Q980J1 - SULSO - GREMLIN Contacts

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Q980J1 - Chorismate mutase/prephenate dehydratase, putative (TyrA)

UniProt:	Q980J1	Sequences: MTEEITRLREEIDKVDEQLVKLLSYRLELSRKIGKAKSNSNISVTDENREMKVREKWIANAKKYNIPNSLVESILPLIFSYSKLVQINPGEKERVVIYGYGGMAKSIVSILSLAGHEVSITGRDLSKAEMLANQFKCVSMSLLKAIDWGDIIIFAIPPSAILNNSDELFSKALKDKIVMDISSSKFKIFGFLEELSRKLEFRYISTHPLFGPIEYPIGERVVIIPSKTSSNDDVMKVENFWRKSGLVPVITDVETHEKAMAIVQVLTHYYLLGLSNAIDTLSLELGVDYSNFHTTNFRELNKILKRVKDLKNVITEIQNQNPYSYKVRNIGLEELKKIKEELEGGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	346 (321)
Sequences:	280 (180)
Seq/√Len:	10.0

ECOLI - TYRA
SULSO - Q980J1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
179_M	204_I	6.701	1.00
219_E	227_K	4.514	1.00
329_N	343_E	4.421	0.99
95_V	111_L	3.649	0.98
30_S	266_L	3.648	0.98
219_E	228_T	3.446	0.97
94_R	119_S	3.444	0.97
332_L	336_K	3.298	0.96
74_I	78_I	3.275	0.96
20_V	64_Y	3.094	0.94
220_R	227_K	3.025	0.93
86_Q	328_R	2.961	0.92
222_V	241_W	2.951	0.92
281_L	330_I	2.782	0.90
97_I	108_V	2.585	0.86
252_D	255_T	2.476	0.83
15_V	29_L	2.437	0.82
220_R	228_T	2.418	0.82
125_L	255_T	2.411	0.81
30_S	86_Q	2.278	0.77
261_A	321_N	2.233	0.76
219_E	226_S	2.177	0.74
189_F	253_V	2.077	0.70
165_S	192_L	2.070	0.70
103_M	277_A	2.061	0.70
111_L	283_L	2.059	0.70
119_S	148_W	2.019	0.68
150_D	175_D	2.007	0.67
72_E	76_P	2.005	0.67
8_L	36_A	1.999	0.67
167_E	194_E	1.990	0.67
19_L	29_L	1.981	0.66
178_V	297_F	1.972	0.66
18_Q	21_K	1.939	0.65
14_K	28_E	1.878	0.62
162_L	285_L	1.867	0.62
297_F	303_I	1.865	0.62
67_P	216_P	1.852	0.61
92_K	150_D	1.810	0.59
251_T	292_F	1.810	0.59
338_I	342_L	1.762	0.57
87_I	155_A	1.758	0.57
108_V	120_I	1.741	0.56
209_L	313_V	1.713	0.55
262_I	327_V	1.675	0.53
180_D	208_P	1.674	0.53
58_I	69_S	1.664	0.52
38_S	335_L	1.660	0.52
86_Q	265_V	1.659	0.52
296_N	303_I	1.658	0.52
86_Q	113_L	1.656	0.52
23_L	78_I	1.630	0.51
87_I	90_G	1.627	0.51
151_I	177_I	1.620	0.50
86_Q	266_L	1.612	0.50
173_L	176_K	1.588	0.49
103_M	266_L	1.579	0.49
219_E	225_P	1.575	0.48
330_I	334_E	1.562	0.48
46_D	55_E	1.558	0.48
97_I	153_I	1.557	0.48
193_E	228_T	1.534	0.47
61_A	72_E	1.519	0.46
30_S	53_V	1.513	0.46
72_E	75_L	1.507	0.45
226_S	234_V	1.505	0.45
7_R	63_K	1.504	0.45
95_V	106_S	1.494	0.45
15_V	113_L	1.476	0.44
9_R	37_K	1.461	0.43
143_L	170_S	1.450	0.43
95_V	222_V	1.446	0.43
225_P	228_T	1.411	0.41
27_L	30_S	1.399	0.40
78_I	343_E	1.386	0.40
6_T	28_E	1.379	0.40
