GREMLIN Database
Q980J8 - Uncharacterized protein
UniProt: Q980J8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (315)
Sequences: 896 (620)
Seq/√Len: 35.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_V79_F5.8471.00
10_V77_I5.2191.00
290_D310_K4.6081.00
5_F33_F4.5521.00
140_K144_E4.4881.00
271_V292_F4.0361.00
37_I41_L3.7391.00
7_E37_I3.5541.00
293_L318_A3.3131.00
26_F37_I3.2571.00
170_Y192_G3.1901.00
6_E9_R3.1801.00
62_D83_P3.0601.00
237_S267_D3.0511.00
41_L48_V2.9511.00
38_V50_F2.8081.00
260_K264_K2.6151.00
128_A136_L2.5951.00
259_D263_E2.5591.00
21_R74_D2.3630.99
238_W318_A2.3450.99
235_K290_D2.2640.99
237_S288_Y2.2420.99
75_L94_I2.1520.99
289_I292_F2.0820.99
238_W261_L2.0470.98
256_Y319_K2.0380.98
108_A183_V1.9880.98
26_F52_I1.9870.98
105_S142_F1.9830.98
240_I258_Y1.9450.98
107_N111_S1.9240.98
242_Q254_I1.8860.97
125_S177_A1.8810.97
45_L50_F1.8750.97
235_K291_V1.8690.97
243_G296_S1.8670.97
112_L181_V1.8330.97
258_Y270_T1.8070.97
20_K74_D1.7910.96
164_Q169_D1.7840.96
109_L113_E1.7750.96
113_E146_K1.7650.96
107_N209_Q1.7570.96
26_F79_F1.7200.95
61_C297_C1.7100.95
225_R317_E1.7060.95
243_G246_V1.6980.95
239_V284_L1.6880.95
7_E10_V1.6810.95
123_K178_D1.6790.95
13_E75_L1.6630.95
12_K16_E1.6540.94
257_F315_P1.6530.94
109_L139_I1.6490.94
224_V306_Y1.6320.94
252_N255_K1.5940.93
189_H299_R1.5910.93
17_K75_L1.5790.93
262_T268_V1.5630.93
127_T184_S1.5470.92
99_E134_R1.5290.92
127_T182_I1.5270.92
147_G150_I1.5130.91
184_S296_S1.4970.91
159_F166_L1.4730.90
279_D282_R1.4660.90
141_S145_D1.4330.89
261_L318_A1.4320.89
117_S122_R1.4070.88
68_A73_A1.3840.87
13_E94_I1.3640.86
81_H299_R1.3620.86
318_A322_I1.3430.85
13_E16_E1.3420.85
41_L92_P1.3340.85
179_I200_P1.3320.85
13_E17_K1.3270.85
135_L139_I1.3220.84
165_V182_I1.3200.84
26_F34_S1.3100.84
151_V238_W1.3020.83
54_G71_V1.3000.83
247_G250_R1.2970.83
104_I109_L1.2890.83
30_L232_A1.2840.83
238_W291_V1.2640.82
180_Y193_L1.2630.82
231_Q234_D1.2600.81
56_P275_V1.2540.81
219_R223_K1.2530.81
188_F248_Q1.2450.81
108_A128_A1.2330.80
159_F164_Q1.2280.80
77_I114_N1.2280.80
102_L135_L1.2240.79
59_G81_H1.2220.79
232_A314_T1.2100.79
14_I48_V1.2010.78
294_V301_P1.1890.77
240_I268_V1.1890.77
72_N93_T1.1840.77
41_L50_F1.1790.77
16_E213_D1.1760.77
180_Y201_T1.1680.76
236_R266_Y1.1670.76
223_K227_G1.1640.76
185_G205_D1.1480.75
18_N284_L1.1390.74
81_H131_Q1.1230.73
31_K55_E1.1210.73
21_R72_N1.1190.73
28_E56_P1.1190.73
188_F300_L1.1150.73
22_V48_V1.1060.72
204_L209_Q1.0990.72
38_V126_L1.0980.71
