Q980M6 - SULSO - GREMLIN Contacts

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Q980M6 - DNA modification methylase, type II R/M system

UniProt:	Q980M6	Sequences: MELIKIIDLFSGAGGFSLGFKKLGIEPKLAIDINHAATRTYSLNFPNTIVIEDDIREISGGEILKNVGNDIDVVIGGPPCEGYTAANPLRMQDPLDRLYLDQRGNLTLEFIRIVDEVKPKIFVMENVPAIIETQSLRDALINEFKKAGYGNIFFNILHAEDYGNPSKRSRVFISNVRISPIKNQKRITVYDAIHDLDNKLDVPNNEVSEPNEKKLLKISKIGYGKYLTMYRASKGRSIPLYIRLSPFDLAPTILGNSRFIHPFHDRFLTVREQARLMSYPDDHVFLGSKDEQYNQVGESVPVALSTAIAKEILGILNERTIFRPT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (290)
Sequences:	6961 (5643)
Seq/√Len:	331.3

ECOLI - DCM
BACSU - YDIO MTBP YDIP
SULSO - Q980M6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
275_R	281_D	4.121	1.00
109_E	112_R	4.120	1.00
22_K	306_T	3.805	1.00
122_F	175_N	3.232	1.00
128_P	169_S	3.211	1.00
72_D	120_K	3.173	1.00
8_D	17_S	3.098	1.00
20_F	309_A	3.075	1.00
306_T	310_K	3.056	1.00
278_S	303_A	3.003	1.00
36_A	291_E	2.829	1.00
5_K	26_E	2.687	1.00
76_G	110_F	2.686	1.00
6_I	27_P	2.625	1.00
82_G	104_G	2.546	1.00
159_A	301_P	2.513	1.00
311_E	314_G	2.446	1.00
118_K	177_R	2.408	1.00
11_S	32_D	2.374	1.00
151_N	178_I	2.334	1.00
40_T	295_Q	2.308	1.00
9_L	74_V	2.148	1.00
82_G	101_D	2.105	1.00
279_Y	299_S	2.088	1.00
114_V	122_F	2.019	1.00
60_G	116_E	2.002	1.00
6_I	25_I	1.997	1.00
43_L	286_L	1.982	1.00
111_I	143_E	1.953	1.00
158_H	167_K	1.844	1.00
70_D	117_V	1.826	1.00
266_R	272_E	1.822	1.00
20_F	75_I	1.816	1.00
43_L	284_V	1.807	1.00
245_S	248_D	1.792	1.00
271_R	274_A	1.792	1.00
56_R	109_E	1.779	1.00
7_I	29_L	1.763	1.00
81_E	103_R	1.762	1.00
130_I	171_V	1.747	1.00
112_R	116_E	1.719	1.00
15_G	279_Y	1.711	1.00
5_K	28_K	1.711	1.00
53_D	57_E	1.642	1.00
54_D	57_E	1.627	1.00
4_I	25_I	1.621	1.00
34_N	294_N	1.614	1.00
131_I	171_V	1.605	1.00
164_N	278_S	1.595	1.00
159_A	304_L	1.582	1.00
190_Y	247_F	1.580	1.00
176_V	179_S	1.571	1.00
35_H	39_R	1.533	1.00
288_S	291_E	1.523	1.00
115_D	147_A	1.519	1.00
268_L	273_Q	1.516	1.00
38_T	52_E	1.514	1.00
158_H	161_D	1.507	1.00
59_S	62_E	1.503	1.00
18_L	280_P	1.489	1.00
73_V	121_I	1.488	1.00
301_P	304_L	1.483	1.00
271_R	275_R	1.469	1.00
137_R	154_F	1.468	1.00
172_F	304_L	1.464	1.00
164_N	301_P	1.457	1.00
60_G	113_I	1.456	1.00
19_G	23_L	1.453	1.00
160_E	167_K	1.445	1.00
187_I	191_D	1.430	1.00
270_V	292_Q	1.426	1.00
165_P	278_S	1.400	1.00
20_F	73_V	1.391	1.00
273_Q	293_Y	1.387	1.00
212_E	216_L	1.353	1.00
142_N	146_K	1.349	1.00
218_I	221_I	1.343	1.00
23_L	306_T	1.343	1.00
8_D	11_S	1.321	1.00
123_V	312_I	1.309	1.00
38_T	42_S	1.302	1.00
39_R	286_L	1.301	1.00
119_P	149_Y	1.297	1.00
121_I	176_V	1.291	1.00
34_N	37_A	1.280	1.00
303_A	306_T	1.280	1.00
121_I	312_I	1.274	1.00
133_T	136_L	1.271	1.00
141_I	152_I	1.270	1.00
10_F	106_L	1.263	1.00
145_K	178_I	1.258	1.00
218_I	222_G	1.258	1.00
