GREMLIN Database
Q980M6 - DNA modification methylase, type II R/M system
UniProt: Q980M6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (290)
Sequences: 6961 (5643)
Seq/√Len: 331.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
275_R281_D4.1211.00
109_E112_R4.1201.00
22_K306_T3.8051.00
122_F175_N3.2321.00
128_P169_S3.2111.00
72_D120_K3.1731.00
8_D17_S3.0981.00
20_F309_A3.0751.00
306_T310_K3.0561.00
278_S303_A3.0031.00
36_A291_E2.8291.00
5_K26_E2.6871.00
76_G110_F2.6861.00
6_I27_P2.6251.00
82_G104_G2.5461.00
159_A301_P2.5131.00
311_E314_G2.4461.00
118_K177_R2.4081.00
11_S32_D2.3741.00
151_N178_I2.3341.00
40_T295_Q2.3081.00
9_L74_V2.1481.00
82_G101_D2.1051.00
279_Y299_S2.0881.00
114_V122_F2.0191.00
60_G116_E2.0021.00
6_I25_I1.9971.00
43_L286_L1.9821.00
111_I143_E1.9531.00
158_H167_K1.8441.00
70_D117_V1.8261.00
266_R272_E1.8221.00
20_F75_I1.8161.00
43_L284_V1.8071.00
245_S248_D1.7921.00
271_R274_A1.7921.00
56_R109_E1.7791.00
7_I29_L1.7631.00
81_E103_R1.7621.00
130_I171_V1.7471.00
112_R116_E1.7191.00
15_G279_Y1.7111.00
5_K28_K1.7111.00
53_D57_E1.6421.00
54_D57_E1.6271.00
4_I25_I1.6211.00
34_N294_N1.6141.00
131_I171_V1.6051.00
164_N278_S1.5951.00
159_A304_L1.5821.00
190_Y247_F1.5801.00
176_V179_S1.5711.00
35_H39_R1.5331.00
288_S291_E1.5231.00
115_D147_A1.5191.00
268_L273_Q1.5161.00
38_T52_E1.5141.00
158_H161_D1.5071.00
59_S62_E1.5031.00
18_L280_P1.4891.00
73_V121_I1.4881.00
301_P304_L1.4831.00
271_R275_R1.4691.00
137_R154_F1.4681.00
172_F304_L1.4641.00
164_N301_P1.4571.00
60_G113_I1.4561.00
19_G23_L1.4531.00
160_E167_K1.4451.00
187_I191_D1.4301.00
270_V292_Q1.4261.00
165_P278_S1.4001.00
20_F73_V1.3911.00
273_Q293_Y1.3871.00
212_E216_L1.3531.00
142_N146_K1.3491.00
218_I221_I1.3431.00
23_L306_T1.3431.00
8_D11_S1.3211.00
123_V312_I1.3091.00
38_T42_S1.3021.00
39_R286_L1.3011.00
119_P149_Y1.2971.00
121_I176_V1.2911.00
34_N37_A1.2801.00
303_A306_T1.2801.00
121_I312_I1.2741.00
133_T136_L1.2711.00
141_I152_I1.2701.00
10_F106_L1.2631.00
145_K178_I1.2581.00
218_I222_G1.2581.00
214_K217_K1.2581.00
16_F77_G1.2491.00
98_L101_D1.2451.00
42_S52_E1.2451.00
188_T191_D1.2411.00
292_Q296_V1.2381.00
307_A310_K1.2341.00
274_A296_V1.2331.00
32_D38_T1.2291.00
78_P124_M1.2101.00
122_F144_F1.2001.00
61_G116_E1.1921.00
215_L218_I1.1891.00
71_I74_V1.1871.00
81_E298_E1.1661.00
18_L45_F1.1641.00
160_E186_R1.1631.00
219_S222_G1.1551.00
21_K45_F1.1521.00
137_R173_I1.1421.00
18_L21_K1.1391.00
7_I71_I1.1381.00
123_V308_I1.1361.00
13_A283_H1.1281.00
277_M301_P1.1161.00
130_I140_L1.1071.00
214_K221_I1.1051.00
38_T50_V1.1011.00
121_I316_L1.0881.00
45_F283_H1.0791.00
18_L22_K1.0781.00
20_F123_V1.0671.00
69_N117_V1.0661.00
5_K72_D1.0661.00
274_A285_F1.0621.00
18_L283_H1.0591.00
25_I73_V1.0541.00
143_E146_K1.0511.00
21_K27_P1.0501.00
36_A288_S1.0451.00
141_I154_F1.0401.00
139_A143_E1.0401.00
113_I117_V1.0341.00
17_S21_K1.0251.00
235_G238_I1.0201.00
16_F305_S1.0161.00
102_Q105_N1.0141.00
13_A295_Q1.0141.00
37_A295_Q1.0091.00
190_Y246_P1.0091.00
115_D143_E1.0061.00
16_F75_I1.0051.00
213_K217_K1.0031.00
287_G295_Q1.0031.00