14_I75_L1.0940.71
126_L136_L1.0930.71
65_E90_K1.0920.71
259_D262_T1.0880.71
22_V25_Q1.0860.71
95_F301_P1.0840.70
90_K93_T1.0730.70
17_K34_S1.0630.69
258_Y262_T1.0630.69
133_V162_D1.0610.69
239_V271_V1.0580.69
62_D245_K1.0570.69
240_I290_D1.0540.68
104_I183_V1.0540.68
109_L141_S1.0460.68
223_K293_L1.0450.68
29_G168_C1.0420.67
200_P213_D1.0420.67
34_S293_L1.0350.67
81_H168_C1.0330.67
27_P30_L1.0250.66
256_Y260_K1.0250.66
144_E149_D1.0170.65
241_I276_L1.0170.65
230_L266_Y1.0170.65
300_L303_D1.0170.65
235_K318_A1.0160.65
31_K295_T1.0160.65
81_H188_F1.0140.65
238_W266_Y1.0120.65
170_Y196_A1.0110.65
173_A199_K1.0090.65
123_K149_D1.0090.65
271_V310_K1.0030.64
29_G188_F0.9920.64
241_I281_L0.9910.63
229_I320_M0.9840.63
64_A83_P0.9820.63
103_D209_Q0.9770.62
127_T193_L0.9760.62
128_A182_I0.9680.62
5_F73_A0.9670.62
188_F299_R0.9580.61
261_L268_V0.9530.60
23_L73_A0.9430.60
23_L55_E0.9410.59
194_G197_T0.9410.59
230_L233_L0.9400.59
132_H207_Y0.9370.59
182_I257_F0.9340.59
253_M257_F0.9310.59
144_E150_I0.9270.58
80_G244_V0.9230.58
291_V313_L0.9220.58
320_M327_E0.9190.58
43_E176_E0.9170.57
64_A280_I0.9110.57
238_W322_I0.9110.57
248_Q299_R0.9110.57
57_S278_L0.9100.57
253_M319_K0.9050.56
108_A211_S0.9030.56
136_L152_I0.9030.56
186_G191_L0.9010.56
57_S272_T0.8980.56
188_F191_L0.8930.55
110_H145_D0.8920.55
188_F303_D0.8910.55
111_S115_D0.8850.55
260_K263_E0.8830.55
83_P280_I0.8810.54
164_Q168_C0.8780.54
254_I295_T0.8760.54
109_L142_F0.8730.54
192_G196_A0.8700.53
117_S149_D0.8640.53
258_Y264_K0.8610.53
75_L79_F0.8600.53
187_L191_L0.8570.52
114_N259_D0.8570.52
205_D308_Y0.8570.52
274_K280_I0.8560.52
240_I257_F0.8530.52
258_Y268_V0.8490.52
8_E15_R0.8490.52
295_T314_T0.8480.52
107_N204_L0.8440.51
5_F37_I0.8430.51
261_L272_T0.8430.51
73_A91_F0.8410.51
131_Q168_C0.8380.51
57_S68_A0.8340.50
280_I284_L0.8260.50
83_P297_C0.8180.49
220_K306_Y0.8160.49
24_L77_I0.8160.49
236_R267_D0.8160.49
138_K142_F0.8160.49
233_L321_I0.8140.49
257_F296_S0.8100.48
65_E84_Y0.8080.48
155_P159_F0.8050.48
26_F53_S0.8030.48
108_A199_K0.8030.48
163_G168_C0.8010.48
244_V272_T0.7990.47
276_L299_R0.7990.47
148_Y165_V0.7970.47
76_I127_T0.7890.46
276_L312_V0.7880.46
29_G59_G0.7860.46
22_V109_L0.7800.46
240_I261_L0.7790.46
241_I268_V0.7790.46
131_Q189_H0.7780.46
65_E246_V0.7750.45
181_V199_K0.7740.45
29_G248_Q0.7730.45
40_K44_K0.7670.45
303_D312_V0.7660.45
8_E47_N0.7640.44
203_K214_I0.7640.44
8_E44_K0.7630.44
313_L318_A0.7570.44
189_H303_D0.7560.44
269_F274_K0.7550.44
214_I246_V0.7550.44
