Q980J2 - SULSO - GREMLIN Contacts

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Q980J2 - Transketolase, C-terminal section (Tkt-2)

UniProt:	Q980J2	Sequences: MMQGNIYSMRETFGRLLADLGDKNKDLVVITADVGDSTRALYFREKFKDRYFNVGIAEQDMVNFAAGLAAVGKKPAIVNFGMFLMRAWEQIRNSIARMNLDVKMFVTHTGYSDHGDGSSHQVLEDIALMRVLPNMKVVVPADPKDIERSLPVIINEERGPLYYRIGREYSPPITIGQEYEFKIGKAYVIKDGSDLAIIGAGVVLWDALKAAEELEKLGISVAVINLFSIKPIDENTIEYYARKAGKIITIEEHSIYGGIGSAVAEVTARRYPVPIRFVGATTFGRSARSQRDLLDYYNINYKTIIREAIDLLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	313 (301)
Sequences:	15305 (8362)
Seq/√Len:	482.0

ECOLI - DXS TKT2 TKT1
BACSU - ODPB ODBB ACOB DXS TKT
HALSA - Q9HN76
SULSO - Q980J2 Q97Y22 Q97YF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
217_L	309_I	4.484	1.00
22_D	46_K	3.678	1.00
213_E	305_I	3.277	1.00
195_L	308_A	2.876	1.00
300_N	303_T	2.875	1.00
276_R	307_E	2.774	1.00
186_A	236_T	2.669	1.00
65_A	77_I	2.648	1.00
276_R	310_D	2.586	1.00
190_K	211_A	2.466	1.00
208_L	223_V	2.389	1.00
18_A	46_K	2.327	1.00
190_K	212_E	2.316	1.00
209_K	301_Y	2.280	1.00
213_E	301_Y	2.185	1.00
211_A	223_V	2.184	1.00
301_Y	305_I	2.125	1.00
138_V	149_S	2.123	1.00
193_S	220_S	2.035	1.00
18_A	47_F	2.001	1.00
196_A	244_A	1.976	1.00
295_D	300_N	1.972	1.00
234_E	266_V	1.971	1.00
195_L	221_V	1.933	1.00
7_Y	15_R	1.927	1.00
206_D	301_Y	1.906	1.00
194_D	220_S	1.877	1.00
222_A	240_Y	1.861	1.00
156_E	159_G	1.836	1.00
269_R	277_F	1.829	1.00
68_L	73_K	1.824	1.00
234_E	270_R	1.822	1.00
238_E	266_V	1.810	1.00
222_A	243_K	1.806	1.00
215_E	220_S	1.794	1.00
74_K	101_D	1.793	1.00
190_K	215_E	1.762	1.00
213_E	216_K	1.751	1.00
213_E	302_K	1.742	1.00
188_V	222_A	1.733	1.00
62_V	95_I	1.718	1.00
186_A	226_L	1.716	1.00
22_D	47_F	1.689	1.00
238_E	270_R	1.685	1.00
197_I	207_A	1.667	1.00
209_K	212_E	1.658	1.00
99_N	134_N	1.649	1.00
222_A	244_A	1.648	1.00
66_A	95_I	1.645	1.00
199_G	207_A	1.642	1.00
255_I	279_G	1.631	1.00
194_D	245_G	1.607	1.00
207_A	250_I	1.590	1.00
130_R	262_A	1.585	1.00
305_I	309_I	1.584	1.00
136_K	156_E	1.576	1.00
191_D	222_A	1.563	1.00
292_D	295_D	1.538	1.00
19_D	147_E	1.536	1.00
276_R	311_L	1.534	1.00
206_D	209_K	1.525	1.00
188_V	191_D	1.502	1.00
76_A	154_I	1.500	1.00
20_L	151_P	1.499	1.00
135_M	162_Y	1.497	1.00
261_S	265_E	1.493	1.00
307_E	310_D	1.482	1.00
199_G	204_L	1.478	1.00
