GREMLIN Database
Q980N3 - tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS
UniProt: Q980N3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 443 (394)
Sequences: 221 (173)
Seq/√Len: 8.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_K145_G4.6560.99
161_D413_L4.5020.99
22_S249_F4.1480.98
301_K304_G3.8960.98
225_A413_L3.6920.97
274_V291_T3.6580.96
85_V100_I3.5300.96
363_N372_R3.2750.93
347_D389_N3.0630.91
50_I126_I2.9860.89
129_I150_I2.9840.89
175_W214_G2.9020.88
302_E307_N2.8030.86
256_D339_R2.6500.83
302_E403_S2.6490.83
301_K307_N2.6290.82
301_K306_L2.4720.78
97_K144_R2.4030.76
193_T197_T2.3490.74
400_Q411_I2.3230.73
8_D11_D2.3120.73
172_K175_W2.3060.73
199_A401_T2.2290.70
46_L154_A2.2290.70
306_L402_R2.2160.69
121_K125_D2.1880.68
400_Q404_Y2.1720.68
310_A340_F2.1650.68
354_K361_S2.1070.65
289_V297_L2.1000.65
198_F209_L2.0580.63
136_A143_L2.0400.63
161_D225_A2.0090.61
189_V200_N2.0060.61
49_N324_A1.9850.60
288_I298_F1.9780.60
118_F153_I1.9140.58
178_K244_D1.9090.57
281_I311_K1.9090.57
299_V400_Q1.8960.57
326_K332_G1.8640.55
168_T220_Y1.8180.54
297_L321_A1.8100.53
22_S60_I1.8080.53
306_L339_R1.8080.53
307_N402_R1.7450.50
10_H20_H1.7330.50
197_T233_A1.7310.50
404_Y408_T1.7190.49
125_D268_Q1.7170.49
230_L248_I1.7160.49
307_N339_R1.6820.48
312_L393_N1.6810.48
81_S102_I1.6750.47
23_V245_F1.6740.47
146_D167_I1.6680.47
96_R401_T1.6570.47
189_V233_A1.6510.46
182_N303_T1.6500.46
158_M257_I1.6430.46
78_F102_I1.6370.46
298_F334_I1.6210.45
5_I25_L1.6070.45
258_H338_E1.5870.44
149_I200_N1.5860.44
299_V404_Y1.5700.43
342_I345_L1.5540.42
274_V289_V1.5510.42
198_F210_I1.5500.42
200_N210_I1.5450.42
52_W96_R1.5450.42
170_R179_R1.5380.42
126_I216_D1.5320.41
41_P247_A1.5270.41
304_G402_R1.5160.41
115_L153_I1.4930.40
9_D12_S1.4900.40
121_K131_Y1.4730.39
320_V341_E1.4600.38
302_E339_R1.4590.38
105_Y111_L1.4510.38
339_R404_Y1.4500.38
373_C376_C1.4340.37
256_D402_R1.4310.37
195_P311_K1.4260.37
31_K244_D1.3930.36
302_E306_L1.3930.36
97_K133_K1.3840.35
123_I260_Q1.3820.35
227_I363_N1.3820.35
184_D344_K1.3790.35
274_V296_I1.3770.35
21_F50_I1.3750.35
31_K276_V1.3730.35
296_I335_I1.3720.35
213_H347_D1.3660.35
314_K346_Y1.3480.34
60_I288_I1.3470.34
123_I257_I1.3410.34
282_L288_I1.3400.34
309_A340_F1.3340.33
166_L230_L1.3230.33
303_T403_S1.3170.33
49_N237_I1.3130.33
304_G307_N1.3080.32
356_P378_Y1.3070.32
360_G413_L1.3070.32
304_G339_R1.3030.32
128_P150_I1.2970.32
99_G146_D1.2920.32
206_D273_V1.2820.32
58_A133_K1.2820.32
27_S128_P1.2750.31
