GREMLIN Database
RL10E - 50S ribosomal protein L10e
UniProt: Q980J7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (167)
Sequences: 320 (176)
Seq/√Len: 13.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_K132_E3.8140.99
73_L137_I3.7350.99
4_R8_C3.2230.98
72_T153_I3.0540.97
17_Y117_F2.9420.97
73_L77_T2.8080.96
77_T82_S2.8050.96
139_V147_A2.5970.93
87_I135_I2.4270.91
69_T154_A2.4220.91
16_A93_H2.2830.88
35_T86_W2.2790.88
98_N109_L2.1580.84
86_W152_K2.1280.84
73_L147_A2.0830.82
95_L124_A2.0810.82
1_M5_P1.9740.79
22_Y111_D1.9470.78
59_H123_T1.9300.77
100_M109_L1.8560.74
139_V143_H1.8380.73
16_A46_E1.8260.73
98_N110_Q1.8260.73
35_T84_F1.8170.72
149_E152_K1.7780.71
144_L169_L1.7730.70
73_L139_V1.7580.70
4_R116_S1.7520.69
151_L159_P1.7240.68
149_E153_I1.7100.68
34_F145_E1.7050.67
145_E164_I1.6610.65
144_L147_A1.6470.64
74_S83_F1.6460.64
77_T85_M1.6170.63
85_M135_I1.5900.62
52_T163_R1.5840.61
96_R114_R1.5230.58
71_K109_L1.5180.58
116_S123_T1.4800.56
4_R121_I1.4690.55
73_L94_V1.4650.55
105_G108_R1.4410.54
47_V147_A1.4390.54
127_I132_E1.4140.52
101_M110_Q1.3380.48
3_L10_R1.3220.48
101_M109_L1.3200.47
23_I94_V1.3180.47
147_A159_P1.2660.45
12_F54_I1.2650.45
8_C110_Q1.2550.44
92_H164_I1.2510.44
72_T149_E1.2410.43
25_G53_E1.2310.43
51_T160_L1.2250.42
57_I144_L1.2030.41
66_R96_R1.1940.41
5_P9_Y1.1860.40
4_R24_P1.1790.40
7_R100_M1.1650.39
8_C101_M1.1370.38
32_T120_P1.1290.37
33_K101_M1.1270.37
11_H14_G1.1250.37
36_S164_I1.0990.36
26_I123_T1.0960.36
139_V159_P1.0940.36
16_A39_P1.0910.36
13_S30_K1.0830.35
31_I34_F1.0830.35
87_I166_I1.0480.34
54_I68_L1.0390.33
11_H15_P1.0340.33
29_P123_T1.0220.32
25_G154_A1.0200.32
69_T147_A1.0140.32
61_A64_A1.0110.32
14_G126_R1.0040.31
4_R7_R1.0020.31
19_R23_I0.9960.31
137_I147_A0.9910.31
8_C100_M0.9880.31
77_T146_F0.9860.31
70_L127_I0.9740.30
50_I64_A0.9690.30
98_N114_R0.9660.30
62_L89_K0.9660.30
69_T85_M0.9560.29
70_L125_A0.9550.29
36_S142_E0.9470.29
92_H148_K0.9410.29
128_E159_P0.9380.28
72_T93_H0.9350.28
24_P55_G0.9250.28
85_M147_A0.9150.27
100_M110_Q0.9110.27
58_R124_A0.9070.27
68_L74_S0.8900.26
64_A93_H0.8870.26
69_T137_I0.8860.26
64_A122_G0.8820.26
103_F109_L0.8770.26
41_G83_F0.8740.26
4_R160_L0.8680.26
23_I117_F0.8640.25
7_R98_N0.8640.25
47_V166_I0.8500.25
38_N82_S0.8480.25
56_Q63_E0.8450.25
56_Q126_R0.8440.25
57_I68_L0.8390.24
3_L15_P0.8390.24
3_L60_N0.8330.24
148_K168_P0.8300.24
17_Y23_I0.8230.24
6_G115_L0.8180.24
49_L96_R0.8120.23
133_T164_I0.8060.23
48_R88_L0.8050.23
15_P93_H0.8000.23
147_A164_I0.7980.23
61_A94_V0.7970.23
53_E130_L0.7920.23
49_L57_I0.7900.22
96_R107_D0.7890.22
104_A107_D0.7870.22
62_L65_V0.7810.22
92_H101_M0.7800.22
36_S57_I0.7740.22
93_H123_T0.7640.22
69_T139_V0.7630.22
51_T54_I0.7580.21
