GREMLIN Database
Q980J3 - Transketolase, N-terminal section (Tkt-1)
UniProt: Q980J3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (235)
Sequences: 10104 (4674)
Seq/√Len: 304.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_K215_E3.2381.00
66_K233_T3.1751.00
175_M214_W2.7681.00
228_D231_S2.7371.00
184_D243_S2.6531.00
148_I155_G2.5861.00
172_W217_V2.4311.00
211_P223_N2.4061.00
161_M188_A2.3471.00
222_L246_V2.3391.00
222_L238_E2.3271.00
209_F212_K2.2771.00
67_H233_T2.2481.00
156_R187_I2.2021.00
141_G159_V2.1471.00
189_F236_V2.1361.00
188_A219_W2.1061.00
223_N251_K2.0761.00
156_R240_Y2.0661.00
220_K246_V2.0621.00
211_P215_E2.0621.00
129_M140_F2.0611.00
31_A61_T1.9301.00
177_H181_R1.9291.00
253_V256_K1.9231.00
180_V206_P1.9001.00
59_I250_A1.8831.00
75_V126_G1.8761.00
148_I157_V1.8431.00
194_N251_K1.8331.00
256_K262_E1.7701.00
38_V93_A1.7581.00
226_G252_T1.7071.00
62_T233_T1.6851.00
192_M249_F1.6791.00
214_W247_V1.6761.00
67_H240_Y1.6711.00
52_S87_A1.6481.00
59_I189_F1.6341.00
81_I144_V1.6251.00
233_T237_N1.5601.00
80_L160_I1.5441.00
56_S160_I1.5291.00
162_G165_E1.5281.00
190_I247_V1.5151.00
34_A57_I1.4731.00
187_I239_A1.4651.00
178_A186_L1.4411.00
104_E107_W1.4221.00
253_V263_N1.4181.00
122_T130_S1.4131.00
148_I153_G1.4051.00
207_K213_V1.3891.00
137_G161_M1.3831.00
224_C231_S1.3751.00
31_A58_E1.3561.00
37_N103_E1.3521.00
220_K238_E1.3511.00
149_K184_D1.3411.00
239_A246_V1.3151.00
200_S203_E1.3101.00
79_W155_G1.3051.00
207_K211_P1.2961.00
67_H237_N1.2891.00
175_M217_V1.2841.00
146_T177_H1.2781.00
146_T181_R1.2711.00
138_L171_I1.2651.00
139_S170_E1.2581.00
102_K105_E1.2561.00
138_L175_M1.2521.00
224_C232_I1.2461.00
29_Q33_K1.2361.00
142_I177_H1.2331.00
220_K244_K1.2321.00
120_P131_T1.2161.00
135_G168_E1.2101.00
142_I183_L1.2091.00
222_L235_A1.2031.00
117_Q124_I1.1961.00
79_W148_I1.1861.00
138_L188_A1.1841.00
62_T229_F1.1801.00
237_N241_K1.1791.00
81_I141_G1.1771.00
158_Y187_I1.1671.00
225_D231_S1.1631.00
225_D228_D1.1561.00
167_D196_Q1.1521.00
161_M166_Q1.1431.00
234_N238_E1.1331.00
68_I77_K1.1291.00
184_D242_A1.1261.00
60_L94_V1.1241.00
229_F233_T1.1221.00
253_V262_E1.1221.00
211_P249_F1.1171.00
37_N41_M1.1121.00
142_I178_A1.1101.00
230_I234_N1.1081.00
32_E36_R1.1071.00
36_R39_I1.1071.00
161_M171_I1.1061.00
169_G173_E1.1061.00
105_E108_R1.1041.00
207_K212_K1.0951.00
166_Q190_I1.0921.00
84_K87_A1.0861.00
28_R230_I1.0831.00
44_Y107_W1.0831.00
220_K242_A1.0741.00
26_K29_Q1.0741.00
232_I236_V1.0691.00
62_T232_I1.0651.00
58_E229_F1.0651.00
222_L239_A1.0551.00
192_M201_T1.0491.00