189_V198_F1.2740.31
251_T256_D1.2720.31
319_I368_N1.2700.31
47_N169_Y1.2600.31
44_V150_I1.2570.31
10_H405_R1.2510.30
53_K169_Y1.2500.30
44_V153_I1.2490.30
197_T248_I1.2440.30
259_F271_K1.2400.30
51_P267_Y1.2400.30
39_D42_Y1.2400.30
250_K319_I1.2310.30
84_Y88_V1.2290.30
213_H248_I1.2260.29
145_G213_H1.2200.29
27_S164_Y1.2030.29
5_I29_L1.2020.29
10_H96_R1.2010.29
336_E403_S1.1990.29
4_V60_I1.1980.29
147_R150_I1.1970.28
44_V119_Y1.1860.28
339_R402_R1.1850.28
322_Y398_M1.1820.28
176_L411_I1.1800.28
118_F132_A1.1770.28
96_R400_Q1.1770.28
51_P123_I1.1760.28
276_V317_D1.1760.28
58_A158_M1.1760.28
207_T216_D1.1730.28
300_Y326_K1.1730.28
139_N291_T1.1710.28
302_E336_E1.1700.28
6_G156_L1.1610.27
96_R404_Y1.1560.27
63_I326_K1.1390.26
10_H404_Y1.1320.26
185_S297_L1.1310.26
9_D148_G1.1270.26
254_S405_R1.1230.26
293_D372_R1.1220.26
5_I239_S1.1200.26
353_P362_T1.1180.26
52_W401_T1.1110.26
39_D113_D1.1030.25
30_Y244_D1.1010.25
176_L241_E1.0990.25
96_R402_R1.0970.25
52_W326_K1.0970.25
97_K304_G1.0950.25
190_D282_L1.0930.25
401_T404_Y1.0910.25
179_R317_D1.0890.25
105_Y136_A1.0860.25
6_G9_D1.0860.25
185_S219_L1.0790.25
302_E402_R1.0790.25
111_L119_Y1.0760.24
88_V294_N1.0760.24
133_K368_N1.0740.24
171_K242_D1.0710.24
119_Y158_M1.0660.24
141_I157_G1.0620.24
59_S118_F1.0590.24
122_G127_I1.0580.24
227_I374_K1.0520.24
5_I374_K1.0500.24
199_A404_Y1.0500.24
119_Y136_A1.0490.24
157_G216_D1.0470.24
4_V61_K1.0470.24
83_E249_F1.0460.24
198_F337_L1.0450.23
299_V402_R1.0450.23
371_Y397_G1.0420.23
219_L251_T1.0410.23
119_Y257_I1.0390.23
199_A400_Q1.0370.23
219_L241_E1.0370.23
149_I413_L1.0370.23
41_P51_P1.0360.23
369_K378_Y1.0330.23
20_H96_R1.0290.23
103_M112_F1.0280.23
146_D149_I1.0280.23
15_F51_P1.0260.23
60_I102_I1.0180.23
300_Y336_E1.0180.23
277_K290_E1.0180.23
197_T200_N1.0130.23
179_R241_E1.0080.22
307_N400_Q1.0030.22
121_K127_I1.0000.22
121_K150_I1.0000.22
47_N53_K0.9970.22
119_Y288_I0.9860.22
281_I369_K0.9840.22
4_V372_R0.9830.22
96_R299_V0.9820.22
200_N220_Y0.9780.21
11_D19_T0.9770.21
8_D17_C0.9770.21
8_D19_T0.9770.21
11_D17_C0.9770.21
85_V99_G0.9760.21
233_A336_E0.9760.21
205_N220_Y0.9750.21
212_P286_D0.9740.21
301_K402_R0.9740.21
112_F119_Y0.9670.21
78_F142_E0.9590.21
187_K201_Y0.9520.21
369_K382_T0.9450.21
52_W129_I0.9440.21
49_N216_D0.9400.20
174_N378_Y0.9370.20
325_V356_P0.9360.20
77_I367_K0.9340.20
106_D236_L0.9330.20
42_Y167_I0.9260.20
225_A360_G0.9250.20
273_V318_E0.9230.20
322_Y401_T0.9230.20
162_Y250_K0.9230.20
5_I121_K0.9140.20