214_K	217_K	1.258	1.00
16_F	77_G	1.249	1.00
98_L	101_D	1.245	1.00
42_S	52_E	1.245	1.00
188_T	191_D	1.241	1.00
292_Q	296_V	1.238	1.00
307_A	310_K	1.234	1.00
274_A	296_V	1.233	1.00
32_D	38_T	1.229	1.00
78_P	124_M	1.210	1.00
122_F	144_F	1.200	1.00
61_G	116_E	1.192	1.00
215_L	218_I	1.189	1.00
71_I	74_V	1.187	1.00
81_E	298_E	1.166	1.00
18_L	45_F	1.164	1.00
160_E	186_R	1.163	1.00
219_S	222_G	1.155	1.00
21_K	45_F	1.152	1.00
137_R	173_I	1.142	1.00
18_L	21_K	1.139	1.00
7_I	71_I	1.138	1.00
123_V	308_I	1.136	1.00
13_A	283_H	1.128	1.00
277_M	301_P	1.116	1.00
130_I	140_L	1.107	1.00
214_K	221_I	1.105	1.00
38_T	50_V	1.101	1.00
121_I	316_L	1.088	1.00
45_F	283_H	1.079	1.00
18_L	22_K	1.078	1.00
20_F	123_V	1.067	1.00
69_N	117_V	1.066	1.00
5_K	72_D	1.066	1.00
274_A	285_F	1.062	1.00
18_L	283_H	1.059	1.00
25_I	73_V	1.054	1.00
143_E	146_K	1.051	1.00
21_K	27_P	1.050	1.00
36_A	288_S	1.045	1.00
141_I	154_F	1.040	1.00
139_A	143_E	1.040	1.00
113_I	117_V	1.034	1.00
17_S	21_K	1.025	1.00
235_G	238_I	1.020	1.00
16_F	305_S	1.016	1.00
102_Q	105_N	1.014	1.00
13_A	295_Q	1.014	1.00
37_A	295_Q	1.009	1.00
190_Y	246_P	1.009	1.00
115_D	143_E	1.006	1.00
16_F	75_I	1.005	1.00
213_K	217_K	1.003	1.00
287_G	295_Q	1.003	1.00
212_E	215_L	1.000	1.00
287_G	292_Q	0.994	1.00
189_V	276_L	0.994	1.00
195_D	275_R	0.988	1.00
246_P	262_P	0.987	1.00
110_F	124_M	0.982	1.00
11_S	30_A	0.981	1.00
214_K	218_I	0.979	1.00
291_E	294_N	0.978	1.00
234_K	237_S	0.972	1.00
110_F	114_V	0.969	1.00
30_A	41_Y	0.968	1.00
60_G	112_R	0.968	1.00
216_L	219_S	0.966	1.00
270_V	296_V	0.960	1.00
217_K	220_K	0.960	1.00
232_A	236_R	0.958	1.00
236_R	241_Y	0.955	1.00
141_I	145_K	0.954	1.00
6_I	20_F	0.953	1.00
74_V	113_I	0.952	1.00
217_K	221_I	0.950	1.00
35_H	52_E	0.950	1.00
303_A	307_A	0.947	1.00
36_A	39_R	0.947	1.00
107_T	140_L	0.947	1.00
87_N	90_R	0.943	1.00
257_S	260_I	0.939	1.00
120_K	177_R	0.938	1.00
157_L	162_Y	0.932	1.00
128_P	156_I	0.925	1.00
85_A	129_A	0.925	1.00
25_I	313_L	0.924	1.00
159_A	164_N	0.919	1.00
23_L	310_K	0.919	1.00
239_P	242_I	0.915	1.00
6_I	75_I	0.906	1.00
233_S	236_R	0.901	1.00
271_R	281_D	0.898	1.00
310_K	313_L	0.894	1.00
212_E	219_S	0.893	1.00
156_I	169_S	0.892	1.00
213_K	216_L	0.889	1.00
237_S	241_Y	0.883	1.00
151_N	179_S	0.881	1.00
278_S	302_V	0.877	1.00
78_P	110_F	0.876	1.00
71_I	117_V	0.875	1.00
236_R	240_L	0.875	1.00
232_A	237_S	0.872	1.00
16_F	300_V	0.860	1.00
161_D	186_R	0.857	1.00
215_L	222_G	0.856	1.00
232_A	235_G	0.852	1.00
18_L	302_V	0.850	1.00
257_S	261_H	0.850	1.00
212_E	221_I	0.849	1.00
39_R	42_S	0.845	1.00
233_S	238_I	0.845	1.00
250_A	253_I	0.845	1.00
29_L	51_I	0.844	1.00
236_R	239_P	0.837	1.00
25_I	309_A	0.834	1.00
250_A	276_L	0.832	1.00
244_L	251_P	0.831	1.00
214_K	219_S	0.827	1.00
31_I	58_I	0.823	1.00
144_F	175_N	0.821	1.00
