GREMLIN Database
Q980M2 - Multiprotein Bridging Factor (MBP-like), putative (MBP-like)
UniProt: Q980M2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (155)
Sequences: 181 (156)
Seq/√Len: 12.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_Y113_G3.2730.98
74_I134_V3.1490.97
101_K108_K3.1100.97
86_R111_E2.7980.94
14_S35_S2.6300.92
82_I110_F2.4610.89
94_Q104_E2.4510.89
44_A132_K2.2740.85
23_V32_V2.2300.84
102_V107_V2.1280.81
125_L133_L2.1210.80
109_R119_I1.9640.75
72_L134_V1.9430.74
91_I154_L1.9250.73
26_E29_I1.8560.70
8_Y15_Q1.8000.68
28_S80_K1.7950.68
28_S101_K1.7570.66
74_I123_R1.7500.66
93_Q97_A1.7220.64
93_Q107_V1.7160.64
7_E118_T1.6390.60
106_I115_L1.6320.60
77_D81_I1.5870.58
15_Q75_V1.5790.58
100_L118_T1.5640.57
21_I34_N1.5250.55
118_T121_Q1.5170.54
11_L28_S1.4950.53
66_K109_R1.4870.53
69_N77_D1.4740.52
106_I152_L1.4700.52
30_I43_H1.4520.51
32_V125_L1.4400.50
32_V143_S1.4300.50
97_A129_L1.4150.49
94_Q103_S1.3940.48
16_I20_G1.3830.48
23_V78_Y1.3700.47
16_I70_A1.3650.47
119_I122_A1.3530.46
38_D120_S1.3450.46
14_S120_S1.3260.45
77_D131_I1.3250.45
51_S54_S1.3230.44
40_I109_R1.3210.44
85_A127_K1.3080.44
66_K69_N1.3020.43
84_T95_Q1.2850.43
11_L24_S1.2780.42
104_E108_K1.2650.42
28_S157_V1.2620.41
26_E42_K1.2560.41
91_I95_Q1.2330.40
102_V124_Q1.2240.40
23_V120_S1.2160.39
25_Y84_T1.2130.39
111_E129_L1.2020.38
40_I124_Q1.1790.37
109_R114_K1.1780.37
66_K71_E1.1740.37
75_V81_I1.1660.37
19_K25_Y1.1580.36
86_R129_L1.1490.36
32_V152_L1.1420.36
96_L125_L1.1390.35
51_S55_E1.1340.35
28_S116_K1.1270.35
41_R75_V1.1220.35
97_A111_E1.1090.34
106_I121_Q1.1090.34
89_L123_R1.1090.34
44_A94_Q1.1010.34
110_F125_L1.1010.34
102_V133_L1.0940.33
115_L125_L1.0910.33
72_L136_P1.0850.33
86_R97_A1.0530.32
100_L135_T1.0430.31
23_V84_T1.0360.31
9_C13_G1.0270.30
9_C12_C1.0270.30
127_K130_G1.0260.30
34_N77_D1.0240.30
74_I151_G1.0230.30
15_Q161_K1.0220.30
66_K119_I1.0160.30
74_I147_F1.0140.30
52_K55_E1.0130.30
24_S28_S1.0120.30
26_E78_Y1.0030.29
86_R102_V0.9910.29
25_Y30_I0.9780.28
110_F121_Q0.9650.28
74_I119_I0.9470.27
23_V139_N0.9370.27
126_E155_G0.9280.26
25_Y32_V0.9230.26
57_R62_L0.9200.26
40_I94_Q0.9170.26
118_T122_A0.9070.25
44_A92_S0.9000.25
101_K104_E0.8980.25
29_I109_R0.8980.25
119_I134_V0.8970.25
94_Q98_Q0.8850.25
88_Q161_K0.8830.25
95_Q131_I0.8810.24
30_I124_Q0.8790.24
83_K130_G0.8750.24
89_L131_I0.8680.24
102_V111_E0.8640.24
30_I106_I0.8580.24
25_Y40_I0.8490.23
109_R122_A0.8480.23
66_K83_K0.8430.23
62_L148_D0.8400.23
122_A134_V0.8380.23
86_R153_T0.8180.22
72_L140_N0.8160.22
63_K83_K0.8060.22
26_E98_Q0.8060.22
55_E59_K0.8040.22
