GREMLIN Database
Q980J2 - Transketolase, C-terminal section (Tkt-2)
UniProt: Q980J2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (301)
Sequences: 15305 (8362)
Seq/√Len: 482.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_L309_I4.4841.00
22_D46_K3.6781.00
213_E305_I3.2771.00
195_L308_A2.8761.00
300_N303_T2.8751.00
276_R307_E2.7741.00
186_A236_T2.6691.00
65_A77_I2.6481.00
276_R310_D2.5861.00
190_K211_A2.4661.00
208_L223_V2.3891.00
18_A46_K2.3271.00
190_K212_E2.3161.00
209_K301_Y2.2801.00
213_E301_Y2.1851.00
211_A223_V2.1841.00
301_Y305_I2.1251.00
138_V149_S2.1231.00
193_S220_S2.0351.00
18_A47_F2.0011.00
196_A244_A1.9761.00
295_D300_N1.9721.00
234_E266_V1.9711.00
195_L221_V1.9331.00
7_Y15_R1.9271.00
206_D301_Y1.9061.00
194_D220_S1.8771.00
222_A240_Y1.8611.00
156_E159_G1.8361.00
269_R277_F1.8291.00
68_L73_K1.8241.00
234_E270_R1.8221.00
238_E266_V1.8101.00
222_A243_K1.8061.00
215_E220_S1.7941.00
74_K101_D1.7931.00
190_K215_E1.7621.00
213_E216_K1.7511.00
213_E302_K1.7421.00
188_V222_A1.7331.00
62_V95_I1.7181.00
186_A226_L1.7161.00
22_D47_F1.6891.00
238_E270_R1.6851.00
197_I207_A1.6671.00
209_K212_E1.6581.00
99_N134_N1.6491.00
222_A244_A1.6481.00
66_A95_I1.6451.00
199_G207_A1.6421.00
255_I279_G1.6311.00
194_D245_G1.6071.00
207_A250_I1.5901.00
130_R262_A1.5851.00
305_I309_I1.5841.00
136_K156_E1.5761.00
191_D222_A1.5631.00
292_D295_D1.5381.00
19_D147_E1.5361.00
276_R311_L1.5341.00
206_D209_K1.5251.00
188_V191_D1.5021.00
76_A154_I1.5001.00
20_L151_P1.4991.00
135_M162_Y1.4971.00
261_S265_E1.4931.00
307_E310_D1.4821.00
199_G204_L1.4781.00
28_V68_L1.4741.00
212_E216_K1.4701.00
306_R310_D1.4651.00
103_K153_I1.4491.00
198_I226_L1.4291.00
295_D302_K1.4141.00
136_K159_G1.4041.00
233_D270_R1.3981.00
11_E39_R1.3971.00
205_W209_K1.3921.00
224_I236_T1.3841.00
264_A275_I1.3761.00
264_A268_A1.3751.00
127_A253_H1.3691.00
62_V77_I1.3641.00
213_E217_L1.3581.00
62_V104_M1.3551.00
95_I104_M1.3541.00
20_L155_N1.3521.00
210_A305_I1.3411.00
16_L147_E1.3341.00
206_D304_I1.3271.00
130_R265_E1.3221.00
303_T307_E1.3181.00
197_I308_A1.3181.00
24_N74_K1.3091.00
182_K185_K1.3041.00
43_F47_F1.2981.00
152_V183_I1.2881.00
151_P155_N1.2871.00
196_A240_Y1.2781.00
224_I240_Y1.2611.00
237_I246_K1.2591.00
187_Y225_N1.2521.00
62_V87_A1.2491.00
74_K103_K1.2471.00
136_K228_S1.2411.00
145_D225_N1.2391.00
258_G277_F1.2361.00
16_L151_P1.2341.00
101_D159_G1.2241.00
26_D73_K1.2231.00
