GREMLIN Database
CDC61 - ORC1-type DNA replication protein 1
UniProt: Q980N4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (324)
Sequences: 4252 (2919)
Seq/√Len: 162.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_Y27_D3.8601.00
242_A245_E3.0841.00
18_F91_V2.8571.00
327_L331_K2.7691.00
340_Q344_S2.6571.00
339_T343_V2.5691.00
328_N332_K2.4981.00
347_I351_D2.3831.00
20_N89_K2.3721.00
19_I24_L2.3281.00
316_V320_G2.2511.00
296_P299_S2.2221.00
326_Y330_C2.1921.00
323_Y327_L2.1691.00
285_R288_V2.1171.00
313_E316_V2.0761.00
288_V291_I2.0251.00
299_S303_L2.0211.00
340_Q343_V1.9941.00
272_K275_Y1.9341.00
247_G251_R1.9311.00
325_T328_N1.9171.00
330_C334_G1.9091.00
341_R344_S1.9061.00
341_R345_D1.9031.00
296_P300_K1.8781.00
268_D275_Y1.8381.00
339_T342_R1.8291.00
336_E340_Q1.8231.00
132_K136_D1.8221.00
246_H251_R1.7941.00
285_R291_I1.7831.00
237_L241_L1.7721.00
237_L240_A1.7681.00
344_S347_I1.7411.00
345_D349_E1.7291.00
278_M281_E1.6941.00
273_E276_V1.6891.00
324_E328_N1.6831.00
348_N352_M1.6731.00
280_K283_I1.6631.00
209_N212_E1.6561.00
343_V347_I1.6501.00
236_K240_A1.6171.00
300_K303_L1.6041.00
232_D236_K1.5931.00
322_V326_Y1.5831.00
188_D191_D1.5821.00
306_V309_I1.5811.00
345_D348_N1.5781.00
339_T344_S1.5741.00
287_R291_I1.5711.00
330_C333_L1.5601.00
297_F301_L1.5521.00
326_Y329_I1.5441.00
234_V241_L1.5381.00
342_R345_D1.5381.00
284_E288_V1.5271.00
337_A341_R1.5181.00
320_G324_E1.5151.00
319_T323_Y1.5071.00
269_T272_K1.4971.00
162_K166_I1.4931.00
317_S320_G1.4901.00
293_L297_F1.4881.00
338_V344_S1.4731.00
316_V319_T1.4691.00
234_V238_C1.4691.00
339_T347_I1.4621.00
331_K335_V1.4411.00
344_S348_N1.4391.00
323_Y326_Y1.4341.00
303_L309_I1.4301.00
329_I333_L1.4261.00
272_K276_V1.4161.00
276_V279_A1.4101.00
350_L354_G1.4031.00
349_E353_V1.4021.00
230_L234_V1.3981.00
248_D251_R1.3971.00
214_E236_K1.3911.00
336_E339_T1.3871.00
342_R346_I1.3841.00
299_S302_V1.3691.00
159_I162_K1.3691.00
234_V237_L1.3651.00
347_I350_L1.3641.00
343_V346_I1.3531.00
346_I349_E1.3531.00
300_K304_M1.3471.00
214_E218_T1.3341.00
297_F300_K1.3321.00
340_Q347_I1.3231.00
224_A227_P1.3191.00
338_V343_V1.3191.00
313_E320_G1.3061.00
159_I163_L1.3031.00
217_L252_A1.3001.00
186_F191_D1.3001.00
320_G323_Y1.2951.00
299_S309_I1.2941.00
305_A309_I1.2901.00
316_V323_Y1.2731.00
276_V283_I1.2691.00
313_E317_S1.2601.00
207_P246_H1.2461.00
349_E352_M1.2451.00
270_K276_V1.2441.00
341_R350_L1.2421.00
162_K165_R1.2311.00
327_L330_C1.2271.00
318_T321_A1.2261.00
303_L307_V1.2181.00
348_N351_D1.2151.00
266_M275_Y1.2091.00
286_D290_D1.1961.00
271_V274_E1.1951.00
279_A283_I1.1871.00
161_Y166_I1.1851.00