242_Q272_T0.7550.44
23_L67_E0.7550.44
276_L324_N0.7530.43
82_T99_E0.7520.43
158_R166_L0.7480.43
155_P169_D0.7470.43
26_F82_T0.7470.43
210_K260_K0.7460.43
80_G253_M0.7440.43
180_Y230_L0.7410.42
65_E277_T0.7400.42
188_F298_P0.7400.42
6_E305_L0.7380.42
131_Q163_G0.7370.42
84_Y97_N0.7370.42
168_C188_F0.7350.42
42_R46_P0.7310.42
135_L266_Y0.7290.41
222_L226_Y0.7270.41
122_R179_I0.7260.41
239_V289_I0.7260.41
15_R141_S0.7260.41
61_C83_P0.7250.41
64_A67_E0.7220.41
52_I177_A0.7210.41
306_Y312_V0.7210.41
60_A186_G0.7180.41
294_V300_L0.7180.41
80_G196_A0.7170.40
19_A291_V0.7150.40
28_E31_K0.7140.40
155_P160_M0.7130.40
232_A313_L0.7130.40
135_L308_Y0.7130.40
55_E273_N0.7130.40
168_C248_Q0.7100.40
113_E123_K0.7080.40
7_E112_L0.7060.40
163_G248_Q0.7060.40
113_E117_S0.7030.39
71_V312_V0.6990.39
247_G304_D0.6980.39
29_G299_R0.6970.39
186_G248_Q0.6960.39
136_L175_V0.6960.39
55_E274_K0.6930.38
28_E57_S0.6900.38
131_Q206_P0.6890.38
299_R303_D0.6880.38
42_R50_F0.6860.38
221_I271_V0.6850.38
78_H84_Y0.6840.38
141_S144_E0.6830.38
63_I267_D0.6830.38
139_I183_V0.6790.37
145_D150_I0.6770.37
39_K77_I0.6770.37
128_A133_V0.6750.37
142_F210_K0.6730.37
90_K282_R0.6730.37
70_Q284_L0.6710.37
54_G57_S0.6650.36
62_D247_G0.6650.36
138_K289_I0.6650.36
60_A75_L0.6640.36
102_L312_V0.6640.36
267_D279_D0.6620.36
62_D297_C0.6620.36
239_V292_F0.6610.36
109_L143_L0.6600.36
63_I67_E0.6590.36
68_A280_I0.6580.36
103_D158_R0.6560.35
162_D166_L0.6520.35
166_L298_P0.6510.35
123_K259_D0.6500.35
52_I55_E0.6450.35
116_I211_S0.6440.35
282_R309_E0.6430.34
188_F192_G0.6410.34
248_Q295_T0.6400.34
197_T291_V0.6390.34
21_R49_N0.6380.34
167_G188_F0.6380.34
206_P214_I0.6360.34
20_K47_N0.6350.34
63_I142_F0.6340.34
305_L320_M0.6330.34
8_E12_K0.6320.34
270_T314_T0.6270.33
66_D70_Q0.6270.33
235_K327_E0.6260.33
125_S180_Y0.6250.33
67_E71_V0.6240.33
85_T300_L0.6230.33
9_R13_E0.6200.33
139_I151_V0.6170.32
256_Y259_D0.6160.32
138_K257_F0.6160.32
250_R304_D0.6140.32
181_V318_A0.6110.32
83_P95_F0.6100.32
189_H248_Q0.6090.32
189_H192_G0.6090.32
124_I202_I0.6090.32
206_P296_S0.6080.32
160_M168_C0.6070.32
111_S211_S0.6060.32
131_Q167_G0.6050.32
98_A274_K0.6050.32
146_K174_E0.6040.32
254_I268_V0.6030.31
7_E261_L0.6020.31
184_S278_L0.6020.31
151_V323_N0.6020.31
186_G189_H0.6010.31
257_F271_V0.6010.31
236_R259_D0.6000.31
112_L124_I0.5990.31
142_F145_D0.5990.31
163_G166_L0.5960.31
148_Y158_R0.5940.31
267_D314_T0.5930.31
66_D90_K0.5930.31
251_P255_K0.5930.31
93_T253_M0.5900.31
141_S149_D0.5900.31
