GREMLIN Database
TFE - Transcription factor E
UniProt: Q980M5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (161)
Sequences: 164 (112)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_K156_E4.4550.99
103_K163_E4.3440.99
92_L166_I3.5290.96
58_E63_V2.9790.90
99_L159_I2.7760.86
108_Y114_F2.6750.84
33_E66_R2.5660.81
108_Y112_N2.5020.79
85_D162_I2.4160.77
35_T70_D2.3640.75
103_K133_E2.1560.68
124_Y128_E2.1270.67
23_V45_I2.0980.66
102_L105_R2.0900.65
102_L159_I1.9550.60
55_N76_F1.8710.56
100_D104_T1.8460.55
5_E87_I1.8270.54
44_N91_L1.8240.54
6_D32_T1.8000.53
148_T152_K1.7870.53
19_D43_L1.7510.51
11_L79_Y1.7310.50
105_R114_F1.7230.50
8_F12_A1.7020.49
44_N137_L1.6760.48
99_L157_Q1.5780.44
5_E42_Q1.5540.43
17_G115_F1.5270.42
37_E50_V1.5140.41
11_L158_K1.4630.39
5_E25_R1.4580.39
50_V134_F1.4520.39
18_D161_Q1.4020.36
33_E59_E1.4010.36
65_Y72_D1.3950.36
17_G74_G1.3920.36
61_G65_Y1.3890.36
39_I166_I1.3800.36
19_D103_K1.3650.35
56_L110_K1.3580.35
15_L141_S1.3300.34
149_D156_E1.3290.34
50_V63_V1.3170.33
6_D9_I1.3070.33
36_D131_E1.2710.31
62_F115_F1.2460.31
132_N143_L1.2250.30
24_L127_E1.2230.30
14_S23_V1.2150.29
106_L127_E1.2140.29
43_L116_I1.2130.29
62_F78_Y1.2080.29
12_A79_Y1.1960.29
106_L109_E1.1790.28
43_L135_K1.1740.28
78_Y139_C1.1480.27
97_L125_S1.1470.27
52_K167_D1.1420.27
40_A78_Y1.1420.27
6_D93_N1.1300.26
15_L56_L1.1270.26
14_S34_M1.1230.26
156_E160_R1.1180.26
70_D75_W1.1120.26
55_N78_Y1.1050.26
105_R108_Y1.1020.26
67_K148_T1.0910.25
43_L71_K1.0900.25
18_D162_I1.0870.25
104_T141_S1.0760.25
15_L91_L1.0760.25
88_N148_T1.0710.25
17_G69_R1.0700.25
36_D99_L1.0650.24
13_K18_D1.0630.24
12_A16_L1.0610.24
111_N118_P1.0490.24
43_L120_D1.0390.24
67_K78_Y1.0280.23
50_V126_F1.0220.23
153_S160_R0.9890.22
7_L18_D0.9810.22
106_L152_K0.9810.22
63_V67_K0.9770.22
115_F154_F0.9720.22
126_F134_F0.9620.21
19_D98_I0.9500.21
65_Y86_Q0.9420.21
55_N75_W0.9410.21
59_E69_R0.9400.21
133_E161_Q0.9370.21
102_L109_E0.9350.20
118_P122_S0.9340.20
26_I112_N0.9300.20
47_V114_F0.9270.20
106_L137_L0.9240.20
18_D29_D0.9200.20
67_K70_D0.9180.20
29_D38_E0.9160.20
39_I152_K0.9120.20
37_E149_D0.9120.20
36_D56_L0.8960.19
82_P138_K0.8950.19
62_F67_K0.8900.19
47_V75_W0.8880.19
48_N75_W0.8830.19
35_T52_K0.8760.19
133_E151_I0.8760.19
33_E40_A0.8580.18
27_L97_L0.8560.18
140_G150_K0.8470.18
62_F131_E0.8460.18
17_G36_D0.8310.18
51_R136_C0.8310.18
138_K156_E0.8280.18
79_Y94_R0.8260.18
52_K76_F0.8210.17
69_R74_G0.8140.17
100_D133_E0.8090.17
100_D141_S0.8060.17
23_V34_M0.8040.17
29_D64_S0.8030.17
50_V58_E0.8030.17
33_E62_F0.8010.17
93_N141_S0.7990.17
12_A159_I0.7940.17
8_F32_T0.7920.17
118_P124_Y0.7880.17