28_V	68_L	1.474	1.00
212_E	216_K	1.470	1.00
306_R	310_D	1.465	1.00
103_K	153_I	1.449	1.00
198_I	226_L	1.429	1.00
295_D	302_K	1.414	1.00
136_K	159_G	1.404	1.00
233_D	270_R	1.398	1.00
11_E	39_R	1.397	1.00
205_W	209_K	1.392	1.00
224_I	236_T	1.384	1.00
264_A	275_I	1.376	1.00
264_A	268_A	1.375	1.00
127_A	253_H	1.369	1.00
62_V	77_I	1.364	1.00
213_E	217_L	1.358	1.00
62_V	104_M	1.355	1.00
95_I	104_M	1.354	1.00
20_L	155_N	1.352	1.00
210_A	305_I	1.341	1.00
16_L	147_E	1.334	1.00
206_D	304_I	1.327	1.00
130_R	265_E	1.322	1.00
303_T	307_E	1.318	1.00
197_I	308_A	1.318	1.00
24_N	74_K	1.309	1.00
182_K	185_K	1.304	1.00
43_F	47_F	1.298	1.00
152_V	183_I	1.288	1.00
151_P	155_N	1.287	1.00
196_A	240_Y	1.278	1.00
224_I	240_Y	1.261	1.00
237_I	246_K	1.259	1.00
187_Y	225_N	1.252	1.00
62_V	87_A	1.249	1.00
74_K	103_K	1.247	1.00
136_K	228_S	1.241	1.00
145_D	225_N	1.239	1.00
258_G	277_F	1.236	1.00
16_L	151_P	1.234	1.00
101_D	159_G	1.224	1.00
26_D	73_K	1.223	1.00
138_V	228_S	1.221	1.00
21_G	43_F	1.219	1.00
30_I	65_A	1.216	1.00
20_L	27_L	1.215	1.00
289_S	292_D	1.208	1.00
17_L	76_A	1.206	1.00
266_V	270_R	1.204	1.00
212_E	215_E	1.198	1.00
189_I	204_L	1.192	1.00
11_E	15_R	1.190	1.00
91_I	135_M	1.180	1.00
226_L	259_I	1.176	1.00
264_A	277_F	1.162	1.00
30_I	54_V	1.151	1.00
145_D	227_F	1.147	1.00
186_A	224_I	1.141	1.00
197_I	221_V	1.140	1.00
20_L	154_I	1.138	1.00
15_R	147_E	1.138	1.00
251_E	260_G	1.137	1.00
240_Y	243_K	1.126	1.00
203_V	206_D	1.125	1.00
198_I	247_I	1.121	1.00
141_A	204_L	1.116	1.00
141_A	225_N	1.111	1.00
171_P	205_W	1.108	1.00
15_R	19_D	1.106	1.00
249_T	260_G	1.106	1.00
246_K	251_E	1.094	1.00
288_R	292_D	1.094	1.00
20_L	23_K	1.082	1.00
28_V	73_K	1.079	1.00
185_K	235_N	1.079	1.00
248_I	311_L	1.077	1.00
16_L	19_D	1.072	1.00
248_I	278_V	1.057	1.00
190_K	220_S	1.057	1.00
188_V	224_I	1.050	1.00
12_T	143_P	1.050	1.00
303_T	306_R	1.050	1.00
278_V	307_E	1.048	1.00
24_N	27_L	1.045	1.00
247_I	267_T	1.044	1.00
250_I	304_I	1.043	1.00
127_A	131_V	1.038	1.00
265_E	277_F	1.037	1.00
23_K	151_P	1.035	1.00
188_V	236_T	1.034	1.00
238_E	242_R	1.025	1.00
129_M	162_Y	1.023	1.00
91_I	106_V	1.020	1.00
233_D	269_R	1.016	1.00
126_I	200_A	1.012	1.00
19_D	151_P	1.008	1.00
196_A	222_A	1.006	1.00
241_A	267_T	1.004	1.00
88_W	128_L	1.004	1.00
6_I	169_Y	1.004	1.00
221_V	308_A	0.999	1.00
18_A	22_D	0.994	1.00