212_E215_L1.0001.00
287_G292_Q0.9941.00
189_V276_L0.9941.00
195_D275_R0.9881.00
246_P262_P0.9871.00
110_F124_M0.9821.00
11_S30_A0.9811.00
214_K218_I0.9791.00
291_E294_N0.9781.00
234_K237_S0.9721.00
110_F114_V0.9691.00
30_A41_Y0.9681.00
60_G112_R0.9681.00
216_L219_S0.9661.00
270_V296_V0.9601.00
217_K220_K0.9601.00
232_A236_R0.9581.00
236_R241_Y0.9551.00
141_I145_K0.9541.00
6_I20_F0.9531.00
74_V113_I0.9521.00
217_K221_I0.9501.00
35_H52_E0.9501.00
303_A307_A0.9471.00
36_A39_R0.9471.00
107_T140_L0.9471.00
87_N90_R0.9431.00
257_S260_I0.9391.00
120_K177_R0.9381.00
157_L162_Y0.9321.00
128_P156_I0.9251.00
85_A129_A0.9251.00
25_I313_L0.9241.00
159_A164_N0.9191.00
23_L310_K0.9191.00
239_P242_I0.9151.00
6_I75_I0.9061.00
233_S236_R0.9011.00
271_R281_D0.8981.00
310_K313_L0.8941.00
212_E219_S0.8931.00
156_I169_S0.8921.00
213_K216_L0.8891.00
237_S241_Y0.8831.00
151_N179_S0.8811.00
278_S302_V0.8771.00
78_P110_F0.8761.00
71_I117_V0.8751.00
236_R240_L0.8751.00
232_A237_S0.8721.00
16_F300_V0.8601.00
161_D186_R0.8571.00
215_L222_G0.8561.00
232_A235_G0.8521.00
18_L302_V0.8501.00
257_S261_H0.8501.00
212_E221_I0.8491.00
39_R42_S0.8451.00
233_S238_I0.8451.00
250_A253_I0.8451.00
29_L51_I0.8441.00
236_R239_P0.8371.00
25_I309_A0.8341.00
250_A276_L0.8321.00
244_L251_P0.8311.00
214_K219_S0.8271.00
31_I58_I0.8231.00
144_F175_N0.8211.00
19_G309_A0.8171.00
233_S237_S0.8061.00
246_P263_F0.8061.00
165_P192_A0.8001.00
13_A40_T0.7961.00
201_D204_N0.7941.00
90_R100_L0.7901.00
5_K70_D0.7891.00
157_L172_F0.7891.00
235_G240_L0.7881.00
6_I73_V0.7871.00
166_S277_M0.7751.00
215_L219_S0.7741.00
192_A196_L0.7681.00
7_I74_V0.7671.00
215_L221_I0.7611.00
11_S41_Y0.7591.00
167_K248_D0.7591.00
17_S30_A0.7581.00
199_K202_V0.7581.00
180_P183_N0.7581.00
10_F78_P0.7551.00
16_F123_V0.7541.00
158_H169_S0.7541.00
249_L252_T0.7530.99
237_S240_L0.7530.99
74_V117_V0.7510.99
83_Y104_G0.7470.99
157_L308_I0.7470.99
41_Y48_T0.7460.99
235_G239_P0.7460.99
107_T143_E0.7430.99
124_M173_I0.7430.99
212_E217_K0.7430.99
74_V110_F0.7390.99
17_S27_P0.7370.99
212_E218_I0.7330.99
291_E295_Q0.7320.99
232_A238_I0.7310.99
53_D62_E0.7300.99
31_I53_D0.7300.99
230_Y236_R0.7290.99
19_G305_S0.7280.99
188_T192_A0.7250.99
89_L129_A0.7240.99
230_Y234_K0.7230.99
214_K222_G0.7190.99
123_V174_S0.7170.99
233_S239_P0.7150.99
270_V289_K0.7140.99
229_M232_A0.7130.99
253_I273_Q0.7120.99
232_A240_L0.7100.99
139_A142_N0.7090.99
114_V175_N0.7020.99
30_A50_V0.7010.99
196_L199_K0.6990.99
200_L203_P0.6980.99
197_D201_D0.6960.99
195_D281_D0.6950.99
193_I196_L0.6950.99
243_R251_P0.6950.99
32_D50_V0.6940.99
200_L204_N0.6930.99
137_R141_I0.6870.99
273_Q296_V0.6850.99
17_S45_F0.6810.99
198_N202_V0.6810.99
15_G300_V0.6810.99
238_I241_Y0.6800.99
138_D142_N0.6770.99
80_C170_R0.6770.99
240_L243_R0.6760.99
274_A292_Q0.6760.99
172_F301_P0.6750.99
153_F176_V0.6720.99
37_A298_E0.6680.99
22_K303_A0.6650.99
44_N283_H0.6630.99
244_L268_L0.6630.99
29_L32_D0.6620.99
185_K191_D0.6610.99
82_G105_N0.6610.99
11_S17_S0.6600.99
189_V193_I0.6600.99
271_R285_F0.6560.99
182_K186_R0.6550.99
237_S244_L0.6550.99
