GREMLIN Database
Q980L0 - Uncharacterized protein
UniProt: Q980L0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 542 (434)
Sequences: 2079 (1576)
Seq/√Len: 75.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
457_S475_L6.1431.00
242_G460_R5.2631.00
249_A469_I4.8831.00
276_L397_I4.8661.00
235_I467_C4.8191.00
140_D146_F4.4011.00
459_I464_I4.3021.00
237_I249_A4.1251.00
232_T241_T4.0021.00
140_D145_S3.4941.00
438_D469_I3.4041.00
142_E145_S3.3781.00
453_D457_S3.2781.00
209_D213_G3.2631.00
237_I248_T3.1561.00
269_H458_E3.1221.00
273_D277_K3.1171.00
248_T488_I3.1071.00
269_H461_K3.0431.00
456_A466_L3.0371.00
338_N378_S2.9711.00
297_I300_D2.8601.00
246_T250_I2.7681.00
133_R136_Q2.6281.00
234_H241_T2.6201.00
126_G133_R2.5171.00
128_S133_R2.4731.00
124_K127_S2.4261.00
270_G399_N2.3891.00
329_L340_L2.2471.00
140_D149_E2.2371.00
500_A503_D2.2161.00
437_L452_I2.1871.00
441_Q475_L2.1741.00
490_H523_A2.1721.00
263_V395_S2.1111.00
234_H459_I2.0931.00
206_E209_D2.0851.00
253_A436_I2.0831.00
499_K503_D2.0721.00
206_E213_G2.0251.00
256_L434_L2.0201.00
329_L343_V2.0141.00
250_I271_E2.0101.00
246_T271_E2.0071.00
142_E146_F1.9721.00
472_S482_K1.9661.00
265_I272_Y1.9321.00
239_G243_S1.9321.00
127_S133_R1.9311.00
318_Q360_A1.9211.00
128_S131_I1.9131.00
441_Q457_S1.8951.00
336_S378_S1.8431.00
324_T366_F1.8431.00
241_T483_N1.8431.00
273_D282_I1.7571.00
246_T461_K1.7541.00
317_P360_A1.7461.00
237_I467_C1.7461.00
215_A218_G1.7341.00
508_D511_L1.7151.00
280_F285_E1.7111.00
458_E462_Y1.7081.00
496_V501_I1.6981.00
290_K379_T1.6881.00
455_L459_I1.6861.00
124_K133_R1.6561.00
345_N366_F1.6301.00
442_N458_E1.6271.00
328_K343_V1.6201.00
257_N395_S1.6071.00
127_S132_Y1.6011.00
204_V213_G1.5770.99
295_H381_D1.5710.99
312_L315_T1.5680.99
519_D522_E1.5630.99
262_K431_Q1.5580.99
309_G319_R1.5580.99
115_I119_I1.5410.99
234_H464_I1.5250.99
127_S131_I1.5170.99
304_T307_I1.5170.99
84_K87_P1.5080.99
253_A265_I1.5020.99
125_L131_I1.5010.99
131_I136_Q1.4870.99
294_L340_L1.4850.99
475_L479_N1.4820.99
265_I397_I1.4750.99
157_A161_A1.4470.99
275_L279_G1.4350.99
297_I303_D1.4330.99
87_P91_K1.4300.99
127_S136_Q1.4240.99
119_I122_K1.4230.99
488_I525_I1.4210.99
205_S213_G1.4190.99
502_R512_T1.4160.99
472_S475_L1.4130.99
281_R393_T1.4100.99
88_T91_K1.4080.99
127_S130_I1.4000.99
344_I361_L1.3990.99
300_D303_D1.3910.99
257_N263_V1.3790.98
125_L128_S1.3780.98
79_M83_G1.3730.98
130_I133_R1.3680.98
210_V213_G1.3660.98
336_S339_Q1.3450.98
207_D213_G1.3430.98
434_L467_C1.3400.98
140_D143_L1.3380.98
436_I440_A1.3320.98
276_L282_I1.3240.98
205_S210_V1.3240.98
340_L365_I1.3210.98
248_T490_H1.3030.98
251_L255_Q1.3000.98
164_L171_P1.2970.98
132_Y135_L1.2870.98
284_D402_F1.2870.98
284_D399_N1.2830.98
400_L443_Y1.2790.98
