GREMLIN Database
ATGT - tRNA-guanine(15) transglycosylase
UniProt: Q980L7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 503 (453)
Sequences: 192 (151)
Seq/√Len: 7.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
276_F288_P6.3421.00
20_T23_G6.3161.00
278_C283_C4.3480.98
130_Y134_K4.0270.96
210_D347_R3.6670.94
273_L320_Q3.4000.91
7_K17_T3.3950.90
275_Y319_K3.3320.90
139_E142_K3.2320.88
204_M207_T3.1640.87
180_G183_K3.0430.85
26_E319_K2.8920.81
223_I318_T2.8910.81
92_I123_P2.8470.80
242_L319_K2.8450.80
89_A92_I2.7610.78
251_S311_I2.7530.78
13_G240_V2.7230.77
216_K225_F2.6910.76
93_L195_S2.6270.74
23_G82_I2.5960.73
160_I189_N2.5930.73
280_C283_C2.5780.73
330_Y334_K2.5060.71
117_G159_I2.4920.70
37_L62_L2.4800.70
203_Y338_H2.4220.68
55_F72_I2.3850.67
163_Y188_Y2.3360.65
31_F54_N2.3220.64
48_R80_E2.3150.64
119_I144_A2.2740.63
298_E315_F2.2580.62
126_N198_V2.2150.61
17_T24_T2.1640.59
212_I319_K2.1540.58
216_K228_F2.1460.58
84_M114_P2.1280.57
55_F83_I2.1060.57
72_I83_I2.0700.55
165_I276_F2.0260.53
15_I319_K2.0220.53
201_E328_F1.9790.52
52_F312_L1.9760.52
126_N197_T1.9740.51
241_A254_I1.9640.51
102_N146_E1.9500.51
174_V198_V1.9420.50
132_N136_T1.9410.50
118_V162_V1.9230.49
130_Y172_D1.9090.49
68_I75_E1.8950.48
8_Y15_I1.8920.48
26_E275_Y1.8720.48
89_A123_P1.8610.47
72_I400_S1.8530.47
93_L254_I1.8510.47
240_V318_T1.8500.47
213_Y319_K1.8260.46
200_L208_V1.8220.46
59_S62_L1.8200.46
174_V215_A1.8170.45
259_N296_E1.8070.45
52_F251_S1.8020.45
123_P254_I1.7950.45
192_A196_P1.7890.44
17_T83_I1.7690.44
345_F349_M1.7630.43
90_Y118_V1.7580.43
90_Y174_V1.7430.43
319_K380_P1.7400.42
462_E472_I1.7320.42
84_M162_V1.7220.42
317_A321_A1.6920.41
23_G120_L1.6710.40
225_F228_F1.6610.40
37_L65_N1.6430.39
90_Y192_A1.6250.38
106_V326_R1.5760.36
259_N299_R1.5660.36
15_I275_Y1.5640.36
37_L303_L1.5640.36
192_A195_S1.5630.36
11_L118_V1.5520.36
174_V195_S1.5250.35
314_E334_K1.5190.34
11_L89_A1.4980.34
174_V197_T1.4840.33
125_G132_N1.4820.33
7_K24_T1.4760.33
236_I311_I1.4760.33
315_F318_T1.4690.33
165_I286_Y1.4660.33
20_T345_F1.4660.33
90_Y197_T1.4580.32
31_F367_K1.4570.32
270_L385_H1.4410.32
280_C329_E1.4310.31
71_D174_V1.4220.31
285_K324_E1.4180.31
90_Y196_P1.4110.31
228_F380_P1.3990.30
212_I242_L1.3850.30
89_A195_S1.3840.30
162_V197_T1.3730.30
127_I204_M1.3710.29
264_R344_A1.3700.29
301_K305_I1.3640.29
197_T331_L1.3600.29