28_S73_E0.8000.22
30_I121_Q0.7980.21
56_T60_A0.7910.21
102_V121_Q0.7890.21
57_R63_K0.7880.21
11_L160_I0.7870.21
99_K137_L0.7860.21
25_Y159_N0.7850.21
83_K87_E0.7840.21
43_H69_N0.7790.21
22_T31_T0.7660.20
32_V144_E0.7540.20
147_F158_V0.7500.20
36_C117_P0.7470.20
33_C36_C0.7470.20
33_C117_P0.7470.20
11_L23_V0.7450.20
130_G152_L0.7430.20
48_K108_K0.7350.19
30_I41_R0.7320.19
8_Y109_R0.7310.19
37_Y40_I0.7240.19
32_V142_E0.7200.19
79_Y103_S0.7190.19
88_Q128_I0.7160.19
69_N119_I0.7160.19
108_K120_S0.7090.19
26_E103_S0.7080.18
16_I157_V0.7040.18
144_E147_F0.6990.18
11_L27_G0.6990.18
49_A55_E0.6970.18
83_K90_G0.6900.18
131_I139_N0.6890.18
59_K62_L0.6890.18
22_T87_E0.6870.18
93_Q113_G0.6870.18
123_R140_N0.6840.18
79_Y105_N0.6790.18
138_E143_S0.6760.18
53_K74_I0.6750.17
89_L128_I0.6740.17
14_S25_Y0.6730.17
111_E153_T0.6720.17
101_K116_K0.6700.17
75_V140_N0.6660.17
11_L39_R0.6640.17
16_I143_S0.6560.17
101_K118_T0.6550.17
135_T161_K0.6520.17
114_K129_L0.6510.17
74_I122_A0.6500.17
74_I88_Q0.6460.17
20_G73_E0.6330.16
121_Q154_L0.6330.16
11_L139_N0.6330.16
82_I126_E0.6310.16
60_A78_Y0.6260.16
124_Q136_P0.6260.16
11_L150_T0.6250.16
34_N41_R0.6200.16
120_S135_T0.6190.16
79_Y158_V0.6180.16
107_V113_G0.6170.16
53_K57_R0.6150.16
46_I49_A0.6120.16
152_L161_K0.6110.16
42_K66_K0.6070.16
67_M77_D0.6060.16
93_Q118_T0.6060.16
68_E123_R0.6020.15
23_V90_G0.5970.15
58_K81_I0.5940.15
82_I111_E0.5920.15
30_I95_Q0.5910.15
30_I78_Y0.5900.15
83_K86_R0.5840.15
10_E13_G0.5840.15
134_V140_N0.5830.15
131_I146_E0.5780.15
54_S59_K0.5760.15
23_V152_L0.5750.15
58_K131_I0.5740.15
106_I127_K0.5680.15
157_V160_I0.5580.14
8_Y122_A0.5570.14
63_K107_V0.5560.14
40_I103_S0.5490.14
80_K127_K0.5480.14
148_D162_E0.5360.14
122_A152_L0.5350.14
91_I99_K0.5340.14
101_K121_Q0.5310.14
8_Y130_G0.5300.14
34_N113_G0.5250.13
106_I118_T0.5250.13
142_E152_L0.5190.13
26_E93_Q0.5180.13
82_I97_A0.5160.13
25_Y42_K0.5160.13
30_I45_V0.5120.13
82_I86_R0.5120.13
10_E126_E0.5120.13
83_K111_E0.5080.13
8_Y121_Q0.5080.13
91_I162_E0.5070.13
53_K80_K0.5070.13
77_D85_A0.5060.13
95_Q149_D0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o9xA 2 0.7273 99.4 0.735 Contact Map
2mezA 1 0.5939 99.3 0.758 Contact Map
2jvlA 1 0.6364 98.6 0.811 Contact Map
1x57A 1 0.5515 98.6 0.813 Contact Map
3fymA 1 0.4545 98.6 0.814 Contact Map
4i6rA 2 0.4667 98.5 0.817 Contact Map
2wusR 1 0.4909 98.5 0.817 Contact Map
1y9qA 1 0.5818 98.5 0.817 Contact Map
2b5aA 2 0.4667 98.5 0.818 Contact Map
3g5gA 2 0.4788 98.5 0.819 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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