161_Y164_S1.1791.00
347_I353_V1.1781.00
290_D294_T1.1771.00
315_V318_T1.1751.00
298_H301_L1.1741.00
307_V310_S1.1731.00
343_V350_L1.1631.00
343_V351_D1.1591.00
326_Y333_L1.1581.00
352_M356_L1.1581.00
346_I350_L1.1581.00
230_L236_K1.1571.00
164_S167_N1.1571.00
304_M308_S1.1501.00
161_Y165_R1.1431.00
60_F148_I1.1411.00
331_K334_G1.1411.00
221_A256_L1.1371.00
341_R347_I1.1351.00
270_K275_Y1.1291.00
87_K140_Q1.1241.00
338_V347_I1.1231.00
309_I312_E1.1211.00
337_A340_Q1.1191.00
302_V306_V1.1181.00
351_D355_I1.1171.00
315_V319_T1.1161.00
157_D161_Y1.1101.00
274_E278_M1.1091.00
336_E343_V1.1071.00
262_I265_R1.1071.00
338_V341_R1.0991.00
233_N236_K1.0971.00
305_A308_S1.0951.00
336_E344_S1.0951.00
343_V348_N1.0891.00
303_L306_V1.0881.00
230_L237_L1.0871.00
323_Y330_C1.0861.00
230_L233_N1.0840.99
284_E291_I1.0810.99
315_V326_Y1.0800.99
342_R347_I1.0680.99
294_T298_H1.0680.99
229_V233_N1.0670.99
158_D161_Y1.0620.99
158_D163_L1.0620.99
337_A342_R1.0580.99
345_D351_D1.0540.99
347_I356_L1.0530.99
275_Y279_A1.0520.99
351_D356_L1.0500.99
316_V326_Y1.0490.99
233_N241_L1.0460.99
337_A347_I1.0440.99
296_P302_V1.0420.99
337_A346_I1.0420.99
159_I165_R1.0380.99
340_Q346_I1.0370.99
300_K309_I1.0340.99
186_F189_L1.0330.99
304_M307_V1.0320.99
299_S306_V1.0310.99
294_T300_K1.0300.99
238_C241_L1.0210.99
322_V329_I1.0210.99
298_H302_V1.0130.99
341_R346_I1.0060.99
340_Q348_N1.0030.99
190_L196_S1.0030.99
285_R292_I1.0000.99
302_V309_I1.0000.99
336_E341_R0.9960.99
186_F190_L0.9950.99
285_R289_R0.9940.99
274_E277_Y0.9910.99
163_L166_I0.9900.99
314_N323_Y0.9900.99
315_V323_Y0.9880.99
232_D237_L0.9850.99
336_E347_I0.9780.99
318_T323_Y0.9770.99
312_E316_V0.9770.99
296_P301_L0.9740.99
319_T322_V0.9720.99
295_L299_S0.9710.99
348_N355_I0.9710.99
323_Y331_K0.9700.99
301_L304_M0.9680.99
159_I164_S0.9670.99
229_V232_D0.9660.99
302_V305_A0.9580.99
232_D241_L0.9570.99
232_D235_I0.9550.99
337_A345_D0.9540.99
225_F228_G0.9530.99
111_S115_K0.9510.99
341_R349_E0.9500.99
294_T299_S0.9490.99
271_V276_V0.9400.99
337_A344_S0.9370.99
232_D238_C0.9370.99
293_L296_P0.9370.99
188_D193_R0.9320.98
277_Y281_E0.9260.98
286_D289_R0.9230.98
232_D240_A0.9230.98
355_I358_A0.9210.98
187_V190_L0.9210.98
135_R174_K0.9200.98
306_V310_S0.9120.98
148_I179_G0.9100.98
43_I59_I0.9090.98
330_C335_V0.9020.98
313_E323_Y0.8990.98
132_K135_R0.8980.98
293_L300_K0.8970.98
163_L168_S0.8950.98
19_I92_Y0.8950.98
317_S321_A0.8950.98
233_N240_A0.8940.98
296_P303_L0.8930.98
313_E327_L0.8920.98
275_Y281_E0.8910.98
164_S168_S0.8840.98
234_V240_A0.8770.98
347_I355_I0.8740.98
159_I166_I0.8730.98
224_A228_G0.8730.98
159_I167_N0.8720.98
349_E355_I0.8700.98