160_I190_M1.3530.29
119_I164_P1.3530.29
114_P230_G1.3480.29
275_Y320_Q1.3470.29
108_Y266_R1.3420.29
174_V196_P1.3390.28
470_T476_L1.3390.28
23_G345_F1.3380.28
29_A78_S1.3290.28
270_L427_N1.3050.27
64_K80_E1.3030.27
103_L146_E1.2980.27
251_S369_L1.2920.27
445_I448_S1.2910.27
55_F76_L1.2900.27
359_D384_R1.2870.27
15_I26_E1.2860.27
277_P376_S1.2840.27
404_Y407_A1.2830.27
40_D337_S1.2750.27
227_L239_A1.2720.26
164_P228_F1.2590.26
20_T82_I1.2590.26
34_I294_M1.2540.26
31_F68_I1.2530.26
76_L147_A1.2520.26
123_P381_E1.2440.26
126_N174_V1.2380.25
142_K200_L1.2330.25
22_S333_E1.2290.25
240_V319_K1.2210.25
135_K149_E1.2190.25
14_R27_T1.2150.25
42_I269_K1.2120.25
335_A379_R1.2110.25
266_R330_Y1.2050.24
342_Y371_L1.2050.24
26_E324_E1.2040.24
74_K441_I1.2020.24
192_A198_V1.1990.24
209_I242_L1.1870.24
190_M246_S1.1850.24
30_F193_L1.1770.24
219_I330_Y1.1740.24
30_F311_I1.1740.24
212_I257_R1.1730.24
14_R28_P1.1690.23
193_L242_L1.1670.23
100_I105_I1.1660.23
236_I315_F1.1660.23
114_P162_V1.1650.23
40_D208_V1.1600.23
315_F387_R1.1590.23
90_Y237_P1.1580.23
261_Y283_C1.1570.23
53_K214_T1.1540.23
34_I55_F1.1530.23
181_L262_I1.1520.23
464_V468_M1.1390.23
31_F174_V1.1300.22
182_S220_K1.1270.22
133_A327_L1.1260.22
165_I324_E1.1200.22
210_D356_E1.1190.22
279_S313_E1.1180.22
34_I268_Y1.1060.22
195_S254_I1.1030.22
93_L123_P1.0920.21
44_I303_L1.0920.21
399_I447_D1.0900.21
166_Q231_G1.0900.21
226_H252_Y1.0900.21
261_Y280_C1.0850.21
126_N196_P1.0850.21
251_S262_I1.0840.21
105_I332_Q1.0800.21
123_P261_Y1.0760.21
385_H451_L1.0720.21
214_T452_S1.0670.21
13_G329_E1.0670.21
34_I76_L1.0630.21
90_Y198_V1.0570.20
261_Y278_C1.0560.20
59_S305_I1.0560.20
72_I192_A1.0510.20
69_K185_E1.0460.20
47_I163_Y1.0460.20
192_A237_P1.0400.20
123_P195_S1.0390.20
286_Y291_L1.0390.20
143_R146_E1.0360.20
35_N55_F1.0340.20
468_M472_I1.0330.20
174_V192_A1.0310.20
113_K337_S1.0280.20
460_I464_V1.0270.20
251_S334_K1.0260.20
456_I480_N1.0200.20
348_L355_L1.0190.20
90_Y126_N1.0180.20
25_L54_N1.0170.20
224_P380_P1.0160.19
18_L184_F1.0160.19
163_Y181_L1.0150.19
67_Y93_L1.0130.19
109_Q193_L1.0120.19
44_I47_I1.0110.19
60_Y85_T1.0080.19
119_I139_E1.0030.19
129_D268_Y1.0010.19
335_A381_E0.9970.19
104_Q270_L0.9940.19
37_L312_L0.9920.19
462_E466_D0.9920.19
123_P280_C0.9880.19
161_W174_V0.9820.19
278_C329_E0.9770.19
141_L145_E0.9750.19
90_Y93_L0.9740.18