83_F133_T0.7530.21
6_G88_L0.7490.21
100_M155_S0.7470.21
26_I67_T0.7450.21
97_E121_I0.7420.21
103_F110_Q0.7410.21
107_D112_G0.7390.21
50_I165_E0.7390.21
99_K105_G0.7390.21
8_C102_A0.7390.21
48_R51_T0.7380.21
30_K59_H0.7370.21
95_L144_L0.7360.21
49_L150_A0.7330.20
45_Y57_I0.7260.20
55_G110_Q0.7230.20
18_T46_E0.7200.20
65_V158_L0.7180.20
32_T39_P0.7130.20
26_I29_P0.7070.20
104_A108_R0.7060.20
89_K95_L0.7030.19
24_P153_I0.6980.19
85_M152_K0.6970.19
148_K158_L0.6900.19
145_E165_E0.6870.19
42_D87_I0.6850.19
141_K168_P0.6840.19
39_P86_W0.6800.19
62_L73_L0.6780.19
54_I130_L0.6780.19
3_L8_C0.6740.18
57_I135_I0.6720.18
50_I134_L0.6700.18
35_T162_T0.6660.18
6_G153_I0.6650.18
3_L86_W0.6560.18
66_R118_G0.6550.18
53_E75_K0.6540.18
68_L71_K0.6520.18
22_Y135_I0.6510.18
31_I87_I0.6480.18
56_Q124_A0.6460.18
31_I131_G0.6450.18
88_L161_R0.6440.18
109_L120_P0.6390.17
2_P102_A0.6320.17
44_D84_F0.6270.17
86_W130_L0.6250.17
40_N143_H0.6220.17
13_S120_P0.6190.17
83_F141_K0.6190.17
29_P141_K0.6180.17
4_R161_R0.6170.17
8_C60_N0.6170.17
6_G116_S0.6160.17
128_E149_E0.6120.17
43_Y85_M0.6090.16
29_P87_I0.6030.16
64_A138_K0.6030.16
142_E145_E0.6010.16
47_V95_L0.5990.16
120_P158_L0.5970.16
32_T79_S0.5950.16
31_I77_T0.5940.16
35_T43_Y0.5930.16
3_L11_H0.5910.16
23_I55_G0.5900.16
7_R120_P0.5840.16
98_N120_P0.5830.16
57_I134_L0.5830.16
36_S45_Y0.5830.16
77_T143_H0.5780.16
15_P59_H0.5760.16
84_F158_L0.5760.16
28_Q32_T0.5750.15
76_K128_E0.5730.15
60_N156_K0.5720.15
96_R106_A0.5700.15
26_I59_H0.5700.15
5_P8_C0.5700.15
124_A135_I0.5700.15
128_E145_E0.5660.15
22_Y137_I0.5650.15
31_I166_I0.5630.15
150_A159_P0.5590.15
48_R136_V0.5560.15
63_E104_A0.5550.15
94_V169_L0.5530.15
77_T127_I0.5530.15
41_G44_D0.5520.15
95_L99_K0.5510.15
52_T68_L0.5470.15
8_C109_L0.5470.15
22_Y152_K0.5450.15
108_R112_G0.5430.15
30_K47_V0.5410.15
65_V69_T0.5400.15
144_L168_P0.5390.14
131_G143_H0.5380.14
18_T92_H0.5370.14
85_M89_K0.5340.14
137_I162_T0.5300.14
52_T158_L0.5270.14
135_I145_E0.5180.14
156_K169_L0.5130.14
53_E64_A0.5120.14
109_L114_R0.5120.14
66_R114_R0.5090.14
120_P164_I0.5090.14
152_K156_K0.5070.14
92_H166_I0.5070.14
27_P114_R0.5050.14
101_M111_D0.5050.14
42_D164_I0.5030.14
99_K126_R0.5010.14
48_R130_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a17H 1 0.9213 100 0.265 Contact Map
3j39I 1 0.9831 100 0.266 Contact Map
3zf7K 1 0.9831 100 0.267 Contact Map
3j21N 1 0.9326 100 0.269 Contact Map
1vx7Q 1 0.8933 100 0.271 Contact Map
4ujqL 1 0.9326 100 0.278 Contact Map
1vq8H 1 0.8764 100 0.304 Contact Map
1ffkF 1 0.8708 100 0.392 Contact Map
2pa2A 1 0.5899 100 0.462 Contact Map
3j7yN 1 0.8258 100 0.541 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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