GREMLIN Database
PAN - Proteasome-activating nucleotidase
UniProt: Q980M1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (320)
Sequences: 11178 (6924)
Seq/√Len: 387.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
311_T330_E5.3831.00
331_L335_L3.9421.00
307_F334_Q3.8051.00
325_D328_N3.7411.00
127_E130_N3.6161.00
315_N329_L3.4211.00
306_D309_G3.1431.00
131_V134_S3.0391.00
64_V67_D2.8911.00
129_P133_Y2.8271.00
135_E190_T2.7761.00
219_L231_I2.7131.00
133_Y140_E2.6921.00
314_F344_I2.6391.00
311_T315_N2.5641.00
97_I102_N2.5621.00
312_E316_I2.5341.00
312_E315_N2.5121.00
134_S190_T2.3451.00
232_F279_A2.3401.00
278_A296_F2.3171.00
282_R285_I2.3081.00
32_I36_N2.2671.00
77_G80_L2.1931.00
25_E29_S2.1581.00
81_V85_A2.1531.00
341_G345_K1.9421.00
331_L334_Q1.9351.00
78_P82_V1.8871.00
172_L296_F1.8541.00
345_K349_V1.8311.00
98_S102_N1.7881.00
67_D71_L1.7701.00
63_D67_D1.7481.00
340_S344_I1.7241.00
97_I103_Q1.7241.00
170_G265_L1.7231.00
340_S345_K1.7141.00
239_I261_L1.6871.00
323_I328_N1.6791.00
341_G344_I1.6741.00
157_P160_F1.6621.00
93_I97_I1.6471.00
119_I225_R1.6361.00
348_C352_A1.6311.00
82_V85_A1.6101.00
217_R269_D1.5961.00
118_P273_N1.5771.00
128_R191_E1.5761.00
344_I347_V1.5741.00
39_K42_N1.5701.00
343_D347_V1.5611.00
328_N332_L1.5551.00
347_V351_A1.5551.00
41_L44_Y1.5441.00
83_N87_H1.5401.00
315_N326_N1.5371.00
61_V65_L1.5291.00
340_S343_D1.5131.00
173_L302_V1.5101.00
76_S84_I1.4951.00
353_Y357_R1.4581.00
44_Y47_E1.4441.00
71_L84_I1.4381.00
42_N46_A1.4301.00
197_I231_I1.4071.00
307_F330_E1.4051.00
34_I38_R1.4021.00
185_A277_I1.3941.00
71_L74_S1.3911.00
50_K53_S1.3871.00
264_E276_I1.3821.00
78_P81_V1.3781.00
197_I229_S1.3781.00
77_G81_V1.3701.00
75_S79_N1.3701.00
347_V350_E1.3671.00
188_V277_I1.3501.00
352_A356_I1.3291.00
156_N159_I1.3121.00
93_I103_Q1.3101.00
26_K30_L1.3101.00
327_I333_S1.3021.00
56_L60_V1.3001.00
133_Y143_I1.3001.00
127_E131_V1.2981.00
78_P85_A1.2941.00
68_G71_L1.2931.00
31_Q35_E1.2821.00
131_V191_E1.2821.00
351_A355_A1.2801.00
36_N40_E1.2741.00
61_V64_V1.2711.00
143_I184_L1.2661.00
35_E38_R1.2651.00
95_P98_S1.2591.00
94_K97_I1.2591.00
38_R42_N1.2501.00
330_E334_Q1.2411.00
144_R148_E1.2321.00
137_G316_I1.2311.00
118_P226_K1.2301.00
22_L26_K1.2301.00
60_V64_V1.2301.00
317_Y320_K1.2271.00
220_F269_D1.2241.00
160_F163_I1.2171.00
341_G347_V1.2141.00
68_G72_V1.2131.00
37_L41_L1.2091.00
32_I35_E1.2051.00
172_L236_I1.1831.00
47_E51_M1.1821.00
129_P144_R1.1801.00
349_V353_Y1.1761.00
84_I87_H1.1701.00
77_G85_A1.1701.00
