GREMLIN Database
Q980J1 - Chorismate mutase/prephenate dehydratase, putative (TyrA)
UniProt: Q980J1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (321)
Sequences: 280 (180)
Seq/√Len: 10.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_M204_I6.7011.00
219_E227_K4.5141.00
329_N343_E4.4210.99
95_V111_L3.6490.98
30_S266_L3.6480.98
219_E228_T3.4460.97
94_R119_S3.4440.97
332_L336_K3.2980.96
74_I78_I3.2750.96
20_V64_Y3.0940.94
220_R227_K3.0250.93
86_Q328_R2.9610.92
222_V241_W2.9510.92
281_L330_I2.7820.90
97_I108_V2.5850.86
252_D255_T2.4760.83
15_V29_L2.4370.82
220_R228_T2.4180.82
125_L255_T2.4110.81
30_S86_Q2.2780.77
261_A321_N2.2330.76
219_E226_S2.1770.74
189_F253_V2.0770.70
165_S192_L2.0700.70
103_M277_A2.0610.70
111_L283_L2.0590.70
119_S148_W2.0190.68
150_D175_D2.0070.67
72_E76_P2.0050.67
8_L36_A1.9990.67
167_E194_E1.9900.67
19_L29_L1.9810.66
178_V297_F1.9720.66
18_Q21_K1.9390.65
14_K28_E1.8780.62
162_L285_L1.8670.62
297_F303_I1.8650.62
67_P216_P1.8520.61
92_K150_D1.8100.59
251_T292_F1.8100.59
338_I342_L1.7620.57
87_I155_A1.7580.57
108_V120_I1.7410.56
209_L313_V1.7130.55
262_I327_V1.6750.53
180_D208_P1.6740.53
58_I69_S1.6640.52
38_S335_L1.6600.52
86_Q265_V1.6590.52
296_N303_I1.6580.52
86_Q113_L1.6560.52
23_L78_I1.6300.51
87_I90_G1.6270.51
151_I177_I1.6200.50
86_Q266_L1.6120.50
173_L176_K1.5880.49
103_M266_L1.5790.49
219_E225_P1.5750.48
330_I334_E1.5620.48
46_D55_E1.5580.48
97_I153_I1.5570.48
193_E228_T1.5340.47
61_A72_E1.5190.46
30_S53_V1.5130.46
72_E75_L1.5070.45
226_S234_V1.5050.45
7_R63_K1.5040.45
95_V106_S1.4940.45
15_V113_L1.4760.44
9_R37_K1.4610.43
143_L170_S1.4500.43
95_V222_V1.4460.43
225_P228_T1.4110.41
27_L30_S1.3990.40
78_I343_E1.3860.40
6_T28_E1.3790.40
111_L241_W1.3780.40
207_H211_G1.3750.39
182_S297_F1.3720.39
229_S233_D1.3680.39
220_R225_P1.3640.39
171_K176_K1.3640.39
87_I95_V1.3530.38
128_A144_K1.3420.38
214_E217_I1.3390.38
39_N59_A1.3390.38
151_I179_M1.3330.38
182_S259_A1.3280.37
74_I292_F1.3190.37
217_I320_Q1.3180.37
24_S35_K1.3160.37
188_I297_F1.3100.37
107_I154_F1.2990.36
169_F331_G1.2810.35
163_N194_E1.2770.35
185_K208_P1.2750.35
192_L205_S1.2690.35
261_A266_L1.2660.35
107_I181_I1.2530.34
77_L83_K1.2440.34
27_L86_Q1.2350.33
46_D52_K1.2310.33
114_A240_F1.2290.33
103_M182_S1.2260.33
181_I248_P1.2200.33
143_L167_E1.2170.33
20_V155_A1.2030.32
7_R15_V1.1890.32
280_T337_K1.1860.31
281_L334_E1.1790.31
25_Y66_I1.1630.31
32_K40_S1.1560.30
39_N252_D1.1560.30
11_E39_N1.1530.30
263_V292_F1.1390.30
111_L153_I1.1390.30
38_S321_N1.1300.29