111_L	241_W	1.378	0.40
207_H	211_G	1.375	0.39
182_S	297_F	1.372	0.39
229_S	233_D	1.368	0.39
220_R	225_P	1.364	0.39
171_K	176_K	1.364	0.39
87_I	95_V	1.353	0.38
128_A	144_K	1.342	0.38
214_E	217_I	1.339	0.38
39_N	59_A	1.339	0.38
151_I	179_M	1.333	0.38
182_S	259_A	1.328	0.37
74_I	292_F	1.319	0.37
217_I	320_Q	1.318	0.37
24_S	35_K	1.316	0.37
188_I	297_F	1.310	0.37
107_I	154_F	1.299	0.36
169_F	331_G	1.281	0.35
163_N	194_E	1.277	0.35
185_K	208_P	1.275	0.35
192_L	205_S	1.269	0.35
261_A	266_L	1.266	0.35
107_I	181_I	1.253	0.34
77_L	83_K	1.244	0.34
27_L	86_Q	1.235	0.33
46_D	52_K	1.231	0.33
114_A	240_F	1.229	0.33
103_M	182_S	1.226	0.33
181_I	248_P	1.220	0.33
143_L	167_E	1.217	0.33
20_V	155_A	1.203	0.32
7_R	15_V	1.189	0.32
280_T	337_K	1.186	0.31
281_L	334_E	1.179	0.31
25_Y	66_I	1.163	0.31
32_K	40_S	1.156	0.30
39_N	252_D	1.156	0.30
11_E	39_N	1.153	0.30
263_V	292_F	1.139	0.30
111_L	153_I	1.139	0.30
38_S	321_N	1.130	0.29
241_W	335_L	1.127	0.29
62_K	71_V	1.127	0.29
20_V	108_V	1.121	0.29
267_T	297_F	1.121	0.29
94_R	151_I	1.119	0.29
6_T	23_L	1.113	0.29
246_L	310_L	1.105	0.28
99_G	256_H	1.102	0.28
40_S	44_V	1.095	0.28
34_G	79_F	1.095	0.28
294_T	313_V	1.093	0.28
17_E	60_N	1.092	0.28
226_S	250_I	1.088	0.28
153_I	179_M	1.088	0.28
178_V	303_I	1.085	0.28
20_V	30_S	1.084	0.28
58_I	72_E	1.082	0.28
203_Y	314_I	1.081	0.27
293_H	300_L	1.075	0.27
9_R	50_E	1.073	0.27
204_I	234_V	1.069	0.27
33_I	237_V	1.068	0.27
283_L	331_G	1.068	0.27
14_K	59_A	1.063	0.27
224_I	248_P	1.060	0.27
266_L	321_N	1.060	0.27
103_M	153_I	1.058	0.27
275_S	295_T	1.042	0.26
177_I	204_I	1.040	0.26
26_R	50_E	1.040	0.26
111_L	238_E	1.039	0.26
103_M	327_V	1.038	0.26
321_N	331_G	1.034	0.26
105_K	280_T	1.027	0.26
20_V	24_S	1.026	0.26
14_K	25_Y	1.023	0.25
180_D	245_G	1.022	0.25
37_K	50_E	1.013	0.25
19_L	74_I	1.013	0.25
18_Q	262_I	1.009	0.25
185_K	268_H	1.001	0.25
179_M	237_V	1.000	0.25
20_V	97_I	1.000	0.25
37_K	49_R	0.978	0.24
178_V	300_L	0.970	0.24
183_S	208_P	0.969	0.24
216_P	265_V	0.964	0.23
30_S	113_L	0.963	0.23
249_V	261_A	0.962	0.23
192_L	309_D	0.962	0.23
165_S	315_T	0.956	0.23
30_S	265_V	0.956	0.23
275_S	308_K	0.953	0.23
27_L	328_R	0.952	0.23
330_I	336_K	0.950	0.23
95_V	223_I	0.949	0.23
6_T	14_K	0.949	0.23
178_V	253_V	0.943	0.23
267_T	300_L	0.941	0.23
99_G	207_H	0.939	0.23
207_H	256_H	0.939	0.23
262_I	271_L	0.933	0.22
53_V	86_Q	0.932	0.22
66_I	113_L	0.930	0.22
206_T	293_H	0.926	0.22
54_R	60_N	0.925	0.22