25_D28_R1.0471.00
158_Y240_Y1.0471.00
224_C235_A1.0461.00
141_G188_A1.0391.00
103_E107_W1.0381.00
156_R184_D1.0321.00
65_F233_T1.0291.00
189_F250_A1.0281.00
261_I267_Q1.0271.00
38_V53_S1.0261.00
37_N97_E1.0241.00
79_W144_V1.0201.00
227_H256_K1.0201.00
235_A248_I1.0171.00
41_M107_W1.0111.00
166_Q171_I1.0021.00
64_I94_V0.9841.00
266_K270_S0.9771.00
192_M251_K0.9711.00
166_Q214_W0.9691.00
207_K210_L0.9621.00
124_I127_V0.9611.00
33_K97_E0.9551.00
187_I248_I0.9541.00
43_F46_Q0.9501.00
84_K162_G0.9491.00
53_S93_A0.9481.00
95_L126_G0.9451.00
88_A109_I0.9441.00
142_I174_A0.9431.00
161_M165_E0.9351.00
239_A248_I0.9331.00
38_V57_I0.9281.00
200_S263_N0.9221.00
108_R114_G0.9211.00
110_Q269_S0.9181.00
149_K183_L0.9161.00
175_M219_W0.9151.00
176_T205_K0.9141.00
235_A239_A0.9121.00
184_D220_K0.9121.00
232_I250_A0.9051.00
96_A103_E0.9051.00
171_I175_M0.9041.00
190_I214_W0.8971.00
188_A247_V0.8921.00
85_G120_P0.8901.00
58_E227_H0.8881.00
61_T65_F0.8861.00
192_M202_D0.8861.00
29_Q32_E0.8821.00
63_L80_L0.8781.00
56_S60_L0.8761.00
50_V269_S0.8741.00
231_S234_N0.8731.00
182_N243_S0.8691.00
36_R40_K0.8631.00
81_I129_M0.8621.00
231_S235_A0.8581.00
37_N96_A0.8571.00
223_N249_F0.8551.00
261_I266_K0.8551.00
259_P263_N0.8541.00
194_N200_S0.8541.00
138_L178_A0.8531.00
237_N240_Y0.8521.00
27_L65_F0.8491.00
34_A94_V0.8461.00
37_N40_K0.8451.00
34_A93_A0.8431.00
190_I210_L0.8361.00
77_K128_D0.8321.00
56_S59_I0.8261.00
96_A106_L0.8261.00
159_V188_A0.8241.00
236_V240_Y0.8241.00
33_K36_R0.8221.00
211_P221_V0.8201.00
27_L61_T0.8201.00
187_I246_V0.8191.00
30_V65_F0.8181.00
187_I236_V0.8181.00
142_I186_L0.8171.00
54_L258_F0.8071.00
221_V249_F0.8031.00
68_I80_L0.8021.00
146_T150_M0.7981.00
28_R32_E0.7981.00
30_V97_E0.7971.00
101_I105_E0.7951.00
161_M190_I0.7931.00
41_M106_L0.7931.00
134_L168_E0.7921.00
202_D206_P0.7921.00
31_A229_F0.7921.00
196_Q204_I0.7911.00
267_Q270_S0.7871.00
136_Q170_E0.7830.99
96_A101_I0.7830.99
65_F98_K0.7780.99
57_I61_T0.7770.99
213_V216_A0.7770.99
44_Y111_D0.7680.99
145_A186_L0.7670.99
94_V98_K0.7650.99
255_G267_Q0.7600.99
25_D29_Q0.7520.99
79_W128_D0.7500.99
27_L229_F0.7490.99
264_T267_Q0.7400.99
238_E241_K0.7350.99
181_R205_K0.7350.99
110_Q118_G0.7300.99
34_A61_T0.7280.99
104_E108_R0.7260.99
65_F97_E0.7150.99
209_F213_V0.7120.99
156_R236_V0.7110.99
108_R111_D0.7100.99
184_D246_V0.7080.99
177_H205_K0.7020.99
172_W175_M0.7020.99
144_V157_V0.7010.99
184_D244_K0.6940.99
47_T110_Q0.6940.99
27_L31_A0.6900.99
222_L248_I0.6900.99
82_L85_G0.6870.99
117_Q121_E0.6870.99
52_S56_S0.6860.99