72_V78_P1.1611.00
77_G82_V1.1611.00
197_I223_A1.1591.00
59_A62_L1.1551.00
73_R76_S1.1511.00
351_A356_I1.1351.00
29_S33_E1.1321.00
51_M55_P1.1271.00
236_I278_A1.1221.00
98_S101_L1.1161.00
240_G290_L1.1151.00
140_E144_R1.1131.00
49_E52_L1.1111.00
93_I98_S1.1101.00
74_S77_G1.1081.00
226_K269_D1.1081.00
347_V353_Y1.1011.00
328_N331_L1.0991.00
327_I330_E1.0981.00
195_V226_K1.0971.00
43_Y47_E1.0961.00
131_V190_T1.0881.00
292_R342_A1.0811.00
33_E36_N1.0781.00
347_V352_A1.0681.00
174_Y280_T1.0651.00
185_A232_F1.0641.00
41_L45_K1.0621.00
65_L68_G1.0531.00
69_R81_V1.0501.00
97_I101_L1.0491.00
41_L47_E1.0461.00
76_S80_L1.0451.00
71_L76_S1.0441.00
93_I101_L1.0441.00
288_P291_L1.0411.00
82_V86_S1.0401.00
39_K43_Y1.0381.00
99_V103_Q1.0301.00
46_A49_E1.0261.00
60_V63_D1.0221.00
140_E309_G1.0171.00
329_L333_S1.0161.00
336_T344_I1.0131.00
63_D66_P1.0131.00
339_F347_V1.0121.00
355_A358_D1.0111.00
338_G342_A1.0051.00
95_P102_N1.0041.00
324_E328_N1.0001.00
58_E61_V0.9991.00
84_I88_I0.9981.00
329_L332_L0.9921.00
184_L302_V0.9921.00
338_G343_D0.9911.00
201_A233_I0.9911.00
53_S57_I0.9891.00
84_I110_E0.9881.00
311_T329_L0.9871.00
283_I291_L0.9791.00
64_V68_G0.9761.00
323_I327_I0.9751.00
47_E50_K0.9691.00
24_E28_K0.9691.00
235_E281_N0.9671.00
147_R151_E0.9631.00
352_A355_A0.9591.00
98_S103_Q0.9581.00
338_G341_G0.9551.00
58_E65_L0.9501.00
141_E303_P0.9461.00
27_I31_Q0.9461.00
53_S56_L0.9441.00
241_A244_I0.9411.00
93_I102_N0.9401.00
30_L53_S0.9401.00
324_E327_I0.9391.00
156_N161_R0.9371.00
135_E183_M0.9351.00
119_I195_V0.9321.00
80_L84_I0.9311.00
46_A50_K0.9301.00
196_F232_F0.9291.00
71_L77_G0.9281.00
66_P69_R0.9271.00
304_L340_S0.9261.00
221_E225_R0.9221.00
310_R333_S0.9211.00
69_R72_V0.9171.00
347_V354_M0.9171.00
83_N86_S0.9141.00
308_K311_T0.9061.00
329_L335_L0.9061.00
95_P101_L0.9051.00
57_I60_V0.9051.00
61_V85_A0.9031.00
76_S81_V0.9021.00
344_I348_C0.8991.00
129_P151_E0.8991.00
100_A103_Q0.8971.00
44_Y55_P0.8971.00
314_F332_L0.8771.00
72_V77_G0.8751.00
196_F230_I0.8691.00
350_E353_Y0.8601.00
58_E85_A0.8591.00
243_R246_I0.8581.00
339_F343_D0.8581.00
85_A88_I0.8551.00
328_N334_Q0.8521.00
314_F329_L0.8511.00
199_V219_L0.8501.00
261_L264_E0.8481.00
345_K350_E0.8481.00
307_F311_T0.8471.00
48_M51_M0.8441.00
137_G312_E0.8411.00
135_E187_A0.8381.00
351_A358_D0.8381.00
26_K50_K0.8361.00
72_V81_V0.8341.00
69_R73_R0.8341.00
72_V75_S0.8301.00
303_P309_G0.8291.00
97_I100_A0.8261.00
31_Q34_I0.8251.00
22_L25_E0.8251.00
30_L34_I0.8231.00
21_R24_E0.8211.00