138_V228_S1.2211.00
21_G43_F1.2191.00
30_I65_A1.2161.00
20_L27_L1.2151.00
289_S292_D1.2081.00
17_L76_A1.2061.00
266_V270_R1.2041.00
212_E215_E1.1981.00
189_I204_L1.1921.00
11_E15_R1.1901.00
91_I135_M1.1801.00
226_L259_I1.1761.00
264_A277_F1.1621.00
30_I54_V1.1511.00
145_D227_F1.1471.00
186_A224_I1.1411.00
197_I221_V1.1401.00
20_L154_I1.1381.00
15_R147_E1.1381.00
251_E260_G1.1371.00
240_Y243_K1.1261.00
203_V206_D1.1251.00
198_I247_I1.1211.00
141_A204_L1.1161.00
141_A225_N1.1111.00
171_P205_W1.1081.00
15_R19_D1.1061.00
249_T260_G1.1061.00
246_K251_E1.0941.00
288_R292_D1.0941.00
20_L23_K1.0821.00
28_V73_K1.0791.00
185_K235_N1.0791.00
248_I311_L1.0771.00
16_L19_D1.0721.00
248_I278_V1.0571.00
190_K220_S1.0571.00
188_V224_I1.0501.00
12_T143_P1.0501.00
303_T306_R1.0501.00
278_V307_E1.0481.00
24_N27_L1.0451.00
247_I267_T1.0441.00
250_I304_I1.0431.00
127_A131_V1.0381.00
265_E277_F1.0371.00
23_K151_P1.0351.00
188_V236_T1.0341.00
238_E242_R1.0251.00
129_M162_Y1.0231.00
91_I106_V1.0201.00
233_D269_R1.0161.00
126_I200_A1.0121.00
19_D151_P1.0081.00
196_A222_A1.0061.00
241_A267_T1.0041.00
88_W128_L1.0041.00
6_I169_Y1.0041.00
221_V308_A0.9991.00
18_A22_D0.9941.00
123_L280_A0.9921.00
232_I237_I0.9911.00
101_D157_E0.9891.00
264_A279_G0.9881.00
286_S296_Y0.9811.00
106_V162_Y0.9781.00
19_D22_D0.9761.00
153_I161_L0.9751.00
308_A311_L0.9701.00
190_K208_L0.9661.00
59_Q90_Q0.9601.00
200_A229_I0.9551.00
54_V64_F0.9511.00
230_K282_T0.9501.00
268_A275_I0.9461.00
210_A304_I0.9451.00
95_I102_V0.9441.00
196_A224_I0.9411.00
24_N154_I0.9381.00
65_A102_V0.9331.00
69_A75_P0.9311.00
248_I308_A0.9271.00
217_L305_I0.9261.00
136_K231_P0.9261.00
19_D23_K0.9261.00
11_E14_G0.9221.00
61_M77_I0.9161.00
138_V161_L0.9041.00
254_S274_P0.9001.00
82_M125_D0.8991.00
29_V34_V0.8981.00
7_Y12_T0.8981.00
141_A187_Y0.8921.00
207_A223_V0.8891.00
214_L308_A0.8881.00
84_L129_M0.8821.00
21_G27_L0.8811.00
99_N159_G0.8801.00
295_D303_T0.8791.00
26_D74_K0.8781.00
240_Y244_A0.8761.00
271_Y274_P0.8761.00
96_A132_L0.8761.00
298_N303_T0.8721.00
74_K157_E0.8711.00
152_V155_N0.8711.00
302_K306_R0.8701.00
35_G51_Y0.8681.00
97_R118_S0.8631.00
234_E238_E0.8611.00
99_N158_R0.8601.00
138_V183_I0.8521.00
292_D296_Y0.8511.00
246_K274_P0.8471.00
15_R42_Y0.8461.00
143_P172_P0.8411.00
11_E169_Y0.8361.00
232_I266_V0.8351.00
262_A265_E0.8211.00
204_L223_V0.8151.00
142_D189_I0.8141.00
126_I164_R0.8121.00
43_F46_K0.8111.00