229_M238_I0.6530.99
15_G302_V0.6510.99
34_N291_E0.6500.99
164_N303_A0.6500.99
131_I154_F0.6480.98
229_M236_R0.6480.98
73_V123_V0.6450.98
176_V312_I0.6420.98
199_K203_P0.6410.98
238_I242_I0.6410.98
9_L31_I0.6380.98
243_R246_P0.6370.98
75_I123_V0.6350.98
217_K222_G0.6340.98
236_R242_I0.6330.98
244_L248_D0.6320.98
112_R115_D0.6310.98
58_I112_R0.6270.98
278_S301_P0.6260.98
198_N201_D0.6250.98
236_R243_R0.6240.98
311_E315_I0.6230.98
237_S254_L0.6210.98
212_E222_G0.6210.98
255_G294_N0.6190.98
215_L220_K0.6190.98
23_L309_A0.6180.98
27_P30_A0.6170.98
270_V293_Y0.6170.98
201_D205_N0.6160.98
160_E249_L0.6160.98
17_S41_Y0.6150.98
229_M233_S0.6140.98
181_I185_K0.6140.98
85_A89_L0.6120.98
258_R263_F0.6100.98
183_N186_R0.6070.98
190_Y194_H0.6060.98
74_V114_V0.6060.98
172_F305_S0.6040.98
243_R248_D0.6040.98
27_P41_Y0.6040.98
131_I137_R0.6030.98
233_S241_Y0.6030.98
11_S38_T0.6030.98
222_G228_T0.6020.98
180_P184_Q0.6000.98
46_P49_I0.5970.97
238_I243_R0.5950.97
42_S48_T0.5910.97
6_I17_S0.5880.97
213_K221_I0.5880.97
261_H264_H0.5870.97
181_I184_Q0.5870.97
108_L143_E0.5850.97
42_S50_V0.5850.97
44_N284_V0.5840.97
216_L220_K0.5830.97
231_R237_S0.5820.97
5_K71_I0.5810.97
137_R171_V0.5810.97
271_R282_D0.5790.97
230_Y237_S0.5780.97
258_R262_P0.5760.97
159_A172_F0.5740.97
63_I113_I0.5730.97
257_S262_P0.5710.97
192_A275_R0.5700.97
152_I175_N0.5700.97
111_I147_A0.5700.97
87_N103_R0.5700.97
252_T256_N0.5700.97
216_L222_G0.5690.97
237_S243_R0.5690.97
233_S240_L0.5680.97
216_L221_I0.5650.96
10_F55_I0.5610.96
252_T255_G0.5580.96
131_I156_I0.5580.96
239_P243_R0.5580.96
41_Y45_F0.5580.96
107_T139_A0.5570.96
15_G19_G0.5560.96
32_D37_A0.5540.96
85_A128_P0.5540.96
4_I316_L0.5500.96
285_F296_V0.5480.96
230_Y233_S0.5470.96
104_G136_L0.5440.96
260_I263_F0.5440.96
214_K220_K0.5430.96
90_R101_D0.5420.96
82_G90_R0.5420.96
85_A132_E0.5420.96
162_Y307_A0.5410.95
7_I28_K0.5400.95
299_S305_S0.5400.95
115_D146_K0.5390.95
142_N145_K0.5360.95
73_V309_A0.5340.95
21_K47_N0.5340.95
154_F171_V0.5340.95
259_F263_F0.5330.95
21_K26_E0.5320.95
106_L109_E0.5290.95
157_L304_L0.5280.95
231_R236_R0.5270.95
114_V119_P0.5270.95
259_F262_P0.5240.95
197_D200_L0.5240.95
151_N154_F0.5230.95
251_P254_L0.5230.95
202_V205_N0.5220.95
187_I192_A0.5220.95
8_D75_I0.5200.94
162_Y304_L0.5200.94
108_L139_A0.5190.94
111_I144_F0.5190.94
148_G178_I0.5180.94
229_M235_G0.5180.94
221_I228_T0.5160.94
29_L69_N0.5160.94
236_R244_L0.5150.94
235_G241_Y0.5150.94
78_P140_L0.5110.94
234_K241_Y0.5070.94
130_I173_I0.5050.94
212_E220_K0.5040.93
229_M234_K0.5030.93
15_G299_S0.5020.93
229_M240_L0.5020.93
35_H38_T0.5020.93
176_V315_I0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3swrA 1 0.9631 100 0.137 Contact Map
4ft4B 1 0.9877 100 0.154 Contact Map
4wxxA 1 0.9785 100 0.171 Contact Map
4dkjA 1 0.9292 100 0.172 Contact Map
2c7pA 1 0.9231 100 0.194 Contact Map
3g7uA 1 0.9077 100 0.198 Contact Map
3qv2A 1 0.9323 100 0.217 Contact Map
4h0nA 1 0.9138 100 0.221 Contact Map
1g55A 1 0.8677 100 0.223 Contact Map
3ubtY 2 0.9108 100 0.226 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.