GREMLIN Database
Q980N6 - Uncharacterized protein
UniProt: Q980N6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (257)
Sequences: 993 (788)
Seq/√Len: 49.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_T229_G5.7221.00
12_A72_F5.7081.00
98_G104_L4.2531.00
74_V103_V3.5211.00
250_I253_G3.3131.00
85_R118_E3.1801.00
228_F239_Y2.9391.00
90_K115_K2.5991.00
117_I153_I2.5981.00
28_E42_Y2.5841.00
48_K54_A2.5711.00
181_G194_T2.5381.00
86_P140_F2.4631.00
232_M235_E2.4191.00
181_G196_I2.3371.00
88_I97_I2.3041.00
40_I73_L2.2871.00
49_P188_H2.2721.00
35_N148_S2.2711.00
57_Y241_N2.2701.00
32_K40_I2.2471.00
73_L144_A2.2271.00
85_R100_D2.1241.00
12_A70_T2.0351.00
42_Y45_G2.0331.00
88_I153_I1.9840.99
231_G237_L1.9610.99
88_I156_F1.9480.99
193_A241_N1.9410.99
55_G103_V1.9400.99
115_K159_Q1.9400.99
66_F72_F1.9000.99
32_K41_T1.8790.99
226_K230_Y1.8770.99
35_N38_A1.8130.99
24_N45_G1.7670.99
12_A43_I1.7470.99
47_S58_L1.7340.99
236_L259_L1.7280.99
231_G251_N1.7280.99
90_K114_V1.7200.98
63_Y96_F1.6970.98
13_I27_M1.6570.98
14_L72_F1.6380.98
13_I73_L1.6360.98
143_A156_F1.6240.98
50_F252_K1.6040.98
53_I182_K1.6000.98
48_K51_N1.5880.97
17_F27_M1.5740.97
20_N46_N1.5460.97
197_P200_V1.5400.97
255_A259_L1.5380.97
181_G195_S1.5250.97
183_V254_S1.5240.97
198_K240_F1.5230.97
118_E158_N1.4840.96
71_I144_A1.4810.96
88_I119_I1.4780.96
198_K244_F1.4720.96
32_K39_K1.4690.96
233_E252_K1.4690.96
225_V230_Y1.4540.96
89_I98_G1.4260.95
88_I117_I1.4260.95
55_G74_V1.4240.95
228_F249_G1.4220.95
29_A65_Y1.4170.95
227_T230_Y1.4150.95
89_I116_I1.4120.95
87_L165_L1.3990.95
95_V147_I1.3950.95
215_V261_V1.3900.94
51_N54_A1.3860.94
125_Y143_A1.3470.93
80_V135_H1.3380.93
115_K154_D1.3190.93
124_L146_F1.3160.93
222_C248_I1.3110.93
254_S257_D1.3020.92
228_F247_E1.2920.92
75_V80_V1.2770.91
131_S135_H1.2650.91
222_C238_I1.2590.91
175_S178_E1.2550.91
77_D80_V1.2550.91
22_N26_V1.2530.91
81_G84_R1.2510.91
80_V84_R1.2370.90
89_I96_F1.2300.90
26_V62_S1.2200.89
248_I255_A1.2140.89
57_Y243_Y1.2110.89
109_T172_Y1.1970.89
77_D84_R1.1850.88
25_G62_S1.1790.88
12_A66_F1.1780.88
63_Y94_Y1.1750.88
56_A106_P1.1670.87
47_S55_G1.1650.87
71_I97_I1.1570.87
82_T227_T1.1560.87
24_N42_Y1.1530.87
75_V84_R1.1530.87
116_I165_L1.1480.86
50_F228_F1.1340.86
248_I259_L1.1080.84
146_F151_V1.0890.83
11_I144_A1.0860.83
14_L74_V1.0850.83
72_F94_Y1.0810.83
77_D138_D1.0660.82
186_I256_K1.0630.82
51_N263_E1.0490.81
77_D140_F1.0430.81
174_P180_C1.0390.80
223_R235_E1.0380.80
96_F111_E1.0340.80
91_T94_Y1.0280.80
238_I246_V1.0190.79
28_E45_G1.0180.79
13_I45_G1.0160.79
79_G84_R1.0100.78
85_R160_V0.9990.78
27_M241_N0.9960.77
75_V135_H0.9960.77
24_N28_E0.9870.77
89_I104_L0.9760.76
80_V137_R0.9750.76
28_E66_F0.9740.76
84_R137_R0.9670.75
