Q980J8 - SULSO - GREMLIN Contacts

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Q980J8 - Uncharacterized protein

UniProt:	Q980J8	Sequences: MSYNFEEERVIKEIREKNAKRVLLQFPEGLKYFSIDIVKKLREKLPNVNFIISGEPSWGACDIAEDEAQQVNADLIIHFGHTPYTWYYPKFPTIFINAESNLDISENALHSLENDISKYNGRKISLTATLQHVRLLSKIKSFLEDKGYDIVIGKPSNRFMFDGQVLGCDYKAAEVEADIYVIVSGGLFHALGLGLATNKPTIKLDPYLQKSEDITNDVRKILKVRYGKILQALDKRSWVIIQGVKVGQNRPNMIKYFYDKLTEKGYDVFTVTNKVLTLDILRNLDRNYIDVFLVTSCPRLPIDDLYNYEKPVLTPGEAKMIINNSLEPYIFPW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	333 (315)
Sequences:	896 (620)
Seq/√Len:	35.0

HALSA - Q9HR56
SULSO - Q980J8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
10_V	79_F	5.847	1.00
10_V	77_I	5.219	1.00
290_D	310_K	4.608	1.00
5_F	33_F	4.552	1.00
140_K	144_E	4.488	1.00
271_V	292_F	4.036	1.00
37_I	41_L	3.739	1.00
7_E	37_I	3.554	1.00
293_L	318_A	3.313	1.00
26_F	37_I	3.257	1.00
170_Y	192_G	3.190	1.00
6_E	9_R	3.180	1.00
62_D	83_P	3.060	1.00
237_S	267_D	3.051	1.00
41_L	48_V	2.951	1.00
38_V	50_F	2.808	1.00
260_K	264_K	2.615	1.00
128_A	136_L	2.595	1.00
259_D	263_E	2.559	1.00
21_R	74_D	2.363	0.99
238_W	318_A	2.345	0.99
235_K	290_D	2.264	0.99
237_S	288_Y	2.242	0.99
75_L	94_I	2.152	0.99
289_I	292_F	2.082	0.99
238_W	261_L	2.047	0.98
256_Y	319_K	2.038	0.98
108_A	183_V	1.988	0.98
26_F	52_I	1.987	0.98
105_S	142_F	1.983	0.98
240_I	258_Y	1.945	0.98
107_N	111_S	1.924	0.98
242_Q	254_I	1.886	0.97
125_S	177_A	1.881	0.97
45_L	50_F	1.875	0.97
235_K	291_V	1.869	0.97
243_G	296_S	1.867	0.97
112_L	181_V	1.833	0.97
258_Y	270_T	1.807	0.97
20_K	74_D	1.791	0.96
164_Q	169_D	1.784	0.96
109_L	113_E	1.775	0.96
113_E	146_K	1.765	0.96
107_N	209_Q	1.757	0.96
26_F	79_F	1.720	0.95
61_C	297_C	1.710	0.95
225_R	317_E	1.706	0.95
243_G	246_V	1.698	0.95
239_V	284_L	1.688	0.95
7_E	10_V	1.681	0.95
123_K	178_D	1.679	0.95
13_E	75_L	1.663	0.95
12_K	16_E	1.654	0.94
257_F	315_P	1.653	0.94
109_L	139_I	1.649	0.94
224_V	306_Y	1.632	0.94
252_N	255_K	1.594	0.93
189_H	299_R	1.591	0.93
17_K	75_L	1.579	0.93
262_T	268_V	1.563	0.93
127_T	184_S	1.547	0.92
99_E	134_R	1.529	0.92
127_T	182_I	1.527	0.92
147_G	150_I	1.513	0.91
184_S	296_S	1.497	0.91
159_F	166_L	1.473	0.90
279_D	282_R	1.466	0.90
141_S	145_D	1.433	0.89
261_L	318_A	1.432	0.89
117_S	122_R	1.407	0.88
68_A	73_A	1.384	0.87
13_E	94_I	1.364	0.86
81_H	299_R	1.362	0.86
318_A	322_I	1.343	0.85
13_E	16_E	1.342	0.85