25_L84_Y0.9140.20
264_N315_K0.9120.20
220_Y234_M0.9110.20
339_R400_Q0.9100.20
298_F346_Y0.9100.20
385_K409_K0.9090.20
185_S403_S0.9080.20
101_A178_K0.9060.19
46_L353_P0.9050.19
115_L139_N0.9030.19
50_I372_R0.9030.19
143_L391_M0.9030.19
144_R401_T0.8990.19
215_T308_S0.8960.19
189_V230_L0.8940.19
257_I294_N0.8940.19
214_G404_Y0.8920.19
237_I319_I0.8920.19
174_N249_F0.8910.19
58_A137_E0.8890.19
196_L229_H0.8870.19
42_Y146_D0.8860.19
365_L369_K0.8790.19
179_R370_G0.8780.19
192_S236_L0.8750.19
251_T339_R0.8730.19
23_V249_F0.8720.19
301_K404_Y0.8700.19
198_F413_L0.8690.19
149_I269_E0.8690.19
303_T401_T0.8690.19
8_D18_T0.8670.18
11_D18_T0.8670.18
10_H299_V0.8660.18
58_A145_G0.8660.18
44_V121_K0.8650.18
199_A209_L0.8630.18
25_L29_L0.8610.18
101_A176_L0.8590.18
15_F208_P0.8590.18
238_E335_I0.8580.18
127_I186_V0.8580.18
319_I350_L0.8550.18
119_Y157_G0.8540.18
256_D400_Q0.8530.18
319_I342_I0.8520.18
226_S235_E0.8510.18
20_H97_K0.8510.18
155_G167_I0.8500.18
135_F153_I0.8470.18
189_V210_I0.8420.18
89_S195_P0.8410.18
200_N211_T0.8400.18
400_Q408_T0.8380.18
191_E237_I0.8350.18
306_L310_A0.8350.18
22_S25_L0.8330.18
248_I263_G0.8290.18
190_D336_E0.8280.17
307_N310_A0.8260.17
189_V306_L0.8250.17
83_E184_D0.8150.17
147_R256_D0.8140.17
29_L34_S0.8140.17
215_T286_D0.8110.17
256_D322_Y0.8070.17
97_K175_W0.8060.17
256_D306_L0.8040.17
342_I375_K0.8040.17
185_S241_E0.8030.17
181_I239_S0.8030.17
178_K238_E0.7970.17
6_G11_D0.7960.17
251_T307_N0.7890.17
299_V337_L0.7870.16
209_L216_D0.7870.16
157_G270_T0.7870.16
365_L370_G0.7860.16
214_G400_Q0.7840.16
129_I232_K0.7830.16
349_E367_K0.7810.16
38_L171_K0.7810.16
29_L80_Y0.7800.16
143_L156_L0.7770.16
7_I85_V0.7770.16
65_E69_T0.7760.16
155_G168_T0.7760.16
88_V125_D0.7740.16
150_I409_K0.7710.16
4_V58_A0.7700.16
213_H250_K0.7690.16
123_I362_T0.7680.16
6_G222_I0.7680.16
46_L122_G0.7680.16
62_L287_V0.7670.16
120_I123_I0.7650.16
228_Q232_K0.7640.16
175_W319_I0.7640.16
8_D12_S0.7630.16
301_K339_R0.7610.16
97_K214_G0.7600.16
199_A408_T0.7600.16
153_I157_G0.7590.16
167_I337_L0.7580.16
95_G218_I0.7570.16
215_T365_L0.7530.16
235_E394_L0.7510.16
82_I236_L0.7500.16
214_G324_A0.7490.16
369_K372_R0.7440.16
76_I133_K0.7430.15
16_G336_E0.7420.15
299_V306_L0.7420.15
28_Y191_E0.7400.15
371_Y385_K0.7390.15
20_H199_A0.7390.15
124_S359_G0.7380.15
4_V164_Y0.7370.15
273_V343_L0.7360.15
58_A102_I0.7360.15
49_N112_F0.7340.15
313_L392_R0.7340.15
114_K138_K0.7330.15
168_T248_I0.7320.15
313_L317_D0.7320.15
127_I138_K0.7260.15
