GREMLIN Database
HFLX - GTPase HflX
UniProt: Q980M3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (329)
Sequences: 3528 (2033)
Seq/√Len: 112.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_L77_E3.8901.00
113_K157_M3.7491.00
20_V61_I3.6761.00
183_G258_S3.5171.00
43_I51_I3.4581.00
262_I298_T3.1831.00
48_L74_I3.1481.00
265_I297_V2.9881.00
34_P38_N2.9781.00
218_R229_M2.9671.00
14_E29_S2.8831.00
17_I29_S2.8721.00
220_A227_K2.8581.00
60_L78_L2.8201.00
224_N349_Y2.8161.00
18_A21_E2.7161.00
20_V25_Y2.5981.00
64_E239_G2.5841.00
347_K350_Q2.5471.00
198_S341_L2.4991.00
246_D249_F2.4431.00
108_E152_R2.4121.00
47_K50_Q2.3901.00
30_I51_I2.3311.00
218_R231_V2.3221.00
126_S129_G2.3221.00
132_Q135_L2.3191.00
278_L297_V2.2841.00
282_F295_I2.2581.00
92_E111_R2.1931.00
269_F277_T2.1791.00
242_P284_I2.1411.00
182_I228_I2.1181.00
347_K351_L2.0681.00
74_I78_L1.9831.00
22_G97_H1.9811.00
286_R291_S1.9811.00
205_K209_K1.9751.00
144_S148_F1.9571.00
185_V261_L1.9361.00
194_S335_A1.9041.00
296_L347_K1.8991.00
60_L81_K1.8541.00
129_G134_P1.8391.00
175_K257_Y1.8211.00
155_K159_E1.8041.00
105_M156_L1.7961.00
197_N206_V1.7931.00
265_I278_L1.7381.00
268_T304_K1.7221.00
204_Q217_K1.7171.00
262_I344_L1.7061.00
102_E167_K1.6941.00
123_Y141_G1.6891.00
43_I62_I1.6881.00
279_Q283_E1.6861.00
198_S338_R1.6831.00
22_G209_K1.6821.00
161_E164_K1.6371.00
298_T331_I1.6351.00
164_K253_S1.6221.00
296_L351_L1.6221.00
267_S299_L1.6031.00
164_K249_F1.6001.00
283_E287_E1.5971.00
298_T344_L1.5901.00
302_I332_P1.5731.00
221_I228_I1.5471.00
101_K159_E1.5471.00
125_K141_G1.5451.00
42_Y64_E1.5381.00
282_F297_V1.5301.00
48_L78_L1.5291.00
193_T204_Q1.5291.00
127_K130_E1.5191.00
123_Y126_S1.5101.00
260_A348_I1.5081.00
205_K212_T1.4971.00
52_K77_E1.4921.00
267_S274_L1.4831.00
340_N343_L1.4801.00
299_L332_P1.4751.00
269_F274_L1.4721.00
182_I262_I1.4691.00
274_L299_L1.4651.00
9_S31_Y1.4641.00
221_I230_L1.4541.00
49_Q53_N1.4481.00
337_K340_N1.4311.00
167_K253_S1.4271.00
200_T221_I1.4261.00
223_I228_I1.4081.00
263_L281_S1.3951.00
256_K289_G1.3921.00
128_I134_P1.3761.00
38_N45_Y1.3671.00
154_N158_K1.3631.00
278_L282_F1.3571.00
329_D347_K1.3531.00
20_V89_L1.3281.00
153_I157_M1.3201.00
184_I196_F1.3161.00
222_P227_K1.3151.00
346_D350_Q1.3141.00
166_F170_S1.3141.00
164_K250_V1.2980.99
243_Q287_E1.2890.99
242_P245_V1.2840.99
25_Y58_S1.2830.99
108_E112_L1.2570.99
166_F169_K1.2540.99
181_S229_M1.2350.99
182_I260_A1.2320.99
127_K131_Q1.2300.99
265_I274_L1.2280.99
49_Q77_E1.2260.99
185_V285_L1.2250.99
25_Y61_I1.2200.99
194_S333_I1.2010.99
344_L348_I1.1960.99
28_T55_E1.1780.99
43_I48_L1.1770.99
