CDC61 - SULSO - GREMLIN Contacts

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CDC61 - ORC1-type DNA replication protein 1

UniProt:	Q980N4	Sequences: MSDIIDEVISSFKTSSIFINREYLLPDYIPDELPHREDQIRKIASILAPLYREEKPNNIFIYGLTGTGKTAVVKFVLSKLHKKFLGKFKHVYINTRQIDTPYRVLADLLESLDVKVPFTGLSIAELYRRLVKAVRDYGSQVVIVLDEIDAFVKKYNDDILYKLSRINSEVNKSKISFIGITNDVKFVDLLDPRVKSSLSEEEIIFPPYNAEELEDILTKRAQMAFKPGVLPDNVIKLCAALAAREHGDARRALDLLRVSGEIAERMKDTKVKEEYVYMAKEEIERDRVRDIILTLPFHSKLVLMAVVSISSEENVVSTTGAVYETYLNICKKLGVEAVTQRRVSDIINELDMVGILTAKVVNRGRYGKTKEIGLAVDKNIIVRSLIESDSRFADLWS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	397 (324)
Sequences:	4252 (2919)
Seq/√Len:	162.2

HALSA - CDC6A CDC68 CDC65 CDC64 CDC66 CDC67 Q9HNS7 CDC69 CDC62 CDC61
SULSO - CDC61 CDC62 CDC63

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
23_Y	27_D	3.860	1.00
242_A	245_E	3.084	1.00
18_F	91_V	2.857	1.00
327_L	331_K	2.769	1.00
340_Q	344_S	2.657	1.00
339_T	343_V	2.569	1.00
328_N	332_K	2.498	1.00
347_I	351_D	2.383	1.00
20_N	89_K	2.372	1.00
19_I	24_L	2.328	1.00
316_V	320_G	2.251	1.00
296_P	299_S	2.222	1.00
326_Y	330_C	2.192	1.00
323_Y	327_L	2.169	1.00
285_R	288_V	2.117	1.00
313_E	316_V	2.076	1.00
288_V	291_I	2.025	1.00
299_S	303_L	2.021	1.00
340_Q	343_V	1.994	1.00
272_K	275_Y	1.934	1.00
247_G	251_R	1.931	1.00
325_T	328_N	1.917	1.00
330_C	334_G	1.909	1.00
341_R	344_S	1.906	1.00
341_R	345_D	1.903	1.00
296_P	300_K	1.878	1.00
268_D	275_Y	1.838	1.00
339_T	342_R	1.829	1.00
336_E	340_Q	1.823	1.00
132_K	136_D	1.822	1.00
246_H	251_R	1.794	1.00
285_R	291_I	1.783	1.00
237_L	241_L	1.772	1.00
237_L	240_A	1.768	1.00
344_S	347_I	1.741	1.00
345_D	349_E	1.729	1.00
278_M	281_E	1.694	1.00
273_E	276_V	1.689	1.00
324_E	328_N	1.683	1.00
348_N	352_M	1.673	1.00
280_K	283_I	1.663	1.00
209_N	212_E	1.656	1.00
343_V	347_I	1.650	1.00
236_K	240_A	1.617	1.00
300_K	303_L	1.604	1.00
232_D	236_K	1.593	1.00
322_V	326_Y	1.583	1.00
188_D	191_D	1.582	1.00
306_V	309_I	1.581	1.00
345_D	348_N	1.578	1.00
339_T	344_S	1.574	1.00
287_R	291_I	1.571	1.00
330_C	333_L	1.560	1.00
297_F	301_L	1.552	1.00
326_Y	329_I	1.544	1.00
234_V	241_L	1.538	1.00
342_R	345_D	1.538	1.00
284_E	288_V	1.527	1.00
337_A	341_R	1.518	1.00
320_G	324_E	1.515	1.00
319_T	323_Y	1.507	1.00
269_T	272_K	1.497	1.00
162_K	166_I	1.493	1.00
317_S	320_G	1.490	1.00
293_L	297_F	1.488	1.00
338_V	344_S	1.473	1.00
316_V	319_T	1.469	1.00
234_V	238_C	1.469	1.00
339_T	347_I	1.462	1.00
331_K	335_V	1.441	1.00
344_S	348_N	1.439	1.00
323_Y	326_Y	1.434	1.00
303_L	309_I	1.430	1.00
