Y256 - SULSO - GREMLIN Contacts

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Y256 - UPF0215 protein SSO0256

UniProt:	Q980N5	Sequences: MLISGVDDGYFPLSYKGGKGKTALVVVTFYDYEIIDLDWGFITVDGNDATNVFKQLRKGDIVILDGVIFAGFNYIVPYSDRMIFFYSKMPKIDLIKKTLMKHFQSDTERVREILYVLNNLKQIPTKRGNVFLYSTVELSLAKSIIEKYQIYSKIPEVLKSAHIIASSLGRFLAHYKKKI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	179 (159)
Sequences:	287 (227)
Seq/√Len:	18.0

SULSO - Y256

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
149_Q	152_S	3.523	1.00
37_L	164_I	3.350	1.00
61_I	144_I	2.952	0.99
45_D	71_G	2.662	0.97
67_V	84_F	2.544	0.97
21_K	41_F	2.498	0.96
47_N	109_R	2.315	0.94
9_G	22_T	2.296	0.94
24_L	53_F	2.163	0.92
66_G	158_L	2.161	0.92
156_E	159_K	2.111	0.91
53_F	75_I	2.109	0.91
64_L	84_F	2.100	0.91
71_G	162_H	1.999	0.88
40_G	56_L	1.913	0.86
81_R	135_T	1.893	0.85
8_D	11_F	1.883	0.85
7_D	11_F	1.877	0.85
3_I	148_Y	1.871	0.85
152_S	163_I	1.861	0.84
2_L	5_G	1.858	0.84
8_D	72_F	1.827	0.83
48_D	73_N	1.824	0.83
4_S	9_G	1.759	0.81
90_P	162_H	1.758	0.81
27_V	161_A	1.695	0.78
43_T	48_D	1.646	0.76
7_D	45_D	1.626	0.75
132_L	145_I	1.603	0.74
45_D	162_H	1.598	0.74
8_D	45_D	1.596	0.74
38_D	56_L	1.555	0.72
63_I	145_I	1.554	0.71
63_I	144_I	1.510	0.69
96_K	100_M	1.505	0.69
83_I	141_A	1.460	0.67
64_L	75_I	1.449	0.66
42_I	56_L	1.434	0.65
92_I	95_I	1.424	0.65
24_L	54_K	1.360	0.61
39_W	167_S	1.349	0.60
63_I	150_I	1.345	0.60
52_V	55_Q	1.345	0.60
131_F	158_L	1.323	0.59
94_L	160_S	1.286	0.56
33_E	152_S	1.282	0.56
66_G	131_F	1.277	0.56
82_M	165_A	1.275	0.56
31_D	85_F	1.271	0.56
61_I	83_I	1.258	0.55
100_M	131_F	1.257	0.55
129_N	150_I	1.248	0.54
24_L	85_F	1.225	0.53
138_L	142_K	1.223	0.53
49_A	75_I	1.222	0.53
68_I	99_L	1.209	0.52
62_V	80_D	1.207	0.52
86_Y	131_F	1.204	0.51
19_K	104_Q	1.187	0.50
25_V	168_L	1.176	0.50
8_D	71_G	1.166	0.49
64_L	82_M	1.165	0.49
100_M	137_E	1.160	0.49
21_K	43_T	1.139	0.47
51_N	54_K	1.125	0.47
25_V	164_I	1.116	0.46
96_K	110_V	1.115	0.46
7_D	71_G	1.103	0.45
37_L	167_S	1.090	0.44
58_K	103_F	1.083	0.44
103_F	109_R	1.083	0.44
59_G	80_D	1.079	0.44
99_L	104_Q	1.077	0.44
137_E	140_L	1.070	0.43
7_D	162_H	1.069	0.43
123_I	131_F	1.068	0.43
93_D	143_S	1.063	0.43
27_V	160_S	1.059	0.43
91_K	94_L	1.058	0.43
99_L	103_F	1.055	0.42
145_I	148_Y	1.048	0.42
49_A	130_V	1.035	0.41
65_D	131_F	1.034	0.41
79_S	104_Q	1.028	0.41
98_T	101_K	1.018	0.40
70_A	115_Y	1.016	0.40
106_D	131_F	1.008	0.40
71_G	90_P	1.007	0.39
27_V	34_I	0.994	0.39
77_P	145_I	0.992	0.39
72_F	102_H	0.983	0.38
65_D	158_L	0.976	0.38
98_T	145_I	0.969	0.37
34_I	160_S	0.969	0.37
45_D	90_P	0.964	0.37
66_G	98_T	0.963	0.37
25_V	62_V	0.959	0.37
77_P	84_F	0.959	0.37
110_V	161_A	0.953	0.36
42_I	51_N	0.951	0.36
67_V	98_T	0.945	0.36
72_F	87_S	0.921	0.35
35_I	152_S	0.921	0.35
69_F	102_H	0.916	0.34
22_T	44_V	0.908	0.34
157_V	161_A	0.897	0.33
62_V	136_V	0.894	0.33
77_P	120_L	0.891	0.33
99_L	144_I	0.884	0.33
119_N	124_P	0.881	0.32
41_F	64_L	0.876	0.32
66_G	86_Y	0.860	0.31
42_I	61_I	0.857	0.31
2_L	9_G	0.856	0.31
87_S	90_P	0.852	0.31
40_G	52_V	0.851	0.31
72_F	84_F	0.825	0.29
29_F	34_I	0.819	0.29
64_L	165_A	0.817	0.29
30_Y	160_S	0.817	0.29