178_A215_A0.9720.18
71_D266_R0.9710.18
78_S271_E0.9700.18
126_N192_A0.9660.18
261_Y275_Y0.9650.18
313_E319_K0.9640.18
208_V441_I0.9620.18
91_Q166_Q0.9610.18
295_N298_E0.9610.18
268_Y273_L0.9580.18
106_V351_Y0.9550.18
71_D108_Y0.9550.18
12_A436_P0.9540.18
188_Y201_E0.9520.18
85_T450_P0.9500.18
159_I189_N0.9500.18
359_D438_F0.9500.18
254_I263_T0.9450.18
295_N476_L0.9410.18
91_Q231_G0.9400.18
193_L352_K0.9400.18
283_C329_E0.9400.18
13_G123_P0.9390.18
8_Y150_I0.9380.18
353_D462_E0.9380.18
35_N76_L0.9340.18
109_Q204_M0.9300.17
29_A400_S0.9230.17
259_N270_L0.9220.17
135_K396_K0.9190.17
212_I323_K0.9160.17
282_I302_A0.9130.17
41_E118_V0.9120.17
276_F319_K0.9110.17
216_K380_P0.9080.17
93_L367_K0.9080.17
89_A136_T0.9040.17
26_E380_P0.9040.17
31_F195_S0.9000.17
226_H249_S0.9000.17
48_R55_F0.9000.17
96_G203_Y0.9000.17
122_L143_R0.8950.17
68_I196_P0.8920.17
61_I144_A0.8820.16
59_S68_I0.8790.16
334_K371_L0.8790.16
259_N271_E0.8760.16
162_V196_P0.8750.16
475_F479_N0.8740.16
54_N116_I0.8730.16
192_A197_T0.8660.16
59_S363_R0.8650.16
79_E90_Y0.8640.16
9_E118_V0.8630.16
129_D134_K0.8550.16
46_E146_E0.8550.16
34_I353_D0.8540.16
472_I480_N0.8540.16
436_P475_F0.8520.16
261_Y303_L0.8520.16
210_D352_K0.8490.16
204_M239_A0.8490.16
17_T288_P0.8470.16
184_F271_E0.8460.16
444_E463_D0.8460.16
12_A446_S0.8420.16
5_E10_D0.8390.16
299_R311_I0.8380.16
467_D471_K0.8360.15
329_E439_G0.8360.15
219_I334_K0.8350.15
180_G446_S0.8310.15
45_D182_S0.8300.15
328_F385_H0.8300.15
18_L170_Y0.8290.15
162_V451_L0.8290.15
85_T231_G0.8270.15
249_S252_Y0.8260.15
184_F408_I0.8260.15
382_I455_E0.8250.15
135_K466_D0.8250.15
244_V335_A0.8220.15
185_E297_K0.8180.15
6_V25_L0.8120.15
462_E474_S0.8110.15
65_N68_I0.8100.15
176_T180_G0.8100.15
84_M164_P0.8090.15
62_L72_I0.8070.15
31_F168_G0.8050.15
62_L68_I0.8020.15
468_M480_N0.8020.15
469_K473_I0.8010.15
473_I483_K0.8010.15
30_F445_I0.8010.15
368_G451_L0.8000.15
68_I168_G0.8000.15
145_E180_G0.8000.15
255_Y449_Y0.7970.15
29_A352_K0.7950.15
125_G161_W0.7950.15
35_N44_I0.7950.15
188_Y381_E0.7950.15
26_E160_I0.7930.15
74_K357_K0.7910.15
174_V266_R0.7900.15
19_R24_T0.7890.15
146_E472_I0.7890.15
128_N219_I0.7880.15
35_N47_I0.7870.15
92_I195_S0.7850.14
85_T166_Q0.7850.14
99_G348_L0.7820.14
223_I478_R0.7810.14
379_R385_H0.7810.14
164_P177_S0.7800.14
236_I251_S0.7770.14
141_L180_G0.7760.14
90_Y205_Y0.7710.14
