HFLX - SULSO - GREMLIN Contacts

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HFLX - GTPase HflX

UniProt:	Q980M3	Sequences: MKTAALFVSKEFEEEAIALVEGANYKVTSIYKLPKSPNVKFYIQYDKLQQIKNDEEISTLIIFEQLKPRHFINIRRELKGKEVLDKILLLLEIFALHAGSKEAKMQIELARLKYELPIIKETYTKSKIGEQQGPLGAGTYGVESTIKFYKRRINKLMKELESIKIFKEKSIESNKRNNIPSIGIVGYTNSGKTSLFNSLTGLTQKVDTKLFTTMSPKRYAIPINNRKIMLVDTVGFIRGIPPQIVDAFFVTLSEAKYSDALILVIDSTFSENLLIETLQSSFEILREIGVSGKPILVTLNKIDKINGDLYKKLDLVEKLSKELYSPIFDVIPISALKRTNLELLRDKIYQLATQLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	356 (329)
Sequences:	3528 (2033)
Seq/√Len:	112.1

ECOLI - HFLX MNME
BACSU - HFLX
HALSA - Q9HMC2 Q9HMD6
SULSO - HFLX Q7LXR6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
48_L	77_E	3.890	1.00
113_K	157_M	3.749	1.00
20_V	61_I	3.676	1.00
183_G	258_S	3.517	1.00
43_I	51_I	3.458	1.00
262_I	298_T	3.183	1.00
48_L	74_I	3.148	1.00
265_I	297_V	2.988	1.00
34_P	38_N	2.978	1.00
218_R	229_M	2.967	1.00
14_E	29_S	2.883	1.00
17_I	29_S	2.872	1.00
220_A	227_K	2.858	1.00
60_L	78_L	2.820	1.00
224_N	349_Y	2.816	1.00
18_A	21_E	2.716	1.00
20_V	25_Y	2.598	1.00
64_E	239_G	2.584	1.00
347_K	350_Q	2.547	1.00
198_S	341_L	2.499	1.00
246_D	249_F	2.443	1.00
108_E	152_R	2.412	1.00
47_K	50_Q	2.390	1.00
30_I	51_I	2.331	1.00
218_R	231_V	2.322	1.00
126_S	129_G	2.322	1.00
132_Q	135_L	2.319	1.00
278_L	297_V	2.284	1.00
282_F	295_I	2.258	1.00
92_E	111_R	2.193	1.00
269_F	277_T	2.179	1.00
242_P	284_I	2.141	1.00
182_I	228_I	2.118	1.00
347_K	351_L	2.068	1.00
74_I	78_L	1.983	1.00
22_G	97_H	1.981	1.00
286_R	291_S	1.981	1.00
205_K	209_K	1.975	1.00
144_S	148_F	1.957	1.00
185_V	261_L	1.936	1.00
194_S	335_A	1.904	1.00
296_L	347_K	1.899	1.00
60_L	81_K	1.854	1.00
129_G	134_P	1.839	1.00
175_K	257_Y	1.821	1.00
155_K	159_E	1.804	1.00
105_M	156_L	1.796	1.00
197_N	206_V	1.793	1.00
265_I	278_L	1.738	1.00
268_T	304_K	1.722	1.00
204_Q	217_K	1.717	1.00
262_I	344_L	1.706	1.00
102_E	167_K	1.694	1.00
123_Y	141_G	1.689	1.00
43_I	62_I	1.688	1.00
279_Q	283_E	1.686	1.00
198_S	338_R	1.683	1.00
22_G	209_K	1.682	1.00
161_E	164_K	1.637	1.00
298_T	331_I	1.635	1.00
164_K	253_S	1.622	1.00
296_L	351_L	1.622	1.00
267_S	299_L	1.603	1.00
164_K	249_F	1.600	1.00
283_E	287_E	1.597	1.00
298_T	344_L	1.590	1.00
302_I	332_P	1.573	1.00
221_I	228_I	1.547	1.00
101_K	159_E	1.547	1.00
125_K	141_G	1.545	1.00
42_Y	64_E	1.538	1.00
282_F	297_V	1.530	1.00
48_L	78_L	1.529	1.00
193_T	204_Q	1.529	1.00
127_K	130_E	1.519	1.00
123_Y	126_S	1.510	1.00
260_A	348_I	1.508	1.00
205_K	212_T	1.497	1.00
