GREMLIN Database
Q980K6 - Uncharacterized protein
UniProt: Q980K6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (362)
Sequences: 146 (80)
Seq/√Len: 4.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_V189_L6.6720.99
143_Y186_S4.9790.95
71_E75_N3.7080.80
88_G299_K3.3830.73
5_L125_V3.1460.67
185_E360_R3.1310.67
126_V293_S3.0790.65
5_L117_F2.9210.61
123_E161_M2.5250.49
62_R66_D2.5130.49
355_E358_K2.4970.48
12_I25_T2.3940.45
158_D243_G2.3370.44
62_R68_R2.3100.43
130_A142_L2.2590.41
29_A56_L2.2270.41
248_G287_G2.1370.38
138_Y219_E2.1360.38
315_F338_H2.1240.38
7_V127_I2.1190.37
134_E328_Y2.1100.37
130_A196_P2.1010.37
55_Q129_M2.0740.36
216_V236_M2.0620.36
256_V332_H2.0510.36
3_T123_E2.0400.35
29_A76_A2.0230.35
212_Q244_L1.9950.34
278_K311_D1.9510.33
29_A54_L1.9330.32
317_E320_R1.9230.32
182_T189_L1.9130.32
180_L192_L1.9080.32
59_T303_L1.9080.32
252_E284_R1.8900.31
28_A31_K1.8560.30
43_S69_V1.8490.30
196_P220_R1.8400.30
142_L236_M1.8390.30
150_F334_P1.8240.30
195_T342_P1.7910.29
123_E215_V1.7910.29
244_L328_Y1.7870.29
130_A261_P1.7490.28
284_R315_F1.7450.28
26_I222_N1.7390.28
206_R209_D1.7320.27
21_V315_F1.7000.27
138_Y236_M1.6820.26
195_T336_M1.6530.26
325_I328_Y1.6480.26
252_E315_F1.6460.25
248_G286_D1.6370.25
48_T57_I1.6330.25
41_I69_V1.6310.25
178_I361_F1.6220.25
277_Q294_L1.6180.25
80_A192_L1.6110.25
130_A220_R1.6080.25
264_M270_G1.6050.25
115_I212_Q1.5930.24
43_S161_M1.5920.24
220_R223_L1.5830.24
80_A219_E1.5720.24
32_I76_A1.5630.24
91_A341_E1.5580.24
284_R338_H1.5530.23
75_N302_K1.5520.23
40_N75_N1.5330.23
80_A216_V1.5220.23
127_I237_V1.5160.23
25_T91_A1.4940.22
79_E82_K1.4790.22
118_E130_A1.4640.22
188_D331_K1.4620.22
144_K150_F1.4570.21
14_S204_V1.4550.21
56_L125_V1.4490.21
99_D102_S1.4490.21
261_P341_E1.4260.21
184_E207_K1.4190.21
41_I79_E1.4100.21
291_L336_M1.4020.20
3_T298_I1.3980.20
26_I30_N1.3960.20
207_K244_L1.3930.20
21_V338_H1.3890.20
118_E344_E1.3820.20
256_V331_K1.3810.20
21_V244_L1.3760.20
66_D85_K1.3710.20
162_H188_D1.3570.19
145_I309_L1.3500.19
248_G288_P1.3450.19
263_W270_G1.3360.19
244_L326_A1.3350.19
99_D329_I1.3320.19
29_A33_L1.3270.19
126_V247_L1.3190.19
252_E338_H1.3190.19
272_L313_P1.3180.19
248_G264_M1.3160.19
138_Y216_V1.3090.19
69_V181_N1.3040.19
218_V336_M1.3030.19
122_A303_L1.2990.18
257_P305_G1.2910.18
67_T71_E1.2880.18
83_I212_Q1.2860.18
14_S298_I1.2840.18
130_A138_Y1.2790.18
189_L201_V1.2750.18
295_G305_G1.2750.18
12_I299_K1.2730.18
87_L315_F1.2680.18
5_L283_T1.2640.18
264_M286_D1.2630.18
33_L80_A1.2520.18
98_S299_K1.2470.18
192_L216_V1.2410.17
21_V50_V1.2390.17
29_A80_A1.2380.17
257_P322_A1.2380.17
264_M288_P1.2350.17
80_A138_Y1.2300.17
142_L196_P1.2250.17
5_L75_N1.2230.17
21_V134_E1.2220.17
119_E213_A1.2210.17
264_M287_G1.2170.17
172_V220_R1.2140.17
100_S253_A1.2120.17
82_K106_R1.2120.17
5_L160_T1.2030.17
80_A191_A1.2020.17