19_G	309_A	0.817	1.00
233_S	237_S	0.806	1.00
246_P	263_F	0.806	1.00
165_P	192_A	0.800	1.00
13_A	40_T	0.796	1.00
201_D	204_N	0.794	1.00
90_R	100_L	0.790	1.00
5_K	70_D	0.789	1.00
157_L	172_F	0.789	1.00
235_G	240_L	0.788	1.00
6_I	73_V	0.787	1.00
166_S	277_M	0.775	1.00
215_L	219_S	0.774	1.00
192_A	196_L	0.768	1.00
7_I	74_V	0.767	1.00
215_L	221_I	0.761	1.00
11_S	41_Y	0.759	1.00
167_K	248_D	0.759	1.00
17_S	30_A	0.758	1.00
199_K	202_V	0.758	1.00
180_P	183_N	0.758	1.00
10_F	78_P	0.755	1.00
16_F	123_V	0.754	1.00
158_H	169_S	0.754	1.00
249_L	252_T	0.753	0.99
237_S	240_L	0.753	0.99
74_V	117_V	0.751	0.99
83_Y	104_G	0.747	0.99
157_L	308_I	0.747	0.99
41_Y	48_T	0.746	0.99
235_G	239_P	0.746	0.99
107_T	143_E	0.743	0.99
124_M	173_I	0.743	0.99
212_E	217_K	0.743	0.99
74_V	110_F	0.739	0.99
17_S	27_P	0.737	0.99
212_E	218_I	0.733	0.99
291_E	295_Q	0.732	0.99
232_A	238_I	0.731	0.99
53_D	62_E	0.730	0.99
31_I	53_D	0.730	0.99
230_Y	236_R	0.729	0.99
19_G	305_S	0.728	0.99
188_T	192_A	0.725	0.99
89_L	129_A	0.724	0.99
230_Y	234_K	0.723	0.99
214_K	222_G	0.719	0.99
123_V	174_S	0.717	0.99
233_S	239_P	0.715	0.99
270_V	289_K	0.714	0.99
229_M	232_A	0.713	0.99
253_I	273_Q	0.712	0.99
232_A	240_L	0.710	0.99
139_A	142_N	0.709	0.99
114_V	175_N	0.702	0.99
30_A	50_V	0.701	0.99
196_L	199_K	0.699	0.99
200_L	203_P	0.698	0.99
197_D	201_D	0.696	0.99
195_D	281_D	0.695	0.99
193_I	196_L	0.695	0.99
243_R	251_P	0.695	0.99
32_D	50_V	0.694	0.99
200_L	204_N	0.693	0.99
137_R	141_I	0.687	0.99
273_Q	296_V	0.685	0.99
17_S	45_F	0.681	0.99
198_N	202_V	0.681	0.99
15_G	300_V	0.681	0.99
238_I	241_Y	0.680	0.99
138_D	142_N	0.677	0.99
80_C	170_R	0.677	0.99
240_L	243_R	0.676	0.99
274_A	292_Q	0.676	0.99
172_F	301_P	0.675	0.99
153_F	176_V	0.672	0.99
37_A	298_E	0.668	0.99
22_K	303_A	0.665	0.99
44_N	283_H	0.663	0.99
244_L	268_L	0.663	0.99
29_L	32_D	0.662	0.99
185_K	191_D	0.661	0.99
82_G	105_N	0.661	0.99
11_S	17_S	0.660	0.99
189_V	193_I	0.660	0.99
271_R	285_F	0.656	0.99
182_K	186_R	0.655	0.99
237_S	244_L	0.655	0.99
229_M	238_I	0.653	0.99
15_G	302_V	0.651	0.99
34_N	291_E	0.650	0.99
164_N	303_A	0.650	0.99
131_I	154_F	0.648	0.98
229_M	236_R	0.648	0.98
73_V	123_V	0.645	0.98
176_V	312_I	0.642	0.98
199_K	203_P	0.641	0.98
238_I	242_I	0.641	0.98
9_L	31_I	0.638	0.98
243_R	246_P	0.637	0.98
75_I	123_V	0.635	0.98
217_K	222_G	0.634	0.98
236_R	242_I	0.633	0.98
244_L	248_D	0.632	0.98
112_R	115_D	0.631	0.98
58_I	112_R	0.627	0.98
278_S	301_P	0.626	0.98
198_N	201_D	0.625	0.98
236_R	243_R	0.624	0.98
311_E	315_I	0.623	0.98
237_S	254_L	0.621	0.98
212_E	222_G	0.621	0.98
255_G	294_N	0.619	0.98
215_L	220_K	0.619	0.98
23_L	309_A	0.618	0.98
27_P	30_A	0.617	0.98
270_V	293_Y	0.617	0.98
201_D	205_N	0.616	0.98
160_E	249_L	0.616	0.98
17_S	41_Y	0.615	0.98
229_M	233_S	0.614	0.98
181_I	185_K	0.614	0.98