329_I	333_L	1.426	1.00
272_K	276_V	1.416	1.00
276_V	279_A	1.410	1.00
350_L	354_G	1.403	1.00
349_E	353_V	1.402	1.00
230_L	234_V	1.398	1.00
248_D	251_R	1.397	1.00
214_E	236_K	1.391	1.00
336_E	339_T	1.387	1.00
342_R	346_I	1.384	1.00
299_S	302_V	1.369	1.00
159_I	162_K	1.369	1.00
234_V	237_L	1.365	1.00
347_I	350_L	1.364	1.00
343_V	346_I	1.353	1.00
346_I	349_E	1.353	1.00
300_K	304_M	1.347	1.00
214_E	218_T	1.334	1.00
297_F	300_K	1.332	1.00
340_Q	347_I	1.323	1.00
224_A	227_P	1.319	1.00
338_V	343_V	1.319	1.00
313_E	320_G	1.306	1.00
159_I	163_L	1.303	1.00
217_L	252_A	1.300	1.00
186_F	191_D	1.300	1.00
320_G	323_Y	1.295	1.00
299_S	309_I	1.294	1.00
305_A	309_I	1.290	1.00
316_V	323_Y	1.273	1.00
276_V	283_I	1.269	1.00
313_E	317_S	1.260	1.00
207_P	246_H	1.246	1.00
349_E	352_M	1.245	1.00
270_K	276_V	1.244	1.00
341_R	350_L	1.242	1.00
162_K	165_R	1.231	1.00
327_L	330_C	1.227	1.00
318_T	321_A	1.226	1.00
303_L	307_V	1.218	1.00
348_N	351_D	1.215	1.00
266_M	275_Y	1.209	1.00
286_D	290_D	1.196	1.00
271_V	274_E	1.195	1.00
279_A	283_I	1.187	1.00
161_Y	166_I	1.185	1.00
161_Y	164_S	1.179	1.00
347_I	353_V	1.178	1.00
290_D	294_T	1.177	1.00
315_V	318_T	1.175	1.00
298_H	301_L	1.174	1.00
307_V	310_S	1.173	1.00
343_V	350_L	1.163	1.00
343_V	351_D	1.159	1.00
326_Y	333_L	1.158	1.00
352_M	356_L	1.158	1.00
346_I	350_L	1.158	1.00
230_L	236_K	1.157	1.00
164_S	167_N	1.157	1.00
304_M	308_S	1.150	1.00
161_Y	165_R	1.143	1.00
60_F	148_I	1.141	1.00
331_K	334_G	1.141	1.00
221_A	256_L	1.137	1.00
341_R	347_I	1.135	1.00
270_K	275_Y	1.129	1.00
87_K	140_Q	1.124	1.00
338_V	347_I	1.123	1.00
309_I	312_E	1.121	1.00
337_A	340_Q	1.119	1.00
302_V	306_V	1.118	1.00
351_D	355_I	1.117	1.00
315_V	319_T	1.116	1.00
157_D	161_Y	1.110	1.00
274_E	278_M	1.109	1.00
336_E	343_V	1.107	1.00
262_I	265_R	1.107	1.00
338_V	341_R	1.099	1.00
233_N	236_K	1.097	1.00
305_A	308_S	1.095	1.00
336_E	344_S	1.095	1.00
343_V	348_N	1.089	1.00
303_L	306_V	1.088	1.00
230_L	237_L	1.087	1.00
323_Y	330_C	1.086	1.00
230_L	233_N	1.084	0.99
284_E	291_I	1.081	0.99
315_V	326_Y	1.080	0.99
342_R	347_I	1.068	0.99
294_T	298_H	1.068	0.99
229_V	233_N	1.067	0.99
158_D	161_Y	1.062	0.99
158_D	163_L	1.062	0.99
337_A	342_R	1.058	0.99
345_D	351_D	1.054	0.99
347_I	356_L	1.053	0.99
275_Y	279_A	1.052	0.99
351_D	356_L	1.050	0.99
316_V	326_Y	1.049	0.99
233_N	241_L	1.046	0.99
337_A	347_I	1.044	0.99
296_P	302_V	1.042	0.99
337_A	346_I	1.042	0.99
159_I	165_R	1.038	0.99
340_Q	346_I	1.037	0.99
300_K	309_I	1.034	0.99
186_F	189_L	1.033	0.99
304_M	307_V	1.032	0.99
299_S	306_V	1.031	0.99