113_K243_Q1.1700.99
260_A296_L1.1700.99
116_L150_K1.1690.99
280_S284_I1.1550.99
169_K172_E1.1530.99
73_N76_R1.1500.99
41_F48_L1.1490.99
123_Y129_G1.1480.99
189_N208_T1.1440.99
20_V27_V1.1310.99
28_T57_I1.1300.99
16_A61_I1.1220.98
52_K79_K1.1050.98
111_R115_E1.0960.98
263_L278_L1.0910.98
171_I253_S1.0900.98
196_F280_S1.0850.98
308_D311_K1.0840.98
121_E124_T1.0810.98
208_T304_K1.0800.98
342_E346_D1.0770.98
306_N309_L1.0760.98
199_L345_R1.0730.98
298_T333_I1.0710.98
25_Y92_E1.0680.98
14_E17_I1.0640.98
296_L348_I1.0620.98
25_Y132_Q1.0560.98
263_L269_F1.0530.98
22_G237_I1.0430.97
63_F239_G1.0430.97
343_L346_D1.0430.97
22_G210_L1.0410.97
37_P42_Y1.0310.97
278_L299_L1.0280.97
143_E147_K1.0280.97
290_V293_K1.0260.97
109_L153_I1.0250.97
105_M163_I1.0200.97
122_T125_K1.0170.97
111_R142_V1.0050.97
97_H205_K1.0010.97
25_Y59_T0.9990.97
23_A92_E0.9970.97
139_T147_K0.9940.97
45_Y49_Q0.9930.97
10_K14_E0.9840.96
59_T82_E0.9740.96
193_T206_V0.9690.96
165_I169_K0.9680.96
113_K153_I0.9660.96
23_A95_A0.9640.96
283_E286_R0.9610.96
276_E279_Q0.9570.96
125_K148_F0.9560.96
263_L295_I0.9520.96
333_I341_L0.9490.96
121_E125_K0.9490.96
126_S132_Q0.9380.95
12_F239_G0.9350.95
268_T305_I0.9350.95
126_S130_E0.9330.95
182_I348_I0.9320.95
17_I21_E0.9280.95
172_E176_R0.9230.95
196_F230_L0.9210.95
338_R341_L0.9190.95
310_Y339_T0.9150.95
102_E163_I0.9140.95
100_S103_A0.9130.95
132_Q137_A0.9110.95
141_G148_F0.9080.94
179_I229_M0.9070.94
297_V330_V0.9070.94
228_I348_I0.9040.94
52_K78_L0.9010.94
249_F287_E0.9000.94
139_T143_E0.9000.94
164_K246_D0.8970.94
162_S165_I0.8940.94
123_Y148_F0.8830.94
207_D212_T0.8820.94
103_A137_A0.8810.93
158_K161_E0.8790.93
111_R137_A0.8780.93
119_I142_V0.8730.93
10_K29_S0.8730.93
346_D349_Y0.8710.93
103_A216_P0.8680.93
267_S305_I0.8670.93
282_F286_R0.8670.93
121_E129_G0.8650.93
309_L312_K0.8630.93
274_L278_L0.8610.93
49_Q52_K0.8570.93
95_A111_R0.8520.92
284_I288_I0.8510.92
95_A137_A0.8490.92
209_K212_T0.8470.92
307_G310_Y0.8450.92
18_A238_R0.8400.92
78_L81_K0.8390.92
226_R349_Y0.8380.92
275_I279_Q0.8320.91
13_E16_A0.8310.91
25_Y111_R0.8250.91
121_E141_G0.8220.91
128_I135_L0.8160.91
148_F151_R0.8150.91
225_N349_Y0.8100.90
170_S246_D0.8030.90
280_S283_E0.8020.90
82_E111_R0.8010.90
151_R154_N0.8000.90
279_Q282_F0.7970.90
61_I89_L0.7890.89
128_I132_Q0.7870.89
126_S131_Q0.7870.89
65_Q243_Q0.7820.89
331_I347_K0.7780.88
21_E27_V0.7750.88
299_L330_V0.7740.88
154_N157_M0.7700.88
22_G207_D0.7630.87
299_L327_I0.7630.87
260_A351_L0.7610.87
306_N311_K0.7570.87
41_F45_Y0.7550.87
13_E29_S0.7530.87
94_F98_A0.7520.87
127_K134_P0.7520.87
182_I351_L0.7510.87
84_L89_L0.7500.86