175_K294_M0.7700.14
89_A192_A0.7700.14
271_E279_S0.7690.14
34_I459_E0.7690.14
201_E325_G0.7670.14
135_K287_T0.7670.14
90_Y195_S0.7660.14
315_F333_E0.7620.14
171_L212_I0.7610.14
11_L331_L0.7610.14
123_P363_R0.7610.14
25_L235_I0.7600.14
220_K434_A0.7590.14
130_Y170_Y0.7580.14
30_F348_L0.7580.14
183_K284_S0.7570.14
122_L136_T0.7560.14
31_F198_V0.7550.14
118_V164_P0.7550.14
89_A93_L0.7540.14
75_E236_I0.7480.14
255_Y333_E0.7480.14
82_I317_A0.7470.14
26_E224_P0.7470.14
64_K463_D0.7460.14
100_I388_F0.7450.14
319_K323_K0.7440.14
436_P439_G0.7430.14
176_T401_I0.7420.14
8_Y357_K0.7420.14
250_A254_I0.7390.14
163_Y212_I0.7350.14
54_N98_I0.7330.14
103_L107_N0.7320.14
235_I303_L0.7320.14
280_C325_G0.7320.14
89_A118_V0.7310.13
131_D303_L0.7300.13
136_T195_S0.7290.13
399_I479_N0.7290.13
277_P303_L0.7280.13
132_N350_K0.7250.13
190_M391_R0.7250.13
65_N305_I0.7240.13
253_I330_Y0.7230.13
388_F391_R0.7210.13
133_A240_V0.7200.13
283_C325_G0.7200.13
234_H332_Q0.7200.13
287_T472_I0.7190.13
105_I380_P0.7190.13
189_N305_I0.7180.13
111_K399_I0.7170.13
191_A223_I0.7160.13
315_F428_E0.7160.13
42_I113_K0.7150.13
205_Y388_F0.7140.13
305_I333_E0.7120.13
25_L370_F0.7120.13
197_T214_T0.7090.13
176_T179_E0.7080.13
460_I463_D0.7070.13
45_D271_E0.7060.13
29_A257_R0.7040.13
99_G319_K0.7030.13
48_R70_D0.7030.13
108_Y197_T0.7020.13
45_D386_S0.7000.13
86_D256_A0.7000.13
86_D194_G0.7000.13
167_G194_G0.7000.13
167_G229_G0.7000.13
167_G248_D0.7000.13
167_G256_A0.7000.13
248_D256_A0.7000.13
86_D121_D0.7000.13
87_S121_D0.7000.13
86_D167_G0.7000.13
194_G229_G0.7000.13
194_G248_D0.7000.13
229_G256_A0.7000.13
229_G248_D0.7000.13
194_G256_A0.7000.13
121_D256_A0.7000.13
88_G256_A0.7000.13
86_D248_D0.7000.13
87_S167_G0.7000.13
87_S194_G0.7000.13
87_S229_G0.7000.13
87_S248_D0.7000.13
87_S256_A0.7000.13
86_D229_G0.7000.13
88_G121_D0.7000.13
88_G167_G0.7000.13
88_G194_G0.7000.13
121_D194_G0.7000.13
88_G229_G0.7000.13
88_G248_D0.7000.13
121_D229_G0.7000.13
121_D248_D0.7000.13
121_D167_G0.7000.13
184_F432_F0.6990.13
217_S476_L0.6990.13
261_Y276_F0.6980.13
251_S438_F0.6970.13
190_M361_R0.6970.13
69_K383_I0.6970.13
435_V454_F0.6960.13
44_I235_I0.6960.13
36_V108_Y0.6960.13
329_E360_P0.6940.13
195_S246_S0.6930.13
45_D48_R0.6900.13
162_V174_V0.6890.13
114_P444_E0.6890.13
295_N465_I0.6880.13
441_I479_N0.6870.13
98_I284_S0.6870.13
76_L263_T0.6870.13
70_D294_M0.6870.13