241_W335_L1.1270.29
62_K71_V1.1270.29
20_V108_V1.1210.29
267_T297_F1.1210.29
94_R151_I1.1190.29
6_T23_L1.1130.29
246_L310_L1.1050.28
99_G256_H1.1020.28
40_S44_V1.0950.28
34_G79_F1.0950.28
294_T313_V1.0930.28
17_E60_N1.0920.28
226_S250_I1.0880.28
153_I179_M1.0880.28
178_V303_I1.0850.28
20_V30_S1.0840.28
58_I72_E1.0820.28
203_Y314_I1.0810.27
293_H300_L1.0750.27
9_R50_E1.0730.27
204_I234_V1.0690.27
33_I237_V1.0680.27
283_L331_G1.0680.27
14_K59_A1.0630.27
224_I248_P1.0600.27
266_L321_N1.0600.27
103_M153_I1.0580.27
275_S295_T1.0420.26
177_I204_I1.0400.26
26_R50_E1.0400.26
111_L238_E1.0390.26
103_M327_V1.0380.26
321_N331_G1.0340.26
105_K280_T1.0270.26
20_V24_S1.0260.26
14_K25_Y1.0230.25
180_D245_G1.0220.25
37_K50_E1.0130.25
19_L74_I1.0130.25
18_Q262_I1.0090.25
185_K268_H1.0010.25
179_M237_V1.0000.25
20_V97_I1.0000.25
37_K49_R0.9780.24
178_V300_L0.9700.24
183_S208_P0.9690.24
216_P265_V0.9640.23
30_S113_L0.9630.23
249_V261_A0.9620.23
192_L309_D0.9620.23
165_S315_T0.9560.23
30_S265_V0.9560.23
275_S308_K0.9530.23
27_L328_R0.9520.23
330_I336_K0.9500.23
95_V223_I0.9490.23
6_T14_K0.9490.23
178_V253_V0.9430.23
267_T300_L0.9410.23
99_G207_H0.9390.23
207_H256_H0.9390.23
262_I271_L0.9330.22
53_V86_Q0.9320.22
66_I113_L0.9300.22
206_T293_H0.9260.22
54_R60_N0.9250.22
265_V328_R0.9250.22
205_S309_D0.9230.22
104_A257_E0.9180.22
25_Y95_V0.9140.22
98_Y154_F0.9090.22
196_S201_F0.9090.22
240_F294_T0.9050.22
156_I178_V0.9010.21
75_L81_Y0.9000.21
4_E329_N0.8990.21
241_W327_V0.8980.21
117_E333_E0.8910.21
300_L309_D0.8890.21
295_T307_V0.8880.21
37_K82_S0.8850.21
16_D82_S0.8840.21
264_Q294_T0.8810.21
188_I303_I0.8810.21
158_P314_I0.8760.21
48_N56_K0.8740.21
192_L267_T0.8740.21
277_A334_E0.8730.21
196_S272_L0.8720.21
201_F295_T0.8680.20
101_G256_H0.8660.20
293_H309_D0.8630.20
25_Y62_K0.8570.20
6_T10_E0.8520.20
274_L304_L0.8500.20
38_S261_A0.8500.20
265_V321_N0.8500.20
13_D49_R0.8460.20
261_A324_S0.8460.20
223_I337_K0.8440.20
212_P314_I0.8410.20
259_A329_N0.8380.20
121_T145_A0.8370.19
203_Y313_V0.8350.19
63_K166_D0.8340.19
176_K281_L0.8340.19
111_L163_N0.8310.19
164_N310_L0.8270.19
176_K331_G0.8270.19
160_A282_S0.8250.19
116_H240_F0.8230.19
178_V309_D0.8200.19
245_G264_Q0.8190.19
206_T307_V0.8130.19
144_K177_I0.8050.19
39_N239_N0.8040.19
74_I328_R0.8040.19
263_V335_L0.8020.18
14_K18_Q0.8020.18
76_P80_S0.7990.18
19_L285_L0.7960.18
120_I254_E0.7950.18
15_V46_D0.7940.18
216_P302_K0.7910.18
51_M60_N0.7890.18
177_I186_F0.7890.18
11_E162_L0.7850.18
116_H246_L0.7830.18
98_Y124_D0.7790.18