41_L	92_P	1.334	0.85
179_I	200_P	1.332	0.85
13_E	17_K	1.327	0.85
135_L	139_I	1.322	0.84
165_V	182_I	1.320	0.84
26_F	34_S	1.310	0.84
151_V	238_W	1.302	0.83
54_G	71_V	1.300	0.83
247_G	250_R	1.297	0.83
104_I	109_L	1.289	0.83
30_L	232_A	1.284	0.83
238_W	291_V	1.264	0.82
180_Y	193_L	1.263	0.82
231_Q	234_D	1.260	0.81
56_P	275_V	1.254	0.81
219_R	223_K	1.253	0.81
188_F	248_Q	1.245	0.81
108_A	128_A	1.233	0.80
159_F	164_Q	1.228	0.80
77_I	114_N	1.228	0.80
102_L	135_L	1.224	0.79
59_G	81_H	1.222	0.79
232_A	314_T	1.210	0.79
14_I	48_V	1.201	0.78
294_V	301_P	1.189	0.77
240_I	268_V	1.189	0.77
72_N	93_T	1.184	0.77
41_L	50_F	1.179	0.77
16_E	213_D	1.176	0.77
180_Y	201_T	1.168	0.76
236_R	266_Y	1.167	0.76
223_K	227_G	1.164	0.76
185_G	205_D	1.148	0.75
18_N	284_L	1.139	0.74
81_H	131_Q	1.123	0.73
31_K	55_E	1.121	0.73
21_R	72_N	1.119	0.73
28_E	56_P	1.119	0.73
188_F	300_L	1.115	0.73
22_V	48_V	1.106	0.72
204_L	209_Q	1.099	0.72
38_V	126_L	1.098	0.71
14_I	75_L	1.094	0.71
126_L	136_L	1.093	0.71
65_E	90_K	1.092	0.71
259_D	262_T	1.088	0.71
22_V	25_Q	1.086	0.71
95_F	301_P	1.084	0.70
90_K	93_T	1.073	0.70
17_K	34_S	1.063	0.69
258_Y	262_T	1.063	0.69
133_V	162_D	1.061	0.69
239_V	271_V	1.058	0.69
62_D	245_K	1.057	0.69
240_I	290_D	1.054	0.68
104_I	183_V	1.054	0.68
109_L	141_S	1.046	0.68
223_K	293_L	1.045	0.68
29_G	168_C	1.042	0.67
200_P	213_D	1.042	0.67
34_S	293_L	1.035	0.67
81_H	168_C	1.033	0.67
27_P	30_L	1.025	0.66
256_Y	260_K	1.025	0.66
144_E	149_D	1.017	0.65
241_I	276_L	1.017	0.65
230_L	266_Y	1.017	0.65
300_L	303_D	1.017	0.65
235_K	318_A	1.016	0.65
31_K	295_T	1.016	0.65
81_H	188_F	1.014	0.65
238_W	266_Y	1.012	0.65
170_Y	196_A	1.011	0.65
173_A	199_K	1.009	0.65
123_K	149_D	1.009	0.65
271_V	310_K	1.003	0.64
29_G	188_F	0.992	0.64
241_I	281_L	0.991	0.63
229_I	320_M	0.984	0.63
64_A	83_P	0.982	0.63
103_D	209_Q	0.977	0.62
127_T	193_L	0.976	0.62
128_A	182_I	0.968	0.62
5_F	73_A	0.967	0.62
188_F	299_R	0.958	0.61
261_L	268_V	0.953	0.60
23_L	73_A	0.943	0.60
23_L	55_E	0.941	0.59
194_G	197_T	0.941	0.59
230_L	233_L	0.940	0.59
132_H	207_Y	0.937	0.59
182_I	257_F	0.934	0.59
253_M	257_F	0.931	0.59
144_E	150_I	0.927	0.58
80_G	244_V	0.923	0.58
291_V	313_L	0.922	0.58
320_M	327_E	0.919	0.58
43_E	176_E	0.917	0.57
64_A	280_I	0.911	0.57
238_W	322_I	0.911	0.57
248_Q	299_R	0.911	0.57
57_S	278_L	0.910	0.57
253_M	319_K	0.905	0.56
108_A	211_S	0.903	0.56
136_L	152_I	0.903	0.56
