GREMLIN Database
Y256 - UPF0215 protein SSO0256
UniProt: Q980N5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (159)
Sequences: 287 (227)
Seq/√Len: 18.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_Q152_S3.5231.00
37_L164_I3.3501.00
61_I144_I2.9520.99
45_D71_G2.6620.97
67_V84_F2.5440.97
21_K41_F2.4980.96
47_N109_R2.3150.94
9_G22_T2.2960.94
24_L53_F2.1630.92
66_G158_L2.1610.92
156_E159_K2.1110.91
53_F75_I2.1090.91
64_L84_F2.1000.91
71_G162_H1.9990.88
40_G56_L1.9130.86
81_R135_T1.8930.85
8_D11_F1.8830.85
7_D11_F1.8770.85
3_I148_Y1.8710.85
152_S163_I1.8610.84
2_L5_G1.8580.84
8_D72_F1.8270.83
48_D73_N1.8240.83
4_S9_G1.7590.81
90_P162_H1.7580.81
27_V161_A1.6950.78
43_T48_D1.6460.76
7_D45_D1.6260.75
132_L145_I1.6030.74
45_D162_H1.5980.74
8_D45_D1.5960.74
38_D56_L1.5550.72
63_I145_I1.5540.71
63_I144_I1.5100.69
96_K100_M1.5050.69
83_I141_A1.4600.67
64_L75_I1.4490.66
42_I56_L1.4340.65
92_I95_I1.4240.65
24_L54_K1.3600.61
39_W167_S1.3490.60
63_I150_I1.3450.60
52_V55_Q1.3450.60
131_F158_L1.3230.59
94_L160_S1.2860.56
33_E152_S1.2820.56
66_G131_F1.2770.56
82_M165_A1.2750.56
31_D85_F1.2710.56
61_I83_I1.2580.55
100_M131_F1.2570.55
129_N150_I1.2480.54
24_L85_F1.2250.53
138_L142_K1.2230.53
49_A75_I1.2220.53
68_I99_L1.2090.52
62_V80_D1.2070.52
86_Y131_F1.2040.51
19_K104_Q1.1870.50
25_V168_L1.1760.50
8_D71_G1.1660.49
64_L82_M1.1650.49
100_M137_E1.1600.49
21_K43_T1.1390.47
51_N54_K1.1250.47
25_V164_I1.1160.46
96_K110_V1.1150.46
7_D71_G1.1030.45
37_L167_S1.0900.44
58_K103_F1.0830.44
103_F109_R1.0830.44
59_G80_D1.0790.44
99_L104_Q1.0770.44
137_E140_L1.0700.43
7_D162_H1.0690.43
123_I131_F1.0680.43
93_D143_S1.0630.43
27_V160_S1.0590.43
91_K94_L1.0580.43
99_L103_F1.0550.42
145_I148_Y1.0480.42
49_A130_V1.0350.41
65_D131_F1.0340.41
79_S104_Q1.0280.41
98_T101_K1.0180.40
70_A115_Y1.0160.40
106_D131_F1.0080.40
71_G90_P1.0070.39
27_V34_I0.9940.39
77_P145_I0.9920.39
72_F102_H0.9830.38
65_D158_L0.9760.38
98_T145_I0.9690.37
34_I160_S0.9690.37
45_D90_P0.9640.37
66_G98_T0.9630.37
25_V62_V0.9590.37
77_P84_F0.9590.37
110_V161_A0.9530.36
42_I51_N0.9510.36
67_V98_T0.9450.36
72_F87_S0.9210.35
35_I152_S0.9210.35
69_F102_H0.9160.34
22_T44_V0.9080.34
157_V161_A0.8970.33
62_V136_V0.8940.33
77_P120_L0.8910.33
99_L144_I0.8840.33
119_N124_P0.8810.32
41_F64_L0.8760.32
66_G86_Y0.8600.31
42_I61_I0.8570.31
2_L9_G0.8560.31
87_S90_P0.8520.31
40_G52_V0.8510.31
72_F84_F0.8250.29
29_F34_I0.8190.29
64_L165_A0.8170.29
30_Y160_S0.8170.29
34_I167_S0.8020.28
25_V77_P0.8010.28
83_I102_H0.7980.28
39_W168_L0.7960.28
38_D58_K0.7950.28
46_G73_N0.7870.28
33_E150_I0.7850.27
81_R155_P0.7810.27