294_T	300_K	1.030	0.99
238_C	241_L	1.021	0.99
322_V	329_I	1.021	0.99
298_H	302_V	1.013	0.99
341_R	346_I	1.006	0.99
340_Q	348_N	1.003	0.99
190_L	196_S	1.003	0.99
285_R	292_I	1.000	0.99
302_V	309_I	1.000	0.99
336_E	341_R	0.996	0.99
186_F	190_L	0.995	0.99
285_R	289_R	0.994	0.99
274_E	277_Y	0.991	0.99
163_L	166_I	0.990	0.99
314_N	323_Y	0.990	0.99
315_V	323_Y	0.988	0.99
232_D	237_L	0.985	0.99
336_E	347_I	0.978	0.99
318_T	323_Y	0.977	0.99
312_E	316_V	0.977	0.99
296_P	301_L	0.974	0.99
319_T	322_V	0.972	0.99
295_L	299_S	0.971	0.99
348_N	355_I	0.971	0.99
323_Y	331_K	0.970	0.99
301_L	304_M	0.968	0.99
159_I	164_S	0.967	0.99
229_V	232_D	0.966	0.99
302_V	305_A	0.958	0.99
232_D	241_L	0.957	0.99
232_D	235_I	0.955	0.99
337_A	345_D	0.954	0.99
225_F	228_G	0.953	0.99
111_S	115_K	0.951	0.99
341_R	349_E	0.950	0.99
294_T	299_S	0.949	0.99
271_V	276_V	0.940	0.99
337_A	344_S	0.937	0.99
232_D	238_C	0.937	0.99
293_L	296_P	0.937	0.99
188_D	193_R	0.932	0.98
277_Y	281_E	0.926	0.98
286_D	289_R	0.923	0.98
232_D	240_A	0.923	0.98
355_I	358_A	0.921	0.98
187_V	190_L	0.921	0.98
135_R	174_K	0.920	0.98
306_V	310_S	0.912	0.98
148_I	179_G	0.910	0.98
43_I	59_I	0.909	0.98
330_C	335_V	0.902	0.98
313_E	323_Y	0.899	0.98
132_K	135_R	0.898	0.98
293_L	300_K	0.897	0.98
163_L	168_S	0.895	0.98
19_I	92_Y	0.895	0.98
317_S	321_A	0.895	0.98
233_N	240_A	0.894	0.98
296_P	303_L	0.893	0.98
313_E	327_L	0.892	0.98
275_Y	281_E	0.891	0.98
164_S	168_S	0.884	0.98
234_V	240_A	0.877	0.98
347_I	355_I	0.874	0.98
159_I	166_I	0.873	0.98
224_A	228_G	0.873	0.98
159_I	167_N	0.872	0.98
349_E	355_I	0.870	0.98
314_N	317_S	0.869	0.98
323_Y	333_L	0.866	0.98
191_D	196_S	0.866	0.98
313_E	329_I	0.862	0.97
353_V	356_L	0.861	0.97
351_D	354_G	0.859	0.97
229_V	234_V	0.859	0.97
236_K	241_L	0.855	0.97
221_A	235_I	0.850	0.97
162_K	168_S	0.849	0.97
288_V	295_L	0.849	0.97
343_V	349_E	0.848	0.97
343_V	352_M	0.848	0.97
338_V	342_R	0.843	0.97
293_L	299_S	0.841	0.97
271_V	275_Y	0.839	0.97
289_R	293_L	0.837	0.97
161_Y	167_N	0.834	0.97
336_E	348_N	0.834	0.97
252_A	257_R	0.831	0.97
23_Y	26_P	0.825	0.97
344_S	351_D	0.825	0.97
39_Q	206_P	0.821	0.97
227_P	271_V	0.814	0.96
158_D	162_K	0.813	0.96
322_V	330_C	0.812	0.96
343_V	356_L	0.810	0.96
316_V	330_C	0.807	0.96
231_P	235_I	0.806	0.96
312_E	315_V	0.802	0.96
270_K	273_E	0.802	0.96
96_R	166_I	0.800	0.96
272_K	278_M	0.798	0.96
295_L	302_V	0.791	0.96
323_Y	329_I	0.790	0.96
298_H	306_V	0.789	0.96
296_P	306_V	0.787	0.96
196_S	199_S	0.786	0.96
278_M	283_I	0.786	0.96
190_L	193_R	0.785	0.96