126_G132_Y1.2770.97
304_T308_I1.2750.97
248_T252_L1.2750.97
112_F117_F1.2740.97
140_D150_V1.2690.97
338_N342_E1.2630.97
235_I486_I1.2460.97
133_R153_L1.2440.97
85_I88_T1.2340.97
343_V346_S1.2270.97
130_I136_Q1.2230.97
129_I134_I1.2220.97
398_I419_L1.2140.97
234_H456_A1.2100.97
146_F150_V1.2040.96
276_L395_S1.2030.96
206_E210_V1.2020.96
435_I464_I1.1990.96
206_E212_I1.1850.96
301_V307_I1.1830.96
102_I105_I1.1780.96
88_T92_N1.1720.96
93_D99_K1.1710.96
233_R465_G1.1690.96
303_D307_I1.1690.96
497_D501_I1.1680.96
455_L466_L1.1650.96
87_P90_N1.1640.96
110_S117_F1.1570.96
257_N394_S1.1570.96
78_A82_T1.1540.95
281_R285_E1.1530.95
147_M163_H1.1480.95
457_S472_S1.1430.95
236_G484_T1.1330.95
265_I276_L1.1300.95
489_I515_L1.1280.95
125_L130_I1.1270.95
339_Q342_E1.1200.95
282_I397_I1.1180.95
266_L437_L1.1160.95
145_S150_V1.1160.95
344_I362_L1.1130.94
143_L147_M1.1040.94
112_F120_V1.0920.94
205_S209_D1.0840.94
453_D479_N1.0830.94
209_D212_I1.0810.94
212_I252_L1.0730.93
132_Y136_Q1.0690.93
270_G273_D1.0660.93
260_G394_S1.0630.93
109_D113_K1.0610.93
269_H401_G1.0580.93
117_F120_V1.0580.93
110_S113_K1.0580.93
238_F489_I1.0470.92
215_A219_T1.0440.92
257_N279_G1.0420.92
458_E461_K1.0400.92
93_D102_I1.0350.92
441_Q458_E1.0340.92
149_E152_N1.0300.92
78_A85_I1.0270.92
269_H462_Y1.0250.92
307_I311_V1.0230.92
456_A484_T1.0220.91
126_G131_I1.0210.91
361_L364_K1.0170.91
419_L423_S1.0170.91
80_K84_K1.0160.91
112_F115_I1.0080.91
474_S478_Q1.0070.91
294_L304_T1.0060.91
453_D475_L1.0040.91
124_K132_Y1.0020.91
285_E326_L1.0020.91
100_D104_A0.9990.91
82_T86_E0.9960.90
473_P492_I0.9960.90
79_M82_T0.9920.90
408_L411_L0.9920.90
265_I395_S0.9910.90
206_E211_E0.9890.90
82_T85_I0.9880.90
301_V304_T0.9870.90
255_Q258_A0.9790.90
440_A452_I0.9770.90
109_D112_F0.9720.89
112_F119_I0.9690.89
125_L132_Y0.9670.89
126_G130_I0.9660.89
322_L361_L0.9650.89
348_E355_R0.9630.89
241_T471_Q0.9590.89
109_D115_I0.9540.88
189_T192_E0.9510.88
267_D270_G0.9490.88
442_N454_R0.9470.88
326_L329_L0.9400.88
256_L261_V0.9400.88
104_A107_R0.9390.88
204_V209_D0.9390.88
497_D500_A0.9390.88
106_A112_F0.9330.87
124_K136_Q0.9300.87
308_I322_L0.9270.87
470_T476_L0.9260.87
126_G129_I0.9240.87
488_I523_A0.9170.86
129_I132_Y0.9160.86
84_K88_T0.9130.86
410_K419_L0.9110.86
125_L133_R0.9100.86
498_K502_R0.9090.86
126_G136_Q0.9080.86
325_I329_L0.9070.86
365_I484_T0.9070.86
82_T88_T0.9040.86
440_A444_F0.9020.85
129_I133_R0.9000.85
264_I433_T0.9000.85
507_L511_L0.8990.85
84_K90_N0.8980.85
456_A468_F0.8970.85
249_A294_L0.8960.85
156_L159_A0.8960.85
119_I123_N0.8930.85
437_L443_Y0.8850.84
78_A84_K0.8820.84
472_S483_N0.8790.84
126_G135_L0.8760.84
235_I488_I0.8730.84
249_A436_I0.8730.84
435_I455_L0.8720.83
131_I134_I0.8690.83
457_S470_T0.8640.83
98_L102_I0.8590.83