84_R135_H0.9660.75
14_L43_I0.9640.75
61_T193_A0.9600.75
104_L108_I0.9560.74
23_Y247_E0.9520.74
75_V136_G0.9410.73
78_P137_R0.9410.73
59_L98_G0.9400.73
192_V265_D0.9380.73
109_T167_K0.9370.73
23_Y131_S0.9360.73
89_I108_I0.9320.73
81_G135_H0.9280.72
75_V81_G0.9250.72
75_V79_G0.9250.72
86_P139_I0.9170.71
28_E247_E0.9100.71
237_L249_G0.9100.71
225_V237_L0.9050.70
152_E155_T0.8980.70
183_V192_V0.8970.70
78_P99_P0.8960.70
133_T242_G0.8900.69
123_K155_T0.8880.69
79_G137_R0.8860.69
84_R136_G0.8810.68
22_N43_I0.8770.68
57_Y193_A0.8760.68
81_G133_T0.8720.67
78_P81_G0.8680.67
124_L156_F0.8620.67
17_F131_S0.8620.67
14_L47_S0.8590.66
186_I192_V0.8540.66
241_N247_E0.8500.65
68_R93_N0.8450.65
198_K202_L0.8380.64
79_G82_T0.8380.64
31_I34_I0.8310.64
150_G157_G0.8270.63
75_V137_R0.8250.63
213_I263_E0.8240.63
66_F70_T0.8150.62
77_D134_F0.8140.62
22_N62_S0.8130.62
80_V136_G0.8120.62
121_N124_L0.8080.61
21_D24_N0.8060.61
58_L185_Y0.8050.61
40_I71_I0.7980.61
84_R134_F0.7960.60
57_Y228_F0.7950.60
19_L46_N0.7940.60
78_P136_G0.7870.59
80_V133_T0.7860.59
179_I195_S0.7860.59
80_V138_D0.7770.58
81_G137_R0.7760.58
59_L74_V0.7760.58
132_N226_K0.7760.58
87_L160_V0.7660.57
99_P136_G0.7650.57
54_A58_L0.7610.57
36_P39_K0.7520.56
13_I247_E0.7500.56
84_R99_P0.7480.56
250_I254_S0.7450.55
224_F240_F0.7350.54
23_Y193_A0.7350.54
240_F246_V0.7320.54
121_N125_Y0.7290.54
189_F216_N0.7290.54
85_R164_D0.7290.54
255_A261_V0.7280.54
78_P82_T0.7270.53
236_L250_I0.7270.53
84_R138_D0.7270.53
160_V164_D0.7260.53
108_I112_E0.7260.53
13_I31_I0.7240.53
81_G131_S0.7230.53
249_G261_V0.7210.53
43_I72_F0.7210.53
81_G99_P0.7200.53
91_T113_I0.7190.53
86_P119_I0.7170.52
79_G99_P0.7140.52
134_F137_R0.7130.52
214_K254_S0.7110.52
156_F199_E0.7080.52
77_D135_H0.7040.51
107_A110_S0.7040.51
90_K154_D0.7030.51
31_I144_A0.7030.51
26_V65_Y0.7020.51
140_F144_A0.7000.51
233_E236_L0.6980.51
212_E219_K0.6980.51
12_A74_V0.6970.50
124_L151_V0.6970.50
77_D137_R0.6930.50
71_I148_S0.6920.50
68_R174_P0.6910.50
81_G136_G0.6900.50
92_K183_V0.6880.49
71_I88_I0.6870.49
80_V131_S0.6810.49
215_V267_I0.6790.49
78_P84_R0.6780.48
161_R164_D0.6770.48
23_Y241_N0.6770.48
117_I157_G0.6760.48
23_Y255_A0.6750.48
28_E195_S0.6750.48
173_K200_V0.6740.48
80_V99_P0.6700.48
11_I71_I0.6700.48
22_N57_Y0.6690.48
228_F251_N0.6690.48
146_F243_Y0.6690.48
114_V232_M0.6690.48
90_K95_V0.6660.47
86_P97_I0.6660.47
131_S137_R0.6610.47
97_I104_L0.6600.47
30_V242_G0.6600.47
115_K172_Y0.6590.47
17_F242_G0.6570.46
101_N138_D0.6480.45
262_R265_D0.6480.45
84_R131_S0.6440.45
15_T27_M0.6410.45
238_I248_I0.6360.44
26_V141_S0.6350.44
15_T73_L0.6340.44
88_I147_I0.6340.44
193_A247_E0.6330.44
214_K270_E0.6290.44
192_V261_V0.6240.43
82_T135_H0.6200.43
31_I141_S0.6190.43