170_Y447_D0.6860.13
262_I454_F0.6840.13
92_I137_V0.6840.13
92_I106_V0.6810.13
210_D279_S0.6800.13
120_L201_E0.6780.13
95_Y260_R0.6770.13
93_L335_A0.6740.12
90_Y162_V0.6730.12
434_A452_S0.6730.12
70_D158_N0.6720.12
79_E303_L0.6720.12
148_S396_K0.6710.12
20_T208_V0.6710.12
282_I449_Y0.6710.12
283_C327_L0.6670.12
17_T452_S0.6670.12
392_Y444_E0.6660.12
26_E313_E0.6640.12
205_Y272_D0.6640.12
15_I337_S0.6630.12
22_S208_V0.6590.12
466_D474_S0.6580.12
83_I291_L0.6570.12
133_A282_I0.6560.12
148_S220_K0.6550.12
157_N292_L0.6550.12
78_S184_F0.6550.12
360_P380_P0.6550.12
117_G409_S0.6540.12
103_L206_D0.6530.12
160_I205_Y0.6510.12
102_N120_L0.6510.12
142_K210_D0.6510.12
161_W195_S0.6500.12
338_H370_F0.6500.12
19_R294_M0.6490.12
19_R355_L0.6480.12
26_E212_I0.6460.12
332_Q345_F0.6450.12
106_V357_K0.6450.12
113_K117_G0.6450.12
123_P241_A0.6440.12
104_Q292_L0.6420.12
107_N292_L0.6400.12
332_Q449_Y0.6390.12
314_E338_H0.6370.12
202_K257_R0.6370.12
64_K265_T0.6370.12
462_E473_I0.6360.12
243_G307_N0.6340.12
313_E477_R0.6340.12
200_L205_Y0.6320.12
94_E318_T0.6320.12
137_V251_S0.6310.12
379_R438_F0.6310.12
200_L255_Y0.6290.12
325_G381_E0.6280.12
64_K99_G0.6270.12
67_Y234_H0.6250.12
98_I318_T0.6250.12
359_D385_H0.6240.12
92_I136_T0.6220.12
197_T244_V0.6210.12
124_T370_F0.6180.12
281_P309_Y0.6170.12
175_K217_S0.6160.12
472_I482_Q0.6150.12
28_P32_P0.6130.11
28_P33_V0.6130.11
465_I473_I0.6130.11
314_E379_R0.6130.11
149_E179_E0.6110.11
161_W326_R0.6110.11
95_Y203_Y0.6100.11
157_N404_Y0.6090.11
478_R483_K0.6070.11
378_H401_I0.6070.11
469_K476_L0.6040.11
336_Y375_N0.6030.11
480_N483_K0.6020.11
47_I309_Y0.5990.11
282_I315_F0.5970.11
396_K428_E0.5940.11
6_V351_Y0.5930.11
47_I276_F0.5930.11
42_I150_I0.5930.11
285_K404_Y0.5910.11
261_Y436_P0.5900.11
143_R332_Q0.5890.11
284_S287_T0.5880.11
227_L230_G0.5880.11
117_G325_G0.5870.11
396_K401_I0.5860.11
13_G118_V0.5860.11
228_F276_F0.5830.11
356_E359_D0.5830.11
64_K75_E0.5830.11
41_E197_T0.5830.11
31_F161_W0.5830.11
479_N483_K0.5820.11
359_D381_E0.5820.11
385_H438_F0.5800.11
123_P278_C0.5760.11
120_L188_Y0.5750.11
55_F311_I0.5750.11
59_S313_E0.5740.11
265_T349_M0.5730.11
7_K193_L0.5730.11
51_G140_T0.5730.11
211_M434_A0.5720.11
298_E441_I0.5720.11
259_N294_M0.5720.11
377_L401_I0.5710.11
105_I388_F0.5710.11
6_V15_I0.5700.11
280_C321_A0.5690.11
177_S211_M0.5690.11
236_I326_R0.5680.11