52_K	77_E	1.492	1.00
267_S	274_L	1.483	1.00
340_N	343_L	1.480	1.00
299_L	332_P	1.475	1.00
269_F	274_L	1.472	1.00
182_I	262_I	1.469	1.00
274_L	299_L	1.465	1.00
9_S	31_Y	1.464	1.00
221_I	230_L	1.454	1.00
49_Q	53_N	1.448	1.00
337_K	340_N	1.431	1.00
167_K	253_S	1.427	1.00
200_T	221_I	1.426	1.00
223_I	228_I	1.408	1.00
263_L	281_S	1.395	1.00
256_K	289_G	1.392	1.00
128_I	134_P	1.376	1.00
38_N	45_Y	1.367	1.00
154_N	158_K	1.363	1.00
278_L	282_F	1.357	1.00
329_D	347_K	1.353	1.00
20_V	89_L	1.328	1.00
153_I	157_M	1.320	1.00
184_I	196_F	1.316	1.00
222_P	227_K	1.315	1.00
346_D	350_Q	1.314	1.00
166_F	170_S	1.314	1.00
164_K	250_V	1.298	0.99
243_Q	287_E	1.289	0.99
242_P	245_V	1.284	0.99
25_Y	58_S	1.283	0.99
108_E	112_L	1.257	0.99
166_F	169_K	1.254	0.99
181_S	229_M	1.235	0.99
182_I	260_A	1.232	0.99
127_K	131_Q	1.230	0.99
265_I	274_L	1.228	0.99
49_Q	77_E	1.226	0.99
185_V	285_L	1.225	0.99
25_Y	61_I	1.220	0.99
194_S	333_I	1.201	0.99
344_L	348_I	1.196	0.99
28_T	55_E	1.178	0.99
43_I	48_L	1.177	0.99
113_K	243_Q	1.170	0.99
260_A	296_L	1.170	0.99
116_L	150_K	1.169	0.99
280_S	284_I	1.155	0.99
169_K	172_E	1.153	0.99
73_N	76_R	1.150	0.99
41_F	48_L	1.149	0.99
123_Y	129_G	1.148	0.99
189_N	208_T	1.144	0.99
20_V	27_V	1.131	0.99
28_T	57_I	1.130	0.99
16_A	61_I	1.122	0.98
52_K	79_K	1.105	0.98
111_R	115_E	1.096	0.98
263_L	278_L	1.091	0.98
171_I	253_S	1.090	0.98
196_F	280_S	1.085	0.98
308_D	311_K	1.084	0.98
121_E	124_T	1.081	0.98
208_T	304_K	1.080	0.98
342_E	346_D	1.077	0.98
306_N	309_L	1.076	0.98
199_L	345_R	1.073	0.98
298_T	333_I	1.071	0.98
25_Y	92_E	1.068	0.98
14_E	17_I	1.064	0.98
296_L	348_I	1.062	0.98
25_Y	132_Q	1.056	0.98
263_L	269_F	1.053	0.98
22_G	237_I	1.043	0.97
63_F	239_G	1.043	0.97
343_L	346_D	1.043	0.97
22_G	210_L	1.041	0.97
37_P	42_Y	1.031	0.97
278_L	299_L	1.028	0.97
143_E	147_K	1.028	0.97
290_V	293_K	1.026	0.97
109_L	153_I	1.025	0.97
105_M	163_I	1.020	0.97
122_T	125_K	1.017	0.97
111_R	142_V	1.005	0.97
97_H	205_K	1.001	0.97
25_Y	59_T	0.999	0.97
23_A	92_E	0.997	0.97
139_T	147_K	0.994	0.97
45_Y	49_Q	0.993	0.97
10_K	14_E	0.984	0.96
59_T	82_E	0.974	0.96
193_T	206_V	0.969	0.96
165_I	169_K	0.968	0.96
113_K	153_I	0.966	0.96
23_A	95_A	0.964	0.96
283_E	286_R	0.961	0.96
276_E	279_Q	0.957	0.96
125_K	148_F	0.956	0.96
263_L	295_I	0.952	0.96
333_I	341_L	0.949	0.96
121_E	125_K	0.949	0.96
126_S	132_Q	0.938	0.95
12_F	239_G	0.935	0.95
268_T	305_I	0.935	0.95
126_S	130_E	0.933	0.95
182_I	348_I	0.932	0.95
17_I	21_E	0.928	0.95
172_E	176_R	0.923	0.95
196_F	230_L	0.921	0.95