123_L	280_A	0.992	1.00
232_I	237_I	0.991	1.00
101_D	157_E	0.989	1.00
264_A	279_G	0.988	1.00
286_S	296_Y	0.981	1.00
106_V	162_Y	0.978	1.00
19_D	22_D	0.976	1.00
153_I	161_L	0.975	1.00
308_A	311_L	0.970	1.00
190_K	208_L	0.966	1.00
59_Q	90_Q	0.960	1.00
200_A	229_I	0.955	1.00
54_V	64_F	0.951	1.00
230_K	282_T	0.950	1.00
268_A	275_I	0.946	1.00
210_A	304_I	0.945	1.00
95_I	102_V	0.944	1.00
196_A	224_I	0.941	1.00
24_N	154_I	0.938	1.00
65_A	102_V	0.933	1.00
69_A	75_P	0.931	1.00
248_I	308_A	0.927	1.00
217_L	305_I	0.926	1.00
136_K	231_P	0.926	1.00
19_D	23_K	0.926	1.00
11_E	14_G	0.922	1.00
61_M	77_I	0.916	1.00
138_V	161_L	0.904	1.00
254_S	274_P	0.900	1.00
82_M	125_D	0.899	1.00
29_V	34_V	0.898	1.00
7_Y	12_T	0.898	1.00
141_A	187_Y	0.892	1.00
207_A	223_V	0.889	1.00
214_L	308_A	0.888	1.00
84_L	129_M	0.882	1.00
21_G	27_L	0.881	1.00
99_N	159_G	0.880	1.00
295_D	303_T	0.879	1.00
26_D	74_K	0.878	1.00
240_Y	244_A	0.876	1.00
271_Y	274_P	0.876	1.00
96_A	132_L	0.876	1.00
298_N	303_T	0.872	1.00
74_K	157_E	0.871	1.00
152_V	155_N	0.871	1.00
302_K	306_R	0.870	1.00
35_G	51_Y	0.868	1.00
97_R	118_S	0.863	1.00
234_E	238_E	0.861	1.00
99_N	158_R	0.860	1.00
138_V	183_I	0.852	1.00
292_D	296_Y	0.851	1.00
246_K	274_P	0.847	1.00
15_R	42_Y	0.846	1.00
143_P	172_P	0.841	1.00
11_E	169_Y	0.836	1.00
232_I	266_V	0.835	1.00
262_A	265_E	0.821	1.00
204_L	223_V	0.815	1.00
142_D	189_I	0.814	1.00
126_I	164_R	0.812	1.00
43_F	46_K	0.811	1.00
181_F	184_G	0.811	1.00
28_V	52_F	0.810	1.00
64_F	68_L	0.809	1.00
91_I	129_M	0.808	1.00
198_I	224_I	0.807	1.00
219_I	309_I	0.806	1.00
60_D	64_F	0.802	1.00
47_F	50_R	0.796	1.00
84_L	106_V	0.796	1.00
84_L	108_H	0.794	1.00
206_D	294_L	0.793	1.00
206_D	300_N	0.792	1.00
7_Y	11_E	0.791	1.00
139_V	200_A	0.791	1.00
165_I	169_Y	0.790	1.00
256_Y	282_T	0.787	1.00
246_K	311_L	0.784	1.00
32_A	61_M	0.783	1.00
30_I	52_F	0.781	1.00
111_Y	293_L	0.780	1.00
38_T	78_V	0.774	1.00
29_V	76_A	0.767	1.00
211_A	215_E	0.763	1.00
16_L	150_L	0.762	1.00
214_L	305_I	0.761	1.00
293_L	297_Y	0.758	1.00
126_I	253_H	0.754	1.00
195_L	248_I	0.753	1.00
280_A	297_Y	0.749	1.00
81_G	129_M	0.749	1.00
85_M	88_W	0.746	1.00
152_V	182_K	0.744	1.00
166_G	170_S	0.742	1.00
166_G	169_Y	0.742	1.00
135_M	160_P	0.741	1.00
148_R	151_P	0.740	1.00
112_S	294_L	0.740	1.00
130_R	229_I	0.736	1.00