78_A81_I0.8590.83
80_K88_T0.8580.82
270_G401_G0.8570.82
208_F227_R0.8550.82
83_G87_P0.8530.82
262_K423_S0.8510.82
109_D121_E0.8500.82
294_L326_L0.8480.82
300_D307_I0.8480.82
442_N457_S0.8480.82
341_L345_N0.8460.82
436_I467_C0.8440.81
87_P97_E0.8400.81
129_I136_Q0.8350.81
304_T313_Q0.8330.81
218_G222_S0.8330.81
112_F116_I0.8300.80
253_A434_L0.8260.80
322_L340_L0.8250.80
468_F484_T0.8250.80
79_M84_K0.8220.80
234_H484_T0.8180.79
154_L157_A0.8150.79
102_I108_K0.8150.79
116_I120_V0.8150.79
247_N491_S0.8120.79
482_K497_D0.8100.79
219_T222_S0.8080.79
323_Y326_L0.8070.78
142_E154_L0.8040.78
308_I312_L0.8040.78
261_V434_L0.8020.78
322_L344_I0.8020.78
83_G90_N0.8010.78
328_K347_I0.8000.78
243_S490_H0.7970.78
300_D304_T0.7960.77
284_D287_T0.7960.77
91_K95_E0.7950.77
247_N469_I0.7900.77
124_K134_I0.7900.77
110_S114_F0.7880.77
523_A526_S0.7880.77
503_D506_S0.7830.76
99_K102_I0.7750.76
482_K496_V0.7740.75
145_S152_N0.7710.75
198_P201_S0.7680.75
96_K99_K0.7680.75
202_N213_G0.7640.75
172_S177_P0.7630.74
231_I520_V0.7620.74
264_I398_I0.7610.74
124_K130_I0.7600.74
502_R505_L0.7590.74
89_S92_N0.7590.74
209_D215_A0.7590.74
255_Q259_K0.7580.74
142_E204_V0.7570.74
167_K171_P0.7570.74
143_L154_L0.7560.74
304_T326_L0.7540.74
307_I312_L0.7540.74
341_L369_F0.7520.73
454_R458_E0.7520.73
308_I314_L0.7510.73
292_N295_H0.7510.73
124_K128_S0.7510.73
113_K118_T0.7500.73
103_N106_A0.7490.73
100_D103_N0.7490.73
164_L167_K0.7480.73
346_S392_L0.7470.73
174_N182_F0.7450.73
358_K362_L0.7450.73
136_Q142_E0.7440.73
106_A120_V0.7440.73
124_K129_I0.7440.73
440_A468_F0.7430.72
456_A483_N0.7410.72
271_E461_K0.7410.72
428_K463_N0.7400.72
405_N454_R0.7390.72
486_I525_I0.7370.72
107_R113_K0.7330.71
281_R396_T0.7330.71
128_S132_Y0.7330.71
451_F455_L0.7300.71
122_K135_L0.7290.71
145_S149_E0.7230.70
86_E97_E0.7200.70
308_I365_I0.7190.70
213_G521_G0.7180.70
243_S491_S0.7170.70
108_K112_F0.7170.70
333_R336_S0.7170.70
414_L418_K0.7150.70
496_V499_K0.7140.69
403_I438_D0.7140.69
228_V467_C0.7130.69
441_Q470_T0.7110.69
410_K413_S0.7110.69
201_S218_G0.7100.69
81_I90_N0.7090.69
245_K460_R0.7090.69
254_S258_A0.7040.68
146_F154_L0.7040.68
474_S497_D0.7030.68
216_T219_T0.7020.68
239_G242_G0.7020.68
390_D467_C0.7010.68
507_L515_L0.7010.68
372_T377_F0.6990.68
240_S491_S0.6990.68
89_S392_L0.6970.68
292_N336_S0.6950.67
509_E513_Q0.6940.67
285_E416_L0.6930.67
202_N212_I0.6930.67
146_F158_K0.6920.67
81_I85_I0.6910.67
168_I172_S0.6910.67
411_L415_F0.6900.67
340_L344_I0.6900.67
270_G447_E0.6880.67
292_N304_T0.6860.66
324_T347_I0.6850.66
326_L340_L0.6850.66
321_L325_I0.6850.66
382_E391_Y0.6840.66
250_I272_Y0.6840.66
419_L424_Y0.6830.66
316_D323_Y0.6830.66
440_A476_L0.6820.66
236_G496_V0.6810.66
460_R471_Q0.6800.66
446_R449_N0.6800.66