164_Q167_G0.5890.30
320_M323_N0.5880.30
170_Y207_Y0.5880.30
130_L276_L0.5880.30
155_P164_Q0.5870.30
112_L175_V0.5840.30
95_F185_G0.5840.30
123_K151_V0.5820.30
16_E183_V0.5800.30
139_I296_S0.5770.30
236_R291_V0.5770.30
82_T97_N0.5770.30
101_N141_S0.5760.29
41_L258_Y0.5760.29
253_M325_S0.5740.29
110_H113_E0.5730.29
273_N281_L0.5730.29
236_R290_D0.5720.29
70_Q274_K0.5710.29
85_T250_R0.5690.29
243_G294_V0.5680.29
217_D220_K0.5680.29
247_G303_D0.5680.29
85_T304_D0.5670.29
173_A180_Y0.5660.29
76_I93_T0.5650.29
156_S161_F0.5650.29
51_I224_V0.5650.29
110_H126_L0.5650.29
159_F169_D0.5630.29
123_K229_I0.5620.29
239_V321_I0.5570.28
34_S205_D0.5570.28
105_S110_H0.5560.28
49_N323_N0.5550.28
109_L267_D0.5530.28
186_G300_L0.5520.28
11_I176_E0.5520.28
223_K287_N0.5520.28
55_E67_E0.5510.28
84_Y305_L0.5500.28
117_S145_D0.5490.28
141_S146_K0.5490.28
206_P243_G0.5480.28
191_L304_D0.5470.27
51_I73_A0.5470.27
124_I127_T0.5450.27
284_L289_I0.5450.27
56_P66_D0.5440.27
27_P31_K0.5410.27
277_T283_N0.5400.27
139_I324_N0.5400.27
29_G189_H0.5390.27
253_M295_T0.5380.27
168_C299_R0.5370.27
274_K283_N0.5370.27
67_E91_F0.5360.27
236_R242_Q0.5350.27
8_E11_I0.5340.27
69_Q261_L0.5330.27
34_S37_I0.5320.26
22_V230_L0.5310.26
287_N292_F0.5300.26
50_F295_T0.5290.26
120_N139_I0.5290.26
284_L292_F0.5290.26
16_E292_F0.5290.26
82_T233_L0.5270.26
156_S163_G0.5260.26
156_S171_K0.5240.26
6_E10_V0.5240.26
58_W244_V0.5220.26
79_F84_Y0.5220.26
76_I323_N0.5220.26
31_K250_R0.5210.26
163_G171_K0.5200.26
103_D161_F0.5190.26
81_H298_P0.5180.26
34_S52_I0.5160.25
81_H248_Q0.5160.25
143_L147_G0.5140.25
166_L186_G0.5130.25
122_R271_V0.5110.25
108_A145_D0.5090.25
151_V175_V0.5090.25
14_I41_L0.5080.25
24_L205_D0.5080.25
26_F78_H0.5070.25
67_E274_K0.5070.25
74_D113_E0.5060.25
28_E53_S0.5060.25
79_F86_W0.5050.25
287_N293_L0.5040.25
52_I75_L0.5030.25
66_D234_D0.5020.25
5_F9_R0.5020.25
116_I212_E0.5020.25
129_T275_V0.5010.24
111_S126_L0.5010.24
46_P110_H0.5000.24
70_Q269_F0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lzdA 2 0.958 100 0.074 Contact Map
4xxhA 2 0.2763 81.1 0.956 Contact Map
1gudA 1 0.2973 78.1 0.958 Contact Map
3hs3A 2 0.2913 71.9 0.96 Contact Map
3mizA 2 0.6066 70 0.96 Contact Map
3brsA 1 0.2973 69.4 0.96 Contact Map
3e61A 3 0.2853 68.7 0.961 Contact Map
3cs3A 2 0.2973 68.5 0.961 Contact Map
4rweA 1 0.3003 68.4 0.961 Contact Map
3d8uA 2 0.2913 67.7 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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