GREMLIN Database
CSL4 - Exosome complex component Csl4
UniProt: Q980J9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (177)
Sequences: 442 (318)
Seq/√Len: 23.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_I114_V5.9241.00
26_T33_V5.8171.00
101_L124_I5.0251.00
71_G83_V4.6501.00
73_V83_V4.3821.00
118_I139_I3.7851.00
156_Y168_C3.3621.00
126_A137_L3.2791.00
162_D165_N2.9731.00
127_K141_M2.5380.99
101_L118_I2.4600.98
154_C171_C2.4580.98
106_I118_I2.4130.98
27_Y36_A2.3060.97
93_L96_P2.2400.97
14_L22_T2.1100.96
156_Y169_Q2.0360.95
81_A124_I1.9130.93
166_L171_C1.7150.88
105_Q109_K1.7140.88
120_I137_L1.7120.88
116_D176_Q1.6430.86
158_L166_L1.6220.85
49_K52_V1.6100.84
102_H107_S1.5880.84
12_E87_G1.5570.82
102_H105_Q1.5440.82
8_T52_V1.5290.81
102_H136_A1.3700.73
152_S175_E1.3480.72
102_H112_N1.3460.72
160_K181_S1.3380.71
110_K113_N1.3210.70
83_V124_I1.3180.70
35_A84_S1.3130.70
28_E31_G1.2960.69
113_N158_L1.2930.69
51_N58_I1.2910.69
129_L138_T1.2900.69
163_E171_C1.2810.68
7_L38_V1.2710.67
67_K89_E1.2610.67
20_F183_M1.2560.66
130_S136_A1.2560.66
146_V149_A1.2540.66
25_G102_H1.2440.66
70_I147_I1.2340.65
165_N174_I1.2280.65
84_S111_I1.2070.63
84_S94_A1.2040.63
18_E168_C1.1950.62
104_S125_K1.1520.60
108_N152_S1.1510.60
14_L18_E1.1480.59
150_R157_L1.1430.59
7_L30_N1.1400.59
120_I126_A1.1400.59
162_D175_E1.1400.59
71_G124_I1.1330.58
156_Y170_R1.1290.58
107_S110_K1.1010.56
33_V173_N1.1010.56
37_V41_I1.0980.56
50_S147_I1.0950.56
88_I106_I1.0850.55
76_I79_D1.0770.54
12_E174_I1.0680.54
9_L38_V1.0390.52
71_G147_I1.0320.51
22_T26_T1.0270.51
50_S68_Y1.0270.51
60_F73_V1.0230.51
106_I169_Q1.0130.50
165_N179_I1.0070.49
24_D35_A1.0020.49
32_I123_V0.9990.49
102_H149_A0.9940.48
39_G122_D0.9770.47
50_S73_V0.9690.47
33_V42_F0.9650.46
119_K175_E0.9640.46
107_S112_N0.9630.46
62_H70_I0.9630.46
75_S182_Y0.9580.46
81_A118_I0.9550.46
15_A32_I0.9510.45
13_E34_R0.9500.45
62_H119_K0.9490.45
106_I139_I0.9490.45
43_Y126_A0.9480.45
7_L54_G0.9320.44
109_K131_Y0.9290.44
22_T49_K0.9270.44
106_I112_N0.9260.44
8_T101_L0.9200.43
92_G111_I0.9170.43
101_L169_Q0.9170.43
99_A137_L0.9130.43
8_T41_I0.9120.43
76_I117_A0.9110.43
42_F53_L0.9090.43
15_A58_I0.9030.42
13_E32_I0.8990.42
63_L135_L0.8990.42
86_V130_S0.8970.42
12_E16_V0.8960.42
123_V161_Q0.8890.41
179_I182_Y0.8880.41
27_Y125_K0.8840.41
70_I125_K0.8750.40
102_H110_K0.8630.39
83_V101_L0.8620.39
160_K171_C0.8480.38
12_E19_E0.8470.38
159_I183_M0.8390.38
76_I126_A0.8320.37
28_E157_L0.8260.37
146_V178_K0.8220.37
17_I28_E0.8190.36
35_A61_Q0.8080.36
63_L97_I0.8040.35
105_Q130_S0.8030.35
160_K180_G0.8020.35
77_K124_I0.8020.35
99_A149_A0.8010.35
113_N161_Q0.8010.35
21_M56_K0.7990.35
67_K98_S0.7960.35
45_M50_S0.7960.35
104_S127_K0.7940.35
60_F71_G0.7860.34
22_T46_L0.7850.34
18_E31_G0.7830.34
40_K127_K0.7830.34
37_V96_P0.7810.34
21_M80_S0.7790.34
85_I178_K0.7780.34
43_Y47_N0.7770.34
130_S135_L0.7760.34
73_V108_N0.7740.34