187_A190_T0.8161.00
62_L65_L0.8151.00
291_L298_R0.8151.00
48_M55_P0.8151.00
99_V102_N0.8141.00
28_K32_I0.8131.00
141_E144_R0.8111.00
119_I127_E0.8091.00
327_I331_L0.8091.00
242_K245_D0.8071.00
339_F342_A0.8011.00
35_E42_N0.7991.00
41_L55_P0.7991.00
35_E39_K0.7961.00
340_S349_V0.7961.00
43_Y46_A0.7941.00
343_D348_C0.7911.00
350_E355_A0.7881.00
33_E37_L0.7871.00
307_F333_S0.7841.00
69_R77_G0.7831.00
349_V357_R0.7801.00
48_M52_L0.7731.00
205_A242_K0.7731.00
156_N160_F0.7721.00
311_T326_N0.7721.00
72_V82_V0.7701.00
291_L299_I0.7681.00
75_S78_P0.7681.00
46_A53_S0.7671.00
49_E53_S0.7611.00
323_I332_L0.7591.00
74_S81_V0.7591.00
227_A273_N0.7581.00
76_S79_N0.7581.00
352_A358_D0.7581.00
343_D350_E0.7561.00
80_L83_N0.7551.00
76_S83_N0.7511.00
353_Y356_I0.7461.00
24_E43_Y0.7451.00
226_K273_N0.7441.00
332_L335_L0.7411.00
64_V76_S0.7391.00
73_R78_P0.7391.00
94_K98_S0.7381.00
77_G84_I0.7361.00
117_D120_V0.7331.00
87_H90_Q0.7321.00
345_K348_C0.7271.00
79_N84_I0.7271.00
20_V24_E0.7261.00
355_A360_R0.7241.00
68_G73_R0.7241.00
58_E64_V0.7231.00
44_Y51_M0.7191.00
234_D295_R0.7191.00
336_T339_F0.7171.00
204_F218_E0.7171.00
338_G345_K0.7161.00
351_A357_R0.7131.00
89_D92_L0.7131.00
37_L40_E0.7101.00
164_G194_A0.7091.00
20_V23_L0.7081.00
23_L27_I0.7061.00
197_I219_L0.7051.00
34_I53_S0.7021.00
80_L86_S0.7011.00
81_V86_S0.7001.00
235_E262_L0.6981.00
78_P86_S0.6971.00
34_I43_Y0.6961.00
346_N352_A0.6961.00
321_M348_C0.6940.99
330_E333_S0.6910.99
340_S347_V0.6900.99
349_V359_G0.6880.99
192_S275_K0.6870.99
135_E193_N0.6800.99
235_E295_R0.6800.99
76_S82_V0.6780.99
81_V84_I0.6770.99
352_A360_R0.6750.99
61_V80_L0.6750.99
326_N330_E0.6750.99
58_E62_L0.6720.99
339_F345_K0.6710.99
349_V354_M0.6710.99
69_R78_P0.6710.99
78_P83_N0.6690.99
196_F200_V0.6670.99
28_K31_Q0.6670.99
54_P57_I0.6650.99
71_L88_I0.6640.99
344_I349_V0.6640.99
240_G243_R0.6630.99
21_R25_E0.6630.99
93_I100_A0.6570.99
338_G347_V0.6570.99
353_Y360_R0.6560.99
30_L33_E0.6550.99
113_P269_D0.6550.99
50_K54_P0.6540.99
40_E49_E0.6530.99
87_H91_K0.6510.99
42_N45_K0.6480.99
25_E28_K0.6470.99
336_T343_D0.6440.99
322_K327_I0.6420.99
96_G101_L0.6410.99
27_I30_L0.6380.99
353_Y359_G0.6380.99
110_E113_P0.6360.99
27_I32_I0.6360.99
348_C358_D0.6350.99
25_E32_I0.6340.99
59_A63_D0.6330.99
55_P59_A0.6310.99
57_I61_V0.6310.99
230_I277_I0.6260.99
346_N349_V0.6210.99
354_M360_R0.6180.99
70_V74_S0.6180.99
350_E357_R0.6160.99
106_S114_Q0.6120.99
342_A348_C0.6090.99
30_L35_E0.6080.99
31_Q50_K0.6060.99
327_I332_L0.6050.99