34_I	167_S	0.802	0.28
25_V	77_P	0.801	0.28
83_I	102_H	0.798	0.28
39_W	168_L	0.796	0.28
38_D	58_K	0.795	0.28
46_G	73_N	0.787	0.28
33_E	150_I	0.785	0.27
81_R	155_P	0.781	0.27
96_K	106_D	0.780	0.27
8_D	162_H	0.778	0.27
117_L	125_T	0.777	0.27
80_D	165_A	0.775	0.27
64_L	106_D	0.774	0.27
30_Y	35_I	0.769	0.27
34_I	54_K	0.768	0.27
109_R	166_S	0.761	0.26
87_S	162_H	0.760	0.26
66_G	76_V	0.759	0.26
83_I	104_Q	0.758	0.26
49_A	119_N	0.754	0.26
29_F	160_S	0.749	0.26
41_F	93_D	0.748	0.26
54_K	85_F	0.744	0.25
30_Y	50_T	0.738	0.25
157_V	165_A	0.736	0.25
71_G	120_L	0.734	0.25
40_G	55_Q	0.731	0.25
4_S	26_V	0.727	0.25
73_N	90_P	0.724	0.25
43_T	52_V	0.723	0.24
58_K	165_A	0.721	0.24
8_D	22_T	0.715	0.24
55_Q	93_D	0.708	0.24
23_A	39_W	0.707	0.24
70_A	105_S	0.700	0.23
115_Y	118_N	0.697	0.23
35_I	58_K	0.683	0.23
33_E	132_L	0.683	0.23
34_I	129_N	0.681	0.23
95_I	99_L	0.678	0.23
23_A	144_I	0.677	0.22
2_L	44_V	0.676	0.22
21_K	139_S	0.672	0.22
83_I	154_I	0.672	0.22
22_T	45_D	0.671	0.22
103_F	106_D	0.670	0.22
27_V	85_F	0.669	0.22
140_L	145_I	0.662	0.22
63_I	157_V	0.654	0.21
90_P	94_L	0.651	0.21
40_G	119_N	0.651	0.21
51_N	140_L	0.648	0.21
47_N	53_F	0.648	0.21
83_I	146_E	0.645	0.21
79_S	141_A	0.645	0.21
67_V	120_L	0.644	0.21
70_A	162_H	0.642	0.21
35_I	133_Y	0.640	0.21
32_Y	150_I	0.639	0.21
152_S	156_E	0.627	0.20
140_L	157_V	0.623	0.20
67_V	117_L	0.621	0.20
6_V	121_K	0.619	0.20
156_E	163_I	0.617	0.20
144_I	147_K	0.615	0.20
8_D	70_A	0.614	0.20
3_I	95_I	0.614	0.20
69_F	165_A	0.612	0.20
137_E	141_A	0.610	0.20
136_V	141_A	0.609	0.20
70_A	120_L	0.606	0.20
41_F	132_L	0.596	0.19
80_D	130_V	0.595	0.19
36_D	53_F	0.594	0.19
116_V	145_I	0.593	0.19
34_I	164_I	0.593	0.19
35_I	167_S	0.592	0.19
65_D	86_Y	0.591	0.19
66_G	163_I	0.585	0.19
105_S	108_E	0.582	0.19
45_D	91_K	0.580	0.19
19_K	84_F	0.578	0.19
25_V	152_S	0.576	0.18
81_R	159_K	0.575	0.18
158_L	168_L	0.569	0.18
132_L	141_A	0.567	0.18
105_S	143_S	0.566	0.18
43_T	108_E	0.560	0.18
53_F	69_F	0.558	0.18
47_N	108_E	0.557	0.18
3_I	69_F	0.557	0.18
69_F	153_K	0.556	0.18
6_V	26_V	0.555	0.18
67_V	70_A	0.554	0.18
109_R	123_I	0.549	0.17
45_D	70_A	0.539	0.17
54_K	137_E	0.536	0.17
34_I	37_L	0.534	0.17
102_H	130_V	0.533	0.17
66_G	72_F	0.532	0.17
45_D	87_S	0.531	0.17
134_S	163_I	0.526	0.17
67_V	140_L	0.524	0.17
106_D	110_V	0.524	0.17
65_D	84_F	0.523	0.17
11_F	72_F	0.515	0.16
85_F	145_I	0.515	0.16
102_H	115_Y	0.514	0.16
159_K	167_S	0.514	0.16
65_D	87_S	0.514	0.16
3_I	144_I	0.512	0.16
109_R	161_A	0.510	0.16
19_K	70_A	0.508	0.16
29_F	65_D	0.508	0.16
24_L	74_Y	0.505	0.16
31_D	141_A	0.504	0.16
67_V	125_T	0.503	0.16
71_G	87_S	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qh9A	2	0.8827	100	0.494	Contact Map
4nspA	1	0.9218	99.9	0.593	Contact Map
3gocA	2	0.9106	99.8	0.693	Contact Map
3ga2A	1	0.9218	99.7	0.711	Contact Map
2w36A	1	0.8939	99.7	0.715	Contact Map
2nrtA	1	0.8994	60	0.938	Contact Map
3zvlA	1	0.7654	54.6	0.941	Contact Map
3c65A	1	0.5531	53	0.941	Contact Map
2vycA	5	0.838	40.3	0.945	Contact Map
3n75A	4	0.8715	28.4	0.95	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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