128_A146_I0.7790.18
189_F225_P0.7780.18
126_S269_Y0.7780.18
77_L81_Y0.7760.18
60_N86_Q0.7760.18
180_D185_K0.7750.18
271_L283_L0.7740.18
155_A276_N0.7730.18
267_T296_N0.7720.18
14_K48_N0.7650.17
53_V102_G0.7630.17
162_L166_D0.7630.17
16_D26_R0.7620.17
17_E342_L0.7600.17
14_K32_K0.7590.17
10_E48_N0.7590.17
18_Q25_Y0.7550.17
14_K175_D0.7540.17
174_K252_D0.7540.17
154_F331_G0.7520.17
182_S312_N0.7500.17
31_R74_I0.7450.17
29_L41_N0.7440.17
106_S154_F0.7430.17
9_R82_S0.7420.17
27_L113_L0.7420.17
97_I251_T0.7410.17
236_K290_S0.7410.17
218_G328_R0.7320.17
7_R28_E0.7260.16
163_N167_E0.7240.16
4_E10_E0.7240.16
59_A63_K0.7240.16
210_F264_Q0.7220.16
192_L295_T0.7210.16
294_T299_E0.7210.16
321_N332_L0.7190.16
92_K217_I0.7140.16
144_K239_N0.7130.16
206_T267_T0.7110.16
106_S109_S0.7110.16
7_R10_E0.7110.16
128_A286_G0.7090.16
17_E56_K0.7070.16
117_E242_R0.7060.16
28_E31_R0.7000.16
9_R26_R0.6970.16
296_N300_L0.6960.16
101_G207_H0.6960.16
321_N330_I0.6930.16
249_V341_E0.6930.16
70_L77_L0.6920.16
11_E174_K0.6910.16
6_T224_I0.6910.16
89_P150_D0.6900.16
29_L60_N0.6890.16
44_V56_K0.6840.15
157_P309_D0.6790.15
29_L86_Q0.6790.15
203_Y294_T0.6770.15
64_Y233_D0.6750.15
6_T18_Q0.6740.15
276_N279_D0.6740.15
273_G342_L0.6740.15
158_P213_I0.6720.15
10_E36_A0.6710.15
297_F308_K0.6710.15
6_T144_K0.6700.15
190_G194_E0.6660.15
30_S216_P0.6630.15
54_R69_S0.6620.15
174_K337_K0.6580.15
100_Y122_G0.6580.15
158_P161_I0.6570.15
184_S257_E0.6550.15
104_A185_K0.6530.15
161_I289_Y0.6520.15
91_E98_Y0.6520.15
124_D194_E0.6510.15
150_D270_Y0.6510.15
205_S209_L0.6500.15
63_K337_K0.6490.15
309_D317_I0.6480.15
276_N284_E0.6460.15
153_I250_I0.6440.15
100_Y124_D0.6440.15
57_W60_N0.6440.15
158_P203_Y0.6440.15
253_V303_I0.6430.14
239_N340_E0.6420.14
126_S206_T0.6410.14
295_T299_E0.6400.14
153_I248_P0.6390.14
109_S252_D0.6380.14
28_E32_K0.6380.14
9_R49_R0.6380.14
260_M264_Q0.6370.14
32_K67_P0.6370.14
88_N259_A0.6370.14
108_V153_I0.6360.14
178_V267_T0.6360.14
79_F82_S0.6350.14
18_Q182_S0.6340.14
196_S316_E0.6340.14
39_N52_K0.6330.14
295_T306_R0.6330.14
45_T307_V0.6300.14
222_V327_V0.6290.14
157_P317_I0.6280.14
223_I280_T0.6280.14
75_L79_F0.6280.14
95_V230_S0.6280.14
190_G239_N0.6270.14
209_L316_E0.6260.14
180_D268_H0.6260.14
295_T309_D0.6200.14
83_K289_Y0.6190.14
253_V297_F0.6150.14
202_R281_L0.6140.14
99_G211_G0.6140.14
211_G256_H0.6140.14
10_E44_V0.6120.14
235_M285_L0.6110.14
219_E224_I0.6100.14
35_K39_N0.6100.14
336_K341_E0.6050.14
43_S58_I0.6050.14
264_Q306_R0.6020.14
267_T303_I0.6010.14
10_E154_F0.6000.14