321_A	324_E	0.784	0.96
340_Q	345_D	0.783	0.96
95_T	145_L	0.782	0.96
326_Y	334_G	0.781	0.95
158_D	166_I	0.781	0.95
233_N	237_L	0.779	0.95
215_D	218_T	0.778	0.95
314_N	319_T	0.777	0.95
337_A	349_E	0.777	0.95
229_V	236_K	0.776	0.95
165_R	168_S	0.772	0.95
320_G	331_K	0.770	0.95
299_S	304_M	0.766	0.95
35_H	215_D	0.765	0.95
297_F	304_M	0.765	0.95
306_V	312_E	0.762	0.95
339_T	348_N	0.762	0.95
30_P	33_L	0.762	0.95
36_R	39_Q	0.759	0.95
187_V	191_D	0.758	0.95
344_S	350_L	0.758	0.95
362_N	365_R	0.758	0.95
210_A	240_A	0.757	0.95
230_L	241_L	0.755	0.95
346_I	355_I	0.748	0.94
319_T	326_Y	0.746	0.94
163_L	167_N	0.742	0.94
350_L	357_T	0.742	0.94
339_T	346_I	0.741	0.94
301_L	308_S	0.740	0.94
270_K	283_I	0.738	0.94
340_Q	350_L	0.733	0.94
298_H	308_S	0.728	0.93
342_R	348_N	0.727	0.93
113_D	116_V	0.726	0.93
191_D	195_K	0.724	0.93
325_T	330_C	0.723	0.93
231_P	240_A	0.721	0.93
290_D	297_F	0.721	0.93
298_H	305_A	0.720	0.93
261_E	265_R	0.716	0.93
314_N	322_V	0.715	0.93
318_T	322_V	0.714	0.93
162_K	167_N	0.713	0.93
188_D	196_S	0.711	0.93
273_E	281_E	0.709	0.93
343_V	353_V	0.706	0.92
270_K	278_M	0.705	0.92
353_V	358_A	0.704	0.92
352_M	355_I	0.703	0.92
230_L	238_C	0.695	0.92
337_A	343_V	0.693	0.92
347_I	354_G	0.691	0.92
307_V	311_S	0.688	0.91
355_I	362_N	0.686	0.91
346_I	354_G	0.685	0.91
235_I	240_A	0.684	0.91
275_Y	278_M	0.684	0.91
313_E	330_C	0.683	0.91
276_V	281_E	0.680	0.91
288_V	292_I	0.680	0.91
338_V	351_D	0.680	0.91
354_G	357_T	0.678	0.91
301_L	309_I	0.678	0.91
316_V	333_L	0.677	0.91
346_I	351_D	0.675	0.91
338_V	346_I	0.673	0.90
315_V	333_L	0.673	0.90
269_T	273_E	0.670	0.90
257_R	261_E	0.668	0.90
256_L	276_V	0.667	0.90
269_T	275_Y	0.667	0.90
193_R	196_S	0.666	0.90
326_Y	332_K	0.666	0.90
314_N	318_T	0.665	0.90
313_E	333_L	0.662	0.90
358_A	362_N	0.660	0.90
296_P	308_S	0.660	0.90
227_P	230_L	0.658	0.89
298_H	309_I	0.657	0.89
343_V	355_I	0.655	0.89
293_L	298_H	0.652	0.89
339_T	354_G	0.651	0.89
320_G	333_L	0.650	0.89
320_G	334_G	0.650	0.89
262_I	266_M	0.648	0.89
339_T	351_D	0.647	0.89
339_T	350_L	0.645	0.89
229_V	235_I	0.645	0.89
77_L	144_V	0.643	0.88
336_E	345_D	0.642	0.88
186_F	196_S	0.642	0.88
341_R	348_N	0.641	0.88
270_K	279_A	0.641	0.88
354_G	358_A	0.641	0.88
213_L	239_A	0.641	0.88
324_E	327_L	0.640	0.88
188_D	195_K	0.639	0.88
313_E	326_Y	0.637	0.88
266_M	278_M	0.636	0.88
300_K	306_V	0.634	0.88
323_Y	334_G	0.634	0.88
276_V	280_K	0.627	0.87
342_R	356_L	0.621	0.87
230_L	235_I	0.621	0.87
46_I	59_I	0.617	0.86
301_L	305_A	0.615	0.86
287_R	292_I	0.610	0.86
148_I	202_E	0.609	0.86