99_K103_N0.6780.65
279_G395_S0.6760.65
207_D212_I0.6750.65
439_E460_R0.6750.65
325_I347_I0.6720.65
245_K439_E0.6690.64
144_D150_V0.6690.64
144_D153_L0.6660.64
309_G315_T0.6660.64
131_I135_L0.6660.64
79_M88_T0.6650.64
272_Y275_L0.6640.64
92_N110_S0.6610.63
126_G134_I0.6610.63
116_I126_G0.6600.63
224_V227_R0.6570.63
234_H250_I0.6540.63
86_E91_K0.6540.63
189_T194_T0.6530.63
89_S98_L0.6530.63
227_R234_H0.6520.62
214_E219_T0.6520.62
252_L467_C0.6510.62
498_K504_T0.6500.62
435_I466_L0.6490.62
110_S116_I0.6480.62
254_S279_G0.6480.62
331_S509_E0.6480.62
395_S400_L0.6480.62
403_I412_Y0.6480.62
246_T395_S0.6480.62
216_T522_E0.6450.62
286_K376_L0.6450.62
106_A123_N0.6420.61
339_Q378_S0.6420.61
414_L424_Y0.6410.61
415_F418_K0.6410.61
167_K170_Q0.6410.61
311_V314_L0.6390.61
245_K471_Q0.6390.61
150_V153_L0.6390.61
289_V340_L0.6380.61
203_I209_D0.6370.61
470_T475_L0.6370.61
207_D210_V0.6360.61
444_F449_N0.6350.60
246_T489_I0.6350.60
127_S135_L0.6350.60
412_Y424_Y0.6340.60
152_N515_L0.6330.60
397_I445_N0.6330.60
412_Y415_F0.6330.60
86_E90_N0.6310.60
445_N453_D0.6310.60
418_K424_Y0.6310.60
419_L422_E0.6310.60
297_I302_E0.6300.60
270_G402_F0.6290.60
246_T523_A0.6270.59
316_D324_T0.6260.59
81_I88_T0.6260.59
144_D148_E0.6250.59
334_K380_V0.6240.59
301_V327_L0.6230.59
277_K326_L0.6230.59
95_E100_D0.6220.59
169_I174_N0.6200.59
168_I250_I0.6190.58
325_I340_L0.6190.58
376_L379_T0.6160.58
113_K119_I0.6160.58
124_K191_S0.6140.58
104_A112_F0.6120.58
280_F286_K0.6120.58
203_I213_G0.6110.57
434_L465_G0.6110.57
305_V323_Y0.6080.57
295_H335_F0.6080.57
324_T363_R0.6060.57
338_N369_F0.6030.56
323_Y367_I0.6030.56
280_F397_I0.6030.56
95_E98_L0.6030.56
85_I92_N0.6020.56
226_I520_V0.6020.56
141_I145_S0.6010.56
242_G245_K0.5980.56
81_I116_I0.5970.56
276_L279_G0.5970.56
355_R359_Y0.5970.56
213_G216_T0.5960.56
213_G218_G0.5950.55
498_K501_I0.5950.55
118_T122_K0.5950.55
409_R413_S0.5940.55
496_V500_A0.5930.55
107_R344_I0.5930.55
203_I215_A0.5930.55
202_N206_E0.5910.55
335_F339_Q0.5900.55
128_S136_Q0.5900.55
310_D315_T0.5890.55
78_A83_G0.5880.55
103_N115_I0.5870.54
164_L515_L0.5870.54
342_E345_N0.5870.54
125_L129_I0.5860.54
341_L366_F0.5850.54
202_N209_D0.5840.54
153_L347_I0.5840.54
310_D313_Q0.5830.54
374_S379_T0.5810.54
280_F292_N0.5810.54
80_K83_G0.5790.53
116_I127_S0.5790.53
337_I369_F0.5780.53
282_I294_L0.5770.53
105_I112_F0.5770.53
246_T370_T0.5760.53
112_F122_K0.5760.53
424_Y427_Y0.5750.53
241_T250_I0.5740.53
403_I406_L0.5730.53
268_W271_E0.5730.53
124_K131_I0.5730.53
223_R365_I0.5720.53
143_L156_L0.5710.52
104_A109_D0.5700.52
373_A436_I0.5690.52
316_D363_R0.5690.52
227_R489_I0.5680.52
413_S417_I0.5670.52
189_T196_T0.5660.52
280_F287_T0.5660.52
283_Y396_T0.5650.52
441_Q471_Q0.5640.52
104_A108_K0.5640.52