101_I106_L0.6830.99
39_I54_L0.6810.99
195_F263_N0.6810.99
40_K107_W0.6800.99
62_T66_K0.6790.99
219_W247_V0.6780.99
30_V33_K0.6770.99
258_F261_I0.6740.98
199_G265_H0.6720.98
67_H156_R0.6680.98
61_T97_E0.6640.98
59_I160_I0.6620.98
58_E61_T0.6580.98
41_M93_A0.6580.98
227_H232_I0.6560.98
85_G88_A0.6530.98
76_N153_G0.6500.98
37_N107_W0.6480.98
40_K44_Y0.6440.98
26_K30_V0.6430.98
95_L98_K0.6420.98
215_E221_V0.6400.98
121_E130_S0.6390.98
138_L159_V0.6370.98
101_I116_L0.6350.98
41_M46_Q0.6330.98
194_N202_D0.6320.98
61_T229_F0.6280.98
97_E103_E0.6220.97
108_R116_L0.6210.97
138_L174_A0.6210.97
176_T207_K0.6200.97
63_L67_H0.6200.97
82_L86_H0.6180.97
194_N201_T0.6170.97
147_G155_G0.6160.97
199_G203_E0.6160.97
59_I62_T0.6150.97
182_N206_P0.6110.97
259_P262_E0.6100.97
242_A246_V0.6050.97
47_T269_S0.6050.97
42_L50_V0.6040.97
38_V42_L0.6030.97
214_W221_V0.5990.97
52_S84_K0.5990.97
140_F144_V0.5980.97
94_V97_E0.5960.97
83_S86_H0.5950.97
183_L186_L0.5940.97
170_E174_A0.5880.96
200_S265_H0.5870.96
30_V61_T0.5820.96
105_E116_L0.5810.96
162_G254_R0.5800.96
141_G186_L0.5740.96
84_K165_E0.5740.96
166_Q210_L0.5740.96
46_Q109_I0.5710.96
64_I75_V0.5670.96
129_M144_V0.5640.95
267_Q272_D0.5620.95
101_I124_I0.5600.95
77_K154_T0.5590.95
212_K216_A0.5570.95
234_N237_N0.5560.95
221_V247_V0.5540.95
122_T129_M0.5530.95
52_S160_I0.5520.95
225_D256_K0.5510.95
213_V217_V0.5460.95
83_S137_G0.5450.95
229_F232_I0.5410.94
42_L48_I0.5410.94
96_A102_K0.5390.94
162_G171_I0.5390.94
85_G131_T0.5370.94
189_F248_I0.5360.94
49_H86_H0.5350.94
52_S55_S0.5340.94
66_K237_N0.5290.94
160_I189_F0.5290.94
187_I240_Y0.5290.94
146_T183_L0.5290.94
197_L265_H0.5280.94
66_K236_V0.5280.94
135_G170_E0.5270.94
42_L46_Q0.5270.94
77_K155_G0.5260.93
67_H158_Y0.5230.93
59_I63_L0.5220.93
63_L160_I0.5220.93
214_W219_W0.5190.93
210_L213_V0.5190.93
190_I249_F0.5150.93
175_M188_A0.5110.92
227_H252_T0.5080.92
84_K160_I0.5080.92
84_K254_R0.5060.92
197_L200_S0.5060.92
51_G198_D0.5060.92
106_L109_I0.5060.92
63_L68_I0.5040.92
230_I233_T0.5010.92
56_S84_K0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rimA 2 0.9573 100 0.233 Contact Map
3komA 2 0.8968 100 0.238 Contact Map
2r8oA 2 0.911 100 0.24 Contact Map
4kxvA 2 0.9466 100 0.241 Contact Map
3uk1A 2 0.9181 100 0.245 Contact Map
1r9jA 2 0.9181 100 0.25 Contact Map
1itzA 2 0.9253 100 0.253 Contact Map
3l84A 2 0.9181 100 0.258 Contact Map
3m49A 2 0.9146 100 0.258 Contact Map
4c7vA 2 0.9146 100 0.264 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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