186_G	191_L	0.901	0.56
57_S	272_T	0.898	0.56
188_F	191_L	0.893	0.55
110_H	145_D	0.892	0.55
188_F	303_D	0.891	0.55
111_S	115_D	0.885	0.55
260_K	263_E	0.883	0.55
83_P	280_I	0.881	0.54
164_Q	168_C	0.878	0.54
254_I	295_T	0.876	0.54
109_L	142_F	0.873	0.54
192_G	196_A	0.870	0.53
117_S	149_D	0.864	0.53
258_Y	264_K	0.861	0.53
75_L	79_F	0.860	0.53
187_L	191_L	0.857	0.52
114_N	259_D	0.857	0.52
205_D	308_Y	0.857	0.52
274_K	280_I	0.856	0.52
240_I	257_F	0.853	0.52
258_Y	268_V	0.849	0.52
8_E	15_R	0.849	0.52
295_T	314_T	0.848	0.52
107_N	204_L	0.844	0.51
5_F	37_I	0.843	0.51
261_L	272_T	0.843	0.51
73_A	91_F	0.841	0.51
131_Q	168_C	0.838	0.51
57_S	68_A	0.834	0.50
280_I	284_L	0.826	0.50
83_P	297_C	0.818	0.49
220_K	306_Y	0.816	0.49
24_L	77_I	0.816	0.49
236_R	267_D	0.816	0.49
138_K	142_F	0.816	0.49
233_L	321_I	0.814	0.49
257_F	296_S	0.810	0.48
65_E	84_Y	0.808	0.48
155_P	159_F	0.805	0.48
26_F	53_S	0.803	0.48
108_A	199_K	0.803	0.48
163_G	168_C	0.801	0.48
244_V	272_T	0.799	0.47
276_L	299_R	0.799	0.47
148_Y	165_V	0.797	0.47
76_I	127_T	0.789	0.46
276_L	312_V	0.788	0.46
29_G	59_G	0.786	0.46
22_V	109_L	0.780	0.46
240_I	261_L	0.779	0.46
241_I	268_V	0.779	0.46
131_Q	189_H	0.778	0.46
65_E	246_V	0.775	0.45
181_V	199_K	0.774	0.45
29_G	248_Q	0.773	0.45
40_K	44_K	0.767	0.45
303_D	312_V	0.766	0.45
8_E	47_N	0.764	0.44
203_K	214_I	0.764	0.44
8_E	44_K	0.763	0.44
313_L	318_A	0.757	0.44
189_H	303_D	0.756	0.44
269_F	274_K	0.755	0.44
214_I	246_V	0.755	0.44
242_Q	272_T	0.755	0.44
23_L	67_E	0.755	0.44
276_L	324_N	0.753	0.43
82_T	99_E	0.752	0.43
158_R	166_L	0.748	0.43
155_P	169_D	0.747	0.43
26_F	82_T	0.747	0.43
210_K	260_K	0.746	0.43
80_G	253_M	0.744	0.43
180_Y	230_L	0.741	0.42
65_E	277_T	0.740	0.42
188_F	298_P	0.740	0.42
6_E	305_L	0.738	0.42
131_Q	163_G	0.737	0.42
84_Y	97_N	0.737	0.42
168_C	188_F	0.735	0.42
42_R	46_P	0.731	0.42
135_L	266_Y	0.729	0.41
222_L	226_Y	0.727	0.41
122_R	179_I	0.726	0.41
239_V	289_I	0.726	0.41
15_R	141_S	0.726	0.41
61_C	83_P	0.725	0.41
64_A	67_E	0.722	0.41
52_I	177_A	0.721	0.41
306_Y	312_V	0.721	0.41
60_A	186_G	0.718	0.41
294_V	300_L	0.718	0.41
80_G	196_A	0.717	0.40
19_A	291_V	0.715	0.40
28_E	31_K	0.714	0.40
155_P	160_M	0.713	0.40
232_A	313_L	0.713	0.40
135_L	308_Y	0.713	0.40
55_E	273_N	0.713	0.40
168_C	248_Q	0.710	0.40
113_E	123_K	0.708	0.40
7_E	112_L	0.706	0.40
163_G	248_Q	0.706	0.40
113_E	117_S	0.703	0.39
71_V	312_V	0.699	0.39