478_Q482_K0.5620.51
234_H483_N0.5620.51
237_I469_I0.5610.51
425_I428_K0.5610.51
413_S448_G0.5610.51
338_N370_T0.5610.51
307_I411_L0.5600.51
336_S380_V0.5600.51
420_I435_I0.5600.51
174_N181_A0.5590.51
86_E99_K0.5590.51
107_R117_F0.5590.51
88_T95_E0.5590.51
498_K512_T0.5590.51
113_K117_F0.5580.51
411_L418_K0.5570.51
439_E471_Q0.5560.51
96_K104_A0.5550.50
499_K512_T0.5550.50
171_P192_E0.5540.50
103_N113_K0.5530.50
105_I110_S0.5530.50
457_S479_N0.5530.50
148_E478_Q0.5530.50
85_I96_K0.5520.50
416_L515_L0.5520.50
293_P460_R0.5510.50
292_N335_F0.5510.50
266_L464_I0.5500.50
156_L160_I0.5500.50
495_D500_A0.5490.50
103_N109_D0.5490.50
92_N97_E0.5480.50
514_S518_L0.5460.49
275_L278_N0.5460.49
206_E219_T0.5460.49
187_F308_I0.5460.49
234_H515_L0.5440.49
420_I424_Y0.5440.49
445_N449_N0.5440.49
93_D98_L0.5430.49
125_L136_Q0.5430.49
211_E223_R0.5420.49
105_I108_K0.5410.49
239_G244_G0.5400.49
471_Q483_N0.5400.49
128_S134_I0.5400.49
143_L150_V0.5390.48
116_I123_N0.5390.48
411_L417_I0.5380.48
271_E335_F0.5370.48
117_F121_E0.5370.48
99_K108_K0.5360.48
177_P276_L0.5360.48
267_D461_K0.5360.48
232_T457_S0.5350.48
333_R380_V0.5340.48
307_I315_T0.5330.48
82_T92_N0.5320.48
192_E197_N0.5320.48
108_K118_T0.5320.48
146_F159_A0.5320.48
212_I215_A0.5310.47
400_L456_A0.5310.47
213_G271_E0.5310.47
95_E99_K0.5310.47
411_L419_L0.5310.47
512_T516_D0.5300.47
399_N402_F0.5300.47
133_R326_L0.5300.47
320_F324_T0.5300.47
97_E100_D0.5290.47
241_T247_N0.5280.47
395_S438_D0.5280.47
205_S211_E0.5270.47
263_V436_I0.5270.47
103_N110_S0.5270.47
154_L159_A0.5270.47
202_N210_V0.5260.47
92_N96_K0.5250.47
424_Y459_I0.5250.47
240_S492_I0.5240.47
282_I399_N0.5230.46
368_L454_R0.5230.46
421_V425_I0.5220.46
345_N362_L0.5200.46
85_I89_S0.5190.46
438_D483_N0.5190.46
111_E513_Q0.5170.46
361_L490_H0.5150.45
265_I513_Q0.5140.45
109_D122_K0.5140.45
92_N95_E0.5130.45
441_Q454_R0.5120.45
336_S369_F0.5110.45
175_V179_P0.5110.45
364_K368_L0.5110.45
489_I492_I0.5110.45
239_G490_H0.5110.45
482_K492_I0.5110.45
231_I243_S0.5100.45
267_D470_T0.5090.45
171_P177_P0.5070.44
470_T484_T0.5060.44
193_I437_L0.5050.44
269_H441_Q0.5040.44
269_H459_I0.5030.44
495_D499_K0.5030.44
417_I452_I0.5030.44
150_V155_V0.5030.44
234_H466_L0.5020.44
272_Y468_F0.5010.44
487_K493_K0.5000.44
101_F106_A0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ag6A 2 0.6052 100 0.488 Contact Map
4d2iA 3 0.7491 100 0.567 Contact Map
1e9rA 3 0.655 100 0.673 Contact Map
2iusA 1 0.6494 99.6 0.837 Contact Map
4lyaA 1 0.452 99.3 0.867 Contact Map
2iutA 2 0.6015 99.2 0.872 Contact Map
4kfuA 1 0.3745 98.7 0.893 Contact Map
4nh0A 1 0.6956 98.7 0.893 Contact Map
2r2aA 1 0.3284 98.3 0.905 Contact Map
1sxjE 1 0.3745 98.1 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.013 seconds.