204_I335_L0.6000.14
143_L174_K0.5990.14
28_E162_L0.5990.14
166_D191_F0.5980.14
279_D284_E0.5960.13
68_N76_P0.5950.13
30_S60_N0.5940.13
182_S303_I0.5930.13
159_S312_N0.5910.13
95_V282_S0.5900.13
204_I237_V0.5900.13
155_A321_N0.5880.13
78_I82_S0.5870.13
81_Y218_G0.5860.13
267_T295_T0.5860.13
157_P311_K0.5850.13
97_I103_M0.5840.13
164_N292_F0.5840.13
105_K153_I0.5840.13
73_S77_L0.5820.13
148_W258_K0.5820.13
196_S203_Y0.5800.13
11_E32_K0.5800.13
177_I282_S0.5790.13
18_Q66_I0.5780.13
112_S252_D0.5780.13
34_G96_V0.5750.13
48_N242_R0.5740.13
19_L331_G0.5730.13
171_K202_R0.5720.13
105_K166_D0.5720.13
222_V273_G0.5710.13
24_S66_I0.5710.13
7_R14_K0.5690.13
52_K78_I0.5690.13
48_N263_V0.5690.13
297_F301_N0.5680.13
179_M335_L0.5670.13
15_V325_Y0.5660.13
34_G75_L0.5650.13
201_F305_K0.5650.13
44_V55_E0.5640.13
97_I184_S0.5640.13
264_Q267_T0.5630.13
274_L331_G0.5620.13
30_S102_G0.5610.13
155_A331_G0.5610.13
124_D254_E0.5600.13
22_L36_A0.5560.13
105_K170_S0.5550.13
61_A314_I0.5550.13
28_E42_I0.5530.13
15_V27_L0.5520.13
281_L320_Q0.5520.13
94_R159_S0.5510.13
108_V119_S0.5500.13
122_G204_I0.5500.13
162_L258_K0.5490.12
178_V201_F0.5490.12
7_R40_S0.5480.12
192_L296_N0.5470.12
280_T291_N0.5470.12
97_I222_V0.5460.12
162_L191_F0.5450.12
24_S279_D0.5420.12
16_D49_R0.5400.12
71_V218_G0.5390.12
121_T142_L0.5380.12
212_P264_Q0.5370.12
10_E56_K0.5370.12
21_K340_E0.5370.12
151_I319_N0.5360.12
14_K162_L0.5350.12
53_V328_R0.5340.12
15_V22_L0.5330.12
144_K163_N0.5310.12
156_I260_M0.5310.12
10_E25_Y0.5300.12
7_R35_K0.5300.12
18_Q63_K0.5300.12
180_D183_S0.5290.12
192_L297_F0.5290.12
165_S253_V0.5290.12
234_V277_A0.5290.12
244_S303_I0.5270.12
164_N332_L0.5250.12
113_L328_R0.5240.12
26_R157_P0.5230.12
123_R266_L0.5210.12
102_G153_I0.5200.12
178_V192_L0.5180.12
24_S56_K0.5180.12
243_K261_A0.5180.12
84_L232_D0.5140.12
110_I334_E0.5120.12
297_F300_L0.5120.12
151_I204_I0.5120.12
205_S271_L0.5110.12
48_N52_K0.5100.12
123_R160_A0.5090.12
18_Q258_K0.5090.12
216_P246_L0.5040.12
4_E17_E0.5040.12
41_N95_V0.5020.12
21_K67_P0.5020.12
36_A48_N0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pv7A 2 0.6908 100 0.631 Contact Map
3b1fA 2 0.7254 100 0.667 Contact Map
3ktdA 2 0.711 100 0.673 Contact Map
3ggoA 2 0.7283 100 0.682 Contact Map
2g5cA 2 0.7139 100 0.683 Contact Map
4wjiA 2 0.7283 100 0.687 Contact Map
2f1kA 2 0.7052 100 0.706 Contact Map
4kqwA 2 0.7514 99.9 0.78 Contact Map
4xdzA 2 0.7514 99.9 0.783 Contact Map
3triA 2 0.7081 99.9 0.786 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.