32_A	38_T	0.733	1.00
194_D	219_I	0.731	1.00
14_G	18_A	0.731	1.00
70_A	100_L	0.730	1.00
152_V	180_E	0.728	1.00
209_K	213_E	0.727	1.00
272_P	275_I	0.726	1.00
136_K	161_L	0.725	1.00
215_E	221_V	0.725	1.00
30_I	61_M	0.725	1.00
146_I	165_I	0.723	1.00
16_L	20_L	0.716	1.00
18_A	42_Y	0.715	1.00
226_L	229_I	0.714	1.00
249_T	275_I	0.713	1.00
199_G	203_V	0.711	1.00
69_A	100_L	0.711	1.00
127_A	262_A	0.708	1.00
200_A	226_L	0.708	1.00
255_I	277_F	0.706	1.00
150_L	163_Y	0.706	1.00
188_V	240_Y	0.703	1.00
44_R	47_F	0.702	1.00
25_K	50_R	0.701	1.00
149_S	227_F	0.700	1.00
130_R	257_G	0.696	1.00
306_R	309_I	0.690	1.00
96_A	284_G	0.690	1.00
268_A	277_F	0.687	1.00
165_I	168_E	0.686	1.00
128_L	132_L	0.686	1.00
42_Y	46_K	0.684	1.00
30_I	64_F	0.683	1.00
12_T	16_L	0.683	1.00
43_F	51_Y	0.679	1.00
132_L	135_M	0.679	1.00
136_K	230_K	0.679	1.00
148_R	180_E	0.679	1.00
126_I	137_V	0.679	1.00
260_G	279_G	0.679	1.00
96_A	135_M	0.678	1.00
136_K	157_E	0.678	1.00
283_F	296_Y	0.676	1.00
271_Y	277_F	0.675	1.00
136_K	183_I	0.675	1.00
198_I	249_T	0.674	1.00
69_A	102_V	0.672	1.00
249_T	253_H	0.671	1.00
307_E	311_L	0.669	1.00
13_F	78_V	0.668	1.00
237_I	266_V	0.666	1.00
115_G	289_S	0.658	1.00
27_L	76_A	0.656	1.00
103_K	161_L	0.655	1.00
128_L	131_V	0.655	1.00
138_V	152_V	0.655	1.00
210_A	308_A	0.653	1.00
138_V	153_I	0.649	1.00
229_I	233_D	0.649	1.00
35_G	41_L	0.648	1.00
210_A	250_I	0.647	1.00
117_G	120_H	0.647	1.00
91_I	104_M	0.646	1.00
191_D	243_K	0.645	1.00
260_G	277_F	0.644	1.00
44_R	51_Y	0.639	1.00
42_Y	45_E	0.639	1.00
35_G	44_R	0.635	1.00
278_V	299_I	0.634	1.00
87_A	91_I	0.634	1.00
285_R	297_Y	0.633	1.00
62_V	106_V	0.631	1.00
210_A	301_Y	0.631	1.00
237_I	267_T	0.630	1.00
249_T	252_E	0.630	1.00
171_P	209_K	0.626	1.00
76_A	150_L	0.621	0.99
210_A	278_V	0.619	0.99
233_D	237_I	0.619	0.99
144_K	179_Y	0.618	0.99
236_T	240_Y	0.615	0.99
118_S	121_Q	0.614	0.99
63_N	90_Q	0.612	0.99
281_T	297_Y	0.611	0.99
247_I	275_I	0.611	0.99
151_P	180_E	0.611	0.99
251_E	258_G	0.609	0.99
94_S	104_M	0.608	0.99
144_K	148_R	0.608	0.99
189_I	208_L	0.605	0.99
8_S	11_E	0.601	0.99
214_L	221_V	0.601	0.99
192_G	220_S	0.599	0.99
81_G	125_D	0.596	0.99
57_A	60_D	0.595	0.99
77_I	104_M	0.595	0.99
185_K	233_D	0.595	0.99
44_R	48_K	0.594	0.99
130_R	137_V	0.594	0.99
249_T	263_V	0.593	0.99
88_W	131_V	0.593	0.99
89_E	93_N	0.590	0.99