109_E148_T0.7850.17
59_E76_F0.7830.17
11_L76_F0.7820.17
67_K75_W0.7800.16
101_K115_F0.7790.16
50_V67_K0.7790.16
47_V58_E0.7710.16
70_D74_G0.7710.16
117_C136_C0.7700.16
51_R117_C0.7700.16
59_E94_R0.7640.16
67_K109_E0.7630.16
18_D104_T0.7630.16
93_N115_F0.7600.16
33_E91_L0.7560.16
86_Q105_R0.7550.16
86_Q115_F0.7480.16
47_V110_K0.7450.16
160_R164_E0.7420.16
142_Q152_K0.7380.15
61_G158_K0.7380.15
85_D124_Y0.7280.15
38_E155_L0.7170.15
36_D63_V0.7150.15
87_I128_E0.7070.15
109_E126_F0.7050.15
73_S98_I0.7030.15
74_G158_K0.6910.14
12_A24_L0.6850.14
108_Y164_E0.6830.14
64_S76_F0.6830.14
61_G83_N0.6800.14
135_K140_G0.6790.14
74_G113_T0.6780.14
103_K128_E0.6770.14
23_V133_E0.6740.14
32_T147_D0.6730.14
76_F94_R0.6710.14
104_T152_K0.6680.14
104_T127_E0.6650.14
131_E143_L0.6640.14
11_L114_F0.6610.14
58_E73_S0.6610.14
67_K73_S0.6610.14
18_D97_L0.6510.14
52_K64_S0.6500.14
10_N60_Q0.6450.14
74_G79_Y0.6440.13
22_D89_E0.6370.13
16_L21_I0.6340.13
9_I85_D0.6320.13
124_Y130_F0.6300.13
117_C139_C0.6290.13
88_N140_G0.6280.13
143_L149_D0.6260.13
137_L144_T0.6210.13
22_D127_E0.6190.13
90_I107_E0.6170.13
51_R54_L0.6140.13
54_L136_C0.6140.13
123_R148_T0.6110.13
38_E50_V0.6100.13
50_V73_S0.6080.13
35_T50_V0.6080.13
115_F124_Y0.6050.13
58_E67_K0.6040.13
48_N134_F0.6020.13
89_E131_E0.6010.13
37_E43_L0.6000.13
9_I12_A0.6000.13
95_K165_E0.5980.13
54_L57_L0.5940.13
141_S153_S0.5940.13
105_R112_N0.5940.13
102_L106_L0.5820.12
16_L155_L0.5800.12
131_E134_F0.5760.12
47_V79_Y0.5710.12
48_N114_F0.5710.12
10_N83_N0.5700.12
81_K111_N0.5690.12
35_T131_E0.5680.12
21_I153_S0.5670.12
39_I139_C0.5670.12
84_I127_E0.5640.12
6_D98_I0.5620.12
23_V69_R0.5610.12
6_D71_K0.5610.12
34_M91_L0.5600.12
40_A66_R0.5530.12
107_E111_N0.5530.12
150_K155_L0.5510.12
91_L94_R0.5480.12
96_R132_N0.5480.12
69_R87_I0.5460.12
17_G105_R0.5440.12
58_E75_W0.5410.12
54_L117_C0.5400.12
11_L37_E0.5360.11
20_V28_L0.5300.11
60_Q115_F0.5300.11
99_L162_I0.5250.11
154_F160_R0.5230.11
12_A77_I0.5220.11
5_E8_F0.5220.11
23_V68_T0.5210.11
16_L118_P0.5150.11
73_S130_F0.5120.11
32_T82_P0.5100.11
96_R105_R0.5090.11
26_I53_K0.5060.11
39_I133_E0.5030.11
124_Y132_N0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xubA 1 0.7809 99.9 0.662 Contact Map
1q1hA 1 0.4775 99.2 0.8 Contact Map
1vd4A 1 0.3146 98.1 0.86 Contact Map
4qiwP 1 0.236 97.1 0.885 Contact Map
2w57A 2 0.5843 97 0.887 Contact Map
3r0aA 2 0.6348 96.7 0.89 Contact Map
2xigA 4 0.6461 96.7 0.89 Contact Map
3mwmA 2 0.5674 96.7 0.891 Contact Map
4aybP 1 0.2416 96.6 0.892 Contact Map
2o03A 2 0.5787 96.6 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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