GREMLIN Database
PSB1 - Proteasome subunit beta 1
UniProt: Q980L4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (183)
Sequences: 4309 (2406)
Seq/√Len: 177.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_S155_V5.2381.00
20_A160_I3.7101.00
14_N150_N3.2271.00
10_G19_L3.0631.00
13_V16_G2.7641.00
8_A48_A2.5191.00
10_G115_L2.5171.00
114_Q126_E2.4481.00
153_L184_D2.4301.00
146_E162_K2.4211.00
13_V156_A2.4071.00
184_D187_G2.3591.00
71_E77_P2.3361.00
46_L80_V2.2261.00
128_N149_P2.2131.00
153_L157_T2.1031.00
41_K44_K2.0921.00
109_D112_G2.0501.00
19_L106_G2.0091.00
148_D155_V1.9281.00
151_M159_L1.9261.00
11_L160_I1.9131.00
15_D185_K1.8631.00
43_N71_E1.8381.00
12_K126_E1.8291.00
104_L130_A1.7961.00
17_I106_G1.7851.00
92_Y95_K1.7781.00
14_N152_S1.7591.00
80_V107_G1.7371.00
18_V182_I1.7021.00
46_L83_A1.6601.00
18_V157_T1.6511.00
45_F77_P1.6301.00
18_V160_I1.6121.00
148_D151_M1.5691.00
146_E159_L1.5671.00
79_S82_A1.5481.00
11_L156_A1.5191.00
157_T180_L1.4811.00
67_I83_A1.4811.00
157_T182_I1.4791.00
15_D153_L1.4581.00
39_V181_A1.4581.00
13_V153_L1.4571.00
13_V184_D1.4461.00
102_E120_P1.4331.00
63_M87_L1.4021.00
116_Y126_E1.3981.00
16_G156_A1.3801.00
84_A124_L1.3791.00
158_Q162_K1.3771.00
37_K179_D1.3751.00
49_G56_L1.3621.00
147_Y150_N1.3591.00
7_T135_G1.3281.00
25_L36_A1.2911.00
97_M100_I1.2481.00
47_M60_T1.2471.00
12_K128_N1.2351.00
78_I83_A1.2071.00
147_Y151_M1.1971.00
62_I66_E1.1931.00
43_N77_P1.1931.00
143_L163_A1.1891.00
20_A180_L1.1711.00
18_V156_A1.1701.00
94_Y99_F1.1641.00
59_L101_S1.1621.00
131_A143_L1.1541.00
66_E86_L1.1531.00
142_V163_A1.1501.00
47_M105_F1.1461.00
12_K113_P1.1421.00
66_E69_Y1.1411.00
39_V48_A1.1311.00
142_V146_E1.1231.00
42_I67_I1.0861.00
7_T139_A1.0811.00
16_G153_L1.0721.00
70_Y74_T1.0691.00
108_V185_K1.0641.00
62_I90_I1.0621.00
104_L132_V1.0351.00
154_D158_Q1.0210.99
161_T178_I1.0210.99
17_I115_L1.0170.99
23_R179_D1.0080.99
91_L118_L1.0070.99
65_V69_Y0.9960.99
27_Y32_L0.9880.99
119_D123_S0.9830.99
24_R31_V0.9830.99
151_M155_V0.9810.99
162_K165_K0.9800.99
42_I47_M0.9800.99
117_V130_A0.9780.99
40_Y60_T0.9780.99
86_L90_I0.9680.99
19_L181_A0.9620.99
158_Q161_T0.9600.99
9_V143_L0.9580.99
91_L103_I0.9540.99
161_T180_L0.9520.99
60_T64_N0.9520.99
151_M156_A0.9510.99
129_Y143_L0.9480.99
17_I113_P0.9280.99
105_F118_L0.9110.99
90_I93_Q0.9050.99
17_I20_A0.8950.99
43_N46_L0.8940.99
69_Y73_S0.8920.99
19_L48_A0.8910.98
45_F78_I0.8910.98
56_L101_S0.8900.98
163_A167_S0.8870.98
69_Y72_V0.8780.98
109_D114_Q0.8780.98
50_A132_V0.8750.98
47_M103_I0.8640.98
127_D130_A0.8530.98
80_V114_Q0.8510.98
23_R177_G0.8440.98
40_Y49_G0.8420.98
87_L105_F0.8370.98
78_I82_A0.8340.98
154_D157_T0.8270.98
21_S50_A0.8270.98
108_V113_P0.8250.98
79_S110_E0.8250.98
104_L115_L0.8240.97
142_V159_L0.8080.97
139_A163_A0.8060.97
108_V183_I0.8060.97
40_Y58_T0.8020.97
155_V158_Q0.8020.97
162_K166_A0.7900.97
165_K168_I0.7900.97
131_A139_A0.7890.97
8_A21_S0.7870.97
65_V68_K0.7860.97
70_Y79_S0.7860.97