215_A469_K0.5680.11
175_K218_N0.5670.11
124_T338_H0.5650.11
266_R334_K0.5630.11
12_A181_L0.5630.11
89_A280_C0.5620.11
116_I476_L0.5610.11
6_V302_A0.5610.11
209_I238_F0.5590.11
448_S477_R0.5580.11
90_Y324_E0.5580.11
224_P319_K0.5570.11
95_Y140_T0.5570.11
59_S204_M0.5540.11
212_I310_T0.5540.11
356_E384_R0.5530.11
60_Y266_R0.5520.11
74_K348_L0.5510.11
117_G294_M0.5500.11
219_I266_R0.5500.11
165_I209_I0.5500.11
183_K242_L0.5490.11
170_Y281_P0.5480.11
475_F481_Y0.5470.11
93_L125_G0.5470.11
111_K395_K0.5460.10
342_Y373_D0.5450.10
18_L261_Y0.5440.10
333_E430_D0.5430.10
227_L336_Y0.5430.10
95_Y250_A0.5420.10
69_K382_I0.5420.10
35_N253_I0.5410.10
142_K387_R0.5400.10
112_I322_I0.5400.10
13_G92_I0.5390.10
196_P211_M0.5370.10
84_M118_V0.5370.10
224_P360_P0.5370.10
180_G466_D0.5360.10
29_A239_A0.5350.10
38_K253_I0.5350.10
7_K64_K0.5340.10
294_M302_A0.5340.10
72_I205_Y0.5330.10
25_L114_P0.5290.10
59_S367_K0.5290.10
217_S392_Y0.5280.10
29_A281_P0.5280.10
179_E390_E0.5270.10
140_T250_A0.5270.10
123_P436_P0.5270.10
228_F261_Y0.5250.10
150_I184_F0.5250.10
216_K321_A0.5240.10
13_G282_I0.5240.10
195_S205_Y0.5230.10
68_I192_A0.5210.10
257_R349_M0.5200.10
180_G242_L0.5200.10
353_D390_E0.5200.10
31_F197_T0.5190.10
74_K210_D0.5170.10
290_D470_T0.5160.10
173_L336_Y0.5160.10
262_I385_H0.5160.10
7_K393_I0.5160.10
289_K292_L0.5150.10
203_Y250_A0.5140.10
454_F468_M0.5120.10
85_T91_Q0.5120.10
285_K401_I0.5110.10
95_Y232_L0.5110.10
261_Y363_R0.5090.10
164_P261_Y0.5090.10
195_S237_P0.5090.10
131_D135_K0.5070.10
221_R385_H0.5070.10
251_S310_T0.5060.10
195_S198_V0.5060.10
175_K477_R0.5060.10
117_G224_P0.5050.10
162_V198_V0.5040.10
21_R53_K0.5040.10
148_S401_I0.5040.10
463_D481_Y0.5030.10
118_V254_I0.5030.10
258_D345_F0.5030.10
55_F74_K0.5010.10
401_I430_D0.5010.10
8_Y103_L0.5000.10
135_K138_Y0.5000.10
145_E205_Y0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iq8A 2 0.9085 100 0.383 Contact Map
4q8wA 2 0.664 100 0.533 Contact Map
2ashA 3 0.6481 100 0.537 Contact Map
2q07A 1 0.2127 99.9 0.874 Contact Map
2qiwA 2 0.4254 86 0.975 Contact Map
3vkjA 4 0.5746 78.8 0.977 Contact Map
2ze3A 2 0.4513 76.8 0.977 Contact Map
4oqvA 1 0.5129 72.8 0.978 Contact Map
1nvmA 2 0.5845 67.8 0.979 Contact Map
1goxA 4 0.5408 62.6 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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