275_Q377_K0.7250.15
170_R216_D0.7240.15
301_K403_S0.7240.15
137_E178_K0.7230.15
96_R144_R0.7210.15
161_D360_G0.7210.15
207_T247_A0.7200.15
5_I293_D0.7130.15
198_F405_R0.7080.15
197_T407_L0.7080.15
96_R199_A0.7050.15
307_N404_Y0.7050.15
388_K415_L0.7040.15
129_I144_R0.7030.15
94_H390_I0.7030.15
164_Y186_V0.7020.15
392_R399_Y0.6980.14
80_Y111_L0.6970.14
91_A144_R0.6960.14
307_N403_S0.6960.14
100_I257_I0.6940.14
241_E287_V0.6930.14
285_G352_N0.6930.14
27_S391_M0.6890.14
51_P91_A0.6880.14
129_I283_E0.6870.14
99_G150_I0.6870.14
159_S237_I0.6860.14
51_P214_G0.6860.14
306_L404_Y0.6840.14
191_E335_I0.6830.14
58_A408_T0.6810.14
260_Q324_A0.6800.14
41_P127_I0.6800.14
231_I409_K0.6790.14
86_K248_I0.6780.14
307_N336_E0.6780.14
90_L123_I0.6770.14
60_I263_G0.6770.14
159_S257_I0.6760.14
128_P275_Q0.6740.14
232_K235_E0.6720.14
100_I382_T0.6710.14
241_E345_L0.6670.14
275_Q278_N0.6650.14
120_I124_S0.6640.14
210_I267_Y0.6630.14
15_F21_F0.6620.14
83_E180_M0.6610.14
174_N367_K0.6600.14
39_D250_K0.6590.14
96_R251_T0.6580.14
125_D130_D0.6560.14
247_A295_D0.6530.14
254_S392_R0.6520.14
362_T413_L0.6520.14
128_P278_N0.6510.14
175_W244_D0.6510.14
274_V297_L0.6500.14
123_I156_L0.6500.14
350_L387_T0.6500.14
179_R219_L0.6490.13
174_N177_K0.6470.13
206_D277_K0.6460.13
13_Y93_E0.6450.13
122_G154_A0.6440.13
113_D138_K0.6440.13
49_N413_L0.6430.13
31_K396_L0.6410.13
13_Y372_R0.6410.13
96_R286_D0.6410.13
149_I210_I0.6400.13
185_S303_T0.6400.13
303_T399_Y0.6400.13
306_L400_Q0.6400.13
273_V320_V0.6380.13
272_K335_I0.6380.13
89_S356_P0.6380.13
16_G145_G0.6370.13
185_S189_V0.6370.13
132_A153_I0.6340.13
268_Q363_N0.6320.13
58_A209_L0.6320.13
164_Y227_I0.6310.13
97_K172_K0.6300.13
270_T413_L0.6290.13
136_A351_V0.6290.13
256_D307_N0.6290.13
155_G202_D0.6270.13
76_I318_E0.6250.13
248_I396_L0.6250.13
306_L401_T0.6240.13
149_I362_T0.6230.13
367_K409_K0.6230.13
297_L337_L0.6230.13
267_Y398_M0.6220.13
7_I205_N0.6210.13
172_K181_I0.6210.13
113_D391_M0.6180.13
238_E383_T0.6160.13
241_E276_V0.6140.13
58_A81_S0.6140.13
3_Y324_A0.6130.13
123_I321_A0.6120.13
51_P60_I0.6090.13
50_I214_G0.6090.13
153_I385_K0.6080.13
21_F214_G0.6030.13
293_D325_V0.6030.13
260_Q361_S0.6020.13
241_E399_Y0.5990.13
288_I334_I0.5980.13
82_I277_K0.5970.12
266_F300_Y0.5970.12
35_T39_D0.5950.12
162_Y190_D0.5940.12
339_R401_T0.5940.12
34_S127_I0.5920.12
141_I167_I0.5910.12
256_D299_V0.5870.12
317_D392_R0.5860.12
202_D303_T0.5860.12
253_Q364_S0.5850.12
96_R403_S0.5840.12
321_A397_G0.5840.12