85_A	89_L	0.612	0.98
258_R	263_F	0.610	0.98
183_N	186_R	0.607	0.98
190_Y	194_H	0.606	0.98
74_V	114_V	0.606	0.98
172_F	305_S	0.604	0.98
243_R	248_D	0.604	0.98
27_P	41_Y	0.604	0.98
131_I	137_R	0.603	0.98
233_S	241_Y	0.603	0.98
11_S	38_T	0.603	0.98
222_G	228_T	0.602	0.98
180_P	184_Q	0.600	0.98
46_P	49_I	0.597	0.97
238_I	243_R	0.595	0.97
42_S	48_T	0.591	0.97
6_I	17_S	0.588	0.97
213_K	221_I	0.588	0.97
261_H	264_H	0.587	0.97
181_I	184_Q	0.587	0.97
108_L	143_E	0.585	0.97
42_S	50_V	0.585	0.97
44_N	284_V	0.584	0.97
216_L	220_K	0.583	0.97
231_R	237_S	0.582	0.97
5_K	71_I	0.581	0.97
137_R	171_V	0.581	0.97
271_R	282_D	0.579	0.97
230_Y	237_S	0.578	0.97
258_R	262_P	0.576	0.97
159_A	172_F	0.574	0.97
63_I	113_I	0.573	0.97
257_S	262_P	0.571	0.97
192_A	275_R	0.570	0.97
152_I	175_N	0.570	0.97
111_I	147_A	0.570	0.97
87_N	103_R	0.570	0.97
252_T	256_N	0.570	0.97
216_L	222_G	0.569	0.97
237_S	243_R	0.569	0.97
233_S	240_L	0.568	0.97
216_L	221_I	0.565	0.96
10_F	55_I	0.561	0.96
252_T	255_G	0.558	0.96
131_I	156_I	0.558	0.96
239_P	243_R	0.558	0.96
41_Y	45_F	0.558	0.96
107_T	139_A	0.557	0.96
15_G	19_G	0.556	0.96
32_D	37_A	0.554	0.96
85_A	128_P	0.554	0.96
4_I	316_L	0.550	0.96
285_F	296_V	0.548	0.96
230_Y	233_S	0.547	0.96
104_G	136_L	0.544	0.96
260_I	263_F	0.544	0.96
214_K	220_K	0.543	0.96
90_R	101_D	0.542	0.96
82_G	90_R	0.542	0.96
85_A	132_E	0.542	0.96
162_Y	307_A	0.541	0.95
7_I	28_K	0.540	0.95
299_S	305_S	0.540	0.95
115_D	146_K	0.539	0.95
142_N	145_K	0.536	0.95
73_V	309_A	0.534	0.95
21_K	47_N	0.534	0.95
154_F	171_V	0.534	0.95
259_F	263_F	0.533	0.95
21_K	26_E	0.532	0.95
106_L	109_E	0.529	0.95
157_L	304_L	0.528	0.95
231_R	236_R	0.527	0.95
114_V	119_P	0.527	0.95
259_F	262_P	0.524	0.95
197_D	200_L	0.524	0.95
151_N	154_F	0.523	0.95
251_P	254_L	0.523	0.95
202_V	205_N	0.522	0.95
187_I	192_A	0.522	0.95
8_D	75_I	0.520	0.94
162_Y	304_L	0.520	0.94
108_L	139_A	0.519	0.94
111_I	144_F	0.519	0.94
148_G	178_I	0.518	0.94
229_M	235_G	0.518	0.94
221_I	228_T	0.516	0.94
29_L	69_N	0.516	0.94
236_R	244_L	0.515	0.94
235_G	241_Y	0.515	0.94
78_P	140_L	0.511	0.94
234_K	241_Y	0.507	0.94
130_I	173_I	0.505	0.94
212_E	220_K	0.504	0.93
229_M	234_K	0.503	0.93
15_G	299_S	0.502	0.93
229_M	240_L	0.502	0.93
35_H	38_T	0.502	0.93
176_V	315_I	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3swrA	1	0.9631	100	0.137	Contact Map
4ft4B	1	0.9877	100	0.154	Contact Map
4wxxA	1	0.9785	100	0.171	Contact Map
4dkjA	1	0.9292	100	0.172	Contact Map
2c7pA	1	0.9231	100	0.194	Contact Map
3g7uA	1	0.9077	100	0.198	Contact Map
3qv2A	1	0.9323	100	0.217	Contact Map
4h0nA	1	0.9138	100	0.221	Contact Map
1g55A	1	0.8677	100	0.223	Contact Map
3ubtY	2	0.9108	100	0.226	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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