120_K123_Y0.7490.86
51_I78_L0.7480.86
71_F88_L0.7470.86
112_L149_Y0.7420.86
123_Y127_K0.7410.86
8_V276_E0.7370.86
157_M246_D0.7370.86
203_T207_D0.7360.85
130_E134_P0.7340.85
128_I141_G0.7340.85
12_F18_A0.7340.85
15_E19_L0.7330.85
255_A258_S0.7290.85
201_G222_P0.7280.85
22_G92_E0.7210.84
82_E92_E0.7210.84
126_S134_P0.7180.84
116_L153_I0.7160.84
115_E122_T0.7130.84
184_I195_L0.7120.84
329_D351_L0.7110.83
102_E247_A0.7070.83
84_L88_L0.7050.83
265_I299_L0.7040.83
128_I131_Q0.7030.83
72_I75_R0.6990.82
141_G145_T0.6960.82
103_A247_A0.6950.82
65_Q87_I0.6950.82
216_P230_L0.6910.82
136_G139_T0.6900.82
22_G184_I0.6900.82
345_R349_Y0.6890.81
22_G205_K0.6890.81
167_K247_A0.6880.81
109_L156_L0.6860.81
193_T230_L0.6840.81
173_S177_N0.6800.81
75_R82_E0.6780.80
75_R125_K0.6770.80
41_F77_E0.6760.80
288_I293_K0.6730.80
99_G115_E0.6720.80
129_G132_Q0.6680.79
159_E246_D0.6670.79
51_I96_L0.6660.79
12_F238_R0.6660.79
18_A22_G0.6640.79
192_K232_D0.6640.79
71_F170_S0.6630.79
213_T232_D0.6620.79
23_A111_R0.6610.79
266_D301_K0.6590.79
125_K128_I0.6570.78
238_R276_E0.6570.78
305_I310_Y0.6540.78
341_L345_R0.6510.78
196_F231_V0.6510.78
256_K293_K0.6490.77
30_I57_I0.6480.77
42_Y62_I0.6480.77
343_L347_K0.6450.77
126_S141_G0.6440.77
111_R144_S0.6440.77
149_Y153_I0.6410.77
255_A261_L0.6410.77
137_A141_G0.6390.76
304_K336_L0.6380.76
168_E175_K0.6360.76
56_E162_S0.6360.76
215_S244_I0.6360.76
112_L153_I0.6350.76
13_E31_Y0.6350.76
284_I287_E0.6350.76
138_G147_K0.6320.76
76_R81_K0.6320.76
327_I330_V0.6310.76
173_S176_R0.6310.76
189_N207_D0.6290.75
119_I147_K0.6280.75
221_I237_I0.6260.75
184_I264_V0.6250.75
18_A246_D0.6240.75
207_D210_L0.6230.75
136_G143_E0.6230.75
17_I27_V0.6220.74
337_K342_E0.6210.74
76_R79_K0.6200.74
120_K130_E0.6180.74
23_A96_L0.6180.74
171_I254_E0.6170.74
52_K81_K0.6160.74
92_E96_L0.6150.74
32_K47_K0.6140.74
310_Y332_P0.6130.73
123_Y137_A0.6130.73
62_I66_L0.6120.73
155_K246_D0.6120.73
26_K56_E0.6120.73
289_G293_K0.6110.73
307_G311_K0.6100.73
285_L290_V0.6100.73
181_S218_R0.6080.73
278_L288_I0.6060.73
164_K167_K0.6050.72
94_F100_S0.6050.72
180_P345_R0.6050.72
198_S206_V0.6050.72
306_N310_Y0.6030.72
180_P352_A0.6020.72
103_A107_I0.6020.72
12_F16_A0.6010.72
166_F206_V0.6000.72
184_I230_L0.5990.72
25_Y82_E0.5970.71
269_F275_I0.5970.71
333_I337_K0.5940.71
304_K307_G0.5920.71
119_I146_I0.5920.71
92_E95_A0.5920.71
11_E269_F0.5910.71
187_Y241_P0.5910.71
161_E350_Q0.5910.71
290_V295_I0.5900.71
258_S302_I0.5900.71
185_V255_A0.5880.70
193_T205_K0.5880.70
342_E345_R0.5870.70
14_E304_K0.5820.70
37_P41_F0.5820.70
91_L94_F0.5810.69
151_R155_K0.5800.69
242_P287_E0.5800.69
