GREMLIN Database
GGGPS - Geranylgeranylglyceryl phosphate synthase
UniProt: Q980N1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (217)
Sequences: 639 (487)
Seq/√Len: 33.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_I149_A8.3581.00
216_R220_V4.8261.00
61_I79_L4.2971.00
205_S209_L4.1521.00
217_S220_V3.9381.00
141_V181_V3.5981.00
113_D154_K3.4471.00
114_I117_I3.1041.00
107_S178_M2.8381.00
30_F233_V2.8151.00
208_P231_I2.7201.00
216_R240_S2.3460.99
33_I75_V2.3360.99
115_Y120_A2.2970.99
90_P105_F2.2800.99
96_L103_L2.2390.99
60_L104_L2.2050.99
150_A157_V2.2010.99
126_P164_E2.1270.99
65_L148_T2.1260.99
166_A197_M2.1100.99
61_I76_I2.0000.98
29_H56_T1.9780.98
173_A207_I1.9480.97
36_F65_L1.8930.97
170_T174_E1.8870.97
69_K97_S1.8870.97
199_S226_E1.8850.97
180_F210_I1.8380.96
144_G160_Y1.8160.96
195_P224_L1.7630.95
36_F66_G1.7450.95
218_V222_L1.7440.95
221_A232_I1.7350.95
241_D244_K1.6980.94
61_I86_K1.6780.94
171_L175_Y1.6460.93
190_P223_K1.6260.93
72_L88_I1.6220.93
199_S203_N1.5640.91
139_A178_M1.5510.91
190_P224_L1.5460.91
73_D97_S1.5430.91
107_S176_L1.4840.89
104_L138_T1.4820.89
44_L78_L1.4790.89
73_D99_K1.4700.89
114_I119_G1.4660.88
51_L59_F1.4630.88
210_I233_V1.4300.87
43_E242_V1.4140.87
118_I176_L1.4030.86
92_N95_L1.3990.86
196_E199_S1.3970.86
145_H160_Y1.3540.84
77_S99_K1.3360.83
244_K247_K1.3310.83
30_F60_L1.3270.83
40_S43_E1.3270.83
217_S223_K1.3110.82
198_I224_L1.3080.82
87_I102_A1.2850.81
88_I201_I1.2760.80
222_L226_E1.2560.79
30_F58_A1.2440.79
215_I221_A1.2340.78
33_I54_A1.2290.78
33_I39_N1.2190.77
159_P162_N1.2160.77
29_H234_T1.2120.77
64_T224_L1.2050.76
157_V160_Y1.1960.76
102_A136_I1.1890.75
106_M153_G1.1870.75
170_T204_A1.1570.73
79_L82_Y1.1470.73
142_I155_A1.1380.72
237_I244_K1.1130.70
27_K230_D1.1050.70
70_D74_F1.1020.70
136_I180_F1.0910.69
123_V161_D1.0890.69
54_A75_V1.0840.68
52_Y84_I1.0810.68
33_I145_H1.0790.68
173_A181_V1.0660.67
171_L206_S1.0610.67
51_L54_A1.0550.66
125_A173_A1.0550.66
221_A225_V1.0380.65
200_F203_N1.0360.65
136_I217_S1.0340.65
147_G155_A1.0270.64
242_V246_I1.0220.64
70_D199_S1.0110.63
79_L86_K1.0100.63
128_I135_V1.0060.62
31_S238_I1.0030.62
169_Y173_A1.0000.62
190_P195_P0.9990.62
185_A191_E0.9900.61
118_I125_A0.9880.61
111_S153_G0.9820.60
36_F148_T0.9750.60
162_N166_A0.9730.60
121_Q171_L0.9610.59
31_S56_T0.9580.59
118_I122_I0.9570.58
110_N142_I0.9560.58
121_Q176_L0.9490.58
71_K74_F0.9360.57
167_T200_F0.9340.57
236_N239_E0.9280.56
109_L139_A0.9270.56
126_P168_A0.9270.56
182_Y212_G0.9260.56
137_P172_A0.9180.55
109_L178_M0.9160.55
78_L82_Y0.9060.54
26_E206_S0.9050.54
66_G71_K0.8920.53
64_T117_I0.8840.52
75_V84_I0.8820.52
89_F108_L0.8770.52
150_A155_A0.8710.51
108_L153_G0.8690.51
139_A181_V0.8680.51
217_S232_I0.8660.51
40_S44_L0.8650.51
163_F167_T0.8600.50
142_I147_G0.8570.50
183_L211_V0.8500.50
151_H159_P0.8490.50
37_K148_T0.8460.49
127_I181_V0.8430.49
95_L111_S0.8350.48
76_I97_S0.8340.48
39_N78_L0.8290.48
56_T184_E0.8240.47
114_I157_V0.8200.47
125_A175_Y0.8100.46
84_I136_I0.8090.46
53_N243_N0.8070.46
172_A181_V0.8050.46
116_Y133_M0.8050.46
182_Y188_G0.8010.46
160_Y194_R0.8010.46
149_A227_A0.7960.45
31_S245_A0.7880.44
195_P223_K0.7870.44
105_F121_Q0.7860.44
29_H110_N0.7860.44
117_I146_G0.7780.44
155_A225_V0.7780.44
118_I137_P0.7750.43
31_S75_V0.7740.43
136_I207_I0.7730.43
61_I84_I0.7730.43
95_L142_I0.7640.42
112_D154_K0.7570.42
218_V244_K0.7560.42
146_G189_A0.7460.41
144_G149_A0.7450.41
141_V201_I0.7420.41
188_G212_G0.7380.40
156_R159_P0.7340.40
164_E179_S0.7330.40
58_A184_E0.7310.40
109_L176_L0.7290.40
121_Q137_P0.7280.40