172_V344_E1.1880.17
315_F327_D1.1870.17
98_S213_A1.1740.16
16_A191_A1.1730.16
27_A30_N1.1680.16
125_V215_V1.1560.16
38_R201_V1.1500.16
143_Y332_H1.1440.16
101_F133_T1.1390.16
7_V237_V1.1380.16
42_I78_K1.1370.16
220_R261_P1.1350.16
134_E244_L1.1350.16
130_A236_M1.1350.16
84_A253_A1.1340.16
345_M351_P1.1340.16
42_I291_L1.1310.16
57_I237_V1.1210.15
3_T14_S1.1150.15
31_K35_E1.1140.15
45_Y304_V1.1090.15
57_I275_V1.1090.15
227_K255_T1.0990.15
76_A80_A1.0950.15
248_G251_L1.0950.15
136_G196_P1.0900.15
197_S343_Q1.0880.15
16_A19_H1.0820.15
139_N271_P1.0820.15
21_V328_Y1.0790.15
180_L329_I1.0720.15
177_S362_K1.0700.15
36_A332_H1.0680.15
65_L329_I1.0650.15
14_S327_D1.0630.15
253_A281_R1.0600.15
43_S61_N1.0600.15
45_Y55_Q1.0600.15
106_R224_I1.0460.14
211_L275_V1.0440.14
65_L204_V1.0420.14
161_M251_L1.0280.14
15_L204_V1.0270.14
185_E335_F1.0220.14
345_M353_V1.0180.14
130_A227_K1.0160.14
130_A170_L1.0150.14
86_D300_N1.0130.14
273_M313_P1.0120.14
134_E261_P1.0090.14
276_S279_D1.0090.14
59_T268_H1.0080.14
64_E356_K1.0070.14
57_I125_V1.0050.14
336_M342_P1.0020.14
142_L213_A1.0010.14
28_A76_A1.0000.14
135_P158_D0.9990.14
138_Y269_Y0.9970.14
123_E301_G0.9960.14
117_F125_V0.9960.14
121_P160_T0.9950.14
48_T294_L0.9940.14
138_Y142_L0.9920.14
75_N272_L0.9920.14
158_D242_H0.9890.14
197_S200_I0.9870.13
248_G270_G0.9850.13
315_F339_R0.9770.13
48_T80_A0.9740.13
340_L346_E0.9740.13
261_P269_Y0.9730.13
16_A138_Y0.9700.13
170_L201_V0.9690.13
142_L244_L0.9670.13
130_A172_V0.9660.13
255_T342_P0.9640.13
29_A129_M0.9630.13
57_I294_L0.9620.13
147_A312_D0.9580.13
247_L293_S0.9520.13
26_I54_L0.9520.13
150_F332_H0.9500.13
251_L287_G0.9500.13
29_A150_F0.9490.13
12_I291_L0.9480.13
178_I293_S0.9460.13
161_M244_L0.9450.13
142_L170_L0.9420.13
86_D166_K0.9370.13
58_M193_I0.9360.13
313_P323_V0.9350.13
80_A180_L0.9300.13
172_V196_P0.9290.13
14_S91_A0.9250.13
12_I179_M0.9170.13
173_Y261_P0.9170.13
12_I80_A0.9150.13
175_G202_R0.9120.12
111_G202_R0.9100.12
65_L105_L0.9040.12
57_I258_Y0.9030.12
106_R219_E0.9030.12
54_L250_I0.9020.12
115_I356_K0.8990.12
82_K220_R0.8970.12
162_H350_L0.8960.12
75_N283_T0.8950.12
195_T218_V0.8940.12
270_G287_G0.8920.12
270_G286_D0.8880.12
121_P170_L0.8840.12
282_A311_D0.8840.12
43_S276_S0.8820.12
335_F348_T0.8820.12
67_T182_T0.8800.12
170_L261_P0.8790.12
327_D338_H0.8790.12
16_A192_L0.8780.12
192_L361_F0.8760.12
42_I250_I0.8730.12
126_V329_I0.8670.12
336_M341_E0.8650.12
135_P242_H0.8610.12
161_M215_V0.8600.12
67_T302_K0.8590.12
241_Q246_A0.8590.12
25_T80_A0.8580.12
138_Y192_L0.8550.12
240_A250_I0.8520.12
36_A136_G0.8510.12
263_W351_P0.8470.12
62_R69_V0.8440.12
227_K352_L0.8410.12
160_T201_V0.8390.12
12_I78_K0.8390.12
168_E205_Y0.8370.12
46_Y341_E0.8370.12
106_R331_K0.8360.12
43_S59_T0.8350.12
27_A105_L0.8340.12
145_I250_I0.8310.11
205_Y364_E0.8290.11
14_S195_T0.8280.11
220_R313_P0.8270.11