191_G232_D0.5790.69
24_N96_L0.5790.69
253_S257_Y0.5780.69
125_K129_G0.5780.69
90_L93_I0.5770.69
117_P196_F0.5750.69
257_Y326_P0.5740.68
195_L298_T0.5730.68
278_L281_S0.5730.68
126_S148_F0.5700.68
97_H107_I0.5680.68
41_F73_N0.5680.68
98_A102_E0.5670.68
134_P140_Y0.5670.68
160_L163_I0.5670.68
86_K106_Q0.5660.67
90_L139_T0.5660.67
154_N162_S0.5660.67
100_S104_K0.5650.67
308_D312_K0.5650.67
36_S39_V0.5620.67
222_P345_R0.5620.67
202_L216_P0.5610.67
300_N335_A0.5610.67
44_Q47_K0.5580.66
204_Q275_I0.5560.66
121_E134_P0.5560.66
297_V327_I0.5550.66
198_S336_L0.5520.65
28_T58_S0.5510.65
32_K35_K0.5510.65
337_K341_L0.5510.65
279_Q339_T0.5500.65
71_F126_S0.5500.65
261_L295_I0.5500.65
164_K168_E0.5500.65
221_I345_R0.5490.65
283_E311_K0.5480.65
142_V145_T0.5470.65
206_V209_K0.5470.65
187_Y211_F0.5470.65
223_I226_R0.5460.65
26_K29_S0.5440.64
345_R348_I0.5430.64
90_L114_Y0.5390.64
101_K105_M0.5390.64
240_I244_I0.5380.64
107_I112_L0.5380.64
195_L334_S0.5370.63
123_Y128_I0.5370.63
186_G232_D0.5370.63
229_M246_D0.5360.63
121_E145_T0.5340.63
122_T126_S0.5330.63
333_I336_L0.5330.63
182_I309_L0.5310.63
136_G147_K0.5300.62
116_L120_K0.5300.62
172_E175_K0.5300.62
212_T244_I0.5280.62
223_I227_K0.5280.62
66_L70_H0.5260.62
279_Q291_S0.5250.62
222_P225_N0.5240.62
84_L95_A0.5230.61
100_S107_I0.5230.61
186_G191_G0.5200.61
237_I281_S0.5200.61
232_D235_G0.5200.61
88_L142_V0.5200.61
130_E139_T0.5190.61
8_V11_E0.5190.61
18_A208_T0.5190.61
10_K49_Q0.5180.61
123_Y134_P0.5170.60
196_F218_R0.5170.60
28_T56_E0.5160.60
16_A62_I0.5150.60
257_Y336_L0.5150.60
215_S281_S0.5140.60
40_K77_E0.5140.60
190_S247_A0.5140.60
296_L332_P0.5130.60
264_V298_T0.5120.60
276_E280_S0.5110.60
186_G235_G0.5110.60
124_T129_G0.5090.59
183_G254_E0.5090.59
339_T342_E0.5090.59
221_I348_I0.5090.59
129_G170_S0.5080.59
185_V290_V0.5080.59
124_T141_G0.5080.59
158_K283_E0.5070.59
340_N347_K0.5070.59
197_N200_T0.5060.59
141_G197_N0.5060.59
212_T215_S0.5060.59
276_E307_G0.5060.59
131_Q135_L0.5050.59
62_I71_F0.5050.59
53_N79_K0.5040.59
11_E17_I0.5010.58
198_S261_L0.5000.58
36_S346_D0.5000.58
195_L200_T0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qtfA 1 0.868 100 0.223 Contact Map
3j65o 1 0.882 100 0.595 Contact Map
3geeA 2 0.823 100 0.649 Contact Map
1xzpA 4 0.9045 100 0.652 Contact Map
3gehA 2 0.8399 100 0.653 Contact Map
2e87A 1 0.9073 100 0.659 Contact Map
4a9aA 1 0.618 100 0.667 Contact Map
3j4jA 1 0.6517 100 0.677 Contact Map
1mkyA 1 0.427 100 0.679 Contact Map
3j8gX 1 0.4101 100 0.682 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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