265_V	328_R	0.925	0.22
205_S	309_D	0.923	0.22
104_A	257_E	0.918	0.22
25_Y	95_V	0.914	0.22
98_Y	154_F	0.909	0.22
196_S	201_F	0.909	0.22
240_F	294_T	0.905	0.22
156_I	178_V	0.901	0.21
75_L	81_Y	0.900	0.21
4_E	329_N	0.899	0.21
241_W	327_V	0.898	0.21
117_E	333_E	0.891	0.21
300_L	309_D	0.889	0.21
295_T	307_V	0.888	0.21
37_K	82_S	0.885	0.21
16_D	82_S	0.884	0.21
264_Q	294_T	0.881	0.21
188_I	303_I	0.881	0.21
158_P	314_I	0.876	0.21
48_N	56_K	0.874	0.21
192_L	267_T	0.874	0.21
277_A	334_E	0.873	0.21
196_S	272_L	0.872	0.21
201_F	295_T	0.868	0.20
101_G	256_H	0.866	0.20
293_H	309_D	0.863	0.20
25_Y	62_K	0.857	0.20
6_T	10_E	0.852	0.20
274_L	304_L	0.850	0.20
38_S	261_A	0.850	0.20
265_V	321_N	0.850	0.20
13_D	49_R	0.846	0.20
261_A	324_S	0.846	0.20
223_I	337_K	0.844	0.20
212_P	314_I	0.841	0.20
259_A	329_N	0.838	0.20
121_T	145_A	0.837	0.19
203_Y	313_V	0.835	0.19
63_K	166_D	0.834	0.19
176_K	281_L	0.834	0.19
111_L	163_N	0.831	0.19
164_N	310_L	0.827	0.19
176_K	331_G	0.827	0.19
160_A	282_S	0.825	0.19
116_H	240_F	0.823	0.19
178_V	309_D	0.820	0.19
245_G	264_Q	0.819	0.19
206_T	307_V	0.813	0.19
144_K	177_I	0.805	0.19
39_N	239_N	0.804	0.19
74_I	328_R	0.804	0.19
263_V	335_L	0.802	0.18
14_K	18_Q	0.802	0.18
76_P	80_S	0.799	0.18
19_L	285_L	0.796	0.18
120_I	254_E	0.795	0.18
15_V	46_D	0.794	0.18
216_P	302_K	0.791	0.18
51_M	60_N	0.789	0.18
177_I	186_F	0.789	0.18
11_E	162_L	0.785	0.18
116_H	246_L	0.783	0.18
98_Y	124_D	0.779	0.18
128_A	146_I	0.779	0.18
189_F	225_P	0.778	0.18
126_S	269_Y	0.778	0.18
77_L	81_Y	0.776	0.18
60_N	86_Q	0.776	0.18
180_D	185_K	0.775	0.18
271_L	283_L	0.774	0.18
155_A	276_N	0.773	0.18
267_T	296_N	0.772	0.18
14_K	48_N	0.765	0.17
53_V	102_G	0.763	0.17
162_L	166_D	0.763	0.17
16_D	26_R	0.762	0.17
17_E	342_L	0.760	0.17
14_K	32_K	0.759	0.17
10_E	48_N	0.759	0.17
18_Q	25_Y	0.755	0.17
14_K	175_D	0.754	0.17
174_K	252_D	0.754	0.17
154_F	331_G	0.752	0.17
182_S	312_N	0.750	0.17
31_R	74_I	0.745	0.17
29_L	41_N	0.744	0.17
106_S	154_F	0.743	0.17
9_R	82_S	0.742	0.17
27_L	113_L	0.742	0.17
97_I	251_T	0.741	0.17
236_K	290_S	0.741	0.17
218_G	328_R	0.732	0.17
7_R	28_E	0.726	0.16
163_N	167_E	0.724	0.16
4_E	10_E	0.724	0.16
59_A	63_K	0.724	0.16
210_F	264_Q	0.722	0.16
192_L	295_T	0.721	0.16
294_T	299_E	0.721	0.16
321_N	332_L	0.719	0.16
92_K	217_I	0.714	0.16
144_K	239_N	0.713	0.16
206_T	267_T	0.711	0.16
106_S	109_S	0.711	0.16
7_R	10_E	0.711	0.16
128_A	286_G	0.709	0.16
17_E	56_K	0.707	0.16