338_R	341_L	0.919	0.95
310_Y	339_T	0.915	0.95
102_E	163_I	0.914	0.95
100_S	103_A	0.913	0.95
132_Q	137_A	0.911	0.95
141_G	148_F	0.908	0.94
179_I	229_M	0.907	0.94
297_V	330_V	0.907	0.94
228_I	348_I	0.904	0.94
52_K	78_L	0.901	0.94
249_F	287_E	0.900	0.94
139_T	143_E	0.900	0.94
164_K	246_D	0.897	0.94
162_S	165_I	0.894	0.94
123_Y	148_F	0.883	0.94
207_D	212_T	0.882	0.94
103_A	137_A	0.881	0.93
158_K	161_E	0.879	0.93
111_R	137_A	0.878	0.93
119_I	142_V	0.873	0.93
10_K	29_S	0.873	0.93
346_D	349_Y	0.871	0.93
103_A	216_P	0.868	0.93
267_S	305_I	0.867	0.93
282_F	286_R	0.867	0.93
121_E	129_G	0.865	0.93
309_L	312_K	0.863	0.93
274_L	278_L	0.861	0.93
49_Q	52_K	0.857	0.93
95_A	111_R	0.852	0.92
284_I	288_I	0.851	0.92
95_A	137_A	0.849	0.92
209_K	212_T	0.847	0.92
307_G	310_Y	0.845	0.92
18_A	238_R	0.840	0.92
78_L	81_K	0.839	0.92
226_R	349_Y	0.838	0.92
275_I	279_Q	0.832	0.91
13_E	16_A	0.831	0.91
25_Y	111_R	0.825	0.91
121_E	141_G	0.822	0.91
128_I	135_L	0.816	0.91
148_F	151_R	0.815	0.91
225_N	349_Y	0.810	0.90
170_S	246_D	0.803	0.90
280_S	283_E	0.802	0.90
82_E	111_R	0.801	0.90
151_R	154_N	0.800	0.90
279_Q	282_F	0.797	0.90
61_I	89_L	0.789	0.89
128_I	132_Q	0.787	0.89
126_S	131_Q	0.787	0.89
65_Q	243_Q	0.782	0.89
331_I	347_K	0.778	0.88
21_E	27_V	0.775	0.88
299_L	330_V	0.774	0.88
154_N	157_M	0.770	0.88
22_G	207_D	0.763	0.87
299_L	327_I	0.763	0.87
260_A	351_L	0.761	0.87
306_N	311_K	0.757	0.87
41_F	45_Y	0.755	0.87
13_E	29_S	0.753	0.87
94_F	98_A	0.752	0.87
127_K	134_P	0.752	0.87
182_I	351_L	0.751	0.87
84_L	89_L	0.750	0.86
120_K	123_Y	0.749	0.86
51_I	78_L	0.748	0.86
71_F	88_L	0.747	0.86
112_L	149_Y	0.742	0.86
123_Y	127_K	0.741	0.86
8_V	276_E	0.737	0.86
157_M	246_D	0.737	0.86
203_T	207_D	0.736	0.85
130_E	134_P	0.734	0.85
128_I	141_G	0.734	0.85
12_F	18_A	0.734	0.85
15_E	19_L	0.733	0.85
255_A	258_S	0.729	0.85
201_G	222_P	0.728	0.85
22_G	92_E	0.721	0.84
82_E	92_E	0.721	0.84
126_S	134_P	0.718	0.84
116_L	153_I	0.716	0.84
115_E	122_T	0.713	0.84
184_I	195_L	0.712	0.84
329_D	351_L	0.711	0.83
102_E	247_A	0.707	0.83
84_L	88_L	0.705	0.83
265_I	299_L	0.704	0.83
128_I	131_Q	0.703	0.83
72_I	75_R	0.699	0.82
141_G	145_T	0.696	0.82
103_A	247_A	0.695	0.82
65_Q	87_I	0.695	0.82
216_P	230_L	0.691	0.82
136_G	139_T	0.690	0.82
22_G	184_I	0.690	0.82
345_R	349_Y	0.689	0.81
22_G	205_K	0.689	0.81
167_K	247_A	0.688	0.81
109_L	156_L	0.686	0.81
193_T	230_L	0.684	0.81
173_S	177_N	0.680	0.81
75_R	82_E	0.678	0.80
75_R	125_K	0.677	0.80
41_F	77_E	0.676	0.80
288_I	293_K	0.673	0.80