181_F184_G0.8111.00
28_V52_F0.8101.00
64_F68_L0.8091.00
91_I129_M0.8081.00
198_I224_I0.8071.00
219_I309_I0.8061.00
60_D64_F0.8021.00
47_F50_R0.7961.00
84_L106_V0.7961.00
84_L108_H0.7941.00
206_D294_L0.7931.00
206_D300_N0.7921.00
7_Y11_E0.7911.00
139_V200_A0.7911.00
165_I169_Y0.7901.00
256_Y282_T0.7871.00
246_K311_L0.7841.00
32_A61_M0.7831.00
30_I52_F0.7811.00
111_Y293_L0.7801.00
38_T78_V0.7741.00
29_V76_A0.7671.00
211_A215_E0.7631.00
16_L150_L0.7621.00
214_L305_I0.7611.00
293_L297_Y0.7581.00
126_I253_H0.7541.00
195_L248_I0.7531.00
280_A297_Y0.7491.00
81_G129_M0.7491.00
85_M88_W0.7461.00
152_V182_K0.7441.00
166_G170_S0.7421.00
166_G169_Y0.7421.00
135_M160_P0.7411.00
148_R151_P0.7401.00
112_S294_L0.7401.00
130_R229_I0.7361.00
32_A38_T0.7331.00
194_D219_I0.7311.00
14_G18_A0.7311.00
70_A100_L0.7301.00
152_V180_E0.7281.00
209_K213_E0.7271.00
272_P275_I0.7261.00
136_K161_L0.7251.00
215_E221_V0.7251.00
30_I61_M0.7251.00
146_I165_I0.7231.00
16_L20_L0.7161.00
18_A42_Y0.7151.00
226_L229_I0.7141.00
249_T275_I0.7131.00
199_G203_V0.7111.00
69_A100_L0.7111.00
127_A262_A0.7081.00
200_A226_L0.7081.00
255_I277_F0.7061.00
150_L163_Y0.7061.00
188_V240_Y0.7031.00
44_R47_F0.7021.00
25_K50_R0.7011.00
149_S227_F0.7001.00
130_R257_G0.6961.00
306_R309_I0.6901.00
96_A284_G0.6901.00
268_A277_F0.6871.00
165_I168_E0.6861.00
128_L132_L0.6861.00
42_Y46_K0.6841.00
30_I64_F0.6831.00
12_T16_L0.6831.00
43_F51_Y0.6791.00
132_L135_M0.6791.00
136_K230_K0.6791.00
148_R180_E0.6791.00
126_I137_V0.6791.00
260_G279_G0.6791.00
96_A135_M0.6781.00
136_K157_E0.6781.00
283_F296_Y0.6761.00
271_Y277_F0.6751.00
136_K183_I0.6751.00
198_I249_T0.6741.00
69_A102_V0.6721.00
249_T253_H0.6711.00
307_E311_L0.6691.00
13_F78_V0.6681.00
237_I266_V0.6661.00
115_G289_S0.6581.00
27_L76_A0.6561.00
103_K161_L0.6551.00
128_L131_V0.6551.00
138_V152_V0.6551.00
210_A308_A0.6531.00
138_V153_I0.6491.00
229_I233_D0.6491.00
35_G41_L0.6481.00
210_A250_I0.6471.00
117_G120_H0.6471.00
91_I104_M0.6461.00
191_D243_K0.6451.00
260_G277_F0.6441.00
44_R51_Y0.6391.00
42_Y45_E0.6391.00
35_G44_R0.6351.00
278_V299_I0.6341.00
87_A91_I0.6341.00
285_R297_Y0.6331.00
62_V106_V0.6311.00
210_A301_Y0.6311.00
237_I267_T0.6301.00
249_T252_E0.6301.00
171_P209_K0.6261.00
76_A150_L0.6210.99
210_A278_V0.6190.99
233_D237_I0.6190.99
144_K179_Y0.6180.99
236_T240_Y0.6150.99
118_S121_Q0.6140.99
63_N90_Q0.6120.99
281_T297_Y0.6110.99