117_E	242_R	0.706	0.16
28_E	31_R	0.700	0.16
9_R	26_R	0.697	0.16
296_N	300_L	0.696	0.16
101_G	207_H	0.696	0.16
321_N	330_I	0.693	0.16
249_V	341_E	0.693	0.16
70_L	77_L	0.692	0.16
11_E	174_K	0.691	0.16
6_T	224_I	0.691	0.16
89_P	150_D	0.690	0.16
29_L	60_N	0.689	0.16
44_V	56_K	0.684	0.15
157_P	309_D	0.679	0.15
29_L	86_Q	0.679	0.15
203_Y	294_T	0.677	0.15
64_Y	233_D	0.675	0.15
6_T	18_Q	0.674	0.15
276_N	279_D	0.674	0.15
273_G	342_L	0.674	0.15
158_P	213_I	0.672	0.15
10_E	36_A	0.671	0.15
297_F	308_K	0.671	0.15
6_T	144_K	0.670	0.15
190_G	194_E	0.666	0.15
30_S	216_P	0.663	0.15
54_R	69_S	0.662	0.15
174_K	337_K	0.658	0.15
100_Y	122_G	0.658	0.15
158_P	161_I	0.657	0.15
184_S	257_E	0.655	0.15
104_A	185_K	0.653	0.15
161_I	289_Y	0.652	0.15
91_E	98_Y	0.652	0.15
124_D	194_E	0.651	0.15
150_D	270_Y	0.651	0.15
205_S	209_L	0.650	0.15
63_K	337_K	0.649	0.15
309_D	317_I	0.648	0.15
276_N	284_E	0.646	0.15
153_I	250_I	0.644	0.15
100_Y	124_D	0.644	0.15
57_W	60_N	0.644	0.15
158_P	203_Y	0.644	0.15
253_V	303_I	0.643	0.14
239_N	340_E	0.642	0.14
126_S	206_T	0.641	0.14
295_T	299_E	0.640	0.14
153_I	248_P	0.639	0.14
109_S	252_D	0.638	0.14
28_E	32_K	0.638	0.14
9_R	49_R	0.638	0.14
260_M	264_Q	0.637	0.14
32_K	67_P	0.637	0.14
88_N	259_A	0.637	0.14
108_V	153_I	0.636	0.14
178_V	267_T	0.636	0.14
79_F	82_S	0.635	0.14
18_Q	182_S	0.634	0.14
196_S	316_E	0.634	0.14
39_N	52_K	0.633	0.14
295_T	306_R	0.633	0.14
45_T	307_V	0.630	0.14
222_V	327_V	0.629	0.14
157_P	317_I	0.628	0.14
223_I	280_T	0.628	0.14
75_L	79_F	0.628	0.14
95_V	230_S	0.628	0.14
190_G	239_N	0.627	0.14
209_L	316_E	0.626	0.14
180_D	268_H	0.626	0.14
295_T	309_D	0.620	0.14
83_K	289_Y	0.619	0.14
253_V	297_F	0.615	0.14
202_R	281_L	0.614	0.14
99_G	211_G	0.614	0.14
211_G	256_H	0.614	0.14
10_E	44_V	0.612	0.14
235_M	285_L	0.611	0.14
219_E	224_I	0.610	0.14
35_K	39_N	0.610	0.14
336_K	341_E	0.605	0.14
43_S	58_I	0.605	0.14
264_Q	306_R	0.602	0.14
267_T	303_I	0.601	0.14
10_E	154_F	0.600	0.14
204_I	335_L	0.600	0.14
143_L	174_K	0.599	0.14
28_E	162_L	0.599	0.14
166_D	191_F	0.598	0.14
279_D	284_E	0.596	0.13
68_N	76_P	0.595	0.13
30_S	60_N	0.594	0.13
182_S	303_I	0.593	0.13
159_S	312_N	0.591	0.13
95_V	282_S	0.590	0.13
204_I	237_V	0.590	0.13
155_A	321_N	0.588	0.13
78_I	82_S	0.587	0.13
81_Y	218_G	0.586	0.13
267_T	295_T	0.586	0.13
157_P	311_K	0.585	0.13
97_I	103_M	0.584	0.13
164_N	292_F	0.584	0.13
105_K	153_I	0.584	0.13
73_S	77_L	0.582	0.13
148_W	258_K	0.582	0.13