80_V134_F0.6170.42
81_G134_F0.6170.42
173_K262_R0.6160.42
192_V236_L0.6150.42
30_V228_F0.6070.41
10_Q72_F0.6070.41
239_Y249_G0.6060.41
23_Y243_Y0.6050.41
36_P40_I0.6040.41
38_A252_K0.6010.41
11_I38_A0.5980.40
212_E221_K0.5970.40
111_E139_I0.5960.40
96_F124_L0.5960.40
76_I167_K0.5920.40
10_Q41_T0.5900.40
13_I24_N0.5890.40
147_I157_G0.5880.39
119_I269_L0.5870.39
82_T131_S0.5860.39
71_I211_I0.5860.39
59_L133_T0.5850.39
121_N139_I0.5850.39
31_I71_I0.5820.39
63_Y68_R0.5820.39
135_H139_I0.5820.39
107_A111_E0.5770.38
15_T236_L0.5740.38
162_Y165_L0.5730.38
75_V138_D0.5720.38
103_V255_A0.5720.38
30_V33_K0.5710.38
224_F246_V0.5710.38
41_T66_F0.5690.38
12_A94_Y0.5690.38
191_N231_G0.5690.38
119_I125_Y0.5680.38
79_G136_G0.5680.38
25_G43_I0.5680.38
143_A146_F0.5680.38
93_N114_V0.5660.37
194_T267_I0.5630.37
34_I146_F0.5630.37
128_K143_A0.5630.37
108_I167_K0.5610.37
189_F245_L0.5610.37
54_A243_Y0.5580.37
104_L147_I0.5570.37
17_F80_V0.5570.37
88_I95_V0.5560.36
183_V225_V0.5560.36
12_A193_A0.5550.36
91_T111_E0.5550.36
84_R140_F0.5520.36
48_K234_N0.5520.36
28_E41_T0.5520.36
10_Q39_K0.5520.36
211_I224_F0.5510.36
11_I188_H0.5500.36
189_F241_N0.5490.36
21_D188_H0.5480.36
166_T169_N0.5470.36
60_Y245_L0.5450.35
45_G55_G0.5450.35
179_I196_I0.5450.35
168_L237_L0.5430.35
78_P133_T0.5430.35
250_I256_K0.5420.35
77_D81_G0.5390.35
119_I140_F0.5360.35
213_I224_F0.5360.35
133_T137_R0.5360.35
99_P242_G0.5360.35
52_L55_G0.5340.34
31_I38_A0.5330.34
193_A239_Y0.5330.34
80_V140_F0.5320.34
21_D126_L0.5320.34
47_S72_F0.5320.34
120_K158_N0.5300.34
213_I220_H0.5300.34
214_K268_C0.5300.34
32_K224_F0.5290.34
79_G135_H0.5260.34
97_I256_K0.5260.34
34_I149_I0.5250.34
75_V99_P0.5240.33
25_G32_K0.5230.33
17_F78_P0.5200.33
58_L243_Y0.5200.33
154_D217_N0.5200.33
231_G239_Y0.5200.33
108_I116_I0.5180.33
28_E191_N0.5150.33
133_T227_T0.5140.33
90_K159_Q0.5140.33
35_N149_I0.5140.33
222_C261_V0.5130.32
180_C266_E0.5130.32
141_S145_A0.5130.32
54_A185_Y0.5130.32
124_L143_A0.5110.32
52_L168_L0.5100.32
105_Y111_E0.5090.32
13_I17_F0.5090.32
63_Y66_F0.5080.32
93_N111_E0.5080.32
203_N223_R0.5070.32
72_F96_F0.5060.32
75_V78_P0.5050.32
26_V61_T0.5040.32
136_G190_G0.5030.32
43_I67_P0.5020.32
66_F195_S0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q6kA 5 0.8932 100 0.108 Contact Map
2zbvA 3 0.9253 100 0.114 Contact Map
1rqpA 4 0.9359 100 0.13 Contact Map
2wr8A 3 0.911 100 0.132 Contact Map
2cw5A 3 0.8861 100 0.133 Contact Map
2f4nA 4 0.8327 100 0.154 Contact Map
4ga6A 2 0.3203 71.3 0.959 Contact Map
3cr8A 4 0.79 66.8 0.96 Contact Map
1wlfA 1 0.3238 22.3 0.97 Contact Map
2kl1A 1 0.242 20.2 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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