67_K97_I0.7730.33
82_L125_K0.7670.33
39_G145_G0.7580.33
76_I114_V0.7540.32
25_G37_V0.7520.32
171_C180_G0.7480.32
70_I172_G0.7470.32
53_L57_K0.7440.32
25_G81_A0.7420.32
66_A127_K0.7400.31
22_T183_M0.7390.31
61_Q147_I0.7380.31
72_I79_D0.7360.31
8_T12_E0.7320.31
91_R170_R0.7260.31
54_G158_L0.7200.30
35_A41_I0.7150.30
27_Y168_C0.7120.30
101_L137_L0.7080.30
72_I86_V0.7010.29
158_L169_Q0.7010.29
109_K112_N0.7010.29
15_A115_T0.6890.28
63_L121_G0.6880.28
17_I138_T0.6880.28
31_G171_C0.6870.28
63_L133_F0.6830.28
20_F49_K0.6820.28
135_L155_G0.6790.28
51_N91_R0.6790.28
40_K44_D0.6770.28
125_K182_Y0.6730.27
11_G145_G0.6720.27
48_R166_L0.6680.27
15_A117_A0.6660.27
98_S132_T0.6650.27
50_S54_G0.6650.27
21_M52_V0.6650.27
152_S155_G0.6640.27
10_P73_V0.6600.27
114_V117_A0.6590.27
35_A114_V0.6580.27
13_E87_G0.6570.27
137_L149_A0.6560.27
75_S134_P0.6550.26
159_I167_K0.6540.26
149_A158_L0.6520.26
129_L174_I0.6450.26
21_M85_I0.6420.26
8_T116_D0.6400.26
171_C182_Y0.6400.26
27_Y73_V0.6380.26
44_D154_C0.6350.25
109_K142_K0.6350.25
177_R180_G0.6290.25
168_C171_C0.6290.25
37_V125_K0.6280.25
52_V147_I0.6270.25
17_I24_D0.6270.25
9_L17_I0.6270.25
110_K152_S0.6260.25
78_E181_S0.6260.25
35_A52_V0.6230.25
126_A162_D0.6220.25
75_S164_N0.6200.25
70_I87_G0.6200.25
167_K172_G0.6170.24
102_H117_A0.6150.24
36_A67_K0.6120.24
15_A34_R0.6110.24
124_I143_D0.6050.24
17_I50_S0.6030.24
18_E154_C0.6020.24
35_A165_N0.5960.23
6_E37_V0.5960.23
109_K113_N0.5950.23
79_D128_L0.5890.23
77_K179_I0.5890.23
166_L179_I0.5870.23
167_K174_I0.5810.23
105_Q121_G0.5800.23
79_D147_I0.5790.22
35_A123_V0.5780.22
36_A162_D0.5730.22
57_K100_Y0.5720.22
12_E18_E0.5700.22
26_T61_Q0.5670.22
16_V136_A0.5550.21
19_E154_C0.5550.21
23_G48_R0.5530.21
20_F56_K0.5520.21
81_A144_L0.5520.21
122_D145_G0.5510.21
8_T172_G0.5500.21
131_Y135_L0.5500.21
27_Y65_K0.5500.21
35_A86_V0.5480.21
9_L64_K0.5470.21
43_Y66_A0.5450.21
63_L78_E0.5400.21
72_I84_S0.5340.20
113_N147_I0.5320.20
107_S140_K0.5320.20
29_Q161_Q0.5280.20
161_Q167_K0.5280.20
172_G176_Q0.5270.20
40_K48_R0.5250.20
137_L173_N0.5210.20
75_S136_A0.5200.20
30_N42_F0.5200.20
89_E99_A0.5200.20
88_I143_D0.5180.20
105_Q166_L0.5180.20
160_K166_L0.5180.20
135_L142_K0.5130.19
35_A40_K0.5120.19
125_K180_G0.5090.19
73_V76_I0.5090.19
63_L178_K0.5080.19
8_T15_A0.5060.19
112_N119_K0.5050.19
25_G170_R0.5030.19
12_E142_K0.5020.19
66_A76_I0.5020.19
31_G127_K0.5000.19
16_V124_I0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ifdI 1 0.9471 100 0.291 Contact Map
2nn6I 1 0.9101 100 0.322 Contact Map
3m7nA 1 0.9365 100 0.367 Contact Map
2z0sA 1 0.6455 100 0.566 Contact Map
2je6I 3 0.873 100 0.574 Contact Map
2nn6G 1 0.8466 100 0.58 Contact Map
4ifdG 1 0.8889 100 0.582 Contact Map
4ifdH 1 0.836 99.9 0.599 Contact Map
2ba0A 1 0.8995 99.9 0.601 Contact Map
2nn6H 1 0.8466 99.9 0.602 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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