107_T	165_I	0.588	0.99
147_E	151_P	0.588	0.99
207_A	304_I	0.583	0.99
193_S	222_A	0.582	0.99
179_Y	187_Y	0.580	0.99
85_M	125_D	0.578	0.99
241_A	247_I	0.577	0.99
34_V	80_F	0.574	0.99
101_D	158_R	0.571	0.99
194_D	221_V	0.571	0.99
123_L	254_S	0.570	0.99
148_R	152_V	0.570	0.99
34_V	79_N	0.569	0.99
65_A	68_L	0.569	0.99
257_G	278_V	0.568	0.99
39_R	42_Y	0.568	0.99
148_R	179_Y	0.568	0.99
13_F	150_L	0.567	0.99
85_M	128_L	0.564	0.99
250_I	278_V	0.562	0.99
103_K	150_L	0.561	0.99
92_R	132_L	0.561	0.99
27_L	154_I	0.560	0.99
136_K	184_G	0.559	0.99
68_L	75_P	0.558	0.99
156_E	161_L	0.557	0.99
245_G	272_P	0.556	0.99
95_I	160_P	0.556	0.99
199_G	226_L	0.555	0.99
11_E	42_Y	0.554	0.99
141_A	145_D	0.550	0.99
173_I	208_L	0.548	0.99
269_R	276_R	0.547	0.99
261_S	277_F	0.545	0.99
281_T	303_T	0.544	0.99
278_V	304_I	0.544	0.99
54_V	61_M	0.542	0.99
284_G	287_A	0.541	0.99
148_R	182_K	0.541	0.99
255_I	269_R	0.541	0.99
144_K	172_P	0.541	0.99
130_R	259_I	0.540	0.99
29_V	40_A	0.540	0.99
283_F	297_Y	0.540	0.99
31_T	35_G	0.540	0.99
14_G	39_R	0.539	0.99
143_P	173_I	0.538	0.99
195_L	246_K	0.535	0.98
139_V	201_G	0.535	0.98
114_H	121_Q	0.533	0.98
52_F	64_F	0.532	0.98
36_D	53_N	0.532	0.98
17_L	40_A	0.532	0.98
149_S	152_V	0.532	0.98
214_L	219_I	0.530	0.98
74_K	154_I	0.530	0.98
248_I	276_R	0.529	0.98
289_S	294_L	0.528	0.98
202_V	206_D	0.525	0.98
276_R	308_A	0.524	0.98
294_L	299_I	0.523	0.98
13_F	146_I	0.521	0.98
186_A	233_D	0.520	0.98
21_G	51_Y	0.520	0.98
183_I	228_S	0.519	0.98
184_G	228_S	0.518	0.98
36_D	41_L	0.518	0.98
149_S	161_L	0.517	0.98
211_A	221_V	0.517	0.98
149_S	182_K	0.517	0.98
65_A	78_V	0.513	0.98
92_R	124_E	0.512	0.98
283_F	286_S	0.511	0.98
197_I	211_A	0.508	0.98
81_G	164_R	0.507	0.98
305_I	308_A	0.506	0.98
18_A	51_Y	0.505	0.98
191_D	220_S	0.503	0.98
302_K	305_I	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4kxvA	2	0.9872	100	0.201	Contact Map
2o1xA	2	0.9808	100	0.207	Contact Map
2o1sA	2	0.9649	100	0.214	Contact Map
1w85B	2	0.9617	100	0.231	Contact Map
1umdB	2	0.9585	100	0.245	Contact Map
1ik6A	3	0.853	100	0.246	Contact Map
1gpuA	2	0.9553	100	0.257	Contact Map
1r9jA	2	0.9521	100	0.257	Contact Map
2ozlB	2	0.9681	100	0.262	Contact Map
1itzA	2	0.9585	100	0.271	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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