314_N317_S0.8690.98
323_Y333_L0.8660.98
191_D196_S0.8660.98
313_E329_I0.8620.97
353_V356_L0.8610.97
351_D354_G0.8590.97
229_V234_V0.8590.97
236_K241_L0.8550.97
221_A235_I0.8500.97
162_K168_S0.8490.97
288_V295_L0.8490.97
343_V349_E0.8480.97
343_V352_M0.8480.97
338_V342_R0.8430.97
293_L299_S0.8410.97
271_V275_Y0.8390.97
289_R293_L0.8370.97
161_Y167_N0.8340.97
336_E348_N0.8340.97
252_A257_R0.8310.97
23_Y26_P0.8250.97
344_S351_D0.8250.97
39_Q206_P0.8210.97
227_P271_V0.8140.96
158_D162_K0.8130.96
322_V330_C0.8120.96
343_V356_L0.8100.96
316_V330_C0.8070.96
231_P235_I0.8060.96
312_E315_V0.8020.96
270_K273_E0.8020.96
96_R166_I0.8000.96
272_K278_M0.7980.96
295_L302_V0.7910.96
323_Y329_I0.7900.96
298_H306_V0.7890.96
296_P306_V0.7870.96
196_S199_S0.7860.96
278_M283_I0.7860.96
190_L193_R0.7850.96
321_A324_E0.7840.96
340_Q345_D0.7830.96
95_T145_L0.7820.96
326_Y334_G0.7810.95
158_D166_I0.7810.95
233_N237_L0.7790.95
215_D218_T0.7780.95
314_N319_T0.7770.95
337_A349_E0.7770.95
229_V236_K0.7760.95
165_R168_S0.7720.95
320_G331_K0.7700.95
299_S304_M0.7660.95
35_H215_D0.7650.95
297_F304_M0.7650.95
306_V312_E0.7620.95
339_T348_N0.7620.95
30_P33_L0.7620.95
36_R39_Q0.7590.95
187_V191_D0.7580.95
344_S350_L0.7580.95
362_N365_R0.7580.95
210_A240_A0.7570.95
230_L241_L0.7550.95
346_I355_I0.7480.94
319_T326_Y0.7460.94
163_L167_N0.7420.94
350_L357_T0.7420.94
339_T346_I0.7410.94
301_L308_S0.7400.94
270_K283_I0.7380.94
340_Q350_L0.7330.94
298_H308_S0.7280.93
342_R348_N0.7270.93
113_D116_V0.7260.93
191_D195_K0.7240.93
325_T330_C0.7230.93
231_P240_A0.7210.93
290_D297_F0.7210.93
298_H305_A0.7200.93
261_E265_R0.7160.93
314_N322_V0.7150.93
318_T322_V0.7140.93
162_K167_N0.7130.93
188_D196_S0.7110.93
273_E281_E0.7090.93
343_V353_V0.7060.92
270_K278_M0.7050.92
353_V358_A0.7040.92
352_M355_I0.7030.92
230_L238_C0.6950.92
337_A343_V0.6930.92
347_I354_G0.6910.92
307_V311_S0.6880.91
355_I362_N0.6860.91
346_I354_G0.6850.91
235_I240_A0.6840.91
275_Y278_M0.6840.91
313_E330_C0.6830.91
276_V281_E0.6800.91
288_V292_I0.6800.91
338_V351_D0.6800.91
354_G357_T0.6780.91
301_L309_I0.6780.91
316_V333_L0.6770.91
346_I351_D0.6750.91
338_V346_I0.6730.90
315_V333_L0.6730.90
269_T273_E0.6700.90
257_R261_E0.6680.90
256_L276_V0.6670.90
269_T275_Y0.6670.90
193_R196_S0.6660.90
326_Y332_K0.6660.90
314_N318_T0.6650.90
313_E333_L0.6620.90
358_A362_N0.6600.90
296_P308_S0.6600.90
227_P230_L0.6580.89
298_H309_I0.6570.89
343_V355_I0.6550.89
293_L298_H0.6520.89
339_T354_G0.6510.89
320_G333_L0.6500.89
320_G334_G0.6500.89
262_I266_M0.6480.89
339_T351_D0.6470.89
339_T350_L0.6450.89
229_V235_I0.6450.89
77_L144_V0.6430.88