96_K106_D0.7800.27
8_D162_H0.7780.27
117_L125_T0.7770.27
80_D165_A0.7750.27
64_L106_D0.7740.27
30_Y35_I0.7690.27
34_I54_K0.7680.27
109_R166_S0.7610.26
87_S162_H0.7600.26
66_G76_V0.7590.26
83_I104_Q0.7580.26
49_A119_N0.7540.26
29_F160_S0.7490.26
41_F93_D0.7480.26
54_K85_F0.7440.25
30_Y50_T0.7380.25
157_V165_A0.7360.25
71_G120_L0.7340.25
40_G55_Q0.7310.25
4_S26_V0.7270.25
73_N90_P0.7240.25
43_T52_V0.7230.24
58_K165_A0.7210.24
8_D22_T0.7150.24
55_Q93_D0.7080.24
23_A39_W0.7070.24
70_A105_S0.7000.23
115_Y118_N0.6970.23
35_I58_K0.6830.23
33_E132_L0.6830.23
34_I129_N0.6810.23
95_I99_L0.6780.23
23_A144_I0.6770.22
2_L44_V0.6760.22
21_K139_S0.6720.22
83_I154_I0.6720.22
22_T45_D0.6710.22
103_F106_D0.6700.22
27_V85_F0.6690.22
140_L145_I0.6620.22
63_I157_V0.6540.21
90_P94_L0.6510.21
40_G119_N0.6510.21
51_N140_L0.6480.21
47_N53_F0.6480.21
83_I146_E0.6450.21
79_S141_A0.6450.21
67_V120_L0.6440.21
70_A162_H0.6420.21
35_I133_Y0.6400.21
32_Y150_I0.6390.21
152_S156_E0.6270.20
140_L157_V0.6230.20
67_V117_L0.6210.20
6_V121_K0.6190.20
156_E163_I0.6170.20
144_I147_K0.6150.20
8_D70_A0.6140.20
3_I95_I0.6140.20
69_F165_A0.6120.20
137_E141_A0.6100.20
136_V141_A0.6090.20
70_A120_L0.6060.20
41_F132_L0.5960.19
80_D130_V0.5950.19
36_D53_F0.5940.19
116_V145_I0.5930.19
34_I164_I0.5930.19
35_I167_S0.5920.19
65_D86_Y0.5910.19
66_G163_I0.5850.19
105_S108_E0.5820.19
45_D91_K0.5800.19
19_K84_F0.5780.19
25_V152_S0.5760.18
81_R159_K0.5750.18
158_L168_L0.5690.18
132_L141_A0.5670.18
105_S143_S0.5660.18
43_T108_E0.5600.18
53_F69_F0.5580.18
47_N108_E0.5570.18
3_I69_F0.5570.18
69_F153_K0.5560.18
6_V26_V0.5550.18
67_V70_A0.5540.18
109_R123_I0.5490.17
45_D70_A0.5390.17
54_K137_E0.5360.17
34_I37_L0.5340.17
102_H130_V0.5330.17
66_G72_F0.5320.17
45_D87_S0.5310.17
134_S163_I0.5260.17
67_V140_L0.5240.17
106_D110_V0.5240.17
65_D84_F0.5230.17
11_F72_F0.5150.16
85_F145_I0.5150.16
102_H115_Y0.5140.16
159_K167_S0.5140.16
65_D87_S0.5140.16
3_I144_I0.5120.16
109_R161_A0.5100.16
19_K70_A0.5080.16
29_F65_D0.5080.16
24_L74_Y0.5050.16
31_D141_A0.5040.16
67_V125_T0.5030.16
71_G87_S0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qh9A 2 0.8827 100 0.494 Contact Map
4nspA 1 0.9218 99.9 0.593 Contact Map
3gocA 2 0.9106 99.8 0.693 Contact Map
3ga2A 1 0.9218 99.7 0.711 Contact Map
2w36A 1 0.8939 99.7 0.715 Contact Map
2nrtA 1 0.8994 60 0.938 Contact Map
3zvlA 1 0.7654 54.6 0.941 Contact Map
3c65A 1 0.5531 53 0.941 Contact Map
2vycA 5 0.838 40.3 0.945 Contact Map
3n75A 4 0.8715 28.4 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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