197_I226_K0.6040.99
205_A245_D0.6040.99
130_N133_Y0.6020.99
28_K39_K0.6020.99
70_V82_V0.6010.99
47_E54_P0.5980.98
281_N295_R0.5980.98
70_V73_R0.5930.98
57_I84_I0.5930.98
51_M54_P0.5920.98
73_R77_G0.5910.98
31_Q39_K0.5880.98
337_E340_S0.5860.98
157_P161_R0.5850.98
43_Y50_K0.5840.98
342_A350_E0.5820.98
107_T114_Q0.5790.98
186_K268_F0.5770.98
283_I298_R0.5760.98
32_I39_K0.5740.98
199_V231_I0.5730.98
83_N88_I0.5730.98
65_L72_V0.5730.98
55_P62_L0.5720.98
54_P58_E0.5710.98
74_S78_P0.5700.98
75_S80_L0.5650.98
281_N289_A0.5650.98
158_E162_E0.5650.98
29_S43_Y0.5650.98
348_C353_Y0.5640.98
68_G74_S0.5640.98
343_D346_N0.5640.98
28_K34_I0.5630.98
161_R168_P0.5630.98
44_Y48_M0.5620.98
62_L67_D0.5610.98
55_P58_E0.5610.98
56_L61_V0.5600.98
289_A295_R0.5590.98
114_Q118_P0.5580.98
41_L51_M0.5570.98
325_D332_L0.5570.98
132_T187_A0.5560.98
352_A357_R0.5560.98
34_I42_N0.5540.98
129_P147_R0.5530.97
348_C351_A0.5530.97
31_Q43_Y0.5520.97
123_M127_E0.5490.97
348_C354_M0.5470.97
105_G109_L0.5460.97
350_E354_M0.5450.97
61_V84_I0.5440.97
174_Y283_I0.5430.97
341_G349_V0.5410.97
82_V88_I0.5400.97
342_A351_A0.5390.97
23_L38_R0.5380.97
96_G99_V0.5370.97
174_Y299_I0.5330.97
261_L265_L0.5330.97
24_E31_Q0.5330.97
318_L348_C0.5330.97
315_N319_K0.5330.97
80_L88_I0.5290.97
354_M357_R0.5290.97
157_P162_E0.5280.97
106_S110_E0.5270.97
233_I261_L0.5260.97
66_P70_V0.5250.97
95_P100_A0.5250.97
74_S80_L0.5240.97
81_V88_I0.5210.96
40_E44_Y0.5210.96
27_I42_N0.5200.96
58_E66_P0.5200.96
347_V355_A0.5200.96
83_N96_G0.5160.96
323_I326_N0.5160.96
36_N42_N0.5150.96
23_L37_L0.5140.96
37_L47_E0.5140.96
52_L55_P0.5130.96
343_D353_Y0.5130.96
122_T127_E0.5130.96
38_R41_L0.5120.96
37_L44_Y0.5120.96
318_L329_L0.5120.96
24_E34_I0.5110.96
24_E27_I0.5090.96
351_A354_M0.5080.96
326_N334_Q0.5070.96
37_L42_N0.5070.96
343_D352_A0.5070.96
356_I360_R0.5070.96
65_L85_A0.5070.96
21_R28_K0.5060.96
337_E341_G0.5060.96
50_K57_I0.5040.96
139_L142_Q0.5040.96
341_G348_C0.5020.96
269_D272_D0.5000.96
266_D295_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cr2J 1 0.9491 100 0.29 Contact Map
4cr2L 1 0.9186 100 0.315 Contact Map
3cf2A 3 0.7888 100 0.349 Contact Map
2ce7A 3 0.6539 100 0.356 Contact Map
4cr2M 1 0.9186 100 0.356 Contact Map
4cr2K 1 0.9466 100 0.366 Contact Map
4ww0A 4 0.6565 100 0.378 Contact Map
4cr2I 1 0.888 100 0.382 Contact Map
4cr2H 1 0.883 100 0.387 Contact Map
3cf0A 3 0.6972 100 0.389 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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