110_R0.7740.49
38_Y66_Y0.7720.49
52_A123_D0.7680.48
35_E105_T0.7660.48
37_V102_P0.7630.48
43_Y100_F0.7590.48
110_R166_S0.7540.47
125_V129_G0.7520.47
27_K114_L0.7520.47
55_I145_I0.7520.47
66_Y97_K0.7510.47
114_L117_S0.7490.47
95_L139_E0.7330.45
52_A110_R0.7330.45
5_E80_E0.7330.45
81_I97_K0.7280.45
41_Y45_N0.7270.45
136_A148_Y0.7270.45
70_K166_S0.7270.45
35_E57_I0.7200.44
62_I88_L0.7170.44
38_Y167_Y0.7150.44
57_I88_L0.7150.44
28_L31_V0.7130.44
6_V120_V0.6980.42
25_D110_R0.6950.42
14_S25_D0.6900.42
136_A149_T0.6890.41
82_S135_E0.6870.41
114_L147_N0.6870.41
72_H75_L0.6780.40
38_Y106_I0.6760.40
38_Y52_A0.6760.40
16_E20_E0.6730.40
46_F51_E0.6720.40
122_L130_Q0.6700.40
64_L111_I0.6690.40
47_K172_I0.6690.40
53_V106_I0.6690.40
91_T113_Y0.6650.39
80_E135_E0.6640.39
120_V139_E0.6600.39
34_Q112_N0.6540.38
37_V57_I0.6500.38
93_E140_I0.6500.38
20_E113_Y0.6490.38
32_E58_N0.6470.38
145_I156_Y0.6440.38
24_K140_I0.6380.37
126_K173_D0.6370.37
106_I125_V0.6360.37
112_N121_S0.6350.37
65_T135_E0.6340.37
26_M134_I0.6290.36
68_G79_E0.6280.36
117_S148_Y0.6270.36
59_N137_I0.6220.36
114_L119_I0.6200.36
106_I170_L0.6180.35
67_K149_T0.6180.35
131_F163_T0.6160.35
14_S19_R0.6160.35
163_T170_L0.6130.35
76_K106_I0.6090.35
60_K140_I0.6080.35
106_I123_D0.6070.34
61_G155_K0.6040.34
69_P78_R0.6000.34
18_L152_F0.5970.34
17_E24_K0.5950.33
81_I84_T0.5940.33
36_D131_F0.5930.33
55_I88_L0.5910.33
144_E147_N0.5870.33
16_E154_R0.5860.33
33_K85_V0.5840.33
4_K10_V0.5820.32
67_K82_S0.5810.32
36_D52_A0.5800.32
51_E125_V0.5710.32
146_Q158_I0.5700.32
36_D127_D0.5690.31
48_I151_N0.5680.31
123_D168_L0.5680.31
25_D115_D0.5670.31
40_N83_I0.5670.31
46_F66_Y0.5660.31
106_I166_S0.5640.31
64_L94_L0.5630.31
58_N163_T0.5630.31
20_E23_G0.5610.31
32_E112_N0.5560.30
122_L131_F0.5540.30
66_Y125_V0.5520.30
30_D119_I0.5510.30
62_I85_V0.5510.30
128_L170_L0.5490.30
82_S132_I0.5490.30
58_N112_N0.5420.29
101_Y159_K0.5420.29
6_V39_F0.5400.29
96_R155_K0.5390.29
37_V88_L0.5350.29
16_E61_G0.5330.29
21_S157_K0.5270.28
44_R51_E0.5230.28
24_K89_N0.5220.28
10_V122_L0.5190.28
142_D170_L0.5150.27
22_L63_E0.5140.27
93_E96_R0.5120.27
27_K151_N0.5100.27
89_N137_I0.5060.27
5_E133_E0.5060.27
102_P105_T0.5050.27
76_K168_L0.5050.27
37_V105_T0.5040.27
70_K78_R0.5040.27
118_F149_T0.5030.27
90_K132_I0.5000.26
48_I157_K0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eenA 2 0.9301 100 0.372 Contact Map
3n10A 2 0.8871 100 0.395 Contact Map
2acaA 2 0.8871 100 0.401 Contact Map
1yemA 2 0.871 100 0.404 Contact Map
2dc4A 2 0.8602 100 0.431 Contact Map
3bhdA 1 0.9624 99.9 0.496 Contact Map
5a67A 1 0.9247 99.9 0.551 Contact Map
5a61A 1 0.9946 99.9 0.574 Contact Map
3tj7A 2 0.828 99.8 0.592 Contact Map
2gfgA 2 0.8925 99.8 0.601 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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