336_E345_D0.6420.88
186_F196_S0.6420.88
341_R348_N0.6410.88
270_K279_A0.6410.88
354_G358_A0.6410.88
213_L239_A0.6410.88
324_E327_L0.6400.88
188_D195_K0.6390.88
313_E326_Y0.6370.88
266_M278_M0.6360.88
300_K306_V0.6340.88
323_Y334_G0.6340.88
276_V280_K0.6270.87
342_R356_L0.6210.87
230_L235_I0.6210.87
46_I59_I0.6170.86
301_L305_A0.6150.86
287_R292_I0.6100.86
148_I202_E0.6090.86
360_V365_R0.6060.85
279_A282_E0.6060.85
125_E129_R0.6060.85
360_V364_G0.6050.85
231_P237_L0.6050.85
347_I352_M0.6020.85
350_L356_L0.6000.85
344_S349_E0.6000.85
355_I359_K0.5980.85
273_E277_Y0.5970.84
186_F195_K0.5950.84
302_V307_V0.5940.84
78_S82_K0.5940.84
325_T329_I0.5930.84
231_P270_K0.5930.84
344_S353_V0.5920.84
316_V331_K0.5920.84
304_M309_I0.5920.84
324_E329_I0.5910.84
230_L240_A0.5880.84
158_D164_S0.5850.83
301_L312_E0.5850.83
270_K274_E0.5850.83
321_A325_T0.5830.83
313_E322_V0.5820.83
352_M358_A0.5800.83
284_E287_R0.5790.83
329_I335_V0.5760.82
344_S355_I0.5760.82
264_E268_D0.5720.82
296_P309_I0.5720.82
303_L308_S0.5700.82
344_S358_A0.5690.82
298_H303_L0.5670.81
299_S305_A0.5650.81
24_L27_D0.5630.81
304_M311_S0.5630.81
320_G326_Y0.5610.81
293_L302_V0.5590.80
297_F307_V0.5570.80
132_K137_Y0.5550.80
190_L195_K0.5540.80
94_N97_Q0.5470.79
299_S312_E0.5470.79
338_V350_L0.5470.79
295_L303_L0.5460.79
322_V334_G0.5440.79
336_E351_D0.5440.79
346_I352_M0.5430.78
341_R355_I0.5430.78
317_S329_I0.5430.78
33_L71_A0.5370.78
315_V334_G0.5350.77
293_L301_L0.5350.77
159_I168_S0.5330.77
324_E331_K0.5320.77
299_S308_S0.5320.77
314_N326_Y0.5310.77
158_D165_R0.5280.77
298_H304_M0.5280.77
42_K45_S0.5270.76
318_T326_Y0.5260.76
306_V311_S0.5250.76
317_S322_V0.5250.76
336_E346_I0.5230.76
294_T303_L0.5230.76
270_K299_S0.5220.76
346_I353_V0.5210.76
229_V237_L0.5180.75
347_I358_A0.5170.75
235_I238_C0.5170.75
317_S330_C0.5170.75
95_T99_D0.5160.75
308_S311_S0.5130.74
329_I334_G0.5100.74
313_E334_G0.5090.74
300_K307_V0.5090.74
253_L257_R0.5060.73
270_K280_K0.5040.73
344_S352_M0.5040.73
197_S200_E0.5040.73
356_L362_N0.5030.73
61_I205_F0.5030.73
188_D194_V0.5020.73
320_G329_I0.5020.73
151_F164_S0.5010.73
299_S307_V0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbyA 1 0.9194 100 0.334 Contact Map
4xgcA 1 0.7758 100 0.353 Contact Map
2v1uA 1 0.9521 100 0.354 Contact Map
1w5sA 1 0.9345 100 0.416 Contact Map
2qbyB 1 0.9018 100 0.429 Contact Map
1fnnA 1 0.9219 100 0.438 Contact Map
4xgcD 1 0.9395 100 0.455 Contact Map
3te6A 1 0.6675 100 0.575 Contact Map
4xgcE 1 0.8413 100 0.61 Contact Map
4ko8A 3 0.6499 100 0.627 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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