247_G	304_D	0.698	0.39
29_G	299_R	0.697	0.39
186_G	248_Q	0.696	0.39
136_L	175_V	0.696	0.39
55_E	274_K	0.693	0.38
28_E	57_S	0.690	0.38
131_Q	206_P	0.689	0.38
299_R	303_D	0.688	0.38
42_R	50_F	0.686	0.38
221_I	271_V	0.685	0.38
78_H	84_Y	0.684	0.38
141_S	144_E	0.683	0.38
63_I	267_D	0.683	0.38
139_I	183_V	0.679	0.37
145_D	150_I	0.677	0.37
39_K	77_I	0.677	0.37
128_A	133_V	0.675	0.37
142_F	210_K	0.673	0.37
90_K	282_R	0.673	0.37
70_Q	284_L	0.671	0.37
54_G	57_S	0.665	0.36
62_D	247_G	0.665	0.36
138_K	289_I	0.665	0.36
60_A	75_L	0.664	0.36
102_L	312_V	0.664	0.36
267_D	279_D	0.662	0.36
62_D	297_C	0.662	0.36
239_V	292_F	0.661	0.36
109_L	143_L	0.660	0.36
63_I	67_E	0.659	0.36
68_A	280_I	0.658	0.36
103_D	158_R	0.656	0.35
162_D	166_L	0.652	0.35
166_L	298_P	0.651	0.35
123_K	259_D	0.650	0.35
52_I	55_E	0.645	0.35
116_I	211_S	0.644	0.35
282_R	309_E	0.643	0.34
188_F	192_G	0.641	0.34
248_Q	295_T	0.640	0.34
197_T	291_V	0.639	0.34
21_R	49_N	0.638	0.34
167_G	188_F	0.638	0.34
206_P	214_I	0.636	0.34
20_K	47_N	0.635	0.34
63_I	142_F	0.634	0.34
305_L	320_M	0.633	0.34
8_E	12_K	0.632	0.34
270_T	314_T	0.627	0.33
66_D	70_Q	0.627	0.33
235_K	327_E	0.626	0.33
125_S	180_Y	0.625	0.33
67_E	71_V	0.624	0.33
85_T	300_L	0.623	0.33
9_R	13_E	0.620	0.33
139_I	151_V	0.617	0.32
256_Y	259_D	0.616	0.32
138_K	257_F	0.616	0.32
250_R	304_D	0.614	0.32
181_V	318_A	0.611	0.32
83_P	95_F	0.610	0.32
189_H	248_Q	0.609	0.32
189_H	192_G	0.609	0.32
124_I	202_I	0.609	0.32
206_P	296_S	0.608	0.32
160_M	168_C	0.607	0.32
111_S	211_S	0.606	0.32
131_Q	167_G	0.605	0.32
98_A	274_K	0.605	0.32
146_K	174_E	0.604	0.32
254_I	268_V	0.603	0.31
7_E	261_L	0.602	0.31
184_S	278_L	0.602	0.31
151_V	323_N	0.602	0.31
186_G	189_H	0.601	0.31
257_F	271_V	0.601	0.31
236_R	259_D	0.600	0.31
112_L	124_I	0.599	0.31
142_F	145_D	0.599	0.31
163_G	166_L	0.596	0.31
148_Y	158_R	0.594	0.31
267_D	314_T	0.593	0.31
66_D	90_K	0.593	0.31
251_P	255_K	0.593	0.31
93_T	253_M	0.590	0.31
141_S	149_D	0.590	0.31
164_Q	167_G	0.589	0.30
320_M	323_N	0.588	0.30
170_Y	207_Y	0.588	0.30
130_L	276_L	0.588	0.30
155_P	164_Q	0.587	0.30
112_L	175_V	0.584	0.30
95_F	185_G	0.584	0.30
123_K	151_V	0.582	0.30
16_E	183_V	0.580	0.30
139_I	296_S	0.577	0.30
236_R	291_V	0.577	0.30
82_T	97_N	0.577	0.30
101_N	141_S	0.576	0.29
41_L	258_Y	0.576	0.29
253_M	325_S	0.574	0.29
110_H	113_E	0.573	0.29
273_N	281_L	0.573	0.29
236_R	290_D	0.572	0.29