99_G	115_E	0.672	0.80
129_G	132_Q	0.668	0.79
159_E	246_D	0.667	0.79
51_I	96_L	0.666	0.79
12_F	238_R	0.666	0.79
18_A	22_G	0.664	0.79
192_K	232_D	0.664	0.79
71_F	170_S	0.663	0.79
213_T	232_D	0.662	0.79
23_A	111_R	0.661	0.79
266_D	301_K	0.659	0.79
125_K	128_I	0.657	0.78
238_R	276_E	0.657	0.78
305_I	310_Y	0.654	0.78
341_L	345_R	0.651	0.78
196_F	231_V	0.651	0.78
256_K	293_K	0.649	0.77
30_I	57_I	0.648	0.77
42_Y	62_I	0.648	0.77
343_L	347_K	0.645	0.77
126_S	141_G	0.644	0.77
111_R	144_S	0.644	0.77
149_Y	153_I	0.641	0.77
255_A	261_L	0.641	0.77
137_A	141_G	0.639	0.76
304_K	336_L	0.638	0.76
168_E	175_K	0.636	0.76
56_E	162_S	0.636	0.76
215_S	244_I	0.636	0.76
112_L	153_I	0.635	0.76
13_E	31_Y	0.635	0.76
284_I	287_E	0.635	0.76
138_G	147_K	0.632	0.76
76_R	81_K	0.632	0.76
327_I	330_V	0.631	0.76
173_S	176_R	0.631	0.76
189_N	207_D	0.629	0.75
119_I	147_K	0.628	0.75
221_I	237_I	0.626	0.75
184_I	264_V	0.625	0.75
18_A	246_D	0.624	0.75
207_D	210_L	0.623	0.75
136_G	143_E	0.623	0.75
17_I	27_V	0.622	0.74
337_K	342_E	0.621	0.74
76_R	79_K	0.620	0.74
120_K	130_E	0.618	0.74
23_A	96_L	0.618	0.74
171_I	254_E	0.617	0.74
52_K	81_K	0.616	0.74
92_E	96_L	0.615	0.74
32_K	47_K	0.614	0.74
310_Y	332_P	0.613	0.73
123_Y	137_A	0.613	0.73
62_I	66_L	0.612	0.73
155_K	246_D	0.612	0.73
26_K	56_E	0.612	0.73
289_G	293_K	0.611	0.73
307_G	311_K	0.610	0.73
285_L	290_V	0.610	0.73
181_S	218_R	0.608	0.73
278_L	288_I	0.606	0.73
164_K	167_K	0.605	0.72
94_F	100_S	0.605	0.72
180_P	345_R	0.605	0.72
198_S	206_V	0.605	0.72
306_N	310_Y	0.603	0.72
180_P	352_A	0.602	0.72
103_A	107_I	0.602	0.72
12_F	16_A	0.601	0.72
166_F	206_V	0.600	0.72
184_I	230_L	0.599	0.72
25_Y	82_E	0.597	0.71
269_F	275_I	0.597	0.71
333_I	337_K	0.594	0.71
304_K	307_G	0.592	0.71
119_I	146_I	0.592	0.71
92_E	95_A	0.592	0.71
11_E	269_F	0.591	0.71
187_Y	241_P	0.591	0.71
161_E	350_Q	0.591	0.71
290_V	295_I	0.590	0.71
258_S	302_I	0.590	0.71
185_V	255_A	0.588	0.70
193_T	205_K	0.588	0.70
342_E	345_R	0.587	0.70
14_E	304_K	0.582	0.70
37_P	41_F	0.582	0.70
91_L	94_F	0.581	0.69
151_R	155_K	0.580	0.69
242_P	287_E	0.580	0.69
191_G	232_D	0.579	0.69
24_N	96_L	0.579	0.69
253_S	257_Y	0.578	0.69
125_K	129_G	0.578	0.69
90_L	93_I	0.577	0.69
117_P	196_F	0.575	0.69
257_Y	326_P	0.574	0.68
195_L	298_T	0.573	0.68
278_L	281_S	0.573	0.68
126_S	148_F	0.570	0.68
97_H	107_I	0.568	0.68
41_F	73_N	0.568	0.68
98_A	102_E	0.567	0.68
134_P	140_Y	0.567	0.68
160_L	163_I	0.567	0.68
86_K	106_Q	0.566	0.67
90_L	139_T	0.566	0.67
154_N	162_S	0.566	0.67
100_S	104_K	0.565	0.67