64_E115_I0.8250.11
206_R212_Q0.8180.11
259_L329_I0.8170.11
171_D198_R0.8140.11
12_I34_A0.8140.11
180_L219_E0.8120.11
140_L213_A0.8120.11
275_V294_L0.8110.11
130_A269_Y0.8110.11
100_S294_L0.8070.11
138_Y191_A0.8060.11
135_P243_G0.8030.11
35_E318_V0.8000.11
199_Y305_G0.7990.11
143_Y301_G0.7970.11
12_I303_L0.7950.11
127_I216_V0.7940.11
149_P183_P0.7920.11
142_L216_V0.7920.11
182_T186_S0.7900.11
73_A254_F0.7890.11
192_L236_M0.7890.11
169_V360_R0.7890.11
75_N210_N0.7880.11
48_T344_E0.7860.11
252_E312_D0.7830.11
293_S309_L0.7820.11
142_L212_Q0.7730.11
142_L220_R0.7690.11
325_I332_H0.7680.11
100_S293_S0.7680.11
98_S189_L0.7660.11
166_K181_N0.7630.11
302_K363_K0.7620.11
144_K334_P0.7600.11
87_L280_A0.7600.11
210_N244_L0.7580.11
220_R242_H0.7570.11
42_I317_E0.7550.11
25_T54_L0.7510.11
76_A174_E0.7500.11
126_V309_L0.7500.11
25_T175_G0.7500.11
134_E343_Q0.7460.10
7_V235_V0.7430.10
21_V135_P0.7420.10
258_Y296_F0.7410.10
28_A105_L0.7390.10
152_T335_F0.7370.10
322_A359_N0.7350.10
197_S353_V0.7310.10
253_A358_K0.7310.10
195_T253_A0.7290.10
193_I338_H0.7290.10
118_E213_A0.7280.10
74_W301_G0.7270.10
130_A213_A0.7260.10
211_L361_F0.7250.10
251_L288_P0.7220.10
138_Y180_L0.7210.10
111_G290_R0.7200.10
170_L206_R0.7190.10
36_A153_A0.7180.10
178_I185_E0.7170.10
191_A236_M0.7150.10
48_T129_M0.7130.10
280_A315_F0.7130.10
54_L129_M0.7130.10
15_L195_T0.7130.10
43_S258_Y0.7120.10
196_P261_P0.7100.10
14_S20_V0.7080.10
244_L261_P0.7070.10
50_V328_Y0.7070.10
88_G247_L0.7060.10
192_L219_E0.7050.10
129_M202_R0.7010.10
21_V284_R0.7010.10
263_W345_M0.7000.10
172_V261_P0.7000.10
29_A334_P0.7000.10
166_K205_Y0.6990.10
146_F238_V0.6970.10
309_L312_D0.6960.10
14_S282_A0.6950.10
49_Y136_G0.6940.10
42_I279_D0.6920.10
270_G288_P0.6920.10
7_V57_I0.6900.10
130_A244_L0.6890.10
214_S303_L0.6840.10
21_V327_D0.6820.10
133_T285_F0.6790.10
65_L293_S0.6790.10
128_F250_I0.6780.10
129_M296_F0.6770.10
196_P213_A0.6760.10
88_G224_I0.6760.10
251_L264_M0.6760.10
138_Y329_I0.6750.10
20_V361_F0.6750.10
15_L138_Y0.6740.10
312_D339_R0.6690.10
48_T277_Q0.6670.10
166_K207_K0.6630.10
206_R218_V0.6630.10
284_R339_R0.6610.10
106_R317_E0.6610.10
353_V360_R0.6610.10
3_T43_S0.6600.10
111_G295_G0.6590.10
191_A216_V0.6580.10
91_A211_L0.6570.10
55_Q193_I0.6550.10
194_G339_R0.6550.10
250_I300_N0.6540.09
290_R335_F0.6530.09
16_A219_E0.6530.09
201_V236_M0.6510.09
57_I277_Q0.6500.09
87_L304_V0.6490.09
161_M205_Y0.6490.09
153_A219_E0.6470.09
196_P269_Y0.6460.09
214_S255_T0.6420.09
22_H321_T0.6390.09
261_P307_T0.6390.09
105_L182_T0.6390.09
192_L323_V0.6370.09
33_L56_L0.6360.09
23_P29_A0.6350.09
55_Q150_F0.6350.09
220_R244_L0.6340.09
112_I129_M0.6340.09
21_V252_E0.6330.09
134_E242_H0.6320.09
170_L244_L0.6320.09
156_V214_S0.6310.09
101_F285_F0.6300.09
210_N273_M0.6260.09
75_N78_K0.6260.09
61_N331_K0.6250.09
177_S299_K0.6220.09
100_S283_T0.6180.09