196_S	203_Y	0.580	0.13
11_E	32_K	0.580	0.13
177_I	282_S	0.579	0.13
18_Q	66_I	0.578	0.13
112_S	252_D	0.578	0.13
34_G	96_V	0.575	0.13
48_N	242_R	0.574	0.13
19_L	331_G	0.573	0.13
171_K	202_R	0.572	0.13
105_K	166_D	0.572	0.13
222_V	273_G	0.571	0.13
24_S	66_I	0.571	0.13
7_R	14_K	0.569	0.13
52_K	78_I	0.569	0.13
48_N	263_V	0.569	0.13
297_F	301_N	0.568	0.13
179_M	335_L	0.567	0.13
15_V	325_Y	0.566	0.13
34_G	75_L	0.565	0.13
201_F	305_K	0.565	0.13
44_V	55_E	0.564	0.13
97_I	184_S	0.564	0.13
264_Q	267_T	0.563	0.13
274_L	331_G	0.562	0.13
30_S	102_G	0.561	0.13
155_A	331_G	0.561	0.13
124_D	254_E	0.560	0.13
22_L	36_A	0.556	0.13
105_K	170_S	0.555	0.13
61_A	314_I	0.555	0.13
28_E	42_I	0.553	0.13
15_V	27_L	0.552	0.13
281_L	320_Q	0.552	0.13
94_R	159_S	0.551	0.13
108_V	119_S	0.550	0.13
122_G	204_I	0.550	0.13
162_L	258_K	0.549	0.12
178_V	201_F	0.549	0.12
7_R	40_S	0.548	0.12
192_L	296_N	0.547	0.12
280_T	291_N	0.547	0.12
97_I	222_V	0.546	0.12
162_L	191_F	0.545	0.12
24_S	279_D	0.542	0.12
16_D	49_R	0.540	0.12
71_V	218_G	0.539	0.12
121_T	142_L	0.538	0.12
212_P	264_Q	0.537	0.12
10_E	56_K	0.537	0.12
21_K	340_E	0.537	0.12
151_I	319_N	0.536	0.12
14_K	162_L	0.535	0.12
53_V	328_R	0.534	0.12
15_V	22_L	0.533	0.12
144_K	163_N	0.531	0.12
156_I	260_M	0.531	0.12
10_E	25_Y	0.530	0.12
7_R	35_K	0.530	0.12
18_Q	63_K	0.530	0.12
180_D	183_S	0.529	0.12
192_L	297_F	0.529	0.12
165_S	253_V	0.529	0.12
234_V	277_A	0.529	0.12
244_S	303_I	0.527	0.12
164_N	332_L	0.525	0.12
113_L	328_R	0.524	0.12
26_R	157_P	0.523	0.12
123_R	266_L	0.521	0.12
102_G	153_I	0.520	0.12
178_V	192_L	0.518	0.12
24_S	56_K	0.518	0.12
243_K	261_A	0.518	0.12
84_L	232_D	0.514	0.12
110_I	334_E	0.512	0.12
297_F	300_L	0.512	0.12
151_I	204_I	0.512	0.12
205_S	271_L	0.511	0.12
48_N	52_K	0.510	0.12
123_R	160_A	0.509	0.12
18_Q	258_K	0.509	0.12
216_P	246_L	0.504	0.12
4_E	17_E	0.504	0.12
41_N	95_V	0.502	0.12
21_K	67_P	0.502	0.12
36_A	48_N	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2pv7A	2	0.6908	100	0.631	Contact Map
3b1fA	2	0.7254	100	0.667	Contact Map
3ktdA	2	0.711	100	0.673	Contact Map
3ggoA	2	0.7283	100	0.682	Contact Map
2g5cA	2	0.7139	100	0.683	Contact Map
4wjiA	2	0.7283	100	0.687	Contact Map
2f1kA	2	0.7052	100	0.706	Contact Map
4kqwA	2	0.7514	99.9	0.78	Contact Map
4xdzA	2	0.7514	99.9	0.783	Contact Map
3triA	2	0.7081	99.9	0.786	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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