122_I189_A0.7220.39
123_V159_P0.7200.39
82_Y86_K0.7200.39
70_D77_S0.7200.39
121_Q166_A0.7200.39
56_T234_T0.7170.39
107_S197_M0.7080.38
60_L131_L0.7070.38
110_N169_Y0.7070.38
60_L138_T0.7040.38
56_T84_I0.6960.37
177_G227_A0.6940.37
91_S149_A0.6940.37
197_M227_A0.6940.37
159_P189_A0.6930.37
166_A201_I0.6930.37
174_E206_S0.6910.37
131_L135_V0.6900.37
107_S117_I0.6860.36
174_E230_D0.6830.36
89_F211_V0.6800.36
96_L128_I0.6770.36
205_S208_P0.6760.36
28_L67_V0.6740.35
125_A231_I0.6710.35
67_V204_A0.6710.35
129_K174_E0.6690.35
133_M172_A0.6660.35
162_N197_M0.6650.35
185_A211_V0.6620.34
72_L130_M0.6610.34
111_S155_A0.6600.34
72_L147_G0.6600.34
139_A230_D0.6590.34
117_I121_Q0.6580.34
181_V207_I0.6550.34
117_I122_I0.6550.34
64_T136_I0.6540.34
76_I208_P0.6540.34
81_D243_N0.6510.34
93_I120_A0.6470.33
50_N96_L0.6470.33
104_L107_S0.6460.33
29_H55_G0.6420.33
177_G216_R0.6410.33
162_N200_F0.6410.33
151_H154_K0.6390.33
124_A181_V0.6370.33
100_A103_L0.6360.33
123_V126_P0.6350.32
68_S191_E0.6340.32
113_D117_I0.6330.32
36_F133_M0.6320.32
93_I124_A0.6320.32
110_N155_A0.6310.32
241_D245_A0.6290.32
26_E199_S0.6260.32
107_S114_I0.6250.32
154_K197_M0.6250.32
90_P146_G0.6230.32
101_D202_K0.6220.32
59_F103_L0.6160.31
183_L197_M0.6150.31
202_K217_S0.6130.31
149_A226_E0.6110.31
52_Y82_Y0.6100.31
125_A133_M0.6080.31
56_T249_I0.6080.31
102_A216_R0.6060.30
220_V223_K0.6050.30
52_Y81_D0.6040.30
69_K83_E0.6030.30
66_G72_L0.5990.30
114_I118_I0.5930.29
53_N77_S0.5920.29
110_N150_A0.5890.29
111_S114_I0.5840.29
40_S230_D0.5830.29
137_P175_Y0.5810.29
43_E115_Y0.5790.29
143_V197_M0.5780.28
106_M110_N0.5770.28
54_A179_S0.5760.28
146_G233_V0.5750.28
33_I76_I0.5740.28
159_P163_F0.5730.28
197_M200_F0.5730.28
142_I196_E0.5700.28
44_L149_A0.5690.28
153_G169_Y0.5680.28
36_F125_A0.5670.28
180_F238_I0.5660.28
64_T71_K0.5660.28
96_L130_M0.5660.28
61_I244_K0.5650.28
240_S243_N0.5640.27
76_I86_K0.5630.27
42_D131_L0.5630.27
110_N145_H0.5620.27
166_A204_A0.5610.27
162_N165_L0.5580.27
177_G240_S0.5580.27
72_L85_P0.5560.27
33_I80_D0.5530.27
185_A189_A0.5530.27
134_E183_L0.5520.27
154_K161_D0.5520.27
132_Q175_Y0.5490.27
33_I97_S0.5490.27
128_I177_G0.5490.27
203_N206_S0.5490.27
133_M137_P0.5490.27
142_I153_G0.5480.26
198_I230_D0.5470.26
73_D80_D0.5460.26
122_I173_A0.5450.26
32_L89_F0.5450.26
140_Y213_G0.5440.26
124_A144_G0.5410.26
111_S173_A0.5380.26
29_H221_A0.5380.26
88_I100_A0.5370.26
110_N153_G0.5360.26
96_L247_K0.5350.26
58_A87_I0.5340.26
187_S212_G0.5330.25
212_G235_G0.5330.25
76_I79_L0.5330.25
42_D67_V0.5330.25
90_P125_A0.5320.25
150_A160_Y0.5310.25
184_E212_G0.5290.25
89_F106_M0.5260.25
114_I137_P0.5250.25
112_D237_I0.5240.25
199_S250_R0.5230.25
111_S117_I0.5230.25
166_A200_F0.5220.25
121_Q168_A0.5210.25
55_G249_I0.5190.25
151_H162_N0.5180.25
52_Y79_L0.5170.24
60_L237_I0.5150.24
134_E243_N0.5150.24
61_I199_S0.5130.24
173_A231_I0.5110.24
107_S146_G0.5100.24
58_A221_A0.5080.24
121_Q133_M0.5080.24
102_A208_P0.5060.24
92_N120_A0.5050.24
36_F85_P0.5020.24
53_N83_E0.5020.24
79_L236_N0.5020.24
69_K197_M0.5010.24
143_V167_T0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f6uA 2 0.851 100 0.636 Contact Map
3vzxA 2 0.8706 100 0.646 Contact Map
4mm1A 3 0.9373 100 0.65 Contact Map
3vk5A 2 0.902 100 0.657 Contact Map
3w01A 2 0.8902 100 0.659 Contact Map
4jejA 2 0.9333 100 0.688 Contact Map
4nafA 2 0.8627 100 0.708 Contact Map
3ktsA 1 0.7255 100 0.716 Contact Map
3thaA 2 0.8039 99.7 0.817 Contact Map
1ujpA 1 0.7686 99.7 0.82 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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