185_E348_T0.6180.09
106_R166_K0.6140.09
180_L216_V0.6120.09
50_V55_Q0.6110.09
170_L213_A0.6100.09
65_L179_M0.6100.09
203_R236_M0.6080.09
20_V307_T0.6050.09
177_S180_L0.6050.09
50_V134_E0.6030.09
76_A180_L0.6020.09
46_Y329_I0.6010.09
77_F103_G0.5980.09
196_P212_Q0.5980.09
15_L192_L0.5970.09
238_V275_V0.5970.09
14_S87_L0.5900.09
224_I246_A0.5900.09
21_V292_I0.5890.09
129_M345_M0.5890.09
227_K307_T0.5890.09
39_N293_S0.5870.09
311_D317_E0.5850.09
124_P288_P0.5850.09
85_K146_F0.5840.09
76_A215_V0.5830.09
36_A296_F0.5820.09
24_D62_R0.5810.09
150_F190_L0.5790.09
14_S108_M0.5780.09
222_N258_Y0.5780.09
29_A125_V0.5740.09
336_M339_R0.5740.09
22_H157_I0.5740.09
318_V325_I0.5740.09
135_P261_P0.5740.09
19_H54_L0.5730.09
190_L194_G0.5700.09
170_L196_P0.5700.09
24_D123_E0.5700.09
176_E220_R0.5690.09
79_E206_R0.5680.09
46_Y294_L0.5680.09
20_V191_A0.5650.09
160_T186_S0.5650.09
80_A240_A0.5650.09
25_T211_L0.5640.09
314_A338_H0.5640.09
90_Y294_L0.5640.09
190_L339_R0.5620.09
206_R261_P0.5610.09
199_Y359_N0.5580.09
165_Y183_P0.5570.09
3_T20_V0.5560.09
173_Y353_V0.5540.09
8_I11_D0.5530.09
187_Y285_F0.5520.09
178_I258_Y0.5520.09
180_L342_P0.5510.08
42_I79_E0.5510.08
75_N354_I0.5490.08
41_I163_E0.5490.08
6_S320_R0.5480.08
26_I34_A0.5440.08
253_A282_A0.5440.08
339_R345_M0.5430.08
87_L284_R0.5400.08
16_A307_T0.5400.08
15_L19_H0.5400.08
295_G322_A0.5390.08
251_L286_D0.5370.08
69_V251_L0.5370.08
227_K302_K0.5360.08
124_P286_D0.5360.08
220_R278_K0.5360.08
163_E189_L0.5330.08
47_I215_V0.5330.08
185_E304_V0.5310.08
76_A138_Y0.5290.08
207_K328_Y0.5280.08
199_Y321_T0.5270.08
158_D328_Y0.5270.08
29_A55_Q0.5260.08
15_L46_Y0.5260.08
152_T290_R0.5250.08
83_I318_V0.5250.08
151_N204_V0.5250.08
157_I325_I0.5240.08
159_P178_I0.5240.08
78_K331_K0.5240.08
5_L38_R0.5200.08
160_T250_I0.5190.08
136_G291_L0.5180.08
185_E215_V0.5180.08
14_S25_T0.5170.08
75_N300_N0.5160.08
15_L216_V0.5160.08
159_P219_E0.5150.08
312_D315_F0.5150.08
83_I302_K0.5130.08
46_Y191_A0.5130.08
128_F235_V0.5130.08
175_G311_D0.5120.08
125_V201_V0.5120.08
3_T85_K0.5120.08
69_V291_L0.5100.08
27_A91_A0.5100.08
21_V314_A0.5100.08
13_G17_G0.5090.08
73_A139_N0.5090.08
30_N283_T0.5080.08
91_A336_M0.5080.08
305_G335_F0.5080.08
84_A316_D0.5060.08
157_I348_T0.5030.08
79_E189_L0.5030.08
124_P229_V0.5030.08
210_N216_V0.5020.08
159_P350_L0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r1mA 5 0.9293 100 0.027 Contact Map
3t2cA 5 0.9738 100 0.044 Contact Map
1nm8A 1 0.2042 36 0.984 Contact Map
2j5cA 1 0.0628 33.3 0.984 Contact Map
4earA 3 0.1545 11.6 0.987 Contact Map
3wd8A 2 0.2827 11.1 0.987 Contact Map
3ozfA 4 0.2827 10.9 0.987 Contact Map
4h7oA 6 0.1806 8.7 0.988 Contact Map
2vofA 1 0.1859 8.2 0.988 Contact Map
3ls0A 1 0.2513 8.2 0.988 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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