70_Q	274_K	0.571	0.29
85_T	250_R	0.569	0.29
243_G	294_V	0.568	0.29
217_D	220_K	0.568	0.29
247_G	303_D	0.568	0.29
85_T	304_D	0.567	0.29
173_A	180_Y	0.566	0.29
76_I	93_T	0.565	0.29
156_S	161_F	0.565	0.29
51_I	224_V	0.565	0.29
110_H	126_L	0.565	0.29
159_F	169_D	0.563	0.29
123_K	229_I	0.562	0.29
239_V	321_I	0.557	0.28
34_S	205_D	0.557	0.28
105_S	110_H	0.556	0.28
49_N	323_N	0.555	0.28
109_L	267_D	0.553	0.28
186_G	300_L	0.552	0.28
11_I	176_E	0.552	0.28
223_K	287_N	0.552	0.28
55_E	67_E	0.551	0.28
84_Y	305_L	0.550	0.28
117_S	145_D	0.549	0.28
141_S	146_K	0.549	0.28
206_P	243_G	0.548	0.28
191_L	304_D	0.547	0.27
51_I	73_A	0.547	0.27
124_I	127_T	0.545	0.27
284_L	289_I	0.545	0.27
56_P	66_D	0.544	0.27
27_P	31_K	0.541	0.27
277_T	283_N	0.540	0.27
139_I	324_N	0.540	0.27
29_G	189_H	0.539	0.27
253_M	295_T	0.538	0.27
168_C	299_R	0.537	0.27
274_K	283_N	0.537	0.27
67_E	91_F	0.536	0.27
236_R	242_Q	0.535	0.27
8_E	11_I	0.534	0.27
69_Q	261_L	0.533	0.27
34_S	37_I	0.532	0.26
22_V	230_L	0.531	0.26
287_N	292_F	0.530	0.26
50_F	295_T	0.529	0.26
120_N	139_I	0.529	0.26
284_L	292_F	0.529	0.26
16_E	292_F	0.529	0.26
82_T	233_L	0.527	0.26
156_S	163_G	0.526	0.26
156_S	171_K	0.524	0.26
6_E	10_V	0.524	0.26
58_W	244_V	0.522	0.26
79_F	84_Y	0.522	0.26
76_I	323_N	0.522	0.26
31_K	250_R	0.521	0.26
163_G	171_K	0.520	0.26
103_D	161_F	0.519	0.26
81_H	298_P	0.518	0.26
34_S	52_I	0.516	0.25
81_H	248_Q	0.516	0.25
143_L	147_G	0.514	0.25
166_L	186_G	0.513	0.25
122_R	271_V	0.511	0.25
108_A	145_D	0.509	0.25
151_V	175_V	0.509	0.25
14_I	41_L	0.508	0.25
24_L	205_D	0.508	0.25
26_F	78_H	0.507	0.25
67_E	274_K	0.507	0.25
74_D	113_E	0.506	0.25
28_E	53_S	0.506	0.25
79_F	86_W	0.505	0.25
287_N	293_L	0.504	0.25
52_I	75_L	0.503	0.25
66_D	234_D	0.502	0.25
5_F	9_R	0.502	0.25
116_I	212_E	0.502	0.25
129_T	275_V	0.501	0.24
111_S	126_L	0.501	0.24
46_P	110_H	0.500	0.24
70_Q	269_F	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lzdA	2	0.958	100	0.074	Contact Map
4xxhA	2	0.2763	81.1	0.956	Contact Map
1gudA	1	0.2973	78.1	0.958	Contact Map
3hs3A	2	0.2913	71.9	0.96	Contact Map
3mizA	2	0.6066	70	0.96	Contact Map
3brsA	1	0.2973	69.4	0.96	Contact Map
3e61A	3	0.2853	68.7	0.961	Contact Map
3cs3A	2	0.2973	68.5	0.961	Contact Map
4rweA	1	0.3003	68.4	0.961	Contact Map
3d8uA	2	0.2913	67.7	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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