360_V	365_R	0.606	0.85
279_A	282_E	0.606	0.85
125_E	129_R	0.606	0.85
360_V	364_G	0.605	0.85
231_P	237_L	0.605	0.85
347_I	352_M	0.602	0.85
350_L	356_L	0.600	0.85
344_S	349_E	0.600	0.85
355_I	359_K	0.598	0.85
273_E	277_Y	0.597	0.84
186_F	195_K	0.595	0.84
302_V	307_V	0.594	0.84
78_S	82_K	0.594	0.84
325_T	329_I	0.593	0.84
231_P	270_K	0.593	0.84
344_S	353_V	0.592	0.84
316_V	331_K	0.592	0.84
304_M	309_I	0.592	0.84
324_E	329_I	0.591	0.84
230_L	240_A	0.588	0.84
158_D	164_S	0.585	0.83
301_L	312_E	0.585	0.83
270_K	274_E	0.585	0.83
321_A	325_T	0.583	0.83
313_E	322_V	0.582	0.83
352_M	358_A	0.580	0.83
284_E	287_R	0.579	0.83
329_I	335_V	0.576	0.82
344_S	355_I	0.576	0.82
264_E	268_D	0.572	0.82
296_P	309_I	0.572	0.82
303_L	308_S	0.570	0.82
344_S	358_A	0.569	0.82
298_H	303_L	0.567	0.81
299_S	305_A	0.565	0.81
24_L	27_D	0.563	0.81
304_M	311_S	0.563	0.81
320_G	326_Y	0.561	0.81
293_L	302_V	0.559	0.80
297_F	307_V	0.557	0.80
132_K	137_Y	0.555	0.80
190_L	195_K	0.554	0.80
94_N	97_Q	0.547	0.79
299_S	312_E	0.547	0.79
338_V	350_L	0.547	0.79
295_L	303_L	0.546	0.79
322_V	334_G	0.544	0.79
336_E	351_D	0.544	0.79
346_I	352_M	0.543	0.78
341_R	355_I	0.543	0.78
317_S	329_I	0.543	0.78
33_L	71_A	0.537	0.78
315_V	334_G	0.535	0.77
293_L	301_L	0.535	0.77
159_I	168_S	0.533	0.77
324_E	331_K	0.532	0.77
299_S	308_S	0.532	0.77
314_N	326_Y	0.531	0.77
158_D	165_R	0.528	0.77
298_H	304_M	0.528	0.77
42_K	45_S	0.527	0.76
318_T	326_Y	0.526	0.76
306_V	311_S	0.525	0.76
317_S	322_V	0.525	0.76
336_E	346_I	0.523	0.76
294_T	303_L	0.523	0.76
270_K	299_S	0.522	0.76
346_I	353_V	0.521	0.76
229_V	237_L	0.518	0.75
347_I	358_A	0.517	0.75
235_I	238_C	0.517	0.75
317_S	330_C	0.517	0.75
95_T	99_D	0.516	0.75
308_S	311_S	0.513	0.74
329_I	334_G	0.510	0.74
313_E	334_G	0.509	0.74
300_K	307_V	0.509	0.74
253_L	257_R	0.506	0.73
270_K	280_K	0.504	0.73
344_S	352_M	0.504	0.73
197_S	200_E	0.504	0.73
356_L	362_N	0.503	0.73
61_I	205_F	0.503	0.73
188_D	194_V	0.502	0.73
320_G	329_I	0.502	0.73
151_F	164_S	0.501	0.73
299_S	307_V	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qbyA	1	0.9194	100	0.334	Contact Map
4xgcA	1	0.7758	100	0.353	Contact Map
2v1uA	1	0.9521	100	0.354	Contact Map
1w5sA	1	0.9345	100	0.416	Contact Map
2qbyB	1	0.9018	100	0.429	Contact Map
1fnnA	1	0.9219	100	0.438	Contact Map
4xgcD	1	0.9395	100	0.455	Contact Map
3te6A	1	0.6675	100	0.575	Contact Map
4xgcE	1	0.8413	100	0.61	Contact Map
4ko8A	3	0.6499	100	0.627	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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