306_L337_L0.5840.12
123_I344_K0.5830.12
177_K241_E0.5820.12
46_L59_S0.5810.12
145_G237_I0.5780.12
20_H306_L0.5780.12
44_V181_I0.5770.12
85_V263_G0.5760.12
254_S326_K0.5760.12
334_I394_L0.5750.12
300_Y337_L0.5750.12
153_I201_Y0.5750.12
23_V218_I0.5720.12
136_A141_I0.5720.12
52_W300_Y0.5720.12
10_H286_D0.5710.12
50_I267_Y0.5680.12
79_S244_D0.5660.12
22_S62_L0.5660.12
127_I264_N0.5660.12
44_V325_V0.5650.12
367_K396_L0.5640.12
41_P407_L0.5640.12
133_K389_N0.5640.12
310_A365_L0.5620.12
291_T296_I0.5620.12
149_I363_N0.5620.12
255_T285_G0.5590.12
400_Q412_F0.5590.12
16_G97_K0.5580.12
318_E354_K0.5580.12
306_L408_T0.5580.12
10_H21_F0.5570.12
25_L277_K0.5570.12
20_H404_Y0.5570.12
20_H401_T0.5560.12
29_L386_S0.5560.12
178_K236_L0.5560.12
277_K315_K0.5520.12
293_D347_D0.5510.12
41_P166_L0.5510.12
193_T226_S0.5500.12
183_K186_V0.5480.12
119_Y415_L0.5480.12
214_G267_Y0.5460.12
128_P327_P0.5450.12
193_T248_I0.5440.12
188_R192_S0.5430.12
58_A78_F0.5430.12
225_A375_K0.5430.12
194_F270_T0.5410.11
352_N385_K0.5410.11
120_I236_L0.5390.11
283_E390_I0.5390.11
226_S300_Y0.5390.11
355_C376_C0.5360.11
355_C373_C0.5360.11
60_I214_G0.5360.11
133_K172_K0.5350.11
40_L250_K0.5320.11
147_R270_T0.5320.11
227_I365_L0.5310.11
239_S374_K0.5310.11
173_E382_T0.5290.11
233_A407_L0.5280.11
299_V302_E0.5270.11
249_F385_K0.5270.11
154_A349_E0.5260.11
300_Y372_R0.5260.11
225_A365_L0.5230.11
115_L157_G0.5220.11
285_G413_L0.5210.11
209_L339_R0.5200.11
62_L203_Y0.5190.11
16_G21_F0.5180.11
85_V167_I0.5180.11
158_M372_R0.5160.11
310_A401_T0.5150.11
16_G167_I0.5150.11
172_K310_A0.5110.11
276_V289_V0.5100.11
142_E237_I0.5090.11
219_L334_I0.5090.11
282_L395_S0.5080.11
339_R408_T0.5080.11
220_Y310_A0.5080.11
58_A210_I0.5080.11
111_L123_I0.5070.11
29_L215_T0.5070.11
361_S369_K0.5060.11
394_L399_Y0.5060.11
130_D386_S0.5050.11
351_V386_S0.5040.11
320_V343_L0.5040.11
202_D316_G0.5030.11
41_P126_I0.5020.11
369_K413_L0.5010.11
147_R199_A0.5000.11
91_A222_I0.5000.11
306_L403_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3au7A 1 0.7675 100 0.288 Contact Map
3u02A 3 0.5553 100 0.507 Contact Map
4gn4B 1 0.2144 95 0.967 Contact Map
1vd4A 1 0.1242 93.1 0.969 Contact Map
4gnxB 1 0.2641 90.7 0.971 Contact Map
1vq8Z 1 0.158 87.4 0.973 Contact Map
2k4xA 1 0.1084 87 0.973 Contact Map
1ffkW 1 0.1467 86.3 0.973 Contact Map
3j21g 1 0.1016 85.4 0.974 Contact Map
3j21i 1 0.158 80.6 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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