106_G183_I0.7830.97
26_S31_V0.7770.96
144_E170_R0.7710.96
24_R175_G0.7670.96
68_K71_E0.7670.96
102_E132_V0.7620.96
78_I86_L0.7610.96
153_L156_A0.7600.96
89_V93_Q0.7570.96
111_K114_Q0.7570.96
46_L105_F0.7490.96
6_A22_E0.7420.95
171_D174_S0.7410.95
24_R134_S0.7390.95
129_Y140_I0.7350.95
155_V159_L0.7350.95
45_F110_E0.7340.95
120_P132_V0.7300.95
142_V166_A0.7240.95
44_K77_P0.7240.95
55_D98_P0.7220.95
84_A116_Y0.7220.95
76_K110_E0.7200.95
95_K100_I0.7180.94
9_V30_Y0.7160.94
52_I55_D0.7120.94
9_V160_I0.7110.94
81_H111_K0.7040.94
101_S143_L0.6960.94
42_I64_N0.6860.93
53_Y56_L0.6850.93
59_L87_L0.6830.93
152_S156_A0.6800.93
8_A104_L0.6700.92
70_Y82_A0.6670.92
171_D175_G0.6660.92
79_S84_A0.6660.92
167_S171_D0.6650.92
18_V153_L0.6630.92
54_G123_S0.6560.91
49_G54_G0.6550.91
87_L103_I0.6530.91
49_G103_I0.6510.91
5_P107_G0.6480.91
21_S39_V0.6480.91
88_S124_L0.6460.91
111_K185_K0.6420.91
97_M101_S0.6410.90
50_A123_S0.6410.90
51_G55_D0.6370.90
68_K72_V0.6360.90
117_V127_D0.6360.90
153_L182_I0.6360.90
19_L39_V0.6330.90
70_Y78_I0.6320.90
80_V105_F0.6210.89
70_Y91_L0.6200.89
92_Y97_M0.6190.89
13_V182_I0.6160.89
69_Y141_G0.6160.89
68_K73_S0.6150.89
90_I99_F0.6140.88
63_M86_L0.6070.88
52_I58_T0.6040.88
161_T164_I0.6040.88
82_A85_K0.6020.87
38_K147_Y0.5970.87
117_V125_I0.5890.86
11_L159_L0.5850.86
135_G139_A0.5820.86
62_I86_L0.5810.86
51_G122_G0.5790.85
56_L60_T0.5760.85
154_D186_K0.5740.85
41_K45_F0.5720.85
62_I65_V0.5620.84
123_S130_A0.5620.84
66_E90_I0.5590.83
142_V162_K0.5590.83
67_I89_V0.5580.83
10_G106_G0.5580.83
110_E185_K0.5550.83
116_Y124_L0.5550.83
43_N78_I0.5510.83
11_L147_Y0.5470.82
5_P57_Q0.5450.82
161_T165_K0.5440.82
157_T161_T0.5440.82
122_G133_G0.5440.82
24_R171_D0.5420.81
94_Y118_L0.5410.81
48_A140_I0.5410.81
59_L99_F0.5400.81
38_K134_S0.5390.81
16_G152_S0.5370.81
38_K50_A0.5360.81
108_V187_G0.5340.81
39_V179_D0.5320.80
37_K40_Y0.5320.80
85_K124_L0.5280.80
87_L118_L0.5270.80
9_V20_A0.5260.80
23_R164_I0.5260.80
81_H114_Q0.5240.79
15_D184_D0.5240.79
110_E187_G0.5240.79
91_L124_L0.5230.79
134_S138_I0.5220.79
95_K129_Y0.5200.79
11_L14_N0.5190.79
42_I83_A0.5180.79
59_L91_L0.5170.78
138_I141_G0.5160.78
24_R174_S0.5140.78
42_I63_M0.5120.78
118_L125_I0.5110.78
53_Y137_R0.5100.77
93_Q158_Q0.5100.77
17_I183_I0.5100.77
73_S82_A0.5100.77
168_I171_D0.5090.77
63_M95_K0.5080.77
131_A140_I0.5070.77
61_R64_N0.5060.77
126_E130_A0.5030.76
121_I129_Y0.5030.76
54_G169_E0.5020.76
12_K17_I0.5020.76
140_I170_R0.5010.76
67_I74_T0.5010.76
153_L172_I0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r3oJ 1 0.9949 100 0.161 Contact Map
3h4pa 5 0.9745 100 0.168 Contact Map
4r3oM 1 0.9949 100 0.168 Contact Map
1rypJ 1 0.9949 100 0.172 Contact Map
1yarH 5 0.9694 100 0.173 Contact Map
1j2qH 5 0.9745 100 0.174 Contact Map
4r3oB 1 0.9898 100 0.178 Contact Map
1rypM 1 0.9949 100 0.18 Contact Map
3nzjK 1 0.9745 100 0.181 Contact Map
3nzjH 1 0.9694 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.