308_D	312_K	0.565	0.67
36_S	39_V	0.562	0.67
222_P	345_R	0.562	0.67
202_L	216_P	0.561	0.67
300_N	335_A	0.561	0.67
44_Q	47_K	0.558	0.66
204_Q	275_I	0.556	0.66
121_E	134_P	0.556	0.66
297_V	327_I	0.555	0.66
198_S	336_L	0.552	0.65
28_T	58_S	0.551	0.65
32_K	35_K	0.551	0.65
337_K	341_L	0.551	0.65
279_Q	339_T	0.550	0.65
71_F	126_S	0.550	0.65
261_L	295_I	0.550	0.65
164_K	168_E	0.550	0.65
221_I	345_R	0.549	0.65
283_E	311_K	0.548	0.65
142_V	145_T	0.547	0.65
206_V	209_K	0.547	0.65
187_Y	211_F	0.547	0.65
223_I	226_R	0.546	0.65
26_K	29_S	0.544	0.64
345_R	348_I	0.543	0.64
90_L	114_Y	0.539	0.64
101_K	105_M	0.539	0.64
240_I	244_I	0.538	0.64
107_I	112_L	0.538	0.64
195_L	334_S	0.537	0.63
123_Y	128_I	0.537	0.63
186_G	232_D	0.537	0.63
229_M	246_D	0.536	0.63
121_E	145_T	0.534	0.63
122_T	126_S	0.533	0.63
333_I	336_L	0.533	0.63
182_I	309_L	0.531	0.63
136_G	147_K	0.530	0.62
116_L	120_K	0.530	0.62
172_E	175_K	0.530	0.62
212_T	244_I	0.528	0.62
223_I	227_K	0.528	0.62
66_L	70_H	0.526	0.62
279_Q	291_S	0.525	0.62
222_P	225_N	0.524	0.62
84_L	95_A	0.523	0.61
100_S	107_I	0.523	0.61
186_G	191_G	0.520	0.61
237_I	281_S	0.520	0.61
232_D	235_G	0.520	0.61
88_L	142_V	0.520	0.61
130_E	139_T	0.519	0.61
8_V	11_E	0.519	0.61
18_A	208_T	0.519	0.61
10_K	49_Q	0.518	0.61
123_Y	134_P	0.517	0.60
196_F	218_R	0.517	0.60
28_T	56_E	0.516	0.60
16_A	62_I	0.515	0.60
257_Y	336_L	0.515	0.60
215_S	281_S	0.514	0.60
40_K	77_E	0.514	0.60
190_S	247_A	0.514	0.60
296_L	332_P	0.513	0.60
264_V	298_T	0.512	0.60
276_E	280_S	0.511	0.60
186_G	235_G	0.511	0.60
124_T	129_G	0.509	0.59
183_G	254_E	0.509	0.59
339_T	342_E	0.509	0.59
221_I	348_I	0.509	0.59
129_G	170_S	0.508	0.59
185_V	290_V	0.508	0.59
124_T	141_G	0.508	0.59
158_K	283_E	0.507	0.59
340_N	347_K	0.507	0.59
197_N	200_T	0.506	0.59
141_G	197_N	0.506	0.59
212_T	215_S	0.506	0.59
276_E	307_G	0.506	0.59
131_Q	135_L	0.505	0.59
62_I	71_F	0.505	0.59
53_N	79_K	0.504	0.59
11_E	17_I	0.501	0.58
198_S	261_L	0.500	0.58
36_S	346_D	0.500	0.58
195_L	200_T	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qtfA	1	0.868	100	0.223	Contact Map
3j65o	1	0.882	100	0.595	Contact Map
3geeA	2	0.823	100	0.649	Contact Map
1xzpA	4	0.9045	100	0.652	Contact Map
3gehA	2	0.8399	100	0.653	Contact Map
2e87A	1	0.9073	100	0.659	Contact Map
4a9aA	1	0.618	100	0.667	Contact Map
3j4jA	1	0.6517	100	0.677	Contact Map
1mkyA	1	0.427	100	0.679	Contact Map
3j8gX	1	0.4101	100	0.682	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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