247_I275_I0.6110.99
151_P180_E0.6110.99
251_E258_G0.6090.99
94_S104_M0.6080.99
144_K148_R0.6080.99
189_I208_L0.6050.99
8_S11_E0.6010.99
214_L221_V0.6010.99
192_G220_S0.5990.99
81_G125_D0.5960.99
57_A60_D0.5950.99
77_I104_M0.5950.99
185_K233_D0.5950.99
44_R48_K0.5940.99
130_R137_V0.5940.99
249_T263_V0.5930.99
88_W131_V0.5930.99
89_E93_N0.5900.99
107_T165_I0.5880.99
147_E151_P0.5880.99
207_A304_I0.5830.99
193_S222_A0.5820.99
179_Y187_Y0.5800.99
85_M125_D0.5780.99
241_A247_I0.5770.99
34_V80_F0.5740.99
101_D158_R0.5710.99
194_D221_V0.5710.99
123_L254_S0.5700.99
148_R152_V0.5700.99
34_V79_N0.5690.99
65_A68_L0.5690.99
257_G278_V0.5680.99
39_R42_Y0.5680.99
148_R179_Y0.5680.99
13_F150_L0.5670.99
85_M128_L0.5640.99
250_I278_V0.5620.99
103_K150_L0.5610.99
92_R132_L0.5610.99
27_L154_I0.5600.99
136_K184_G0.5590.99
68_L75_P0.5580.99
156_E161_L0.5570.99
245_G272_P0.5560.99
95_I160_P0.5560.99
199_G226_L0.5550.99
11_E42_Y0.5540.99
141_A145_D0.5500.99
173_I208_L0.5480.99
269_R276_R0.5470.99
261_S277_F0.5450.99
281_T303_T0.5440.99
278_V304_I0.5440.99
54_V61_M0.5420.99
284_G287_A0.5410.99
148_R182_K0.5410.99
255_I269_R0.5410.99
144_K172_P0.5410.99
130_R259_I0.5400.99
29_V40_A0.5400.99
283_F297_Y0.5400.99
31_T35_G0.5400.99
14_G39_R0.5390.99
143_P173_I0.5380.99
195_L246_K0.5350.98
139_V201_G0.5350.98
114_H121_Q0.5330.98
52_F64_F0.5320.98
36_D53_N0.5320.98
17_L40_A0.5320.98
149_S152_V0.5320.98
214_L219_I0.5300.98
74_K154_I0.5300.98
248_I276_R0.5290.98
289_S294_L0.5280.98
202_V206_D0.5250.98
276_R308_A0.5240.98
294_L299_I0.5230.98
13_F146_I0.5210.98
186_A233_D0.5200.98
21_G51_Y0.5200.98
183_I228_S0.5190.98
184_G228_S0.5180.98
36_D41_L0.5180.98
149_S161_L0.5170.98
211_A221_V0.5170.98
149_S182_K0.5170.98
65_A78_V0.5130.98
92_R124_E0.5120.98
283_F286_S0.5110.98
197_I211_A0.5080.98
81_G164_R0.5070.98
305_I308_A0.5060.98
18_A51_Y0.5050.98
191_D220_S0.5030.98
302_K305_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kxvA 2 0.9872 100 0.201 Contact Map
2o1xA 2 0.9808 100 0.207 Contact Map
2o1sA 2 0.9649 100 0.214 Contact Map
1w85B 2 0.9617 100 0.231 Contact Map
1umdB 2 0.9585 100 0.245 Contact Map
1ik6A 3 0.853 100 0.246 Contact Map
1gpuA 2 0.9553 100 0.257 Contact Map
1r9jA 2 0.9521 100 0.257 Contact Map
2ozlB 2 0.9681 100 0.262 Contact Map
1itzA 2 0.9585 100 0.271 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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